Clinical trials: Neuromuscular Adaptations
Genetic Disease, Communication
The Role of Family Functioning in Promoting Adaptation in Siblings of Individuals With Duchenne Muscular Dystrophy (DMD)
Background: We want to learn more about the relationship between the way families function and how children adapt to having a sibling with Duchenne muscular dystrophy (DMD).
- Trial name
- NCT01386515
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Energy Expenditure, Atrophy, Muscular
Energy Balance in Extreme Environments: Finding the EI Limit
This project is feasibility study looking at extreme exercise and possible diet intervention study to counter muscle and weight loss during a 2 person Greenland Ski Traverse in April 2023.
- Conditions
- Energy Expenditure, Atrophy, Muscular, Energy Intake
- Trial name
- StOMPE (NCT05773469)
- Testing
- Exercise, Nutrition
- Where
- United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Neuromuscular Adaptations
Specific Neurotechnical Strength Training (NeuroTraining)
This study aims to apply a novel study methodology using high density electromyography (HDEMG) to know what are the mechanisms underlying the structural and functional changes obtained by two different training methods, commonly…
- Trial name
- NCT04286022
- Testing
- Speed Loss 20% Strength Training, Reduced Rest Time Strength Training
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Malaga
AChR-Ab Seropositive Generalized Myasthenia Gravis, Myasthenia Gravis (MG)
ADAPT Forward 2 - ISA2 - a Study to Evaluate the Safety, Tolerability and Efficacy of Empasiprubart IV Monotherapy in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis
This study is part of the ADAPT Forward platform study (NCT07294170). ADAPT Forward is a platform study with the aim to look at how safe different drugs are and how well they work for people with myasthenia gravis.
- Conditions
- AChR-Ab Seropositive Generalized Myasthenia Gravis, Myasthenia Gravis (MG), MG - Myasthenia Gravis, gMG
- Trial name
- ADAPT Forward2 (NCT07673627)
- Testing
- Empasiprubart IV, Efgartigimod PH20 SC PFS
- Where
- 8 sites in United States, Greece and 1 more
- Volunteers
- 40 people
- Sponsor
- argenx
Muscle Adaptation, Body Composition
Creatine and Muscle Health in Madrid's Walking Footballers.
Healthy aging requires effective, accessible, and sustainable interventions capable of preserving functional capacity and preventing age-related decline.
- Conditions
- Muscle Adaptation, Body Composition, Physical Activity in Adults
- Trial name
- MyoCreaWalk (NCT07891936)
- Testing
- Monohydrate Creatine supplementation during Walking Football training
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Amyotrophic Lateral Sclerosis (ALS)
"New Perspectives of Adaptation to NIV in ALS"
The purpose of this study is to demonstrate that the adaptation to the Non Invasive Ventilation (NIV) at home is not worse when compared with an adaptation performed in inpatient settings.
- Trial name
- NCT02537132
- Testing
- Adaptation and training to Non Invasive Ventilation (NIV)
- Where
- 2 sites in Italy
- Volunteers
- 48 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Total Knee Arthroplasty (TKA)
Total Knee Arthroplasty Biomechanics
In total knee arthroplasty (TKA), the relationship between implant design, soft tissue balance, neuromuscular contributions, and rehabilitation strategies on patient satisfaction and functional outcomes is highly complex and…
- Trial name
- NCT03671954
- Testing
- Home Strengthening Exercises, Standard Physical Therapy, Preoperative Assessments
- Where
- 4 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Florida
Hypertrophy
Neuromuscular Characteristics of Strict Vegetarians and Non-Vegetarians Women
A strict vegetarian diet includes only foods of plant-based origin and, despite being able to meet the nutritional needs of individuals of different ages, when correctly planned, it commonly offers a lower protein intake than a…
- Trial name
- NCT05576337
- Testing
- 16 weeks of strength training protocol
- Where
- Brazil
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Spinal Cord Injury(SCI)
The Reversal of Neuromuscular Adaptation in Human With Spinal Cord Injury II
Following injury to the spinal cord, the spinal circuit undergoes a series of adaptations. In parallel with the spinal circuit adaptation, the muscular properties also adapt.
- Trial name
- NCT01968096
- Testing
- home-based ankle continuous passive motion machine.
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Athletic Performance, Neuromuscular Adaptations
Squat Jump Performance and Chiropractic Ankle Manipulation
The goal of this clinical trial is to learn if chiropractic ankle manipulation can improve squat jump performance. It will also learn about the relationship among chiropractic ankle manipulation, ankle range of motion, and squat…
- Conditions
- Athletic Performance, Neuromuscular Adaptations, Lower Limb, Chiropractic Manipulation
- Trial name
- NCT07641621
- Testing
- Manual Therapy Procedure: Chiropractic Ankle Manipulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northeast College of Health Sciences
Complex Regional Pain Syndrome I (CRPS I), Distal Radius Fracture
Prism Adaptation Therapy for CRPS Type 1
Complex Regional Pain Syndrome (CRPS) is a clinical condition characterized by pain that arises either without an identifiable triggering factor or with a severity disproportionate to the initiating event.
- Conditions
- Complex Regional Pain Syndrome I (CRPS I), Distal Radius Fracture, CRPS (Complex Regional Pain Syndromes), Neuropathic Pain
- Trial name
- NCT07370012
- Testing
- The Prism Adaptation Therapy Group, The Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Ankara Etlik City Hospital
Postural Stability
Neuromuscular Training & Postural Stability
Background: Postural stability (PS) is a vital function that helps maintain equilibrium during standing still, locomotion, and any activities requiring high balance performance.
- Trial name
- STABLEFIT (NCT06294002)
- Testing
- Dynamic neuromuscular stabilisation group, Whole body vibration group, Dynamic neuromuscular stabilisation with whole body vibration group
- Where
- Serbia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Novi Sad
Exercise Training, Skeletal Muscle
Resistance Training, Detraining, and Retraining Study 2022
The research project is aiming to examine the muscular adaptations to resistance training (RT), detraining (DT) and repeated RT (i.e. retraining).
- Conditions
- Exercise Training, Skeletal Muscle, Skeletal Muscle Atrophy
- Trial name
- TraDeRe2022 (NCT05553769)
- Testing
- Resistance training, detraining, retraining
- Where
- Finland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Jyvaskyla
Spinal Cord Injury(SCI)
Effects of Continuous Passive Motion on the Spinal Circuitries and Its Adaptation in Patients With Spasticity Resulting From Upper Motor Neuron Lesions
In animal and human studies, histochemical and physiological evidences showed that the muscle transferred from slow, fatigue-resistant muscle to fast, fatigable muscle after spinal cord injury.
- Trial name
- NCT02122276
- Testing
- Ankle continuous passive motion machine.
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- Chang Gung University
Healthy
Enhancing Strength Gains With the Power of the Mind
The goal of this clinical trial is to determine the effect of maximal mental effort combined with elastic band training on strength and neuromuscular function in healthy, older females.
- Trial name
- NCT06099678
- Testing
- Elastic Band Training, Elastic Band Training with Maximal Mental Effort
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kennesaw State University
Electrical Stimulation
Neuromuscular Adaptations After Training in the Muscle Belly of Triceps Surae
This study aims to evaluate on an acute session of the central and peripheral contributions of electrical stimulation on the muscle belly of the triceps surae, electrical stimulation of the tibial nerve and voluntary exercise of…
- Trial name
- NCT03905772
- Testing
- Voluntary exercise, Wide pulse responder group, Wide pulse non responder group
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Amyotrophic Lateral Sclerosis, Psychological Stress
Psychological Therapy for Patients With ALS
Amyotrophic lateral sclerosis (ALS) is a disease that is inevitably fatal. To be diagnosed with a terminal illness such as ALS deeply affects one's personal existence and goes along with significant changes regarding the…
- Trial name
- NCT03975608
- Testing
- Adaptation of "CALM"
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- University of Leipzig
Chronic Fatigue Syndrome
Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue
Chronic fatigue is enhanced by adapted physical activity (APA) programs. Patients consulting on St Etienne hospital and suffering from fibromyalgia and long Covid benefit from a 4-6 week APA program, with 2 sessions per week.
- Trial name
- PAF-tVNS (NCT06170645)
- Testing
- APA program, Active transcutaneous VNS
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sarcopenia
Pilates and PNF Methods Induces Similar Strength Gains
To compare the influence of a training program with Pilates and PNF methods to elderly women on the strength gains and motor control during voluntary contractions
- Trial name
- NCT02274909
- Testing
- TRAINING PROGRAM
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual do PiauÍ
Postpartum, Neuromuscular Adaptations
Postpartum Exercise Intervention
The postpartum period is associated with decreases in physical activity levels, muscular strength, muscular endurance, and pelvic floor muscle function, but little scientific evidence exists on how best to initiate and progress…
- Conditions
- Postpartum, Neuromuscular Adaptations, Abdominal Muscles, Pelvic Floor Dysfunctions
- Trial name
- NCT07613333
- Testing
- Progressive exercise, Active Straight Leg Raise Test, Active Straight Leg Raise Fatigue Task
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Carroll University