Neuromuscular AdaptationsNCT04286022
Specific Neurotechnical Strength Training (NeuroTraining)
A study testing Speed Loss 20% Strength Training and Reduced Rest Time Strength Training in people with Neuromuscular Adaptations, run by University of Malaga at 1 site in Spain.
Trial summary
This study aims to apply a novel study methodology using high density electromyography (HDEMG) to know what are the mechanisms underlying the structural and functional changes obtained by two different training methods, commonly used, facilitating their understanding, study and subsequent application according to… Read more about this study
- Who is it for?
- Ages 18 to 35 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Neuromuscular Adaptations
- What is being tested?
- Speed Loss 20% Strength Training and Reduced Rest Time Strength Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 34 participants
- Where
- 1 siteSpain
- Study dates
- 1 Jan 2023to 31 Oct 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- 18-35 years
- men
Who cannot join
- physical exercise that involves work of upper limbs during the time of the intervention
- upper limb injury during the previous 12 months
- systemic diseases
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Specific Neurotechnical Strength Training: Randomized Controlled Trial (NeuroTraining)
This study aims to apply a novel study methodology using high density electromyography (HDEMG) to know what are the mechanisms underlying the structural and functional changes obtained by two different training methods, commonly used, facilitating their understanding, study and subsequent application according to specific needs.
Read the detailed description
Different training methodologies have previously shown similar results in the improvement of structural or functional characteristics such as hypertrophy or strength. However, the different nature of their methods has suggested for years the possibility that different neuromuscular mechanisms could be behind these observed characteristics.
The development of a new technology, such as high-density electromyography (HDEMG), capable of studying new properties previously hidden from assessment methods, such as the speed of nerve impulse propagation or the frequency of motor unit discharge, has allowed a more thorough study of the mechanisms.
This study aims to apply this new study methodology to know what are the mechanisms underlying the changes at the structural and functional level obtained by two different training methods, commonly used, facilitating their understanding, study and subsequent application according to specific needs.
For this reason, the main hypothesis is the generation of different neuromuscular mechanisms and adaptations by executing, for 4 weeks, two different training methodologies, obtaining a dissociation between the results obtained at the structural level (hypertrophy), functional (generation of strength) and HDEMG analysis of the central and peripheral characteristics of the neuromuscular system in each of the programs studied.
- Conditions
- Neuromuscular Adaptations
- Being tested
- Speed Loss 20% Strength Training, Reduced Rest Time Strength Training
- Keywords
- Strength training, Neuromuscular adaptation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Speed Loss 20% Strength TrainingOther
Strength training based on the control of speed loss in execution.
Reduced Rest Time Strength TrainingOther
Strength training based on a protocol that includes reduced rest times between sets.
| Study group | Role | What they receive |
|---|---|---|
| Speed Loss 20% Group | Experimental | The SL20% group will carry out a program based on the limitation of the speed loss, allowing to perform the exercise only until a speed loss of 20% is achieved, following a similar methodology previously published (Pareja-Blanco et al., 2017). The program will consist of a job for 4 weeks, with a frequency of 2 sessions a week. In each session, a 6-series routine with an open number of repetitions will be carried out twice, allowing as many repetitions as possible to perform until a 20% loss of execution speed is reached. The intensity of work will be 70% 1RM, resting 4 minutes between sets. As an only exercise, an elbow flexion (bicep curl) with dumbbell will be performed. Receives: Other: Speed Loss 20% Strength Training |
| Reduced Rest Time Group | Experimental | The RRT group will carry out a program based on the reduction of rest time between series, following a previously published methodology (Stragier et al., 2019). The program will consist of a job for 4 weeks, with a frequency of 2 sessions a week. In each session, a 5 series routine with progressive repetition volume (3 to 7) at 70% 1RM will be performed twice, resting 15 seconds between sets and 150 seconds between each of the 2 blocks. The exercise to be performed will be an elbow flexion (bicep curl) with dumbbell. Receives: Other: Reduced Rest Time Strength Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change from Baseline Mean Discharge Rate of Brachialis Biceps Motor Units at 4 weeks
The mean discharge rate of the Brachialis Biceps motor units will be evaluated using a high density electromyography device (HDEMG). For this, the signal produced during isometric contractions at different submaximal force levels (10, 30, 50, and 70%) will be recorded, using an external analog to digital signal converter Sessantaquattro (64-channel EMG amplifier; OT Bioelettronica, Turin, Italy).
Measured: Baseline and post-intervention (4 weeks after baseline)
Secondary outcomes (5)
Speed of propagation of Brachialis Biceps Motor Units
As a measure of evaluation of the peripheral characteristics of the neuromuscular system, the propagation speed of the action potentials produced by an HDEMG device will be evaluated. For this, the signal produced during isometric contractions at different submaximal force levels (10, 30, 50, and 70%) will be recorded, using the external analog to digital signal converter Sessantaquattro
Measured: Baseline and post-intervention (4 weeks after baseline)
Isometric force of Brachialis Biceps using hand dynamometer
The isometric force at 0º, 45º and 90º will be evaluated during a maximum test of 5 seconds using a digital manual dynamometer. The peak force obtained will be obtained.
Measured: Baseline and post-intervention (4 weeks after baseline)
Isometric force of Brachialis Biceps using s-beam load cell
The isometric force at 90º will also be evaluated through an S-type load cell (Biometrics Ltd., Newport, United Kingdom). In addition, the time needed to obtain the peak force achieved will be recorded.
Measured: Baseline and post-intervention (4 weeks after baseline)
Muscle thickness (thickness) of the brachial biceps using ultrasound
Structural changes will be evaluated through an innocuous procedure such as ultrasound. To do this, ultrasound images will be recorded to measure the muscular and adipose thickness of the arm musculature.
Measured: Baseline and post-intervention (4 weeks after baseline)
Arm circumference
A variable related to structural changes such as arm circumference will also be evaluated. For this, the circumference will be recorded through a measuring tape at the average distance between the acromion and the olecranon.
Measured: Baseline and post-intervention (4 weeks after baseline)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Feb 2020
- Study start1 Jan 2023
- Primary completion30 Oct 2023
- Study completion31 Oct 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Neuromuscular AdaptationsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Two randomly allocated parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 34 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Malaga
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dr. Antonio I Cuesta-Vargas, University of Malaga
- Investigators
- Antonio I Cuesta-Vargas, PhD, Principal investigator, University of Malaga
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04286022
- Sponsor's protocol ID
- NEUROTRAINING
- Status last verified
- Feb 2023
- First submitted
- 24 Feb 2020
- Last updated
- 7 Dec 2023
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 7 Dec 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Specific Neurotechnical Strength Training: Randomized Controlled Trial (NeuroTraining)
- ClinicalTrials.gov ID
- NCT04286022
- Acronym / sponsor ID
- NEUROTRAINING
- Conditions
- Neuromuscular Adaptations
- Keywords
- Strength training, Neuromuscular adaptation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 34 participants (actual)
- Lead sponsor
- University of MalagaUniversity, hospital or other
- Study start
- 1 Jan 2023 (actual)
- Primary completion
- 30 Oct 2023 (actual)
- Study completion
- 31 Oct 2023 (actual)
- First posted
- 26 Feb 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to apply a novel study methodology using high density electromyography (HDEMG) to know what are the mechanisms underlying the structural and functional changes obtained by two different training methods, commonly used, facilitating their understanding, study and subsequent application according to specific needs.
Detailed description
Different training methodologies have previously shown similar results in the improvement of structural or functional characteristics such as hypertrophy or strength. However, the different nature of their methods has suggested for years the possibility that different neuromuscular mechanisms could be behind these observed characteristics.
The development of a new technology, such as high-density electromyography (HDEMG), capable of studying new properties previously hidden from assessment methods, such as the speed of nerve impulse propagation or the frequency of motor unit discharge, has allowed a more thorough study of the mechanisms.
This study aims to apply this new study methodology to know what are the mechanisms underlying the changes at the structural and functional level obtained by two different training methods, commonly used, facilitating their understanding, study and subsequent application according to specific needs.
For this reason, the main hypothesis is the generation of different neuromuscular mechanisms and adaptations by executing, for 4 weeks, two different training methodologies, obtaining a dissociation between the results obtained at the structural level (hypertrophy), functional (generation of strength) and HDEMG analysis of the central and peripheral characteristics of the neuromuscular system in each of the programs studied.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Two randomly allocated parallel groups
| Arm | Type | Receives |
|---|---|---|
| Speed Loss 20% Group | Experimental | Other: Speed Loss 20% Strength TrainingThe SL20% group will carry out a program based on the limitation of the speed loss, allowing to perform the exercise only until a speed loss of 20% is achieved, following a similar methodology previously published (Pareja-Blanco et al., 2017). The program will consist of a job for 4 weeks, with a frequency of 2 sessions a week. In each session, a 6-series routine with an open number of repetitions will be carried out twice, allowing as many repetitions as possible to perform until a 20% loss of execution speed is reached. The intensity of work will be 70% 1RM, resting 4 minutes between sets. As an only exercise, an elbow flexion (bicep curl) with dumbbell will be performed. |
| Reduced Rest Time Group | Experimental | Other: Reduced Rest Time Strength TrainingThe RRT group will carry out a program based on the reduction of rest time between series, following a previously published methodology (Stragier et al., 2019). The program will consist of a job for 4 weeks, with a frequency of 2 sessions a week. In each session, a 5 series routine with progressive repetition volume (3 to 7) at 70% 1RM will be performed twice, resting 15 seconds between sets and 150 seconds between each of the 2 blocks. The exercise to be performed will be an elbow flexion (bicep curl) with dumbbell. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- 18-35 years
- men
Key exclusion criteria (3 listed)
- physical exercise that involves work of upper limbs during the time of the intervention
- upper limb injury during the previous 12 months
- systemic diseases
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Speed Loss 20% Strength TrainingStrength training based on the control of speed loss in execution. | Other | Speed Loss 20% Group |
| Reduced Rest Time Strength TrainingStrength training based on a protocol that includes reduced rest times between sets. | Other | Reduced Rest Time Group |
Primary outcome
Change from Baseline Mean Discharge Rate of Brachialis Biceps Motor Units at 4 weeks
Time frame: Baseline and post-intervention (4 weeks after baseline)
The mean discharge rate of the Brachialis Biceps motor units will be evaluated using a high density electromyography device (HDEMG). For this, the signal produced during isometric contractions at different submaximal force levels (10, 30, 50, and 70%) will be recorded, using an external analog to digital signal converter Sessantaquattro (64-channel EMG amplifier; OT Bioelettronica, Turin, Italy).
5 secondary outcomes
Speed of propagation of Brachialis Biceps Motor Units
Time frame: Baseline and post-intervention (4 weeks after baseline)
Isometric force of Brachialis Biceps using hand dynamometer
Time frame: Baseline and post-intervention (4 weeks after baseline)
Isometric force of Brachialis Biceps using s-beam load cell
Time frame: Baseline and post-intervention (4 weeks after baseline)
Muscle thickness (thickness) of the brachial biceps using ultrasound
Time frame: Baseline and post-intervention (4 weeks after baseline)
Arm circumference
Time frame: Baseline and post-intervention (4 weeks after baseline)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Dec 2023.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Antonio I Cuesta-Vargas, PhD principal investigator
University of Malaga
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Speed Loss 20% Strength Training and Reduced Rest Time Strength Training in people with Neuromuscular Adaptations, run by University of Malaga at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Dec 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change from Baseline Mean Discharge Rate of Brachialis Biceps Motor Units at 4 weeks (time frame: Baseline and post-intervention (4 weeks after baseline)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Dec 2023.