Clinical trials: Neurocognitive Development, active
Psychiatric Disorders, Depression - Major Depressive Disorder
Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Mental Health Hospital
Psychiatric conditions are each defined by different set of symptoms, however, they often share common characteristics such as impairments in cognitive and social functioning.
- Conditions
- Psychiatric Disorders, Depression - Major Depressive Disorder, Schizophrenia and Other Psychotic Disorders, Anxiety and Mood Disorders
- Trial name
- NCT07506070
- Testing
- Action-Based Cognitive Remediation
- Volunteers
- 160 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Frailty, Cognitive Decline
Precision Stratification for Frailty and Cognitive Decline
The Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) trial aim to test the effectiveness of an exercise, cognitive and lifestyle intervention amongst older adults over a 12-weeks…
- Trial name
- NCT07081282
- Testing
- Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB), Centre-Based Exercise Health Session
- Where
- Singapore
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Knee Osteoarthritis, Knee Arthroplasty
Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) is one of the most frequent orthopedic procedures. Over 50% of patients report higher expectations than their surgeons, and 10-50% remain dissatisfied…
- Conditions
- Knee Osteoarthritis, Knee Arthroplasty, Hip Osteoarthritis, Hip Arthroplasty
- Trial name
- KneeApp (NCT07212699)
- Testing
- KneeApp
- Where
- Germany
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Postoperative Delirium
Electroencephalographic Biomarker to Predict Postoperative Delirium
Acute post-operatory cognitive dysfunction states are one of the most important complications in older patients that underwent surgery. Among them postoperative delirium (POD) is the the most studied.
- Trial name
- NCT05992506
- Testing
- POD risk estimation using PEUMA
- Where
- 2 sites in Chile
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University of Chile
Delirium, Postoperative Cognitive Dysfunction
Biomarkers Associated With Postoperative Cognitive Dysfunction
Loss of cognitive function after major surgery is a significant risk in older people. It can occur acutely in the days after surgery as delirium or in months to years later as a persistent reduction in brain function termed…
- Conditions
- Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- NCT05464355
- Testing
- Intraoperative electroencephalography recording, Neurofilament light chain measurement, Tau protein measurement
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Oxford
Alzheimer Disease and Related Dementias, Cognition
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function…
- Conditions
- Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
- Trial name
- TDCS4MCR (NCT06821568)
- Testing
- Personalized Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States, Israel
- Volunteers
- 128 people
- Sponsor
- Hebrew SeniorLife
Post-Traumatic Stress Disorder, Chronic, Depressed Mood
An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma
The researchers are testing a single-group cognitive-behavioral intervention for treating traumatic stress related to interpersonal and developmental trauma in LGBTQ adults.
- Conditions
- Post-Traumatic Stress Disorder, Chronic, Depressed Mood, Depressive and Anxiety Disorders, Anxiety
- Trial name
- NCT07863817
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Postoperative Delirium, Postoperative Cognitive Dysfunction
Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperative Cognitive Assessment Tool
This observational cohort study is designed to validate the CogCheck application as a risk prediction tool for postoperative delirium in patients undergoing cardiac surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- CogCheck-Valid (NCT03360838)
- Testing
- CogCheck
- Where
- Switzerland
- Volunteers
- 475 people
- Sponsor
- University Hospital, Basel, Switzerland
Traumatic Brain Injury, Cerebral Palsy
Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy
This prospective observational study collects real world data on participants receiving regenerative therapies administered internationally and delivered intranasally via the Kurve Therapeutics ViaNase device.
- Conditions
- Traumatic Brain Injury, Cerebral Palsy, Hypoxic Ischemic Encephalopathy, Neurologic Disorders
- Trial name
- MuSE-INSIGHT (NCT07521384)
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Healing Hope International
Math Learning Disability, Child Development
Interventions in Mathematics and Cognitive Skills
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning…
- Conditions
- Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities
- Trial name
- NCT05201534
- Testing
- Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
Digital Solutions for Predicting the Biological Mechanisms of Alzheimer's Disease Through the Analysis of Risk Factors
Population ageing is one of the main factors responsible for the global increase in the prevalence of dementia. Recent evidence suggests that modifiable risk factors, such as cardiovascular disease and lifestyle, may increase the…
- Trial name
- PrevAl (NCT07731191)
- Testing
- Digital solution for the prediction of the biological mechanisms of Alzheimer's disease through the analysis of risk factors
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Huntington's Disease (HD)
Biology-Driven Cognitive Profiling in Huntington's Disease
Huntington's disease (HD) is a genetic, progressive neurodegenerative disorder characterized by early and widespread brain changes that can begin more than a decade before the onset of unequivocal motor signs.
- Trial name
- NCT07503743
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Dementia, Caregiver
ED PLWD/Care Partner Text Messaging
The purpose of this research study is to develop and test a text-messaging intervention for emergency department (ED) discharge care transitions experienced by caregivers of older adults with cognitive impairment.
- Conditions
- Dementia, Caregiver, Emergency Department, Mobile Health Technology (mHealth)
- Trial name
- CAPTURE (NCT07423871)
- Testing
- CAPTURE Text Message Care Transition Support
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Yale University
Long-Term Memory, Inhibitory Control
BID LTM Digital Intervention in Aging
Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM).
- Conditions
- Long-Term Memory, Inhibitory Control, Mild Cognitive Impairment
- Trial name
- NCT06916221
- Testing
- Long Term Memory, Worder
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Francisco
Biospecimen Donation, Brain Injury
University of Central Florida CereBank
Millions of persons are affected by brain diseases. The CereBank will be used to support research studies aimed at improving the diagnosis and treatment of brain diseases.
- Conditions
- Biospecimen Donation, Brain Injury, Brain Diseases
- Trial name
- NCT06876857
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, Including, Sickle Cell Disease
Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
Cell-free fetal DNA (cffDNA) is present in the maternal blood from the early first trimester of gestation and makes up 5%-20% of the total circulating cell-free DNA (cfDNA) in maternal plasma.
- Conditions
- Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, Including, Sickle Cell Disease, Cystic Fibrosis, Fragile X Syndrome
- Trial name
- DANNIgene (NCT06147414)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Emergence Delirium, Postoperative Delirium
Verification of a New Predictive Delirium Score in Adults With Elective Cardiac Valve or Bypass Surgery With Perioperative Use of a Heart-lung Machine; a Monocentric Pilot Observational Study
Basics (state of scientific knowledge): Delirium is an acute disturbance of consciousness and attention that develops over a short period of time and fluctuates in severity.
- Trial name
- MO-FA2-(TB) (NCT07276503)
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Gut Microbiome, Neurocognitive Correlates of Eating Habits
Tiny Tummies - A Milk Study
This is a 12-month, 2-arm randomized controlled trial (n=150) examining whether toddlers randomized at 12 months of age to 1.5 cup-equivalents/day of cow's milk-based dairy versus oat milk-based dairy, and followed to 24 months…
- Conditions
- Gut Microbiome, Neurocognitive Correlates of Eating Habits, Infants and Young Children, Sleep
- Trial name
- NCT07839156
- Testing
- Daily cow's milk products, Daily Oat Milk Exposure
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Dystrophinopathies
Decoding Central Defects in Dystrophinopathies From Diagnostic to Remediation
The study aims to identify a genotype/phenotype correlation by analyzing more finely the neurodevelopmental disorders in DMD patients.
- Trial name
- DECODYS (NCT07125898)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autism, Intellectual Disability
Cognitive-Behavioral Therapy for Irritability in Children With Autism Spectrum Disorder and Intellectual Disability
In addition to the core symptoms, children and adolescents with Autism Spectrum Disorder (ASD) often exhibit disruptive behavior problems including irritability, tantrums, noncompliance, and aggression.
- Trial name
- NCT02914951
- Testing
- Cognitive-Behavioral Therapy, Functional magnetic resonance imaging (fMRI)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Yale University