Long-Term MemoryNCT06916221
BID LTM Digital Intervention in Aging
A study testing Long Term Memory and Worder in people with Long-Term Memory and Inhibitory Control, run by University of California, San Francisco at 1 site in United States.
Trial summary
Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM). The decline in these faculties is accelerated and becomes significant deficits in LTM and cognitive control functions at the level or a diagnosis of Mild Cognitive Impairment (MCI). Read more about this study
- Who is it for?
- Ages 60 to 85 years
- Conditions the study is for
- Long-Term Memory, Inhibitory Control, Mild Cognitive Impairment
- What is being tested?
- Long Term Memory and Worder
- Type of treatment
- Pill or oral medicine, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 150 participants
- Where
- 1 siteUnited States
- Study dates
- 20 Aug 2025to 31 Jul 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Minimum of 12 years of education
- English fluency: All task instructions are presented in English language text. In order to control for sufficient and equivalent participant comprehension of the procedures and instructions, we require their self-report of fluency in English.
- Normal or corrected-to-normal vision
- Normal or corrected-to-normal hearing
- Medically healthy older adults, including those with below-average cognitive performance /MCI patients without dementia referred by neuropsychologists (i.e., no participant medical records will be reviewed).
Who cannot join
- Under the age of 60
- Clinical diagnosis of neurological or psychiatric disorder Clinical diagnosis of dementia or AD8 score of >4
- Visually or hearing impaired without correction to normal
- Regularly (one or more times per week) practicing an instrument within the last year
- 10 years or more of formal musical instrument training
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of California, San Francsico
San Francisco, California, 94158
About this study
Official title: Behavioral Intervention Development Core - Long Term Memory Digital Intervention in Aging
Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM). The decline in these faculties is accelerated and becomes significant deficits in LTM and cognitive control functions at the level or a diagnosis of Mild Cognitive Impairment (MCI). Training with the navigation game, relative to training with control games, is expected to improve LTM performance for older adult participants.
Researchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function.
Read more
Participants will conduct study activities remotely (e.g., at-home):
- Baseline Assessment. Complete a series of cognitive assessments and surveys.
- Intervention. Engage in a digital intervention for up to 8 weeks.
- Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment.
- Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.
Read the detailed description
Older adult participants consent and enroll in the LTM Digital Intervention, which is a randomized control trial (RCT) administered on the Neuroscape Nexus web-based research platform. Enrolled participants are randomly assigned to either of two arms that will play memory-based games.
Participants are provided by the study team with an Apple iPad 10th Generation (2024) at their home address, which will enable them to complete all study tasks at home via Nexus. All required applications will be pre-loaded on the device.
Participants will receive notifications and reminders to complete study tasks by email, through in-app reminders, or SMS. They can view their task list and progress in their personal dashboard in Nexus.
Study procedures include a series of surveys and brief tests of memory and attention as Baseline Tests, which make take up to 120 minutes and can be completed across more than one session.
Participants will engage with their assigned training application to complete 45 minutes of training, several days a week for up to 8 weeks for a total of 1000 minutes of training. Participants will be randomly assigned to one of two intervention apps, which encourage long-term memory.
Once their assigned training regimen is complete, participants will again fulfill a series of surveys and brief tests of memory and attention as Post-Training Tests, which make take up to 120 minutes and can be completed across more than one session.
Six months after completion of all Post-Training Tests, participants will be fulfill a third series of surveys and brief tests of memory and attention as Follow-Up Tests, which make take up to 120 minutes and can be completed across more than one session.
- Being tested
- Long Term Memory, Worder
- Keywords
- cognitive training, cognitive aging, memory
- Medical subject headings
- Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Long Term MemoryBehavioural
Tablet computer game designed to stimulate environmental enrichment via an adaptive and immersive experience learning virtual neighborhoods and errands in order to complete assigned errands.
WorderBehavioural
Tablet computer game designed to stimulate interest in solving word puzzles, much like the Boggle game.
| Study group | Role | What they receive |
|---|---|---|
| Long Term Memory | Active comparator | Multi-session cognitive intervention as a computer game that presents an adaptive spatial wayfinding challenge. Receives: Behavioral: Long Term Memory |
| Worder | Active comparator | Multi-session cognitive intervention as a computer game that presents a word puzzle. Receives: Behavioral: Worder |
What is being measured
The primary outcome is the main question the study is designed to answer.
MDT change in recognition memory
Psychometric test for proportion correct in memory for studied images of common objects versus paired similar lures
Measured: baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests
TOUR change in cued recall memory
Psychometric test for proportion of details correctly recalled from recent autobiographical memory
Measured: baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests
Secondary outcomes (1)
Cognitive Assessment change in working memory
Psychometric test for proportion of number of correctly identified images from working memory span
Measured: baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Apr 2025
- Study start20 Aug 2025
- Primary completion31 Jan 2028 (estimated)
- Study completion31 Jul 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Long-Term MemoryStudies of the same condition, open and under way.
- More trials run by University of California, San FranciscoThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized control trial
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 150 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of California, San Francisco
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Responsible party
- Sponsor
- Investigators
- Peter E Wais, PhD, Principal investigator, University of California, San Francisco
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06916221
- Sponsor's protocol ID
- 24-43268
- Other IDs
- P30AG086635
- Status last verified
- Mar 2026
- First submitted
- 24 Mar 2025
- Last updated
- 2 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified data to be shared includes demographic, cognitive assessments, survey, and behavioral outcomes.
Study at a glance
From the registry record, last updated by the sponsor on 2 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Behavioral Intervention Development Core - Long Term Memory Digital Intervention in Aging
- ClinicalTrials.gov ID
- NCT06916221
- Acronym / sponsor ID
- 24-43268
- Keywords
- cognitive training, cognitive aging, memory
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 150 participants (estimated)
- Lead sponsor
- University of California, San FranciscoUniversity, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Study start
- 20 Aug 2025 (actual)
- Primary completion
- 31 Jan 2028 (estimated)
- Study completion
- 31 Jul 2028 (estimated)
- First posted
- 8 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM). The decline in these faculties is accelerated and becomes significant deficits in LTM and cognitive control functions at the level or a diagnosis of Mild Cognitive Impairment (MCI). Training with the navigation game, relative to training with control games, is expected to improve LTM performance for older adult participants.
Researchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function.
Participants will conduct study activities remotely (e.g., at-home):
- Baseline Assessment. Complete a series of cognitive assessments and surveys.
- Intervention. Engage in a digital intervention for up to 8 weeks.
- Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment.
- Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.
Detailed description
Older adult participants consent and enroll in the LTM Digital Intervention, which is a randomized control trial (RCT) administered on the Neuroscape Nexus web-based research platform. Enrolled participants are randomly assigned to either of two arms that will play memory-based games.
Participants are provided by the study team with an Apple iPad 10th Generation (2024) at their home address, which will enable them to complete all study tasks at home via Nexus. All required applications will be pre-loaded on the device.
Participants will receive notifications and reminders to complete study tasks by email, through in-app reminders, or SMS. They can view their task list and progress in their personal dashboard in Nexus.
Study procedures include a series of surveys and brief tests of memory and attention as Baseline Tests, which make take up to 120 minutes and can be completed across more than one session.
Participants will engage with their assigned training application to complete 45 minutes of training, several days a week for up to 8 weeks for a total of 1000 minutes of training. Participants will be randomly assigned to one of two intervention apps, which encourage long-term memory.
Once their assigned training regimen is complete, participants will again fulfill a series of surveys and brief tests of memory and attention as Post-Training Tests, which make take up to 120 minutes and can be completed across more than one session.
Six months after completion of all Post-Training Tests, participants will be fulfill a third series of surveys and brief tests of memory and attention as Follow-Up Tests, which make take up to 120 minutes and can be completed across more than one session.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- Randomized control trial
| Arm | Type | Receives |
|---|---|---|
| Long Term Memory | Active comparator | Behavioral: Long Term MemoryMulti-session cognitive intervention as a computer game that presents an adaptive spatial wayfinding challenge. |
| Worder | Active comparator | Behavioral: WorderMulti-session cognitive intervention as a computer game that presents a word puzzle. |
Who may qualify
- Ages
- 60 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Minimum of 12 years of education
- English fluency: All task instructions are presented in English language text. In order to control for sufficient and equivalent participant comprehension of the procedures and instructions, we require their self-report of fluency in English.
- Normal or corrected-to-normal vision
- Normal or corrected-to-normal hearing
- Medically healthy older adults, including those with below-average cognitive performance /MCI patients without dementia referred by neuropsychologists (i.e., no participant medical records will be reviewed).
Key exclusion criteria (5 listed)
- Under the age of 60
- Clinical diagnosis of neurological or psychiatric disorder Clinical diagnosis of dementia or AD8 score of >4
- Visually or hearing impaired without correction to normal
- Regularly (one or more times per week) practicing an instrument within the last year
- 10 years or more of formal musical instrument training
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Long Term MemoryTablet computer game designed to stimulate environmental enrichment via an adaptive and immersive experience learning virtual neighborhoods and errands in order to complete assigned errands. | Behavioural | Long Term Memory |
| WorderTablet computer game designed to stimulate interest in solving word puzzles, much like the Boggle game. | Behavioural | Worder |
Primary outcome
MDT change in recognition memory
Time frame: baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests
Psychometric test for proportion correct in memory for studied images of common objects versus paired similar lures
TOUR change in cued recall memory
Time frame: baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests
Psychometric test for proportion of details correctly recalled from recent autobiographical memory
1 secondary outcome
Cognitive Assessment change in working memory
Time frame: baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Apr 2026.
- Individual participant dataSharing planned: Yes. De-identified data to be shared includes demographic, cognitive assessments, survey, and behavioral outcomes.
Related trials for Long-Term Memory
Active, not recruitingObservational study
Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy
Breast Cancer, Lymphoma
Recruiting
Wayfinding Intervention and Long-Term Memory
Long-Term Memory Decline, Mild Cognitive Impairment
Not yet recruitingObservational study
Effect of Oral Supplement on Influenza Vaccine Long-term Response
Influenza, Immunosenescence
Recruiting
Testosterone-induced Muscle Memory and Underlying Mechanisms
Skeletal Muscle Physiology
Recruiting
Traumatic Long-term Memory of Pain in Humans
Pain, Traumatic Memory
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Peter E Wais, PhD principal investigator
University of California, San Francisco
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Long Term Memory and Worder in people with Long-Term Memory and Inhibitory Control, run by University of California, San Francisco at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 2 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Melissa Arioli, AB ((415) 502-7321, bid.core@ucsf.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
MDT change in recognition memory (time frame: baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Apr 2026.