Clinical trials: Nervous System Disorder
Cerebral Palsy
Strength Training in Children With Cerebral Palsy
This study was set out to assess the effect of stretch-shortening (SSC) exercises on gait-symmetry and balance in children with unilateral cerebral palsy (UCP).
- Trial name
- NCT04892576
- Testing
- Physical Therapy
- Where
- Saudi Arabia
- Volunteers
- 42 people
- Sponsor
- Cairo University
Fabry Disease
A Qualitative Study on the Pain and Quality of Life of Patients With Fabry Disease
Background It is necessary to find out the difficulties experienced by patients with Fabry disease and their families, and to seek solutions for them.
- Trial name
- NCT05679076
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Yonsei University
Sturge Weber Syndrome, Port-wine Mark
Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol
Primary Objective: To assess the possible utility of topical timolol in the management of port-wine mark (PWM) in Sturge-Weber syndrome in children.
- Trial name
- NCT01533376
- Testing
- Timolol, Preservative free artificial tear gel.
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wills Eye
Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
A Study of the Effectiveness of Fampridine in Improving Upper Limb Function in MS
The purpose of this study is to examine the effect of treatment with fampridine in patients with secondary progressive MS (SPMS) or primary progressive MS (PPMS) with upper limb dysfunction (as defined by a 9-HPT time of between…
- Trial name
- NCT02208050
- Testing
- Fampridine
- Where
- 2 sites in Ireland
- Volunteers
- 64 people
- Sponsor
- University College Dublin
Balanced; Rearrangement, Respiratory Function Test
The Effect of Lycra Garment on Spastic Diplegic Cerebral Palsy Individuals With Scoliosis
The primary aim of this study was to investigate the effects of lycra clothing on balance and respiratory functions in individuals with cerebral palsy with scoliosis, and the secondary aim was to investigate the effects of lycra…
- Trial name
- NCT06295991
- Testing
- Lycra garment
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Hacettepe University
Ischemic Stroke
Virtual Reality in Stroke Rehabilitation
The purpose of this research study is to investigate the effects of Virtual Reality (VR) as a treatment intervention to increase physical and cognitive function in stroke survivors.
- Trial name
- NCT04080791
- Testing
- Virtual Reality (VR) System, Standard of care
- Sponsor
- Wake Forest University Health Sciences
Prader-Willi Syndrome, Hyperphagia
Oxytocin vs. Placebo for the Treatment Hyperphagia in Children and Adolescents With Prader-Willi Syndrome
The investigators propose a randomized double-blind 8 week treatment trial of intranasal oxytocin (IN-OXT) vs. placebo in 24 subjects aged 5 to 18 years with PWS in order to assess IN-OXT's affect on (1) Eating behaviors (2)…
- Trial name
- OXT-PWS (NCT02629991)
- Testing
- Intranasal Oxytocin (IN-OXT)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Montefiore Medical Center
Fracture at Wrist and/or Hand Level, Rupture of Tendon of Wrist and Hand
USG Brachial Plexus Block for Upper Extremity Surgery
Ultrasound-guided (USG) brachial plexus (BP) block efficacy at the Supraclavicular (SCL), Lateral- Infraclavicular (LIC) and Axillary (AX) level: Randomized, observer-blinded study of the single-penetration…
- Conditions
- Fracture at Wrist and/or Hand Level, Rupture of Tendon of Wrist and Hand, Injuries to the Wrist, Hand and Fingers (S60-S69), Ganglion Cysts
- Trial name
- NCT01993290
- Testing
- Ropivacaine
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Jens Borglum Neimann
Analgesia, Labor Pain
Efficacy and Safety of Hydromorphone-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia
The purpose of this study is to compare the effects of three different doses of hydromorphone combined with ropivacaine and sufentanil combined with ropivacaine in epidural labor analgesia through prospective clinical trials, so…
- Trial name
- NCT06036797
- Testing
- Hydromorphone, Sufentanil, Ropivacaine
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Brain and Central Nervous System Tumors
Motexafin Gadolinium in Treating Patients With Glioblastoma Multiforme Who Are Undergoing Radiation Therapy to the Brain
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as motexafin gadolinium may make the tumor cells more sensitive to radiation therapy.
- Trial name
- NCT00032097
- Testing
- motexafin gadolinium, radiation therapy
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Neurotoxicity
Monosialoganglioside Preventing Neurotoxicity Induced by Albumin-bound Paclitaxel Chemotherapy in Lung Cancer Patients
The purpose of this study is to determine whether monosialoganglioside are effective in the prevention of neurotoxicity induced by albumin-bound paclitaxel chemotherapy in lung cancer patients, and improve the quality of life of…
- Trial name
- NCT02500810
- Testing
- monosialoganglioside
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Peking University Cancer Hospital & Institute
Stroke, Acute, Stroke, Ischemic
Effects of Atalante Exoskeleton on Gait Recovery in Non- or Poorly Ambulatory Patients With Hemiparesis in the Acute/Subacute Phase (Month 1 to 4)
The present clinical investigation - EarlyExo, is an interventional, international, multicentric, prospective, single-blinded randomized controlled trial.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke, Subacute, Stroke Hemorrhagic
- Trial name
- EarlyExo (NCT06107010)
- Testing
- Use of the Atalante exoskeleton
- Where
- 5 sites in France, Germany and 1 more
- Volunteers
- 66 people
- Sponsor
- Wandercraft
Aphasia, Broca
Effects of MTS-r on Speech Production in Non-fluent Aphasia Post-ischemic Stroke Patients
Aphasia is one of the most disabling complications in language production in patients with left hemisphere stroke. About 19% of patients who experience aphasia may have a spontaneously recovery after several weeks or months.
- Trial name
- Aphasia-ACV (NCT02241213)
- Testing
- Transcranial Magnetic Stimulation (TMS-r)
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Fundación Cardiovascular de Colombia
Syncope
The Diagnostic Performance of Tilt Test in Athletes
In the present study the investigators evaluate the sensitivity and specificity of passive tilt test in athletes, as well as their haemodynamic responses and autonomic nervous system activity during head-up tilt.
- Trial name
- NCT02316860
- Testing
- Passive tilt test
- Where
- Greece
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Spasticity, Muscle, Muscular Diseases
Validity and Inter-Rater Reliability of a Novel Bedside Referral Tool for Spasticity
The purpose of this study is to improve spasticity diagnosis through development of a simple physical examination guide for primary care providers to identify patients who would benefit from being referred to a movement disorders…
- Conditions
- Spasticity, Muscle, Muscular Diseases, Musculoskeletal Disease, Muscle Hypertonia
- Trial name
- NCT03209960
- Testing
- Bedside Referral Tool, Neurological Examination
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Post-Operative Confusion
Braindex Cerebral Tissue Oxygen Saturation (SctO2) Measurement Algorithm Assessment and Improvement
The objective of this clinical trial is to optimize Braindex brain tissue oxygen saturation (SctO2) measurement algorithm compared to a mixed reference value of jugular venous and systemic arterial saturation, during proven…
- Trial name
- POC-SctO2 (NCT05897060)
- Testing
- Venus Jugular O2 Saturation optical fiber
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Braindex
Glioma, Brain Metastases
nTMS for Motor Mapping of Rolandic Lesions
To compare presurgical motor mapping by navigated transcranial magnetic stimulation for surgery (nTMS) of rolandic lesions to surgery with mapping without implementing these data into neuronavigation as control.
- Trial name
- Motorstim (NCT02879682)
- Testing
- nTMS data available for the surgeon, nTMS data not available for the surgeon
- Where
- 7 sites in Germany, Italy and 1 more
- Volunteers
- 330 people
- Sponsor
- Technical University of Munich
Effort Based Decision Making, Prosocial Behavior
Effort and Antidepressant Study Test
The aim of this study is to investigate the behavioural effects and neural correlates of increasing serotonin levels in healthy volunteers, through a 7-day course of the SSRI escitalopram, on an effort-based decision-making task…
- Conditions
- Effort Based Decision Making, Prosocial Behavior, Apathy
- Trial name
- EAST (NCT06696482)
- Testing
- Escitalopram 10mg
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Parturient Who Underwent Epidural Anesthesia During Which an Unintentional Dural Punctur Occurred, Parturient Who Develop a Postdural Puncture Headache
Chronic Headache and Chronic Backache Following Unintentional Dural Puncture at Delivery Room.
he study is a telephone questionnaire. The study will include 400 women, 100 in each group. OBJECTIVE: To investigate the prevalence of chronic and chronic back pain following PDPH accidental dural puncture during epidyral…
- Conditions
- Parturient Who Underwent Epidural Anesthesia During Which an Unintentional Dural Punctur Occurred, Parturient Who Develop a Postdural Puncture Headache, Parturient Who Gave Informed Consent to Participation in the Study
- Trial name
- NCT03908424
- Testing
- Epidural Blood patch.
- Where
- Israel
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Diabetic Neuropathy, Painful
Study to Evaluate MK-6096 in the Treatment of Painful Diabetic Neuropathy (PDN) in Adults (MK-6096-021)
The purpose of this study is to evaluate the safety and effectiveness of MK-6096 in the treatment of painful diabetic neuropathy (PDN) in adults.
- Trial name
- NCT01564459
- Testing
- MK-6096
- Volunteers
- 170 people
- Sponsor
- Merck Sharp & Dohme LLC
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