Clinical trials: Muscle Disuse Atrophy
Disuse Atrophy, Aging
Immobilization and Protein Supplementation (IM-PRO)
In the present study, the effects of 5 days of lower limb immobilization with or without twice-daily protein supplementation on muscle mass and muscle fiber characteristics will be determined.
- Trial name
- IM-PRO (NCT01588808)
- Testing
- Immobilization
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
A Study of the Effect of BIIB023 on Muscle Atrophy in Healthy Male Volunteers
The primary objective of this study is to determine whether muscle atrophy induced by immobilization of the lower limb can be attenuated by BIIB023 in healthy male volunteers.
- Trial name
- NCT01943513
- Testing
- BIIB023
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Biogen
Multifidus Disuse Atrophy
Short Arc Multifidus Study
Patients will be performing Logan short arc banding protocols to see the effect on multifidus size
- Trial name
- NCT00846664
- Testing
- Logan Short Arc Banding
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Logan College of Chiropractic
Muscle Atrophy
n3 PUFA and Muscle-disuse Atrophy in Young Women
This study will examine the influence of n3 PUFA supplementation on the rate of muscle atrophy in women undergoing 2 weeks of unilateral limb immobilization.
- Trial name
- NCT03059836
- Testing
- n3 PUFA-enriched fish oil
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Disuse Atrophy
Can Supplemental Leucine Offset Disuse-induced Muscle Atrophy?
Ageing is associated with a gradual decline in muscle mass that is detrimental to both physical function and metabolic health, increasing the risk of morbidity and mortality.
- Trial name
- LEU-DIMA (NCT03762278)
- Testing
- Leucine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Disuse Atrophy
The Efficacy of Protein Supplementation on Attenuating Muscle Atrophy Following Disuse in the Collegiate Population
Following orthopedic surgery and/or injury, a significant loss of muscle mass is generally observed. While this loss of muscle mass appears to be the norm, it causes significant problems in both the athletic and general…
- Trial name
- NCT03454347
- Testing
- Profile Perform, Lower Limb Suspension
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Sarcopenia, Skeletal Muscle Atrophy
Prehabilitative Exercise Prior to Immobilization
This is a 10-week human study involving 24 younger (20-35 y) and 24 older (65-85 y) healthy individuals. All participants will undergo unilateral immobilization of a knee for 7-10 days, followed by 4 weeks of heavy resistance…
- Conditions
- Sarcopenia, Skeletal Muscle Atrophy, Disuse Atrophy
- Trial name
- PREHAB (NCT06205784)
- Testing
- Prehabilitative exercise
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Muscle Disuse Atrophy, Nutrition, Healthy
Effect of a Natural Source Supplementation on Muscle Mass
Periods of muscle disuse are commonly experienced in young and elderly individuals as a result of short-term hospitalization or leg casting after injury.
- Trial name
- NCT05369026
- Testing
- Single leg immobilization
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscular Atrophy, Immobility Syndrome
Mechanisms of Disuse Atrophy in Human Skeletal Muscle (iMOB)
Loss of muscle can be caused by a variety of stimuli and results in reduced mobility and strength and also impacts whole body health. Whilst it is known that muscles waste the process by which this occurs is not well understood.
- Trial name
- iMOB (NCT04199923)
- Testing
- Single leg immobilisation
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Disuse Atrophy
Leucine Supplementation and Skeletal Muscle Disuse
Leucine supplementation is widely known for promoting strong influence on skeletal muscle remodeling. This study aims to evaluate the effect of leucine supplementation on disuse-induced skeletal muscle atrophy.
- Trial name
- NCT01192009
- Testing
- Leucine
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Disuse Atrophy, Immobilization
Electrical Stimulation During Immobilization
In the present study, the effects of 5 days of lower limb immobilization with or without daily neuromuscular electrical stimulation on muscle mass and muscle fiber characteristics will be determined.
- Conditions
- Disuse Atrophy, Immobilization, Neuromuscular Electrical Stimulation
- Trial name
- ESDIM (NCT01513486)
- Testing
- immobilization
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Atrophy, Muscle Disuse Atrophy
Examining Sex-based Differences in Metabolic and Mechanistic Responses to Disuse Induced Muscle Atrophy
The purpose of the proposed research is to define whether there are differences between females and males (i.e. sex-based differences) in the metabolic and mechanistic regulation of disuse-induced muscle atrophy in vivo in humans.
- Trial name
- NCT05314413
- Testing
- Single Leg Immobilization
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McGill University
Disuse Atrophy
Bed-rest, Muscle Mass and Insulin Sensitivity
In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.
- Trial name
- NCT02109380
- Testing
- Bed rest
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Disuse Atrophy, Immobilization
Cross-education of Skill and Strength in Healthy People Subjected to an Upper-limb Disuse Model
This randomized controlled trial aims to compare manual dexterity and strength between a group undergoing a contralateral manual dexterity training program and a no-intervention control group in healthy, physically inactive…
- Trial name
- IMMO-CROSS (NCT07615062)
- Testing
- Contralateral Manual Dexterity Training
- Where
- Chile
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidad Catolica de Temuco
Physical Inactivity, Vascular Dysfunction
Heat Therapy During Reduced Physical Activity
The purpose of this randomized controlled trial is to determine whether daily Finnish dry sauna therapy attenuates the adverse cardiovascular, muscular, and metabolic effects of seven days of experimentally reduced physical…
- Conditions
- Physical Inactivity, Vascular Dysfunction, Skeletal Muscle Atrophy
- Trial name
- HEAT-RPA (NCT07847424)
- Testing
- Sauna, Reduced Physical Activity
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Immobilization, Muscle Disuse Atrophy
Neuromuscular Electrical Stimulation During Immobilization Due to Ankle Fractures
Rationale: Situations such as fractures of the lower extremity can necessitate a prolonged period of immobilization in otherwise healthy individuals.
- Trial name
- ANKL-ES (NCT02469506)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- Maastricht University Medical Center
Muscle Atrophy, Muscle Disuse Atrophy
n3 PUFA and Muscle-disuse Atrophy in Older Women
This study will examine the influence of n3 PUFA supplementation on the rate of muscle atrophy in older women undergoing 1 week of unilateral limb immobilization.
- Conditions
- Muscle Atrophy, Muscle Disuse Atrophy, Sarcopenia
- Trial name
- NCT03808519
- Testing
- n3 PUFA-enriched fish oil
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- McMaster University
Proteomics, Exercise
Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and Unloading
Skeletal muscle plays several different roles in the promotion and maintenance of health and well-being. The loss of muscle mass that occurs with aging, chronic muscle wasting diseases, and physical inactivity puts people at an…
- Conditions
- Proteomics, Exercise, Atrophy, Disuse, Hypertrophy
- Trial name
- HYPAT (NCT04514744)
- Testing
- Knee bracing, Unilateral Resistance Exercise Training
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Disuse Atrophy
Muscle Damage and Disuse Atrophy
Limb injury generally requires a period of recovery during which time the limb is often immobilised (e.g. with a cast or brace) resulting in a rapid loss of skeletal muscle.
- Trial name
- NCT03559452
- Testing
- Eccentric exercise
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Muscle Atrophy, Disuse Atrophy
Effect of Knee Position on Muscle Loss During Leg Immobilization
This study looks at what happens to leg muscles when the knee is kept straight or bent during five days of wearing a brace. We want to find out if keeping the knee bent (so the thigh muscle is stretched) helps prevent muscle loss…
- Conditions
- Muscle Atrophy, Disuse Atrophy, Immobilization
- Trial name
- NCT07690150
- Testing
- Knee immobilization brace (0°) for 5 days, Knee immobilization brace (60°) for 5 days
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wageningen University