Clinical trials: Multiplex PCR
Echinococcosis, Diagnosis
Evaluation of a New Multiplex Quantitative PCR Technique for the Diagnosis of Echinococcosis
Echinococcosis is a severe parasitosis caused by the development of the tapeworm larva Echinococcus multilocularis, responsible for alveolar echinococcosis (AE) or Echinococcus granulosus, responsible for cystic echinococcosis…
- Trial name
- HIS-QPCR-ECH (NCT05824442)
- Testing
- Blood sample for multiplex QPCR technique
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Sepsis, Bacteremia
Evaluation in the Treatment of Nosocomial Sepsis Comparing Polymerase Chain Reaction With Conventional Blood Culture.
The objective of this study is to evaluate the consumption of antimicrobial therapy in patients comparing a rapid molecular test (PCR in Real-Time Multiplex) with blood cultures to identify the etiological agents of sepsis.
- Conditions
- Sepsis, Bacteremia, Fungemia
- Trial name
- NCT01450358
- Testing
- Antibiotic regimen
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Instituto do Coracao
Community-Acquired Pneumonia (CAP), Pneumonia
Clinical Impact of Rapid Molecular Testing for Pathogens in Patients With Severe Acute Respiratory Illness : A Pragmatic Trial
Community-acquired pneumonia (CAP) is among the most common reasons for emergency department (ED) visits. A clear understanding of the likely pathogens is essential for the rapid institution of adequate antimicrobial therapy.
- Trial name
- CIRT-RMT-SARI (NCT06605352)
- Testing
- The BIOFIRE®FILMARRAY® Pneumonia Panel
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- National Taiwan University Clinical Trial Center
Fever, Viral Infection
Viromes in Infants Presenting With a Septic Syndrome
Fever in infants younger than 3 months is a common reason for emergency department visits and is associated with a significant risk of serious bacterial infections.
- Conditions
- Fever, Viral Infection, Bacterial Infections
- Trial name
- V-NOURSSE (NCT07470541)
- Testing
- biological samples
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
VAP - Ventilator Associated Pneumonia, Antibiotic
EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)
The objective of the study is to determine whether rapid multiplex PCR testing of respiratory samples can reduce exposure to broad-spectrum antibiotics in intensive care unit patients with suspected or confirmed…
- Conditions
- VAP - Ventilator Associated Pneumonia, Antibiotic, Antibiotic Stewardship, Antibiotic Prescribing for Acute Respiratory-tract Infections
- Trial name
- EARLY ADAPT (NCT07267624)
- Testing
- PCR multiplex BioFire Pneumonia plus
- Where
- 5 sites in Switzerland
- Volunteers
- 170 people
- Sponsor
- University Hospital, Geneva
Bloodstream Infections, Bacteremia and Sepsis
Clinical Efectiveness of a Multiplex PCR-Based Rapid Diagnostic Method in Bloodstream Infections
Bloodstream infections (BSIs) are associated with high morbidity and mortality, and delays in initiating appropriate antimicrobial therapy significantly worsen clinical outcomes.
- Conditions
- Bloodstream Infections, Bacteremia and Sepsis, Fungemia
- Trial name
- CEMP-RDI (NCT07408544)
- Testing
- Multiplex PCR-Based Rapid Diagnostic Test, Standard Microbiological Diagnostic Methods
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Istanbul Medipol University Hospital
Community-acquired Pneumonia
Impact on the Use of Antibiotics of a Multimodal Algorithm for the Diagnosis and Management of Acute Community-acquired Pneumonia in the Emergency Room
Reducing antibiotics prescription is still to date, the main goal in low respiratory tract infections (LRTI). Several studies have shown conflicting results on the impact of multiplex PCR as a point of care tool.
- Trial name
- PROMCAP (NCT05657275)
- Testing
- CRP dosage, multiplex PCR, chest scan without injection
- Where
- 2 sites in France
- Volunteers
- 295 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Upper Respiratory Infections
Evaluation of Accuracy and Ease of Use of the FilmArray™ Respiratory Panel (RP EZ) in a CLIA-Waived Clinical Setting
The purpose of this study is to assess the accuracy and ease-of-use of a simplified FilmArray Respiratory Panel test (FilmArray RP EZ) when performed according to the manufacturer's instructions by personnel in laboratories…
- Trial name
- NCT02232711
- Where
- 4 sites in United States
- Volunteers
- 1,082 people
- Sponsor
- BioFire Diagnostics, LLC
Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection
Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium by Real-time Multiplex Polymerase Chain Reaction (PCR) After Pooling Pharyngeal, Anorectal and Urinary Samples
This study aims to compare the sensitivity of detecting Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium by real-time multiplex PCR in a pooled analysis (i.e.
- Conditions
- Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection, Mycoplasma Genitalium Infection, Sensitivity
- Trial name
- ISTPOOL (NCT03568695)
- Testing
- Two samples on each of the three sites (pharynx, rectum, urine)
- Where
- 5 sites in France
- Volunteers
- 166 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Endophthalmitis, Keratitis
Multiplex Strip Polymerase Chain Reaction for Diagnosis of Eye Infection Diseases From Corneal Scraping Samples
The aim of this study is to see if multiplex strip PCR will detect the pathogen that causing eye infection from the corneal scraping samples with higher sensitivity and specificity than the current gold standard.
- Conditions
- Endophthalmitis, Keratitis, Corneal Ulcer, Eye Infections
- Trial name
- NCT04075669
- Testing
- Multiplex Strip PCR
- Where
- Indonesia
- Volunteers
- 65 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Hematologic Diseases, Sepsis
Benefit of SeptiFast Multiplex PCR in the Etiologic Diagnosis and Therapeutic Approach for Onco-hematology Patients Presenting Sepsis
A SpetiFast multiplex PCR kit has recently been placed on the market witch can evidence the DNA of 90% of micro-organisms (bacteria and fungus) implicated in sepsis.
- Trial name
- SEPTIFAST (NCT00561639)
- Where
- France
- Volunteers
- 76 people
- Sponsor
- University Hospital, Grenoble
Bacteremia, Sepsis
Rapid Blood Culture Identification Panel in Pediatric Patients in Guatemala
The purpose of this study is to assess the clinical impact of a rapid multiplex PCR blood culture identification panel on time to optimal antimicrobial therapy when compared to conventional microbiological culture methods in…
- Trial name
- NCT05314816
- Testing
- Blood culture identification panel
- Where
- Guatemala
- Volunteers
- 479 people
- Sponsor
- University of Colorado, Denver
Colorectal Cancer, Stage II and III
Simultaneaous Detection of Quantitative Somatic Alterations Using the Qantitative Multiplex Pcr of Short Fluorescent Fragments Method (QMPSF) in Stage II-III Colon Cancer: a Prospective Study
Lymph node involvement remains the main criteria for postoperative chemotherapy in patients with colon cancer (CC) without distant metastasis.
- Trial name
- Code Barre (NCT02110329)
- Testing
- evaluation of the recurrence rate according to molecular analysis
- Where
- 3 sites in France
- Volunteers
- 401 people
- Sponsor
- University Hospital, Rouen
Infection, Antimicrobial Stewardship Program
Molecular Microbiology- Guided Antimicrobial Stewardship Versus Standard Stewardship in Hospitalized Patients
The goal of this clinical trial is to learn whether integrating rapid multiplex molecular microbiology results with predefined clinical and laboratory criteria into an antimicrobial stewardship program improves antimicrobial use…
- Conditions
- Infection, Antimicrobial Stewardship Program, Antimicrobial Resistance, Multiplex PCR
- Trial name
- PROACT (NCT07684300)
- Testing
- Protocolized Antimicrobial Stewardship Strategy, Standard Antimicrobial Stewardship
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Maria Espinosa Perez
Sepsis
The Clinical and Pharmacoeconomic Impact of Rapid Diagnostic Test (Multiplex PCR FilmArray) on Antimicrobial Decision Making Compared to Conventional Decision Making Among Critically Ill Patients
We will show in this study the impact of use the rapid diagnostic method (multiplex PCR filmArray) on clinical and pharmacoeconomic aspects among Critically Ill Patients.
- Trial name
- NCT05759494
- Testing
- rapid diagnostic test (multiplex PCR filmArray)
- Volunteers
- 100 people
- Sponsor
- Cairo University
Community-acquired Pneumonia
DiagNostic Study of Low-dose CT and multipleX PCR on Antibiotic Treatment and Outcome of Community-Acquired Pneumonia
Rationale: Uncertainty in the clinical and etiological diagnosis of community-acquired pneumonia (CAP) often leads to incorrect treatment and unnecessary use of broad-spectrum antibiotics.
- Trial name
- CAP-NEXT (NCT03360851)
- Testing
- low-dose CT, PoC-PCR
- Where
- 7 sites in Netherlands
- Volunteers
- 3,555 people
- Sponsor
- MJM Bonten
Acute Respiratory Infection, Severe Pneumonia
Early Identification and Severity Prediction of Acute Respiratory Infectious Disease
Early identification and Severity prediction of Acute Respiratory infectious disease has become a top priority for clinicians at department of infectious and respiratory diseases after COVID-19 broke out.
- Conditions
- Acute Respiratory Infection, Severe Pneumonia, Next Generation Sequencing, Multiplex PCR
- Trial name
- ESAR (NCT04955756)
- Testing
- mNGS, Multiplex PCR
- Where
- 3 sites in China
- Volunteers
- 440 people
- Sponsor
- Huashan Hospital
Pneumonia, Bronchoalveolar Lavage
HCAPPED I: HCAP-Pcr in Emergency Department
Prospective Observational Study (on Diagnostic Procedure) - Single-Center, Non-Profit. A pilot study will be conducted on a prospective cohort of patients with HCAP (Healthcare-Associated Pneumonia).
- Conditions
- Pneumonia, Bronchoalveolar Lavage, Antimicrobial Treatment, Sputum
- Trial name
- HCAPPED-I (NCT06506617)
- Where
- Italy
- Volunteers
- 93 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Acute Lower Respiratory Tract Infection, Pneumonia
Fast Identification of Pathogen in the Setting of Pneumonia Using Multiplex PCR
With this study the investigators want to determine, if a fast identification of germs, causing infections of the lower respiratory tract, is possible through the use of Multiplex PCR technology - a method that allows on time…
- Trial name
- NCT01858974
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Göttingen
Viral Diarrhea
Effect of the Use of Probiotic S. Boulardii on Acute Viral Inflammatory Diarrhea Diagnosed With Multiplex PCR.
Acute diarrhea (AD) has been a public health problem throughout the history of Mexico. According to the epidemiological surveillance system, between 2008-2017, five to six million new cases of AD occurred per year.
- Trial name
- NCT05226052
- Testing
- Saccharomyces boulardii (Floratil 600mg)
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Instituto Mexicano del Seguro Social