Clinical trials: Moderate Acute Malnutrition
Moderate Acute Malnutrition
Choline to Prevent SAM in Children With MAM
The goal of this clinical trial is to test choline supplementation in children with moderate acute malnutrition in Malawi. The main question it aims to answer is: Will provision of RUSF with added choline (500mg/day) throughout…
- Trial name
- CHOP-MAM (NCT06214897)
- Testing
- C-RUSF (Ready-to-use Supplemental Food with added Choline), S-RUSF (Ready-to-use Supplemental Food without added Choline)
- Where
- 10 sites in Malawi
- Volunteers
- 1,515 people
- Sponsor
- Washington University School of Medicine
Malnutrition, Infection
Effectiveness of Supplementary Feeding During Infection Among Moderately Malnourished Children
The purpose of this study is to determine whether an outpatient-based strategy of short-term, ready to use supplementary food (RUSF) among moderately malnourished children with acute infections achieves greater improvement in…
- Trial name
- MODMAL (NCT00890695)
- Testing
- Ready to use supplementary food (RUSF)
- Where
- 2 sites in Kenya
- Volunteers
- 64 people
- Sponsor
- University of Oxford
Malnutrition
Moderate Acute Malnutrition (MAM) and Severe Acute Malnutrition (SAM) in Sierra Leone
The long-term objective of this proposal is to develop and demonstrate an effective, integrated and streamlined protocol to treat moderate acute malnutrition (MAM) and non-complicated severe acute malnutrition (SAM) in children…
- Trial name
- NCT01785680
- Testing
- Integrated Protocol, Current protocol
- Where
- Sierra Leone
- Volunteers
- 1,957 people
- Sponsor
- Washington University School of Medicine
Malnutrition
Comparison of a Two Ready-to-use Supplementary Foods of Differing Protein Quality for the Treatment of MAM.
This is a prospective, randomised, double-blinded, controlled clinical effectiveness trial of two supplementary foods in the treatment of MAM. The setting will be 21 rural sites in southern Malawi.
- Trial name
- NCT03549156
- Testing
- C-RUSF, HIPRO RUSF
- Where
- Malawi
- Volunteers
- 1,858 people
- Sponsor
- Washington University School of Medicine
Malnutrition
Package of Interventions After Recovering From Moderate Acute Malnutrition
Children who recover from moderate acute malnutrition in Malawi remain at high risk for relapse or death in the year following recovery.
- Trial name
- NCT02351687
- Testing
- Lipid Nutrient Supplement, Sulfadoxine-pyrimethamine, Albendazole
- Where
- Malawi
- Volunteers
- 1,499 people
- Sponsor
- Washington University School of Medicine
Severe Acute Malnutrition, Moderate Acute Malnutrition
Alternative RUTFs for Treatment of Child Wasting
Acute malnutrition is the most life-threatening form of undernutrition. Moderate and severe acute malnutrition (MAM, SAM) are effectively treated with ready-to-use therapeutic foods (RUTFs) but there is a need to lower the cost…
- Conditions
- Severe Acute Malnutrition, Moderate Acute Malnutrition, Wasting
- Trial name
- NCT06912620
- Testing
- Soy-based RUTF, Soy-maize-sorghum-based RUTF, Standard RUTF
- Where
- Burkina Faso
- Volunteers
- 2,269 people
- Sponsor
- International Food Policy Research Institute
Malnutrition, HIV/AIDS
Nutritional Rehabilitation in Senegalese HIV-infected Children and Adolescents
Severe (SAM, Body Mass Index-z < -3) and moderate (MAM, -3 ≤ BMI-z < -2) acute malnutrition, highly prevalent in HIV-infected children and adolescents, is an independent risk factor of death, even when antiretroviral treatment…
- Trial name
- SNAC'S (NCT03101852)
- Testing
- Plumpy Nut, Plumpy Sup
- Volunteers
- 185 people
- Sponsor
- Institut de Recherche pour le Developpement
Moderate Acute Malnutrition
Modified Dosage for Moderate Acute Malnutrition (MODAM-MAM)
Protocols for the community-based management of acute malnutrition (CMAM) have not changed significantly for more than 20 years, with relatively complex treatment protocols and persistent supply chain challenges that have limited…
- Trial name
- MODAM-MAM (NCT06056089)
- Testing
- ready-to-use supplementary food (RUSF), ready-to-use therapeutic food (RUTF)
- Where
- 3 sites in Ethiopia
- Volunteers
- 2,400 people
- Sponsor
- Action Against Hunger USA
Child Nutrition Disorders
Evaluating the Relative Effectiveness of Two Feeding Interventions for the Treatment of Moderate Acute Malnutrition
Supplementary feeding programs for children with moderate acute malnutrition have been implemented in developing countries using treatment foods with minimal or no evidence of their effectiveness.
- Trial name
- NCT01097889
- Testing
- Fortified blended foods, Corn Soya Bean Flour (CSB) with oil., RUSF (ready-to-use supplementary foods) Supplementary Plumpy®
- Where
- 2 sites in Canada, Ethiopia
- Volunteers
- 2,600 people
- Sponsor
- The Hospital for Sick Children
Malnutrition, Child, Tuberculosis
The Impact of Malnutrition on Immune Responses to Tuberculosis
The aim of this study is to assess immune responses to Mtb in children with MAM compared to well-nourished children and to evaluate the impact of a nutrition intervention on these immune responses.
- Trial name
- TBMAM (NCT05044910)
- Testing
- Ready to Use supplementary food (RUSF)
- Where
- 2 sites in India
- Volunteers
- 200 people
- Sponsor
- Tuberculosis Research Centre, India
Moderate Acute Malnutrition (MAM), Undernutrition
Effectiveness of Positive Deviance/Hearth in Treating Uncomplicated Moderate Acute Malnutrition in Children 6-59 Months in Mymensingh Division, Bangladesh
The goal of this clinical trial (cluster randomized controlled trial) is to learn whether a Positive Deviance/Hearth (PDH) intervention can effectively treat moderate acute malnutrition (MAM) and reduce relapse compared to…
- Conditions
- Moderate Acute Malnutrition (MAM), Undernutrition, Wasting
- Trial name
- PD/Hearth MAM (NCT07591064)
- Testing
- PD/Hearth is a behavioral change program that teaches caregivers how to cook and feed their children. A nutrient-dense meal using local ingredients will be fed to children during Hearth sessions., Standard of Care (Investigator Selected)
- Where
- Bangladesh
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- World Vision US
Severe Acute Malnutrition, Moderate Acute Malnutrition
Optimizing Acute Malnutrition Management in Children Aged 6 to 59 Months in Democratic Republic of Congo
Acute malnutrition affects 51 million children under the age of 5 worldwide. Malnutrition contributes to nearly half of all child deaths each year, with the forms characterized by wasting or oedema (acute malnutrition) associated…
- Conditions
- Severe Acute Malnutrition, Moderate Acute Malnutrition, Child Malnutrition, Acute Malnutrition
- Trial name
- OptiMA-DRC (NCT03751475)
- Testing
- Nutritional Strategy - OptiMA, Effective nutritional standard strategy
- Where
- Democratic Republic of the Congo
- Volunteers
- 896 people
- Sponsor
- Alliance for International Medical Action
Severe Acute Malnutrition, Moderate Acute Malnutrition
Family Mid-Upper Arm Circumference (MUAC) Follow-up After Recovery From Acute Malnutrition (MODAM-fMUAC)
Protocols for the community-based management of acute malnutrition (CMAM) have not changed significantly for more than 20 years, with relatively complex treatment protocols and persistent supply chain challenges that have limited…
- Trial name
- MODAM-fMUAC (NCT06038071)
- Testing
- nutrition, IYCF, WASH education, scheduled anthropometric screening, family MUAC
- Where
- 3 sites in Ethiopia
- Volunteers
- 3,600 people
- Sponsor
- Action Against Hunger USA
Moderate Acute Malnutrition
Acceptability and Efficacy of 'Fish Surimi Peptide' in Under Five Children Suffering From Moderate Acute Malnutrition
Protein-energy malnutrition (PEM) including moderate acute malnutrition (MAM: weight-for-height z-score <-2 to -3, or mid upper arm circumference (MUAC) 115 to < 125 mm) is a major cause of morbidity and mortality in under-5…
- Trial name
- NCT02272543
- Testing
- Fish surimi peptide
- Where
- Bangladesh
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Moderate Acute Malnutrition (MAM)
Development, Feasibility and Acceptability of Recipes for Locally Available, Specially Formulated Foods for the Management of Moderate Acute Malnutrition in Niger (Related to NCT06382857 Protocol)
The study consisted of two phases. Phase 1 was a recipe development phase, which aimed to identify recipes that meet ≥80% of the recommended nutrient profile for Specially Formulated Foods (SFF) used in the standard management of…
- Trial name
- LAF (NCT07506213)
- Testing
- Locally Available Food
- Where
- Niger
- Volunteers
- 30 people
- Sponsor
- Epicentre
Moderate Acute Malnutrition
Ready to Use Supplementary Food in Moderate Childhood Malnutrition
Since 2001, Ready to Use Therapeutic Foods (RUTF) are widely used to treat severe malnutrition. Their efficacy and effectiveness were proven in community therapeutic care programs.
- Trial name
- NCT01147198
- Testing
- Ready to Use Supplementary Food, Premix CSB-oil treatment
- Where
- Sierra Leone
- Volunteers
- 570 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
Moderate Acute Malnutrition (MAM)
Comparison of Four Different Supplementary Foods in the Treatment of Moderate Acute Malnutrition (MAM) in Children in Sierra Leone: a Cluster-randomised, Controlled Clinical Effectiveness Trial
The objective of this study is to test and compare the effectiveness and cost-effectiveness of four supplementary foods for the treatment of moderate acute malnutrition (MAM) in normal programmatic settings in Sierra Leone.
- Trial name
- NCT02077907
- Testing
- Super Cereal Plus (SC+), Super Cereal (SC), fortified oil, sugar, Plumpy Sup
- Volunteers
- 1,147 people, healthy volunteers welcome
- Sponsor
- Tufts University
Moderate Acute Malnutrition
Treating Moderate Malnutrition in 6-24 Months Old Children
Child malnutrition is intimately associated to poverty and may be due to sub-optimal feeding behaviours, food insecurity at household level, or a combination of both.
- Trial name
- LUCOMA (NCT01115647)
- Testing
- Ready-to-Use Therapeutic Food (RUTF), CBS++, CCC
- Where
- Burkina Faso
- Volunteers
- 2,088 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Moderate Acute Malnutrition (MAM)
Management of Children With Moderate Acute Malnutrition in Mali
The objectives of the study are to assess the impact of different dietary strategies for the management of children with MAM on: the children's continued participation in the nutritional rehabilitation program and their physical…
- Trial name
- Mali-MMAM (NCT01015950)
- Testing
- Plumpy'Sup, Local food supplement, Misola
- Where
- Mali
- Volunteers
- 1,260 people
- Sponsor
- Helen Keller International
Moderate Acute Malnutrition, Stunting
Eggs for Gut Health
The goal of this clinical trial is to test egg powder supplementation in children with moderate acute malnutrition in Sierra Leone.
- Conditions
- Moderate Acute Malnutrition, Stunting, Environmental Enteric Dysfunction, Severe Acute Malnutrition
- Trial name
- NCT06002438
- Testing
- Whole egg powder, Corn powder, Supercereal Plus
- Where
- 10 sites in Sierra Leone
- Volunteers
- 461 people
- Sponsor
- Washington University School of Medicine