Clinical trials: Mixed Pain (Nociceptive and Neuropathic)
Chronic Pain, Low Back Pain
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking Either WHO Step I or Step II Analgesics or no Regular Analgesics
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release in subjects suffering from severe chronic low back pain (LBP) who are taking either WHO Step…
- Trial name
- NCT00983385
- Testing
- Tapentadol PR, Observation period
- Where
- 46 sites in Austria, Croatia and 7 more
- Volunteers
- 208 people
- Sponsor
- Grünenthal GmbH
Neuropathic Pain, Nociceptive Pain
PET/MRI in the Diagnosis of Chronic Pain
Several studies have implicated involvement of sigma-1 receptors (SR1s) in the generation of chronic pain, while others are investigating anti SR1 drugs for treatment of chronic pain.
- Conditions
- Neuropathic Pain, Nociceptive Pain, Mixed Pain (Nociceptive and Neuropathic), Spinal Pain
- Trial name
- NCT03556137
- Testing
- [18F]FTC-146
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Stanford University
Chronic Nociceptive Pain, Neuropathic Pain
A Pilot Study of Ultra Rapid Opioid Rotation and Titration of Oxymorphone
This project will explore the safety and feasibility of performing a successful intravenous patient controlled analgesia (IV PCA) Oxymorphone titration and conversion to oral ER Oxymorphone (extended release or OPANA ER) in the…
- Conditions
- Chronic Nociceptive Pain, Neuropathic Pain, Non-cancer Pain
- Trial name
- NCT00945919
- Testing
- Oxymorphone ER
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Pain, Nociceptive Pain
Central Sensitisation in Nociceptive and Neuropathic Pain
This study aims to investigate differences in central sensitization among patients with chronic nociceptive pain, neuropathic pain, and mixed pain conditions.
- Conditions
- Chronic Pain, Nociceptive Pain, Neuropathic Pain, Mixed Pain (Nociceptive and Neuropathic)
- Trial name
- ALGOS (NCT07321080)
- Testing
- Neuropsychological assessment, Laser evoked potentials
- Where
- Italy
- Volunteers
- 185 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Pain, Chronic Pain
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking WHO Step III Analgesics But Showing a Lack of Tolerability
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release in subjects suffering from severe chronic low back pain (LBP) who are taking WHO Step III…
- Conditions
- Pain, Chronic Pain, Low Back Pain, Neuropathic Pain
- Trial name
- NCT00986258
- Testing
- Tapentadol Prolonged Release
- Where
- 27 sites in Belgium, Czechia and 6 more
- Volunteers
- 136 people
- Sponsor
- Grünenthal GmbH
Nerve Pain, Neuropathic Pain
PETMRI for Chronic Pain from Spinal or Peripheral Nerve Origin
The purpose of this study is to compare the uptake of [18F]FTC-146 in healthy volunteers to that of individuals suffering from chronic pain with Spinal or Peripheral Nerve Origin.
- Conditions
- Nerve Pain, Neuropathic Pain, Nociceptive Pain, MIxed Pain (Nociceptive and Neuropathic)
- Trial name
- NCT06599151
- Testing
- [18F]FTC-146
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stanford University
Chronic Pain, Mixed Pain (Nociceptive and Neuropathic)
S1R Imaging-Based Cryoneurolysis in Chronic Pain
The goal of this clinical trial is to determine whether a sigma-1 receptor PET/MRI scan can help identify the specific nerves responsible for chronic pain.
- Trial name
- NCT07768501
- Testing
- [18F]-FTC-146
- Volunteers
- 6 people
- Sponsor
- Davidzon, Guido, M.D.