Clinical trials: Microaspiration
Secretion Removal Above ETT Cuff
Evaluation of Above the Cuff Suctioning During General Anesthesia
The aim of this prospective, randomized, pilot study is compare ease of tracheal intubation, amount of microaspiration and efficacy of secretion removal using three FDA (Food and Drug Administration)-cleared endotracheal tubes…
- Trial name
- NCT01386879
- Testing
- methylene blue
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Ventilator Associated Pneumonia, Aspiration
Ventilator Aspiration With PneuX (PneuX vs Standard Care Feasibility RCT)
This is a single centre, open-label, feasibility randomised controlled trial. The study aims to assess the feasibility of conducting an RCT to compare the PneuX ETT with standard care in hospitalised patients requiring mechanical…
- Conditions
- Ventilator Associated Pneumonia, Aspiration, Infections, Ventilator Lung
- Trial name
- VAP-X (NCT05410106)
- Testing
- PneuX Endotracheal Tube, Standard care (Taperguard, Covidien)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cardiff and Vale University Health Board
Endotracheal Tube Cuff, Microaspiration
Microaspiration and Endotracheal Tubes
The goal of this clinical trial is to learn if a new method for managing breathing tube pressure is better at preventing fluid from leaking into patients' lungs during surgery.
- Conditions
- Endotracheal Tube Cuff, Microaspiration, Endotracheal Tube Cuff Pressure
- Trial name
- NCT07017205
- Testing
- Application of oropharyngeal dye and tracheal aspirate collection
- Where
- Argentina
- Volunteers
- 72 people
- Sponsor
- Argentinian Intensive Care Society
IDIOPATHIC PULMONARY FIBROSIS
The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) is debatable. Looking for an insult to lung parenchyma that generates the pathogenesis of the disease is challenging.
- Trial name
- NCT01714934
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Pulmonary Microaspiration
Microaspiration in ERCP
Endoscopic retrograde cholangiopancreatography (ERCP) is considered the gold standard in diagnosing and treating biliary and pancreatic diseases.
- Trial name
- NCT04831489
- Testing
- Imaging
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Theodor Bilharz Research Institute
Mechanical Ventilation Complication, Tracheal Intubation Morbidity
Continuous Control of Polyurethane Tracheal-cuff Pressure: Efficiency of a Pneumatic Device
Underinflation and overinflation of tracheal cuff are common in intubated patients, including those intubated with polyurethane-cuffed tubes.
- Trial name
- Nosten (NCT01351259)
- Testing
- Pneumatic device, cylindrical or tapered cuff
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Lille
Ventilated-acquired Pneumonia
Tracheal Dosage of Amylase : a New Surrogate for Microaspirations in Ventilated ICU Patients
Microaspirations of the oropharyngeal ± gastric contents through the endotracheal tube cuff contribute to the constitution of VAP.
- Trial name
- NCT01267565
- Testing
- dosage of amylase
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Université Victor Segalen Bordeaux 2
Critical Illness, Mechanical Ventilation Complication
Impact of Tracheal Cuff Shape on Microaspiration in Intensive Care Units
The investigators hypothesized that PVC tapered-cuff tracheal tubes would reduce microaspiration of gastric content as determined by pepsin level in tracheal aspirate.
- Conditions
- Critical Illness, Mechanical Ventilation Complication, Ventilator Associated Pneumonia
- Trial name
- BestCuff (NCT01948635)
- Testing
- tapered PVC-cuffed tracheal tubes, Standard PVC-cuffed tracheal tube
- Where
- 9 sites in France
- Volunteers
- 326 people
- Sponsor
- University Hospital, Lille
Mechanical Ventilation Complication, Ventilator Associated Pneumonia
Effects of Endotracheal Tube Cuff Pressure Control on Microaspiration of Gastric Contents
The purpose of study is to determine effects of three different ET cuff pressure control on microaspiration of the stomach contents.
- Conditions
- Mechanical Ventilation Complication, Ventilator Associated Pneumonia, Nursing Caries, Aspiration, Respiratory
- Trial name
- NCT04061083
- Testing
- Smart Cuff Manager, Manometer
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Afyonkarahisar Health Sciences University
Anesthesia Airway Management, Respiratory Complications
Deflated and Inflated Cuff Endotracheal Extubations
General anesthesia is a treatment with medicine to make a patient unconscious for surgery. This is sometimes called "being put to sleep" or "being put under." Most of the time, a breathing tube is used to help a machine breathe…
- Trial name
- DICEE (NCT06990308)
- Testing
- Inflated Cuff Extubation, Deflated Cuff Extubation
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Naval Medical Center Camp Lejeune
Respiratory Aspiration
The Influence of Endotracheal Tube Design on Fluid Leakage Into the Lungs During Surgery
Surgical patients have an endotracheal tube inserted into their windpipe to help them breathe while under general anesthesia. These tubes have a "cuff" on the outside that is inflated in the trachea to help prevent fluids from…
- Trial name
- NCT01539135
- Testing
- Methylene Blue
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medtronic - MITG
Critical Illness
Impact of Mallinckrodt Electronic Device on Continuous Control of Tracheal Cuff Pressure
Despite intermittent control of tracheal cuff pressure using a manual manometer, cuff underinflations and overinflations frequently occur in critically ill patients, resulting in increased risk for microaspiration and tracheal…
- Trial name
- RCPBALSTAT (NCT01965821)
- Testing
- Continuous control of Pcuff followed by manual control, Manual control of Pcuff followed by continuous control
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Lille
Scleroderma Lung
Scleroderma Lung: Role of Gastroesophageal Reflux, Microaspiration and Cough
This is a mechanistic research study to evaluate the relationship between cough, reflux, and aspiration in patients with systemic sclerosis (scleroderma).
- Trial name
- NCT01667042
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mayo Clinic
Ventilator Acquired Pneumonia, Aspiration
Comparison of Two Strategies of Oropharyngeal and Tracheal Suctioning in Mechanically Ventilated Patients
The purpose of this study is to evaluate the impact of an optimized suctioning procedure on the risk of endotracheal microaspiration, measured by tracheal to oropharyngeal ratio of amylase enzymatic activity.
- Trial name
- AMYLASPI (NCT01807884)
- Testing
- Optimized oral care, Routine oral care
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Bordeaux
Microaspiration, Gastro Esophageal Reflux
Transpyloric Feeding for Prevention of Micro-aspiration
To determine the effect of transpyloric (TP) feeding on microaspiration and lung inflammation in ventilated preterm infants.
- Trial name
- NCT03646045
- Testing
- Transpyloric feeding
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Nemours Children's Clinic
Microaspiration, Acute Respiratory Distress Syndrome (ARDS)
Does Cricoid Pressure Reduce the Risk of Aspiration?
In modern anesthesia practice, the application of cricoid pressure during intubation is not infrequently used with the goal of preventing gastric-to-pulmonary aspiration.
- Conditions
- Microaspiration, Acute Respiratory Distress Syndrome (ARDS), Hospital Acquired Pneumonia
- Trial name
- NCT02058004
- Testing
- Cricoid pressure
- Where
- 2 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pneumonia, Ventilator-Associated Healthcare-associated Pneumonia Respiration, Artificial
Combined Strategy Using Automated Subglottic Secretion Drainage and Continuous Cuff Pressure Monitoring to Prevent Microaspiration: a Multicenter Randomized Controlled Trial.
This trial will study the impact of a combined strategy to prevent microaspiration of oropharyngeal secretions or gastric content using automated subglottic secretion drainage and/or continuous cuff pressure monitoring.
- Trial name
- cosmic (NCT07555236)
- Testing
- Combined strategy, Automated subglottic secretion drainage, Automated continuous cuff pressure monitoring
- Volunteers
- 800 people
- Sponsor
- University Hospital, Lille
Critical Illness
Diagnosis of Microaspiration in Intubated Critically Ill Patients: Pepsin vs 99m Technetium
Microaspiration of contaminated oropharyngeal secretions and gastric contents frequently occurs in intubated critically ill patients, and plays a major role in the pathogenesis of ventilator-associated pneumonia.
- Trial name
- NCT02169193
- Testing
- 99mTc-Rhenium Sulfide Nanocolloid
- Where
- France
- Sponsor
- University Hospital, Lille
Idiopathic Pulmonary Fibrosis
Microaspiration in Pulmonary Fibrosis
Hypothesis 1: Microaspiration, as diagnosed by bronchoalveolar lavage (BAL) pepsin, is common in patients with IPF. Hypothesis 2a: Baseline clinical variables and co-morbid conditions are risk factors for microaspiration in…
- Trial name
- ROMI (NCT01150591)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Critical Illness, Cirrhosis, Liver
Intraabdominal Hypertension and Occurrence of Microaspiration in Cirrhotics Under Mechanical Ventilation
The study aims to demonstrate the relationship between intra-abdominal hypertension (IAH) and abundant microaspirations in mechanically ventilated cirrhotic.
- Trial name
- ATOMIC (NCT04530760)
- Where
- 2 sites in France
- Volunteers
- 226 people
- Sponsor
- University Hospital, Lille