Clinical trials: Metabolome
Pregnancy Complications, Contraception
Impact of the Microbiome on Time to Pregnancy and Pregnancy Outcomes in Fertile Women Attempting to Conceive
This study aims to investigate the microbiome of women with previously proven fertility who plan to become pregnant.
- Conditions
- Pregnancy Complications, Contraception, Pregnancy Loss, Fertility
- Trial name
- SweBioFertil (NCT05127252)
- Testing
- Vaginal and rectal microbiome and metabolome
- Where
- 2 sites in Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Enterocolitis, Necrotizing, Bacteremia
Antibiotic "Dysbiosis" in Preterm Infants
Prolonged antibiotic use in preterm neonates has significant consequences on the developing intestinal microbiome, metabolome and host response, predisposing the neonate to various major morbidities, including necrotizing…
- Conditions
- Enterocolitis, Necrotizing, Bacteremia, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage
- Trial name
- NCT02784821
- Testing
- Antibiotic, Gastric fluid, Breast milk
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Florida
Polycystic Ovary Syndrome
DAISy-PCOS Phenome Study - Dissecting Androgen Excess and Metabolic Dysfunction in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) affects 10% of all women and usually presents with irregular menstrual periods and difficulties conceiving.
- Trial name
- DAISy-PCOS (NCT03911297)
- Testing
- Women with polycystic ovary syndrome
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Microbial Colonization
Effect of Antibiotics on Gut Microbiome and Plasma Metabolome
In recent years it has been observed that the gut microbiome can produce metabolites into systemic circulation and thus have important health effects even outside the gastrointestinal system.
- Trial name
- NCT03273296
- Testing
- Amoxicillin, Azithromycin, Vancomycin
- Where
- Finland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Type 1 Diabetes Mellitus Maturity Onset
Altered Faecal Microbiome and Metabolome in CT1D, AT1D and T2D
To elucidate the characteristics of global gut microbiota and fecal/serum metabolites in patients with childhood-onset type 1 diabetes, adult-onset type 1 diabetes or type 2 diabetes.
- Trial name
- NCT05252728
- Where
- China
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Second Xiangya Hospital of Central South University
Inflammation
Flavonoid-rich Supplement Influence on the Human Metabolome
This study will measure the effect of ingesting a flavonoid-rich supplement on various biomarkers in overweight/obese women during a 12-week period.
- Trial name
- NCT03004742
- Testing
- Flavonoid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
IBS
Fecal Metabolome and the Intestinal Microbiota in Irritable Bowel Syndrome
The purpose of this study is to find out the relationship between the bile acids, fatty acids (fatty acids are part of the diet) and bacteria that are present in the intestines.
- Trial name
- IBS (NCT02981888)
- Testing
- X-Ray
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Indiana University
Endocrine Disease
New Clinical Decision Support Score Based on Steroid Hormone Profiling in the Diagnosis of MACS
The recent development of quantitative steroid metabolome profiling could be of interest for the positive diagnosis of mild autonomous cortisol-secreting adenoma (MACS).
- Trial name
- MACSCORE (NCT07352527)
- Where
- France
- Volunteers
- 291 people
- Sponsor
- University Hospital, Bordeaux
Cardiometabolic Health, Healthy Aging
Impacts of Fruit on the Gut Health and Human Health
The objectives of this study are to investigate the effect of fruit consumption on the gut microbiota and their collective fecal and plasma metabolomes, vascular and cardiometabolic functions, cognition, and motor control.
- Conditions
- Cardiometabolic Health, Healthy Aging, Cognition
- Trial name
- NCT05063929
- Testing
- Fruit (2 cup eq), Fruit restriction (1/2 cup eq)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Phenylketonurias
Nutritional Impacts of Palynziq on Patients With Phenylketonuria (PKU)
Phenylketonuria (PKU) is an inherited metabolic disorder that impairs the metabolism of the essential amino acid phenylalanine (Phe).
- Trial name
- NCT04404530
- Testing
- Palynziq
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Dietary Exposure
Discovery of Novel Biomarkers of Dietary Exposure in the EPIC Calibration Study
This proposal aims at identifying new biomarkers of dietary exposure using metabolomic approaches. This project is based on the European Prospective Investigation on Cancer and Nutrition (EPIC) Calibration Study and more…
- Trial name
- NCT03683654
- Testing
- Identify Biomarkers of Dietary Intake in Healthy Subjects
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
Healthy
Revealing Microbiome Association With (Plant-based) Diet in Freshman
Aim of the study is to evaluate the impact of a vegan vs. vegetarian dietary pattern compared to an omnivore diet on body weight, saliva and stool microbiome profiles, as well as saliva, urine and plasma metabolome profile…
- Trial name
- Freshman (NCT04598022)
- Testing
- cross-sectional observation, cross-sectional follow-up observation
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Kiel
Healthy, Glycaemic Response Measurements
Effects on Glycemia and Insulinemia of Different Grape Varieties
The goal of this intervention study is to examine the glucose increase in blood, during 2 hours after consuming different varieties of grapes, in men and women with normal or excess body weight.
- Trial name
- SUGARGAP (NCT06748430)
- Testing
- Grape variety control, Grape variety 1, Grape variety 2
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Salt-sensitivity of Blood Pressure
Gut Microbiome, Metabolome, and SSBP
The goal of this interventional study is to learn if elevated Na+ alters the gut microbiota and is associated with altered metabolism, inflammation and salt sensitivity of blood pressure (SSBP).
- Trial name
- Gut-SSBP (NCT07790900)
- Testing
- Dietary sodium
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Autism Spectrum Disorder
A Deep Learning Algorithm Platform to Predict Autism Diagnosis and Subtypes
This is the first human study on ASD microbiome with robust methodologies: prospective and sibling designs, metagenomics profiles, establishing an ASD multi-dimensional databank (clinic, behavior, neurocognition, brain imaging…
- Trial name
- NCT04873674
- Testing
- ASD diagnosis, Psychiatric diagnosis
- Where
- Taiwan
- Volunteers
- 420 people
- Sponsor
- National Taiwan University Hospital
Elderly, Probiotics
Effect of Multi-species Probiotic HOWARU® Restore, on Gut Microbiota of Elderly
The study is randomized, double-blinded and placebo-controlled with a duration of 24 weeks. Following randomization, healthy elderly are randomized into two groups receiving probiotics or placebo.
- Conditions
- Elderly, Probiotics, Clostridium Difficile, Gut Microbiota
- Trial name
- NCT02207140
- Testing
- HOWARU Restore
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gabriella C. van Zanten
Metabolism, Gut Microbiota
The Impact of Plant-Based Protein-rich Food Products With Varying Degree of Processing on the Human Gut Microbiome Composition and Human Metabolome
It is observed that replacing meat with protein-rich plant-based food products are associated with lower mortality and obesity prevention.
- Conditions
- Metabolism, Gut Microbiota, Inflammation
- Trial name
- NCT05885750
- Testing
- Unprocessed, Mildly processed, Heavily refined
- Where
- Finland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Turku
Microbiota, Nutrition, Healthy
Effect of the Sustainable Diet on Gut Microbiota and the Metabolome: a Randomised Crossover Study
Unhealthy diets are closely linked to non-communicable diseases and constitute higher risk of morbidity and mortality than unsafe sex, alcohol, tobacco and drugs use combined.
- Trial name
- SUSUGUT (NCT05231317)
- Testing
- Plant-based diet, Western diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Failure to Thrive
Appetite Regulation in Children With Failure to Thrive
Failure to thrive (FTT) is an expression for inadequate growth in the early childhood and thus, a sign of undernutrition. This study will include children with FTT, and compare with existing data from children with normal and…
- Trial name
- NCT02647580
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Lena Kirchner Brahe
Cancer, Urology
Monitoring Treatment Response With Urine and Serum Metabolome Markers in Patients Treated With Novel Hormone Therapy and Have Either Hormone Sensitive Metastatic Prostate Cancer or Disease Progression on Treatment.
80% of patients with newly diagnosed metastatic hormone sensitive prostate cancer have bone metastases. There are mutations that are described with early disease progression when on hormone therapy for prostate cancer.
- Trial name
- Metabolome-PC (NCT07837063)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- The Clatterbridge Cancer Centre NHS Foundation Trust