Clinical trials: Memory Disorder
Advanced Pleural Malignant Mesothelioma, HLA-A*0201 Positive Cells Present
Genetically Modified T Cells in Treating Patients With Stage III-IV Non-small Cell Lung Cancer or Mesothelioma
This phase I/II trial studies the side effects and best dose of genetically modified T cells in treating patients with stage III-IV non-small cell lung cancer (NSCLC) or mesothelioma.
- Conditions
- Advanced Pleural Malignant Mesothelioma, HLA-A*0201 Positive Cells Present, Recurrent Non-Small Cell Lung Carcinoma, Recurrent Pleural Malignant Mesothelioma
- Trial name
- NCT02408016
- Testing
- Aldesleukin, Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes, Cyclophosphamide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Fred Hutchinson Cancer Center
Alzheimer Dementia, Alzheimer Disease
SAD Phase I Study (First-in-human) to Investigate Contraloid Acetate
This is a single-center first-in-human single-ascending-dose clinical trial assessing the safety and tolerability of oral dosing of Contraloid acetate in healthy volunteers.
- Trial name
- NCT03944460
- Testing
- Contraloid
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Dieter Willbold
Transient Global Amnesia
PRevalence Of Transient Global Amnesia in Obstructive Sleep Apnea Syndrome
Amnesic stroke is an amnestic syndrome lasting less than 24 hours characterized by the occurrence of anterograde amnesia often associated with retrograde amnesia, the pathophysiology of which is still poorly understood at…
- Trial name
- PROTOS (NCT06903026)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Strasbourg, France
Active Aging Individuals Aged 65 and Over, Aging
Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables
The goal of this experimental multicentric intervention study is to validate, in Italian, the dynamic Neurocognitive Adaptation (dNA) Scale, which has already been validated in English, among a healthy elderly population (aged 65…
- Conditions
- Active Aging Individuals Aged 65 and Over, Aging, Mild Cognitive Impairment (MCI), Dementia
- Trial name
- NCT07533084
- Where
- 8 sites in Italy
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
HIV Infections
Perspective Memory and Executive Functions in HIV+ Patients
The primary goal of this observational study is to evaluate prospective memory in HIV+ patients compared to healthy subjects. The secondary goal is to examine the relationship between prospective memory and Hot Cognition…
- Trial name
- (3514) (NCT05752578)
- Testing
- Neuropsychological testing
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Central Nervous System Diseases
The Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory
The investigators hypothesize that ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal…
- Trial name
- NCT02006615
- Testing
- Functional near infrared spectroscopy, rTMS
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Haemophilus Influenzae Type b, Neisseria Meningitidis
Dose Ranging Study of Combined Haemophilus Influenzae Type B-Meningococcal Serogroups CY (Hib-MenCY-TT) Vaccine
This study evaluated the safety and immunogenicity of 3 formulations of Hib-MenCY-TT vaccine compared to 2 control groups receiving licensed meningococcal serogroup C conjugate vaccine and/or licensed Hib conjugate vaccine…
- Trial name
- NCT00127855
- Testing
- Hib-MenCY-TT vaccine (MenHibrix), Meningitec®, ActHIB®
- Where
- 3 sites in Australia
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Psychosis
The Relationship Between Autobiographical Memory and Motivation
People with a diagnosis of psychosis often experience low motivation and pleasure when thinking about doing future activities. This leads, quite understandably, to doing fewer activities they used to enjoy and not taking up…
- Trial name
- NCT03677635
- Testing
- Guided Autobiographical Memory Recall
- Where
- 2 sites in United Kingdom
- Volunteers
- 31 people
- Sponsor
- King's College London
Dementia
Memory Study of Youngest Women Enrolled in the Women's Health Initiative Hormone Therapy (HT) Arm
WHIMS-Y provides valuable information on the long-term effects on risk of cognitive impairment of hormone therapy in a subset of WHI participants in the WHI Hormone Trials.
- Trial name
- WHIMS-Y (NCT01124773)
- Where
- United States
- Volunteers
- 1,362 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Alzheimer Disease, Mild Cognitive Impairment
Applying Non-invasive Brain Stimulation in Alzheimer's Rehabilitation
Presently, few studies have evaluated the clinical impact of rTMS in Alzheimer's disease. Though some studies have demonstrated an improvement, there have been conflicting results, as others do not seem to demonstrate beneficial…
- Trial name
- StimoLaMente (NCT04866979)
- Testing
- Experimental: Continuous TBS (cTBS), Intermittent TBS (iTBS), Cognitive training (CT).
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università degli Studi di Trento
Memory Disorders, Age-Related Cognitive Decline
Effect of Vitamin D on Cognitive Decline of Patients With Memory Complaint
As recommended allowance of oral vitamine D are unable to ensure the recommended serum concentration of vitamine D, the purpose of this study is to show that a dose of vitamin D3 higher than the recommended allowance may slow the…
- Trial name
- D-COG (NCT02185222)
- Testing
- Cholecalciferol 100 000 UI
- Where
- 11 sites in France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Tours
Traumatic Brain Injury
Effects of Exercise on Memory in Healthy and Brain-Injured Individuals
Background: Research has shown that one exercise session may improve a person s ability to recall information they learned before the exercise.
- Trial name
- NCT01939769
- Testing
- Exercise - Low-intensity exercise, Exercise - High-intensity exercise
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Posttraumatic Stress Disorder
Effects of Delta9-tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R33 Study
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT04080427
- Testing
- Dronabinol 7.5 milligram oral capsule
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Wayne State University
Epilepsy
fMRI Guided TMS Enhancement of Associative Memory Networks
This is a randomized, single-blinded, controlled phase 1 study to demonstrate feasibility and explore the neurophysiologic and clinical effects of repetitive transcranial magnetic stimulation (TMS) interventions in epilepsy…
- Trial name
- NCT02749422
- Testing
- MagStim RapidStim2
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Alcohol Use Disorder, Substance Use Disorders
Modification of Inhibitory Control and Craving Through Transcranial Direct Current Stimulation (tDCS) as an Add-On Treatment for Substance Use Disorder
The aim of this project is to investigate the potential of transcranial direct current stimulation (tDCS) to reduce cognitive deficits and substance craving in individuals with substance use disorders (SUD), with a focus on…
- Trial name
- NCT06959342
- Testing
- Transcranial direct current stimulation (tDCS), Inhibition Training
- Where
- 2 sites in Germany
- Volunteers
- 162 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Neurologic Disorder, Subarachnoid Hemorrhage, Aneurysmal
Hippocampal Volume and Memory Functions in Aneurysmal Subarachnoid Hemorrhage
Neuropsychological and functional long-term consequences of subarachnoid hemorrhages (SAH) represent a great challenge, since sometimes considerable cognitive deficits occur without evidence of substantial brain damage.
- Trial name
- NCT04449666
- Testing
- Neuropsychological assessment and structural MRI
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Traumatic Brain Injury, Posttraumatic Stress Disorder
Strategic Memory and Reasoning Training for Cognitive Problems
The focus of this study is to test a treatment program (Strategic Memory Advanced Reasoning Training; SMART) that was developed to address specific brain functions found to be crucial for the recovery following traumatic brain…
- Trial name
- SMART (NCT04554537)
- Testing
- SMART, Brain Health Workshop
- Volunteers
- 100 people
- Sponsor
- Dr. Kristin Samuelson
Major Depression, Anxiety Disorder
A Working Memory Training to Decrease Rumination in Depressed and Anxious Individuals
Dysfunctioning executive functioning, including working memory (WM), is related to rumination. Findings show that working memory capacity (WMC) can be increased by training.
- Trial name
- NCT02119975
- Testing
- Working memory training
- Where
- Netherlands
- Volunteers
- 98 people
- Sponsor
- Erasmus Medical Center
Trichotillomania
Cognitive Training in Patients With Trichotillomania (Hair-pulling Disorder)
The principal aim of this study is to establish the impact of Cognitive Training in patients with primary Hair-pulling Disorder.
- Trial name
- CTTTM (NCT02794753)
- Testing
- Working memory training, Game
- Where
- South Africa
- Volunteers
- 40 people
- Sponsor
- University of Stellenbosch
Cannabis, Memory
Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 4
This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users.
- Conditions
- Cannabis, Memory, Electroencephalography
- Trial name
- COBRA 4 (NCT07679581)
- Testing
- Cannabis (smoked flower)
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- L. Cinnamon Bidwell
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