Transient Global AmnesiaPROTOSNCT06903026
PRevalence Of Transient Global Amnesia in Obstructive Sleep Apnea Syndrome
An observational study of Transient Global Amnesia, run by University Hospital, Strasbourg, France at 1 site in France.
Trial summary
Amnesic stroke is an amnestic syndrome lasting less than 24 hours characterized by the occurrence of anterograde amnesia often associated with retrograde amnesia, the pathophysiology of which is still poorly understood at present. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Transient Global Amnesia
- How many people
- 250 participants
- Where
- 1 siteFrance
- Study dates
- 17 Mar 2023to 31 Dec 2025
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients seen for consultation in the Neuropsychology Department of Strasbourg University Hospital between March 1, 2015 and December 31, 2021 following an episode of amnestic stroke meeting the Hodges and Warlow criteria.
Who may be able to join
- Adult patients seen for consultation in the Neuropsychology Department of Strasbourg University Hospital between March 1, 2015 and December 31, 2021 following an episode of amnestic stroke meeting the Hodges and Warlow criteria:
- The stroke must have been documented and reported by a competent witness present during the stroke.
- Anterograde amnesia during the stroke.
- Absence of vigilance, personality, and cognitive disorders other than memory disorders (aphasia, apraxia, etc.).
- Absence of focal neurological symptoms during the episode and its aftermath.
- Absence of epileptic manifestations.
Show all 9Show fewer
- Resolution of the episode in less than 24 hours.
- Exclusion of patients with a history of recent head trauma or active epilepsy (undergoing regular treatment or having experienced a seizure in the last 2 years).
- Subjects who have not expressed opposition to the reuse of their data for scientific research purposes.
Who cannot join
- Patients who have expressed opposition to the retrospective reuse of their data for scientific research purposes.
- Patients with active epilepsy
- Patients with recent head trauma
- Patients with an MMS < or equal to 25
- Subject under guardianship or curatorship
- Subject under judicial protection
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
Service de Neurologie - CHU de Strasbourg - France
Strasbourg, 67091
Benjamin CRETIN, MD, 33 3 88 12 86 34, benjamin.cretin@chru-trasbourg.fr
Benjamin CRETIN, MD
About this study
Amnesic stroke is an amnestic syndrome lasting less than 24 hours characterized by the occurrence of anterograde amnesia often associated with retrograde amnesia, the pathophysiology of which is still poorly understood at present. A recent study on a small sample size (N=29) highlighted an association between obstructive sleep apnea syndrome and amnesic stroke. Our study seeks to confirm or refute these results on a larger cohort (N=200-250). A better understanding of the pathophysiological processes involved would open up new therapeutic avenues.
- Conditions
- Transient Global Amnesia
- Keywords
- Transient Global Amnesia, Sleep apnea syndrome
- Medical subject headings
- Amnesia, Transient Global, Sleep Apnea Syndromes
What is being measured
The primary outcome is the main question the study is designed to answer.
To assess the prevalence of obstructive sleep apnea syndrome in patients who have experienced an amnestic stroke.
Presence or absence of obstructive sleep apnea syndrome reported by a witness present during the stroke.
Measured: Within the last 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Mar 2025
- Study start17 Mar 2023
- Primary completionDec 2025 (estimated)
- Study completion31 Dec 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Transient Global AmnesiaStudies of the same condition, open and under way.
- More trials run by University Hospital, Strasbourg, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Retrospective
- Enrolment
- 250 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Strasbourg, France
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06903026
- Sponsor's protocol ID
- 8781
- Acronym
- PROTOS
- Status last verified
- Mar 2025
- First submitted
- 24 Mar 2025
- Last updated
- 30 Mar 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- PRevalence Of Transient Global Amnesia in Obstructive Sleep Apnea Syndrome
- ClinicalTrials.gov ID
- NCT06903026
- Acronym / sponsor ID
- PROTOS / 8781
- Conditions
- Transient Global Amnesia
- Keywords
- Transient Global Amnesia, Sleep apnea syndrome
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 250 participants (estimated)
- Lead sponsor
- University Hospital, Strasbourg, FranceUniversity, hospital or other
- Study start
- 17 Mar 2023 (actual)
- Primary completion
- Dec 2025 (estimated)
- Study completion
- 31 Dec 2025 (estimated)
- First posted
- 30 Mar 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Amnesic stroke is an amnestic syndrome lasting less than 24 hours characterized by the occurrence of anterograde amnesia often associated with retrograde amnesia, the pathophysiology of which is still poorly understood at present. A recent study on a small sample size (N=29) highlighted an association between obstructive sleep apnea syndrome and amnesic stroke. Our study seeks to confirm or refute these results on a larger cohort (N=200-250). A better understanding of the pathophysiological processes involved would open up new therapeutic avenues.
Study design
- Observational model
- Case only
- Time perspective
- Retrospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients seen for consultation in the Neuropsychology Department of Strasbourg University Hospital between March 1, 2015 and December 31, 2021 following an episode of amnestic stroke meeting the Hodges and Warlow criteria.
Key inclusion criteria (9 listed)
- Adult patients seen for consultation in the Neuropsychology Department of Strasbourg University Hospital between March 1, 2015 and December 31, 2021 following an episode of amnestic stroke meeting the Hodges and Warlow criteria:
- The stroke must have been documented and reported by a competent witness present during the stroke.
- Anterograde amnesia during the stroke.
- Absence of vigilance, personality, and cognitive disorders other than memory disorders (aphasia, apraxia, etc.).
- Absence of focal neurological symptoms during the episode and its aftermath.
Key exclusion criteria (6 listed)
- Patients who have expressed opposition to the retrospective reuse of their data for scientific research purposes.
- Patients with active epilepsy
- Patients with recent head trauma
- Patients with an MMS < or equal to 25
- Subject under guardianship or curatorship
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
To assess the prevalence of obstructive sleep apnea syndrome in patients who have experienced an amnestic stroke.
Time frame: Within the last 2 years
Presence or absence of obstructive sleep apnea syndrome reported by a witness present during the stroke.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Mar 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Transient Global Amnesia, run by University Hospital, Strasbourg, France at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 30 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Benjamin CRETIN, MD (33 3 88 12 86 34, benjamin.cretin@chru-trasbourg.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
To assess the prevalence of obstructive sleep apnea syndrome in patients who have experienced an amnestic stroke. (time frame: Within the last 2 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Mar 2025.