Clinical trials: Malabsorption
Short Bowel Syndrome
Short Bowel Syndrome Research Study for Children Up To 17 Years of Age on Parenteral Nutrition
Teduglutide is approved for treatment of adults with short bowel syndrome (SBS). The purpose of this study is to evaluate the safety and efficacy of teduglutide in children up to the age of 17 with SBS who are dependent on…
- Trial name
- NCT02682381
- Testing
- Teduglutide 0.05mg/kg, Teduglutide 0.025 mg/kg, Standard of Care
- Where
- 27 sites in United States, Belgium and 5 more
- Volunteers
- 59 people
- Sponsor
- Shire
Chronic Pancreatitis, Recurrent Acute Pancreatitis
Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic Pancreatitis
This project uses the Malabsorption Blood Test (MBT) to identify patients with recurrent acute or chronic pancreatitis who have mild to moderate exocrine pancreatic insufficiency.
- Conditions
- Chronic Pancreatitis, Recurrent Acute Pancreatitis, Exocrine Pancreatic Insufficiency
- Trial name
- MBT (NCT07418593)
- Testing
- Pancreatic Enzyme Replacement Therapy, MBT1, MBT 2
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Anna Evans Phillips
Celiac Disease
Double Blind, Placebo-controlled Trial to Establish Safety and Efficacy of Ritlecitinib in Celiac Disease Patients in Remission
Subjects include: aged 18 to 75 years, inclusive, have biopsy-confirmed disease that is clinically inactive as determined by negative celiac disease (CeD) serology and histology (determined via endoscopy at time of screening)…
- Trial name
- NCT05636293
- Testing
- Ritlecitinib, Gluten
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Essential Hypertension
Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine
To evaluate the efficacy of Amlodipine-folic Acid Tablets on reduction of blood pressure and plasma homocystein.
- Trial name
- NCT01848873
- Testing
- Amlodipine, amlodipine-FA tablet, low dose group, amlodipine-FA tablet ,high dose group
- Where
- 16 sites in China
- Volunteers
- 756 people
- Sponsor
- Shenzhen Ausa Pharmed Co.,Ltd
Coeliac Disease, Celiac Disease
Safety Study of Nexvax2 in Subjects With Coeliac Disease
The main purpose of this study is to determine the safety of weekly injections of Nexvax2 given for three weeks to patients with coeliac disease who have been on a gluten-free diet.
- Trial name
- NCT00879749
- Testing
- 9 micrograms Nexvax2, 30 micrograms Nexvax2, 90 micrograms Nexvax2
- Where
- 2 sites in Australia
- Volunteers
- 34 people
- Sponsor
- Nexpep Pty Ltd
Gastrointestinal Disease, Inflammatory Bowel Diseases
Using Virtual Reality for Patients With Gastrointestinal Disease
The primary aim of this study is to evaluate the effect and impact of a technology which creates a virtual reality (VR), personalized representation of a patient's endoscopic findings in comparison our standard practice (SP).
- Trial name
- NCT03719209
- Testing
- HealthVoyager, Standard Practice
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Boston Children's Hospital
Bileacid Malabsorption
Bileacid Malabsorption and GLP-1 Secretion
The aim of this study is to examine the influence of BAM on postprandial GLP--1 secretion and glucose homeostasis, both with and without bile acid sequestration.
- Trial name
- NCT03009916
- Testing
- "cholestagel®" (Colesevelam)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Celiac Disease
Vedolizumab Induction May Prevent Celiac Enteritis
Celiac disease (CD) is characterized as an autoimmune disorder whereby gluten (a protein found in wheat, barley, rye, malt) induces an immunological response in genetically susceptible individuals.
- Trial name
- NCT02929316
- Testing
- Vedolizumab
- Where
- 2 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- AGA Clinical Research Associates, LLC
Vitamin B12 Deficiency
Can Recombinant Human Intrinsic Factor Be Used for Evaluation of the Vitamin B12 Absorption?
Vitamin B12 is an essential nutrient for normal DNA-synthesis and must be supplied by animal products. Vitamin B12 deficiency may cause anemia and irreverible neurological damage.
- Trial name
- NCT00279552
- Testing
- Recombinant human intrinsic factor
- Where
- Denmark
- Volunteers
- 37 people
- Sponsor
- University of Aarhus
Short Bowel Syndrome
Pediatric Teduglutide Registry
Pediatric specific post-marketing registry to evaluate the long-term safety and efficacy of teduglutide.
- Trial name
- PTR (NCT04832087)
- Testing
- Teduglutide
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Boston Children's Hospital
Celiac Disease
Treatment of Mild Enteropathy Celiac Disease
The main purpose of this study is to evaluate the natural history of gluten sensitivity in endomysial antibody positive adults with celiac disease suspicion, who were found to have a only mild enteropathy (Marsh I-II) in the…
- Trial name
- TMCD (NCT00628823)
- Testing
- Gluten-free diet
- Where
- Finland
- Volunteers
- 73 people
- Sponsor
- Tampere University Hospital
Celiac Disease, Celiac Disease in Children
Effects of A2 Dairy Consumption in Celiac Adolescents
The goal of this clinical trial is to evaluate the effect of A2 β-casein-containing milk and dairy product consumption on nutritional status, gastrointestinal symptoms, quality of life, sleep quality, and selected biochemical…
- Conditions
- Celiac Disease, Celiac Disease in Children, A2 β-casein-containing Milk and Dairy Products
- Trial name
- NCT07815821
- Testing
- A2 β-casein milk and dairy products, Standard milk and dairy products
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Halic University
Celiac Disease
Desensitising Celiac Disease Patients With the Human Hookworm
We have established that the hookworm Necator americanus (Na) dramatically alters the local and systemic immune landscape of the infected human host.
- Trial name
- NaCeD (NCT01661933)
- Testing
- Necator americanus
- Where
- Australia
- Volunteers
- 12 people
- Sponsor
- The Prince Charles Hospital
Celiac Disease
Study of the Safety, Pharmacodynamics, Efficacy, and PK of TIMP-GLIA in Subjects With Celiac Disease
Subjects enrolled in this study will be evaluated for immune responses and histological changes in the small bowel following 2 doses of TIMP-GLIA or placebo and a 14-day oral gluten challenge.
- Trial name
- NCT03738475
- Testing
- TIMP-GLIA
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Takeda
Short Bowel Syndrome
A Study in Japanese Children With Short Bowel Syndrome Who Completed SHP633-302
The purpose of this clinical study is to evaluate the long-term safety and tolerability of teduglutide treatment in Japanese pediatric participants with short bowel syndrome (SBS) who completed Study SHP633-302 (NCT02980666).
- Trial name
- NCT03268811
- Testing
- Teduglutide
- Where
- 6 sites in Japan
- Volunteers
- 9 people
- Sponsor
- Shire
Celiac Disease
A Study to Investigate the Pharmacokinetics, Pharmacodynamic Effects, Safety and Tolerability of Repeated Dosing of RO5459072 in Volunteers With Celiac Disease
A randomized, double-blind, placebo-controlled, two treatment, parallel group study to investigate the effects of RO5459072, a cathepsin S inhibitor, on the immune response to a gluten challenge in volunteers with celiac disease.
- Trial name
- NCT02679014
- Testing
- RO5459072
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Hoffmann-La Roche
Lactose Intolerance
MSOT for Assessment of Intestinal Transit Time in Lactose Intolerance Patients
The study aims to investigate gastrointestinal transit using multispectral optoacoustic tomography (MSOT) in a prospective diagnostic study involving patients suspected of primary or secondary lactose intolerance.
- Trial name
- NCT06617364
- Testing
- gastrointestinal transit time measurement using MSOT and ICG contrast agent
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Short Bowel Syndrome
Bridging Intestinal Failure With Teduglutide - a Case Report
In this case report the investigators present a novel strategy for using teduglutide as a bridging therapy to intestinal reconstruction.
- Trial name
- NCT04916665
- Testing
- Teduglutide
- Where
- Austria
- Volunteers
- 1 people
- Sponsor
- Medical University of Vienna
Lactose Intolerance
Efficacy, Safety, and Tolerability Study of RP-G28 in Subjects With Lactose Intolerance
RP-G28 is being investigated for treatment of moderate to severe lactose intolerance and its potential to improve the tolerance of lactose (dairy products).
- Trial name
- NCT02673749
- Testing
- RP-G28
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- Ritter Pharmaceuticals, Inc.
Celiac Disease
A 12-week Exercise Program for Adults With Celiac Disease
Engagement in regular physical activity (PA) is associated with a range of physical and psychological benefits among chronic disease populations.
- Trial name
- MOVE-C (NCT03520244)
- Testing
- Exercise + Holistic Education
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Calgary