Clinical trials: Major Abdominal Surgery
Parenteral Nutrition, Nutritional Status
Effects of Preoperative Parenteral Nutrition With Omega-3 Fish Oil Lipid Emulsion on Postoperative Outcomes in Patients Undergoing Major Abdominal Surgery
The goal of this study is to explore if preoperative ω-3 fish oil lipid emulsion parenteral nutrition (PN) can improve postoperative outcomes in patients undergoing major abdominal surgery.
- Conditions
- Parenteral Nutrition, Nutritional Status, Major Abdominal Surgery
- Trial name
- NCT07878468
- Testing
- ω-3 fish oil lipid emulsion, Conventional lipid without ω-3 fish oil
- Where
- 7 sites in China
- Volunteers
- 158 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Prehabilitation, Major Abdominal Surgeries
PROPOSAL FOR A PREOPERATIVE FUNCTIONAL OPTIMIZATION PATHWAY FOR PATIENTS CANDIDATE FOR MAJOR SURGERY (CARDIAC AND ABDOMINAL ONCOLOGY)
The study aims to evaluate a prehabilitation protocol for patients undergoing cardiac and abdominal surgery. The project for a preparation program for cardiac surgery was developed within the framework of ERAS (Enhanced Recovery…
- Conditions
- Prehabilitation, Major Abdominal Surgeries, Cardiac Surgery, Multimodal and Integrated Program
- Trial name
- PRIME CARE (NCT07851350)
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- ASST Sette Laghi
Patients Undergoing Major Laparoscopic Abdominal Surgery
Intrathecal Morphine for Postoperative Analgesia in Major Laparoscopic Abdominal Surgery, a IMPACT-Scope Trial
The goal of this clinical trial is to learn the clinical and cost effectiveness of intrathecal morphine (ITM) in addition to usual care as a postoperative pain relief strategy following major laparoscopic abdominal surgery…
- Trial name
- IMPACT-Scope (NCT06666985)
- Testing
- ITM + Usual Care
- Where
- China
- Volunteers
- 700 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Anesthesia, General, Major Abdominal Surgeries
The Impact of Multimodal Brain Monitoring on Postoperative Outcomes in Elderly Patients Undergoing Major Abdominal Surgery
The purpose of this clinical trial is to investigate the effect of multimodal brain monitoring under general anesthesia on postoperative outcomes in elderly patients undergoing abdominal surgery.The research hypothesis is that…
- Trial name
- NCT07713355
- Testing
- Multimodal brain monitoring guided anesthesia, Bispectral Index(BIS) monitoring guided anesthesia
- Where
- 4 sites in China
- Volunteers
- 368 people
- Sponsor
- Xuanwu Hospital, Beijing
Adults Waiting to Undergo Lung Cancer or Major Abdominal, Open or Video Assisted Cancer Surgery
Implementing Surgery School Prehabilitation Using Telehealth
The physiological challenge of major surgery has been likened to running a marathon. In both cases, preparation is critical. Yet, many patients undergo major surgery without understanding the potential consequences.
- Trial name
- STTARRS (NCT06631872)
- Testing
- Tele-prehabilitation education session: Surgery School, Individualised Inspiratory Muscle Training and Walking Program, Usual Care
- Where
- 9 sites in Australia
- Volunteers
- 515 people
- Sponsor
- University of Melbourne
CGM, Intensive Care (ICU)
Evaluate the Performance of the Dexcom G7 Continuous Glucose Monitoring (CGM) System in Critically Ill Patients Undergoing Major Abdominal Surgery and Solid Organ Transplantation Which Require Blood Glucose Monitoring for Intensive Insulin Therapy.
Main objective: The goal is to to determine the accuracy of Dexcom G7 Continuous glucose monitor system in critically ill patients, undergoing major abdominal surgery and solid organ transplantation, in the intensive care unit.
- Conditions
- CGM, Intensive Care (ICU), Liver Transplant Surgery, Solid Organ Transplantation
- Trial name
- DREAM-ICU (NCT07611721)
- Testing
- Continuous glucose monitor
- Where
- Czechia
- Volunteers
- 62 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Major Abdominal Surgery
Glycocalyx Monitoring in Major Abdominal Surgery
The study of the microcirculation and glycocalyx could be an essential element in the monitoring of our patients undergoing major abdominal surgery.
- Trial name
- GLYCOCHIP (NCT06285526)
- Testing
- Cytoreduction surgery with Hyperthermic Intraperitoneal Chemotherapy, Cephalic DuodenoPancreatectomy
- Where
- France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Rouen
Perioperative Anxiety, Major Abdominal Surgery
Effect of taVNS on Perioperative Anxiety in Major Abdominal Surgery
It is reported that over 50% of patients undergoing major abdominal surgery experience perioperative anxiety, which often triggers a vicious cycle of "anxiety-pain-gastrointestinal dysfunction" and significantly hinders…
- Trial name
- taVNS-MASAnx (NCT07495163)
- Testing
- transauricular auricular vagus nerve stimulation
- Where
- 4 sites in China
- Volunteers
- 282 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Major Abdominal Surgery, Atelectasis
Optimal Interval for Periodic Alveolar Recruitment Maneuvers Achieving 90% Lung Re-expansion During Intraoperative Ventilation
This study aims to determine the optimal interval for periodic alveolar recruitment maneuvers (PARM) that can achieve effective lung re-expansion in 90% of patients undergoing intraoperative mechanical ventilation during…
- Conditions
- Major Abdominal Surgery, Atelectasis, Lung-protective Ventilation, Lung Ultrasound Score
- Trial name
- NCT07239557
- Testing
- Different interval of PARM
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Major Abdominal Surgery, Postoperative Delirium (POD)
MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES)
This study aims to determine whether, compared with placebo, the nighttime self-administration of a nasal dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in high-risk patients.
- Conditions
- Major Abdominal Surgery, Postoperative Delirium (POD), Sleep Disturbances, Intranasal Dexmedetomidine
- Trial name
- MIDDIES (NCT07538284)
- Testing
- Dexmedetomidine
- Volunteers
- 400 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Major Abdominal Surgeries
Cold Water Gargling After Major Abdominal Surgery
This randomized controlled trial examined the effect of cold water gargling on postoperative oral dryness, thirst severity, and patient satisfaction in patients who underwent major abdominal surgery.
- Trial name
- NCT07506226
- Testing
- Cold water gargling
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- TC Erciyes University
Major Abdominal Surgeries, Mechanical Ventilation
Intraoperative Multimodal Monitoring as a Means in Reducing the Duration of Mechanical Ventilation in High-Risk Patients Undergoing Major Abdominal Procedures - A Pilot Study
This study will include patients aged 50 and older scheduled for elective abdominal oncologic surgery, classified as ASA II and III due to increased anaesthetic and surgical risk. Gender will not be a stratification factor.
- Trial name
- IMMEDIUM (NCT07339449)
- Testing
- Multimodal monitoring
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University Hospital Dubrava
Critical Illness, Major Abdominal Surgeries
Metabolic and Muscle Profile in ICU Survivors
More and more patients survive a critical illness requiring admission to the intensive care unit, but they may be left with sequelae that are independent of the initial pathology.
- Trial name
- IM3SI (NCT07329530)
- Testing
- Inflammation markers, Blood nucleosomes, Erythrocyte membrane fatty acid content
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Anne-Françoise Rousseau
Elective Major Abdominal Surgery
Effectiveness of Goal-Directed Fluid Therapy Guided by Cardiac Index Versus Central Venous Pressure in Major Abdominal Surgery Patients in the ICU.
This study aims to compare two different methods for guiding intravenous (IV) fluid therapy in patients during their first 6 hours in the ICU after major abdominal surgery.
- Trial name
- NCT07303855
- Testing
- Goal-Directed Fluid Therapy (GDFT)
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Major Abdominal Surgery, Colorectal Surgery
Automated Versus Manual Fluid Management for High Risk Abdominal Surgical Patient. A Prospective, Randomized Trial
Dynamic parameters like pulse pressure variation have been shown to be accurate predictors of fluid responsiveness. Hemodynamic optimization based on fluid management and stroke volume optimization have been shown to improve…
- Conditions
- Major Abdominal Surgery, Colorectal Surgery, Hepatectomy, Pancreatectomy
- Trial name
- CL vs CP (NCT01950845)
- Testing
- Closed loop automated System (LIR®: learning intravenous resuscitator), manual current practice by anesthesiologist team
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Hospices Civils de Lyon
Subcostal, Lateral
Combined Subcostal and Lateral Transversus Abdominis Plane Block for Postoperative Analgesia Versus Thoracic Epidural Analgesia in Patients Undergoing Major Abdominal Cancer Surgery
This study aims to evaluate the safety and efficacy of combined subcostal and lateral transversus abdominis plane (TAP) for postoperative analgesia versus thoracic epidural anesthesia (TEA) in patients undergoing major abdominal…
- Conditions
- Subcostal, Lateral, Transversus Abdominis Plane Block, Postoperative Analgesia
- Trial name
- NCT07273136
- Testing
- Subcostal and lateral transversus abdominis plane block, Thoracic epidural anesthesia
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Major Abdominal Surgeries
Low-Flow Desflurane Anesthesia and Its Effects on BIS and Postoperative Cognitive Functions
This study investigates the effects of low-flow desflurane anesthesia in adult patients undergoing major abdominal surgery. The researchers will examine whether different low-flow strategies: Cause differences in the Bispectral…
- Trial name
- NCT07212543
- Testing
- Routine anesthesia care (desflurane at different low-flow rates: 0.5, 1.0, 1.5 L/min); no intervention assigned as part of the study.
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Dolunay ARIK
Norepinephrine, Hypotension
Evaluation of the Early Use of Norepinephrine in Major Abdominal Surgery on Postoperative Organ Dysfunction
Hemodynamic instability is frequent during surgery and intraoperative hypotension is associated with excess morbidity and excess mortality in high-risk patients.
- Conditions
- Norepinephrine, Hypotension, Anesthesiology, Major Abdominal Surgery
- Trial name
- EPON (NCT05276596)
- Testing
- Ephedrine, Norepinephrine
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
To Compare Efficacy of Dexmedetomidine in Bilateral Quadratus Lumborum vs Lumbar Epidural Blocks on Analgesia After Major Lower Abdominal Surgery
Clinical Efficacy and Safety of Dexmedetomidine as an Adjuvant in Quadratus Lumborum Versus Epidural Block in Postoperative Lower Abdominal Cancer Surgeries
Clinical efficacy and safety of dexmedetomidine as an adjuvant in quadratus lumborum versus epidural block in postoperative patients
- Trial name
- NCT06130670
- Testing
- nerve block
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Assiut University
Inspiratory Effort, Mechanical Ventilation
Assessment of Respiratory Drive and Inspiratory Effort Across Pressure Support Levels in Patients After Major Abdominal Surgery
This physiological observational study will assess respiratory drive and inspiratory effort across varying levels of pressure support ventilation (PSV) in adult surgical ICU (SICU) patients after major abdominal surgery.
- Conditions
- Inspiratory Effort, Mechanical Ventilation, Major Abdominal Surgeries
- Trial name
- NCT07199881
- Testing
- Stepwise PSV adjustment protocol
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University