Clinical trials: Lyme Disease, Chronic
Post-Lyme Disease Syndrome (PLDS)
Treating Post-Lyme Disease Syndrome With Acetogenins
To access the effectiveness of Acetogenins in treating Post-Lyme Disease Syndrome (PLDS).
- Trial name
- NCT04078841
- Testing
- ReaLife+ (RLP), Inert Brown powder
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Optimal Health Research
Chronic Fatigue Syndrome
Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health
Background: Post-Infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (PI-ME/CFS) refers to long-lasting and disabling fatigue or malaise, inability to recover after exercise, and physical and emotional discomfort that…
- Trial name
- NCT02669212
- Testing
- Cardiopulmonary Exercise Test (CPET)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Lyme Disease, Lyme Disease, Chronic
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Lyme Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Lyme Disease
- Trial name
- NCT04148222
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Fibromyalgia, Chronic Fatigue Syndrome
Complex Chronic Diseases Program Data Registry
The purpose of this data registry is to prospectively collect data from patients referred to an Complex Chronic Diseases Program (CCDP) at BC Women's Hospital + Health Centre to assess the quality of life of the CCDP Patients…
- Conditions
- Fibromyalgia, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Chronic Lyme-Like Syndrome
- Trial name
- NCT03409653
- Where
- Canada
- Volunteers
- 1,300 people
- Sponsor
- BC Women's Hospital & Health Centre
Post Treatment Lyme Disease Syndrome
Meditation and Stretching for Post Treatment Lyme Disease Syndrome
The investigators wish to conduct a preliminary study to examine the efficacy of meditation among patients with Post Treatment Lyme Syndrome (PTLDS).
- Trial name
- LMS (NCT02344537)
- Testing
- Kundalini Yoga
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Rheumatic Diseases, Adult Onset Still Disease
Rheumatology Patient Registry and Biorepository
To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases.
- Conditions
- Rheumatic Diseases, Adult Onset Still Disease, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT04402086
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Yale University
Fatigue, Quality of Life
Disulfiram: A Test of Symptom Reduction Among Patients With Previously Treated Lyme Disease
Approximately 10-20% of patients experience ongoing symptoms despite having received standard antibiotic therapy for Lyme disease.
- Trial name
- NCT03891667
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Chronic Lyme Borreliosis
The Phenomenon of "Chronic Lyme"; an Observational Study
The current study is set up to chart clinically and laboratory findings in Norwegian patients with symptoms attributed by themselves or their doctor to ongoing chronic Bb infection.
- Trial name
- NCT01151150
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Sorlandet Hospital HF
Post-Treatment Lyme Disease
Transcranial Direct Current Stimulation for Post Treatment Lyme Disease
The primary purpose of this pilot study is to investigate a novel approach to the treatment of cognitive symptoms that persist despite prior antibiotic treatment for Lyme disease (Post treatment Lyme Disease or PTLD).
- Trial name
- NCT06915324
- Testing
- Transcranial Direct Current Stimulation (tDCS), Cognitive training
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Columbia University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Lyme Disease
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seronegative Chronic Lyme Disease
Lyme disease is the most common tick-borne disease in the United States. It is caused by the spirochete Borrelia burgdorferi. It may exist in a chronic form and be the result of: 1) persistent infection by B.
- Trial name
- NCT00000938
- Testing
- ceftriaxone, doxycycline
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Chronic Atrophic Acrodermatitis
Laboratory Characteristics in Chronic Atrophic Acrodermatitis
The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with chronic atrophic dermatitis to gain better insight into pathogenesis of chronic…
- Trial name
- NCT02147262
- Testing
- doxycycline orally, 100 mg, bid, 14 days, doxycycline orally, 100 mg, bid, 28 days
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Post-Lyme Disease Syndrome (PLDS)
A Novel Nutraceutical to Combat Post-Lyme Disease Syndrome
This study will determine the effectiveness of a nutraceutical in treating the lingering effects of Lyme Disease after antibiotic treatment.
- Trial name
- PLDS (NCT04141969)
- Testing
- RLP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Optimal Health Research
Post-Treatment Lyme Disease
Meditation and Kundalini Yoga for Persistent Lyme-related Symptoms - an Online Study
This randomized, controlled study examines whether a daily practice over 8 weeks of Kundalini Yoga or Meditation can help to reduce pain and/or fatigue among patients with symptoms that persist despite prior antibiotic treatment.
- Trial name
- NCT04349605
- Testing
- Meditation, Kundalini Yoga
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Post-Treatment Lyme Disease
Ceftriaxone Pulse Dose for Post-Treatment Lyme Disease
The goal of this clinical trial is to learn if an FDA approved drug, Ceftriaxone, given intermittently, can treat people between 18 and 75 years old with a history of Lyme disease, who are still experiencing persistent or…
- Trial name
- NCT06611111
- Testing
- Ceftriaxone (Rocephin®), Dextrose 5% (D5W)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- State University of New York - Upstate Medical University
Long Covid, Post-treatment Lyme Disease Syndrome
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This will be a pilot multi-arm clinical trial investigating the feasibility of Lumbrokinase (LK) as an intervention in three clinical cohorts: Long Covid (LC) Post-treatment Lyme disease syndrome (PTLDS) Myalgic…
- Conditions
- Long Covid, Post-treatment Lyme Disease Syndrome, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
- Trial name
- NCT06511050
- Testing
- Lumbrokinase
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Post-Treatment Lyme Disease, Chronic Lyme Disease
Effects of Psilocybin in Post-Treatment Lyme Disease
This study will examine the effects of psilocybin on Lyme disease symptom burden and quality of life in people with Post-Treatment Lyme Disease (PTLD).
- Conditions
- Post-Treatment Lyme Disease, Chronic Lyme Disease, Lyme Disease, Chronic
- Trial name
- NCT05305105
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Long COVID, PTLDs
A Prospective Study to Evaluate the Role of T-Cell Dysfunction in Patients Who Present Symptoms Associated With Long COVID, Lyme Disease and Myalic Encephalomyelitis / Chronic Fatigue Syndrome Using the Vira Immune Fluorospot T Cell Assay
This is a longitudinal observational study recruiting individuals that have attended three clinical sites with symptoms associated with a diagnosis of long COVID, PTLDS or ME/CFS.
- Conditions
- Long COVID, PTLDs, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3)
- Trial name
- NCT06731179
- Where
- 3 sites in United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- ViraxBio Labs
Post-treatment Lyme Disease Syndrome, Chronic Pain
Sana Device for Post-Treatment Lyme Disease Syndrome Chronic Pain
This study will investigate the effectiveness of the Sana Pain Reliever (Sana PR) at reducing chronic pain. The Sana PR is a device comprised of one main component (Mask with Earbuds) and two ancillary components (Charger and…
- Trial name
- NCT06655844
- Testing
- Sana Pain Reliever
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai