Clinical trials: Lung Function
Postoperative Pulmonary Complications, Respiratory Insufficiency
The PROtective Ventilation Using Open Lung Approach Or Not Trial
Postoperative Pulmonary Complications (PPC) are very common. It severely affects postoperative recovery, particularly in the abdominal surgery.
- Trial name
- PROVOLON (NCT03160144)
- Testing
- open lung approach
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Chronic Obstructive Pulmonary Disease
Quality of Life in Daxas-treated Patients Older Than 18 Years With Severe Chronic Obstructive Pulmonary Disease (COPD) (DACOTA)
Chronic obstructive pulmonary disease (COPD) is a progressive and largely irreversible lung disease characterized by chronic bronchitis and/or emphysema, resulting in breathlessness, cough and sputum.
- Trial name
- DACOTA (NCT01285167)
- Testing
- Daxas
- Where
- 605 sites in Germany
- Volunteers
- 3,645 people
- Sponsor
- AstraZeneca
Intercostal Nerve Block, Pulmonary Ventilation
EIT Evaluation of Pulmonary Ventilation With Different Ropivacaine Concentrations in Intercostal Nerve Blockade
This study aims to find out how different strengths of the anesthetic drug ropivacaine affect lung breathing function when used in intercostal nerve block (a type of local anesthesia) for breast quadrantectomy surgery.
- Conditions
- Intercostal Nerve Block, Pulmonary Ventilation, Anesthesia, Local, Breast Neoplasms
- Trial name
- EIT (NCT07079436)
- Testing
- 0.25% ropivacaine, 0.375% Ropivacaine, 0.5% Ropivacaine
- Where
- China
- Volunteers
- 67 people
- Sponsor
- Fudan University
Autonomic Function in Patients With Chronic Obstructive Pulmonary Disease
Autonomic Function in Patients With COPD
Conduct an in-depth evaluation of autonomic function using a validated tests, assess genetic aspects of autonomic failure, and determine the correlation between of autonomic function failure and other clinical variables in…
- Trial name
- NCT05667311
- Testing
- ECG
- Where
- Belgium
- Volunteers
- 26 people
- Sponsor
- University Hospital, Ghent
Healthy Volunteers
Healthy Lung Study- Development of 3T MRI Hardware and Software for 3He Gas Imaging of the Lung: Healthy Volunteer Development Study
Healthy volunteers aged 18-75 will undergo hyperpolarized 3-Helium MRI and pulmonary function testing for the development of tools to assess image signal to noise and reproducibility of spin-density and diffusion-weighted imaging.
- Trial name
- NCT03169673
- Testing
- Hyperpolarized Helium 3 Magnetic Resonance Imaging
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
COVID-19
The Evaluation of Hemostasis in Hospitalized COVID-19 Patients
Coronavirus disease 2019 (COVID-19), a viral respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been shown to predispose patients to thrombotic diseases (venous and arterial) with…
- Trial name
- TARGET-COVID (NCT04493307)
- Testing
- Phlebotomy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- LifeBridge Health
Pneumonia Childhood, Rehabilitation
Clinical Efficacy of Respiratory Pediatric Physiotherapy on a Child With Hospital Treated Pneumonia
The accumulation of secretions in the bronchopulmonary air network promotes the detriment of respiratory functions generating hypoxia and causing a decrease in the cardiac output requiring the use of mechanical ventilation and…
- Conditions
- Pneumonia Childhood, Rehabilitation, Recovery of Function
- Trial name
- NCT06174454
- Testing
- Respiratory Pediatric Physiotherapy, Control Group
- Where
- Mexico
- Volunteers
- 88 people
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
COVID-19
Retrospective Study of COVID-19 on Reproductive Function
This multi-center, retrospective cohort study aimed to determine which factors are associated with ongoing pregnancy rates in infertile patients received ART treatments during the current outbreak of COVID-19 infection.Couples…
- Trial name
- NCT05685966
- Testing
- no intervention
- Where
- 3 sites in China
- Volunteers
- 400 people
- Sponsor
- Jinling Hospital, China
Stable COPD Patients
Effect of Vitamin D3 on Lung Function and Exercise Tolerance in COPD Patients
Background: Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality throughout the world which is a preventable as well as treatable disease.
- Trial name
- NCT03781895
- Testing
- Cholecalciferol
- Where
- Bangladesh
- Volunteers
- 48 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Pneumoperitoneum
Influence of Posture and Gas Insufflation on Perioperative Lung Function
Perioperative airway resistance and lung function are evaluated perioperatively in patients, who undergo surgical procedures in different postures and with or without gas insufflation into the peritoneal cavity.
- Trial name
- NCT00948571
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Kliniken Essen-Mitte
Breast Cancer, Postoperative Pain
The Effect of Rhomboid Intercostal Block and Serratus Anterior Plane Block on Postoperative Respiratory Functions
Rhomboid intercostal block is used to block lateral cutaneous branches of intercostal nerves between T3 and T9 dermatomes. Serratus anterior plane block is used to block lateral cutaneous branches of intercostal nerves between T2…
- Conditions
- Breast Cancer, Postoperative Pain, Respiratory Function Impaired
- Trial name
- RIBSAB (NCT05547932)
- Testing
- RIB+SAP blocks
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Muğla Sıtkı Koçman University
Cystic Fibrosis
Sildenafil Exercise: Role of PDE5 Inhibition
Exercise intolerance is an understudied phenomenon in people with CF. The investigators hypothesized that vascular dysfunction plays a significant role, and can be partially reversed by administration of the phosphodiesterase…
- Trial name
- NCT04039087
- Testing
- Sildenafil 40mg oral capsule
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- National Jewish Health
Cystic Fibrosis
Development Of An Innovative Panel of Methods To Measure Intestinal Macronutrient Digestion, Absorption, and Function
Malnutrition is a significant problem in children and adults with Cystic fibrosis (CF). An impaired intestinal digestion and absorption capacity is one of the main factors responsible for the malnutrition in CF.
- Trial name
- NCT01494909
- Testing
- Ensure plus
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Cardiac Disease
The Effects of Neurophysiological Facilitation Techniques After Coronary Artery Bypass Graft Surgery
The aim of the study is to investigate the effects of neurophysiological facilitation techniques, applied in addition to Phase I cardiac rehabilitation in the early postoperative period after coronary artery bypass graft (CABG)…
- Trial name
- NCT06640699
- Testing
- exercise
- Volunteers
- 36 people
- Sponsor
- Istanbul University - Cerrahpasa
Postoperative Cognitive Dysfunction, Acute Postoperative Pain
Effect of TPVB on Postoperative Pain and Cognitive Function After VATS in Elderly Patients
To investigate the effect of ultrasound-guided thoracic paravertebral nerve block on postoperative acute and chronic pain and cognitive function in elderly patients with thoracoscopic partial lung resection.
- Conditions
- Postoperative Cognitive Dysfunction, Acute Postoperative Pain, Chronic Postsurgical Pain
- Trial name
- NCT05364216
- Testing
- Measurement of cognitive function, Thoracic paravertebral block, The assessment of cognitive function
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
COPD
Effects of Endoscopic Lung Volume Reduction on Diaphragm Function and Conformation
Chronic obstructive lung disease (COPD) is a common disease that is frequently complicated by hyperinflation. The resulting increase in lung volume impairs the diaphragmatic function because of a shortening of the diaphragmatic…
- Trial name
- NCT05799352
- Testing
- Endoscopic lung volume reduction
- Where
- Belgium
- Volunteers
- 35 people
- Sponsor
- Erasme University Hospital
Collapsed Lung, Hemodynamic Stability
Role of Inhaled Nitric Oxide in Vascular Mechanics and Right Ventricular Function
The aim of this study is to evaluate the role of nitric oxide on pulmonary vasculature and right ventricular function in postoperative cardiac surgery patients.
- Trial name
- NCT06097026
- Testing
- Alveolar recruitment maneuver, Nitric Oxide
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Fernando Suarez Sipmann
Fear Anxiety, Pulmonary
Preparation Methods on PFT Performance
Background: Successful spirometry in children depends on adequate cooperation and correct performance of respiratory maneuvers. Although several preparation strategies have been proposed, evidence comparing their effects on both…
- Conditions
- Fear Anxiety, Pulmonary, Performance Assessment
- Trial name
- NCT07713225
- Testing
- Verbal Instruction with Demonstration, Animation-Assisted Preparation
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Stem Cell Transplantation
Physical Functions in Allogeneic-HSCT Candidates
Physical inactivity and impairments in physical functions have been observed in patients due to hematological malignancy itself and treatments of chemotherapy, radiotherapy, corticosteroids.
- Trial name
- NCT03915249
- Volunteers
- 49 people
- Sponsor
- Gazi University
Metabolic Syndrome
Exercise Training and Respiratory Muscle Training in Individuals With Metabolic Syndrome(METS)
The study will be conducted on individuals with Metabolic Syndrome. There are many studies showing that aerobic exercise provides significant improvements in waist circumference, fasting glucose, high-density lipoprotein…
- Trial name
- METS (NCT05413434)
- Testing
- exercise, inspiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Hacettepe University