Clinical trials: Lower Limb Amputation
Lower Limb Amputation Below Knee (Injury)
Restoration of Normative Postural Control
The objective of this proposal is to investigate the effects of training to use direct electromyographic (dEMG) control of a powered prosthetic ankle on transtibial amputees'. The aimed questions to answer: 1.
- Trial name
- NCT06452186
- Testing
- direct EMG controlled prosthetic ankle, PT guided prosthetic training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- North Carolina State University
Perineural, Methylene Blue
Perineural Methylene Blue Infusion in Lower Limb Amputation Surgery
This prospective randomized controlled study will be conducted to evaluate the analgesic effect of continuous perineural infusion of methylene blue with bupivacaine on acute postoperative pain and to evaluate its preventive role…
- Conditions
- Perineural, Methylene Blue, Lower Limb Amputation
- Trial name
- NCT05830630
- Testing
- Bupivacaine methylene blue, bupivacaine saline
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Tanta University
Lower Limb Amputation
Identification of Limiting Factors in the Locomotor Activity of Individuals With Lower Limb Amputation:
The experience of amputation leads to a deterioration in quality of life, with undeniable somatic and functional repercussions. The result is a reduction in general mobility, increased metabolic energy requirements and a feeling…
- Trial name
- AMPUTEEFACT (NCT06415955)
- Testing
- None, pure observationnal study
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Amputation, Lower Limb Amputation Below Knee (Injury)
Prosthetic Performance Enhancement Trial
The purpose of this research is to determine the feasibility of an uneven terrain walking program for lower limb prosthesis users.
- Conditions
- Amputation, Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation at Ankle (Injury)
- Trial name
- PROSPER (NCT06419920)
- Testing
- Flat terrain locomotor training, Uneven terrain locomotor training
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Nevada, Las Vegas
Amputation of Lower Limb
Personalized Prosthetic Foot Prescription and Rehabilitation for Veterans With Lower Limb Loss
The goal of clinical trial is to assess an integrated, patient-centered strategy combining user preference-based prosthetic foot prescription and subsequent targeted physical therapy to maximize satisfaction and mobility outcomes…
- Trial name
- OPORP (NCT06844305)
- Testing
- Prosthetic foot, Physical therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwestern University
Transtibial Amputation, Lower Limb Amputation Below Knee
Clinical Evaluation of the Access Socket Flexible Socket for Transtibial Prosthesis
Transtibial amputation significantly impacts patient autonomy and quality of life, primarily due to the limitations of conventional rigid sockets, which restrict comfort and joint range of motion.
- Trial name
- AS-TT (NCT07592325)
- Testing
- Access Socket (AS), Rigid Socket (RS)
- Where
- 5 sites in France
- Volunteers
- 25 people
- Sponsor
- Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est
Stroke, Parkinson Disease
C-STAR Movement Database
The purpose of this study is to develop a database that contains movement and rehabilitation-related data collected through the use of wearable sensors and video.
- Conditions
- Stroke, Parkinson Disease, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
- Trial name
- NCT05471375
- Testing
- Database Entry
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Shirley Ryan AbilityLab
Lower Limb Amputation Below Knee (Injury), Diurnal Residual Limb Fluid Volume Fluctuation
An Automatically Adjusting Prosthetic Socket for People With Transtibial Amputation
People with leg amputations often experience daily changes in the size (volume) of their residual limb. These daily changes can cause a prosthesis to fit poorly. They can also cause limb problems like pain or skin breakdown.
- Trial name
- NCT05124652
- Testing
- Auto Adjusting Prosthesis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Washington
Lower-Limb Amputation
Walking Exercise Sustainability Through Telehealth for Veterans With Lower-limb Amputation
Despite recent advances in physical rehabilitation, Veterans with lower-limb amputation have poor long-term outcomes, including severely limited functional capacity and high levels of disability.
- Trial name
- WEST (NCT05412550)
- Testing
- Exercise self-management, Attention control
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- VA Office of Research and Development
Amputation, Lower Limb
Quantifying Bone and Skin Movement in the Residual Limb of Individuals With Transtibial Amputation Using Dynamic Stereo X-Ray
Individuals with lower extremity amputation are often challenged by complications that arise from poor prosthetic fit, including movement of the residual limb in the socket, known as pistoning.
- Trial name
- NCT05287646
- Testing
- Suction Suspension First, Elevated Vacuum Suspension First
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Lower-Limb Amputation
Evaluation of a New Articulated Prosthetic Foot: Comfort, Safety and Biomechanics in Individuals With a Lower-Limb Amputation
This clinical investigation aims to evaluate a new articulated prosthetic foot during daily-life activities.
- Trial name
- MAP-CSB (NCT07530601)
- Testing
- New Articulated Prosthetic Foot, Current Prosthetic foot
- Where
- 2 sites in Belgium
- Volunteers
- 120 people
- Sponsor
- Vrije Universiteit Brussel
Amputation, Surgical, Amputation, Traumatic
Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation
When a limb is severed, pain perceived in the part of the body that no longer exists often develops and is called "phantom limb" pain.
- Conditions
- Amputation, Surgical, Amputation, Traumatic, Phantom Limb Pain, Phantom Pain Following Amputation of Lower Limb
- Trial name
- NCT06071715
- Testing
- ACTIVE cryoneurolysis
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Diego
Amputation, Lower Limb Amputation
Effect of PNF-Based Upper Extremity Strengthening With Core Stabilization on Fitness in Amputee Football Players
Amputee football (AF) is a disability-specific football in which amputees can participate. This study aims to determine the effect of PNF-based upper extremity strengthening exercises combined with core stabilization exercises on…
- Trial name
- NCT06556082
- Testing
- Training, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Uskudar University
Lower Limb Amputation, Slip Perturbations
Pilot Study on the Evaluation of the Functionality, Safety and Reliability of New Tripping Devices for Lower Limbs.
The study aims to identify prognostic biomarkers of fall risk in patients with lower limb amputation
- Conditions
- Lower Limb Amputation, Slip Perturbations, Fall Risk
- Trial name
- MOTU++ pedane (NCT06883942)
- Testing
- prosthetic group performs the entire protocol with their own prosthesis, Experimental Group
- Where
- Italy
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Parkinson's Disease and Parkinsonism, Dementia
Context- and Terrain-aware Gait Analysis
The average lifespan of individuals in many developed countries is increasing. This factor paired with the increase in global population has the potential to put a strain on healthcare systems with regards to age-related…
- Conditions
- Parkinson's Disease and Parkinsonism, Dementia, Acquired Brain Injury, Multiple Sclerosis
- Trial name
- CTAGA (NCT07491588)
- Testing
- All-terrain Gait Analysis System
- Sponsor
- University of Leeds
Lower Limb Amputation
Study of Locomotor Expectations for Ascending/Descending Slope and Stairs in Patients With Limb Amputations
Patients with lower limb amputations are equipped with prostheses that can be mechanical and/or electronic. These prostheses can be mono-articular (only the ankle) or bi-articular (knee and ankle for example).
- Trial name
- JCE (NCT04030650)
- Testing
- Functional analyses, 3D analysis of walking and balance
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Prosthesis User, Amputation; Traumatic, Limb, Lower
Criteria for Advanced Prosthetic Foot Prescription
The purpose of this study is to develop criteria for prosthetic foot prescription for Veterans and Service Members with transtibial limb loss.
- Trial name
- NCT03505983
- Testing
- ESR Prosthetic Foot First, Articulating ESR Prosthetic Foot First, Powered Prosthetic Foot First
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- VA New York Harbor Healthcare System
Amputation of Lower Limb
Assessment of Safety and Performances of a 3D Printed Prosthetic Foot: A Pilot Study
A dynamic energy storage and return foot prosthesis is a type of prosthesis designed to mimic and restore the functionality and natural movement of the limb that has been amputated.
- Trial name
- NCT06938087
- Testing
- 3D printed prosthesis foot, Current prosthesis foot
- Where
- Italy
- Volunteers
- 3 people
- Sponsor
- Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoro
Stump Neuroma, Residual Limb Pain
Ultrasound-Guided Radiofrequency Ablation Versus Steroid Injection for Stump Neuroma
This prospective clinical study aims to compare the effectiveness of ultrasound-guided radiofrequency ablation and ultrasound-guided corticosteroid injection in individuals with symptomatic stump neuroma following lower extremity…
- Conditions
- Stump Neuroma, Residual Limb Pain, Lower Extremity Amputation
- Trial name
- NCT07431424
- Testing
- Radiofrequency ablation alone, Corticosteroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Lower Limb Amputation, Prosthesis User
Clinical and Psychological Adjustment of Patients With LLA: a Multidisciplinary Rehabilitative Intervention Project
Most of the limb amputation related to vascular disease is often secondary to a diagnosis of type 2 diabetes mellitus. The amputation involves significant motor, psychological, and social challenges for patients, with a major…
- Trial name
- AMPADinRehab (NCT06471855)
- Testing
- Multidisciplinary Conventional and Technology-based Rehabilitation, Multidisciplinary Conventional Rehabilitation
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA