Clinical trials: Larynx Edema
Need for Tracheal Tube Exchange, Presence of Post-extubation Laryngeal Oedema
"Cuffed Versus Uncuffed Tracheal Tubes in Small Children"
This randomized controlled multi-centre trial in children from birth up to < 5 years of age aims to demonstrate equivalence as to the major outcome of post-extubation airway injury (stridor) comparing uncuffed tracheal tubes to…
- Trial name
- NCT00221377
- Testing
- Intubation using tracheal tubes with or without cuff
- Where
- 24 sites in Austria, Belgium and 6 more
- Volunteers
- 4,000 people
- Sponsor
- University Children's Hospital, Zurich
Laryngeal Edema
Ultrafast Ultrasonographic Oro-laryngeal Measurement in Critically Ill Patients During Weaning From Mechanical Ventilation
In ICU, ventilatory weaning failure is common, accounting for up to 25% of extubations. These failures are largely due to swallowing disorders and laryngeal edema. Edema prevalence in ICU varies between 4 and 37%.
- Trial name
- REVEAL (NCT05611437)
- Testing
- Ultrafast ultrasonography
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Groupe Hospitalier du Havre
Hypersensitivity, Anaphylaxis
Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral Challenges
The goal of this exploratory study is to evaluate the effects of inhaled epinephrine in subjects, who may not be eligible for the GHL-101 trial, and who are experiencing systemic allergic reaction (SAR) that occur following…
- Trial name
- NCT07038746
- Testing
- Inhaled Epinephrine
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Dr. George Luciuk
Hypersensitivity, Anaphylaxis
Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing Immunotherapy or Oral Challenges
The purpose of this exploratory study is to evaluate the effects of inhaled epinephrine in patients with known or suspected metabisulfite sensitivity who experience a systemic allergic reaction (SAR) while undergoing allergy…
- Trial name
- NCT06445374
- Testing
- Inhaled Epinephrine
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Dr. George Luciuk
Spinal Stabilization
Comparison of the Effect of Two Methods on Laryngeal Edema in Endotracheal Cuff Inflation
In this study, the investigators aimed to evaluate perioperative laryngeal edema in patients undergoing lumbar stabilization surgery in the pron position, which the investigators use in our routine anesthesia practice, by using…
- Trial name
- NCT06770322
- Testing
- Conventional, manometer
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Post-Extubation Laryngeal Edema
Prevention of Post-Extubation Laryngeal Edema With Intravenous Corticosteroids
Tracheal intubation is a frequent procedure in intensive care units (ICU). Post-extubation laryngeal edema is a frequent complication with potential morbidity and mortality, and may lead to urgent tracheal re-intubation.
- Trial name
- NCT00199576
- Testing
- Methylprednisolone
- Where
- 15 sites in France
- Volunteers
- 670 people
- Sponsor
- University Hospital, Limoges
Respiratory Failure
Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients
The COSMIC trial will be a multicentred, national, parallel-group, pragmatic vanguard pilot trial.
- Trial name
- COSMIC (NCT05456542)
- Testing
- Cuff Leak Test, Dexamethasone 4mg
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Shoulder Arthroscopy, Endotracheal Tube Cuff Pressure
Irrigation Fluid Volume, Tube Cuff Pressure, and Neck Swelling During Shoulder Arthroscopy
During shoulder arthroscopy, fluid is pumped into the shoulder to help the surgeon see inside the joint. Some of this fluid can move into the tissues around the shoulder and neck and cause swelling.
- Conditions
- Shoulder Arthroscopy, Endotracheal Tube Cuff Pressure, Neck Soft Tissue Edema
- Trial name
- NCT07852702
- Testing
- Elective Shoulder Arthroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Laryngeal Edema, Acute Respiratory Failure Requiring Reintubation
Evaluation of Laryngeal Ultrasonography Performance in Predicting Major Post Extubation Laryngeal Edema in Intensive Care Patients
For patient in intensive care unit, extubation failure is defined as the necessity of early reintubation after scheduled extubation, with Increased morbidity and mortality, so it seems important to quickly identify patients with…
- Trial name
- ECHOLPE (NCT01857674)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Dysphonia, Vocal Cord Cyst
Voice Rest Versus Hypofunctional Whispering After Phonosurgery
This randomized controlled trial compares two postoperative voice behavior protocols in patients undergoing microlaryngeal surgery (phonosurgery) for benign vocal fold lesions such as polyps, cysts, and Reinke's edema.
- Conditions
- Dysphonia, Vocal Cord Cyst, Vocal Cord Polyp, Bening Vocal Cord Lesions
- Trial name
- NCT07704125
- Testing
- Absolute Voice Rest, Hypofunctional Whispering
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Celal Emre Çavlan
Laryngeal Edema
Laryngeal Edema Assessment by Cuff Leak Test and Ultrasound in ICU Patients and Its Relationship With Weaning Success
This study evaluates laryngeal edema in ICU patients during weaning from mechanical ventilation. It compares the cuff leak test and ultrasound-based laryngeal air column measurements in predicting weaning success.
- Trial name
- NCT07523828
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Acute Allergic Reaction, Anaphylaxis
Phase 1 Crossover Study Evaluating the Safety, Tolerability, and Pharmacokinetics of KP001 in Healthy Adult Volunteers
The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetics (PK) of several KP001 dose regimens to identify a treatment regimen with a PK profile that safely meets or exceeds the PK profile of…
- Trial name
- NCT06963411
- Testing
- KP001
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Kokua Pharma Inc.
Stridor, Larynx Edema
Predicting Post Extubation Stridor After Maxillomandibular Fixation
Endotracheal intubation can induce laryngotracheal injury which results in narrowing of the airway due to edema of the glottis. This can increase the risk of development of post-extubation stridor (PES)
- Trial name
- airway (NCT05839756)
- Testing
- budesonide, normal saline
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Mansoura University
Laryngeal Edema
Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU
Introduction: Endotracheal intubation and mechanical ventilation are lifesaving interventions that are commonly done in the intensive care unit (ICU).
- Trial name
- COMIC (NCT03372707)
- Testing
- Cuff Leak Test
- Where
- 3 sites in Canada, Poland and 1 more
- Volunteers
- 100 people
- Sponsor
- McMaster University
Airway Obstruction
Comparison of High Dose and Low Dose Dexamethasone in Preventing Post-Extubation Airway Obstruction in Adults
The specific objectives were to determine whether high dose dexamethasone are more effective than low dose dexamethasone in the reduction or prevention of post-extubation airway obstruction among patients with a cuff leak volume…
- Trial name
- NCT00548483
- Testing
- dexamethasone (Oradexon, Nederland)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Mackay Memorial Hospital
Dysphagia, Laryngeal Edema
Corticosteroids for Post-Extubation Dysphagia
This is a placebo-controlled, double-blind randomized trial of a short course of intravenous corticosteroids for Acute Respiratory Failure Survivors with Fiberoptic Endoscopic Evaluation of Swallowing (FEES) documented laryngeal…
- Trial name
- COPED (NCT06670521)
- Testing
- Methylprednisolone, Normal Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver