Clinical trials: Large Language Model
Breast Cancer, Colorectal Cancer
AI-Assisted Chemotherapy Side Effect Management
This two-stage adaptive randomized controlled trial evaluates the feasibility and preliminary efficacy of large language model (LLM)-assisted intervention for managing chemotherapy side effects in patients with solid tumors.
- Trial name
- ALLIANCE (NCT07198581)
- Testing
- LLM-assisted chemotherapy side effect management
- Where
- South Korea
- Volunteers
- 174 people
- Sponsor
- Incheon St.Mary's Hospital
Outpatient Care
A Large Language Model in Outpatient Care
The goal of this clinical trial is to learn how the use of a large language model (LLM) based tool affects outpatient clinical care in adult patients attending general hospital outpatient clinics.
- Trial name
- NCT07641478
- Testing
- Large Language Model Based Tool, Workflow Support for Large Language Model Tool Integration
- Volunteers
- 3,500 people
- Sponsor
- Tsinghua University
Prostate Cancer
Large Language Model-Assisted cTNM Annotation From Chinese PSMA PET/CT Reports
This observational study will develop and validate a large language model-assisted workflow for imaging cTNM staging annotation and uncertainty recognition in prostate cancer using Chinese PSMA PET/CT report texts generated…
- Trial name
- PSMA-LLM-cTNM (NCT07707232)
- Testing
- Large Language Model-Assisted Report Annotation
- Where
- China
- Volunteers
- 4,600 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Diagnosis
Automation Bias in Physician-LLM Diagnostic Reasoning
This study aims to systematically measure the extent and patterns of automation bias among physicians when utilizing ChatGPT-4o in clinical decision-making.
- Trial name
- NCT06963957
- Testing
- ChatGPT-4o Recommendations with Hallucinations
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Any Chronic, Non-traumatic Orthopedic Condition
Testing an AI Large Language Model Tool for Cognitive Debiasing in Musculoskeletal Care
The goal of this clinical trial is to find out whether using an artificial intelligence (AI) tool called a Large Language Model (LLM) can help patients think more clearly about their symptoms and improve their trust and…
- Trial name
- NCT07022769
- Testing
- LLM-facilitated cognitive debiasing aid
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Texas at Austin
Degenerative Knee Disease
LLM-Guided Rehabilitation in Degenerative Knee Disease
This randomized, four-arm clinical trial will investigate the effects of large language model (LLM)-assisted exercise prescriptions integrated with conventional physiotherapy on pain, function and quality of life in adults with…
- Trial name
- LLM-RehabKnee (NCT07267962)
- Testing
- Supervised conventional physiotherapy, ChatGPT-5-assisted exercise planning, DeepSeek V3.1-assisted exercise planning
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Hay Fever, Asthma
Evaluating the Potential of Large Language Models for Respiratory Disease Consultations
The clinical trial aimes to evaluate multiple large language models in respiratory disease consultations by comparing their performance to that of human doctors across three major medical consultation scenarios.
- Conditions
- Hay Fever, Asthma, Acute Upper Respiratory Infection, Pulmonary Embolism
- Trial name
- EPLLMMRDC (NCT06457269)
- Testing
- Diagnosis by three human doctors, Diagnosis by ChatGPT-3.5 (with search capabilities), Diagnosis by ChatGPT-3.5 (without search capabilities)
- Where
- China
- Volunteers
- 703 people
- Sponsor
- North Sichuan Medical College
Heart Failure
Targeted Artificial Intelligence Language mOdel Recommendations for Heart Failure (TAILOR-HF)
This study is an investigator-initiated, cluster-randomized implementation trial evaluating a large language model (LLM)-based clinical decision support (CDS) tool designed to improve guideline-directed medical therapy (GDMT) for…
- Trial name
- TAILOR-HF (NCT07337577)
- Testing
- LLM-GDMT Clinical Decision Support Tool
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Brigham and Women's Hospital
Large Language Models
Physician Response Evaluation With Contextual Insights vs. Standard Engines - Artificial Intelligence RAG vs LLM Clinical Decision Support
Clinical decision support tools powered by artificial intelligence (AI) are being rapidly integrated into medical practice. Two leading systems currently available to clinicians are OpenEvidence, which uses retrieval-augmented…
- Trial name
- PRECISE (NCT07037940)
- Testing
- OpenEvidence, GPT-4
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Healthy Adult
Effectiveness of AI-Assisted Antibiotic Prescribing
This randomized controlled trial aims to evaluate the impact of providing LLM access to physicians on antibiotic prescribing appropriateness, using a composite outcome instrument, the Antibiotic Prescribing Appropriateness Score…
- Trial name
- NCT07833293
- Testing
- ChatGPT
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Virtual Patient, Social Robots
AI-generated Feedback in Social Robotic Virtual Patients
The goal of this quasi-experimental educational study is to learn whether AI-generated post-consultation feedback in social robotic virtual patient interactions improves medical students' clinical performance in medical…
- Conditions
- Virtual Patient, Social Robots, Artificial Intelligence (AI), Large Language Model
- Trial name
- NCT07277829
- Testing
- AI post consultation feedback
- Where
- Sweden
- Volunteers
- 115 people
- Sponsor
- Ioannis Parodis
Eye Disorders, Cataract Extraction
Effectiveness of a Large Language Model-Based Educational Tool on Intraocular Lens Options
Patients with cataracts disease need to choose what type of artificial lens will go into their eye prior to surgery date. Some lenses are standard and are usually covered by insurance.
- Conditions
- Eye Disorders, Cataract Extraction, Cataract and IOL Surgery, Cataract Surgery Experience
- Trial name
- NCT07317661
- Testing
- LLM-based Education
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Stanford University
Alcohol Use Disorder
A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerging Adults
American emerging adults (EAs; aged 18-29 years) have the highest rates of alcohol use disorder (AUD) and the lowest levels of treatment engagement of any age group.
- Trial name
- NCT07214831
- Testing
- Large language model-based chatbot brief alcohol intervention session
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Gastric Cancer (GC), Colorectal Cancer
Agreement Between Large Language Model-Generated Treatment Recommendations With Guideline-Based and Tumor Board Decisions in Gastrointestinal Cancer
The goal of this observational study is to learn whether a computer program can suggest cancer treatments that match expert recommendations for people with gastrointestinal cancer (cancer of the pancreas, stomach, or colon and…
- Conditions
- Gastric Cancer (GC), Colorectal Cancer, Pancreatic Cancer
- Trial name
- KITuKo (NCT07592338)
- Testing
- Treatment recommendation according to official German cancer guideline, Treatment recommendation of a LLM, Treatment recommendation of a multidisciplinary tumor board
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Medizinische Hochschule Brandenburg Theodor Fontane
Unknown Primary Tumors, DNA Methylation
PaCIFiC-CUP Classifies Cancer of Unknown Primary
This study aims to initially utilize machine learning on pan-cancer DNA methylation data from public databases to construct a DNA methylation classification model (PaCIFiC-CUP, pan-cancer integrated fingerprinting classifier of…
- Trial name
- NCT06140992
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Subacromial Pain Syndrome
ChatGPT and DeepSeek-Assisted Rehabilitation in Subacromial Pain
This study aims to evaluate the effects of rehabilitation programs supported by artificial intelligence-based large language models (LLMs), specifically ChatGPT and DeepSeek, in individuals with subacromial pain syndrome (SAPS).
- Trial name
- LLM-RehabSP (NCT07148687)
- Testing
- Conventional Exercise Program, ChatGPT-Guided Rehabilitation, DeepSeek-Guided Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
MCI, Dementia
Tailored Brain Health Insights Through Nurturing Knowledge-based Change - Stakeholder-driven, Human-centered, AI-powered Refinement for Prevention
The goal of this clinical trial is to evaluate whether an AI-powered digital brain health coaching intervention can improve modifiable brain health risk factors in community-dwelling adults aged 40 and above in Singapore.
- Trial name
- THINK-SHARP (NCT07612800)
- Testing
- BLAZE (Brain health Lifestyle Action with personaliZed Engagement)
- Where
- Singapore
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Alexandra Hospital
Stuttering
Large Language Models for Stuttering Assessment and Therapy
This observational study aims to compare the quality of responses generated by four large language models (ChatGPT, Claude, Google Gemini, and Grok-4.20) to questions about stuttering.
- Trial name
- NCT07835347
- Testing
- ChatGPT-Generated Responses, Claude-Generated Responses, Google Gemini-Generated Responses
- Where
- Turkey (Türkiye)
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
HPV Vaccination Intent
Conversations With AI Chatbots Increase Short-Term Vaccine Intentions But Do Not Outperform Standard Public Health Messaging
The goal of this clinical trial is to test whether short conversations with large language model (LLM) chatbots can persuade vaccine-hesitant parents to vaccinate their children against human papillomavirus (HPV).
- Trial name
- NCT07132125
- Testing
- Default-style LLM chatbot, Conversational-style LLM chatbot, Public health informational materials
- Where
- United States
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Thyroid Cancer, Large Language Models
Evaluation of an Artificial Intelligence-enabled Clinical Assistant to Support Thyroid Cancer Management
This study aims to evaluate the clinical feasibility of adopting artificial intelligence (AI)-based models to improve clinical management of thyroid cancer.
- Trial name
- NCT07234539
- Testing
- AI-enabled clinical assistant
- Where
- 2 sites in Hong Kong
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong