Clinical trials: Laparotomy
Malignant Female Reproductive System Neoplasm
Liposomal Bupivacaine With or Without Hydromorphone for the Improvement of Pain Control After Laparotomy in Patients With Gynecological Malignancies
This phase IV trial studies how well liposomal bupivacaine with or without hydromorphone works in improving pain control during the first 24 hours after surgery in patients with gynecological malignancies undergoing laparotomy.
- Trial name
- NCT04258631
- Testing
- Hydromorphone, Laparotomy, Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Mayo Clinic
Prevention of Incisional Hernia in Emergency Surgery
Long-term Follow-up of Prophylactic Mesh Reinforcement After Emergency Laparotomy.
Observational Study analyzing the long-term results of prophylactic mesh used for preventing incisional hernia after emergency midline laparotomies.
- Trial name
- NCT04578561
- Testing
- Prophylactic mesh use
- Volunteers
- 187 people
- Sponsor
- José A. Pereira
Postoperative Pain, Abdominal Surgery by Laparotomy
Rectus Sheath Block as an Adjunct to General Anesthesia for Midline Laparotomy Pain
This study evaluates whether adding an ultrasound-guided rectus sheath block (RSB) to general anesthesia can improve pain control after midline laparotomy.
- Trial name
- RSB-MIDLINE (NCT07393763)
- Testing
- Ultrasound-guided rectus sheath block
- Where
- Indonesia
- Volunteers
- 46 people
- Sponsor
- Udayana University
QLB vs TAPB, Quadratus Lumborum Block
Comparison of the Effects of Bilateral Transversus Abdominis Plane Block and Bilateral Quadratus Lumborum Block on Postoperative Analgesia in Patients Undergoing Midline Laparotomy
Midline incisions provide easy, rapid and excellent exposure of the abdominal cavity and are particularly used for complex, diagnostic or emergency procedures.
- Conditions
- QLB vs TAPB, Quadratus Lumborum Block, Transversus Abdominis Plane (TAP) Block
- Trial name
- NCT06950502
- Testing
- transversus abdominis plane block, Quadratus Lumborum Block (QLB), quadratus lumborum block using bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara University
Surgical Wound Infection
Determining the Worldwide Epidemiology of Surgical Site Infections After Gastrointestinal Surgery
Surgical site infection (SSI) is the most common complication following major gastrointestinal surgery, affecting between 25-40% of patients.
- Trial name
- GlobalSurg 2 (NCT02662231)
- Testing
- Emergency, or elective gastrointestinal resection
- Where
- 2 sites in United Kingdom
- Volunteers
- 12,539 people
- Sponsor
- University of Edinburgh
Gastrointestinal Cancer
The Laparotomy Study
The depth of neuromuscular blockade (NMB) during surgery may cause a clinical dilemma between optimal surgical conditions and the risk of postoperative residual blockade.
- Trial name
- NCT02140593
- Where
- Denmark
- Volunteers
- 128 people
- Sponsor
- Herlev Hospital
Laparotomy
A Study Assessing Circulation Around Surgical Incisions at the Time of Laparotomy Closure
This study is being done to find out if Spectrum Near-Infrared (NIR) imaging with Indocyanine Green (ICG) dye can help measure blood flow around an incision before and after the surgeon closes the incision with staples or…
- Trial name
- NCT03408366
- Testing
- Laparotomy, ICG, Spectrum NIR imaging system
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Indication for Renal and/or Adrenal Surgery
Merits of Continuous Paravertebral Block in the Management of Renal/Adrenal Surgery by Laparotomy
The paravertebral block is an alternative in the analgesia epidural the major interest of which lives in the catheterisation of the paravertébral space allowing to assure/insure an one-sided continuous analgesia.
- Trial name
- BPV (NCT01023854)
- Testing
- Continuous Paravertebral block
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Brest
Incisional Hernia After Midline Laparotomy, Colorectal Cancer
A One-year Follow-up of Incisional Hernia Formation Between Device Assisted and Manual Laparotomy Closure
The study compares one-year incisional hernia formation between two cohorts of patients that underwent open surgery for colorectal diseases.
- Trial name
- NCT07766044
- Testing
- Device assisted laparotomy closure, Manual laparotomy closure
- Where
- Sweden
- Volunteers
- 218 people
- Sponsor
- Suturion AB
Pain Management
Opioid-free Anesthesia as an Alternative to General Anesthesia in Patients Undergoing Duodenopancreatic Surgery by Laparotomy.
Opioid-free anesthesia is not associated with greater pain than opioid anesthesia and reduces the need for opioids in the postoperative period.
- Trial name
- NCT07364864
- Testing
- Opioid, OFA
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Jagiellonian University
Elective Surgery of the Spine by Laparotomy
The Tap Block Technique Via the Anterior Approach in Elective Surgery of the Spine
This is a prospective, single-centre, randomised, double-blind trial, comparing TAP block with continuous infiltration of ropivacaine versus placebo.
- Trial name
- TAPBloc Rachis (NCT02055664)
- Testing
- Ropivacaine 0.2%, Chlorure de sodium 0.9%
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Comparing the Number of Surgical Site Infections, Covering of the Abdominal Wall in Laparotomies With an Approved Abdominal 3M™ Steri-Drape™ Wound Edge Protector and Standard Woven
Covering of the Abdominal Wall in Laparotomies: Differences in Surgical Site Infections Between an Approved Abdominal 3M™ Steri-Drape™ Wound Edge Protector and Standard Woven Swabs at Technische Universität München
BaFo is a prospective, double-blinded randomized controlled clinical trial that assesses the numbers of surgical site infections in two different techniques of covering the abdominal wall in laparotomies.
- Conditions
- Comparing the Number of Surgical Site Infections, Covering of the Abdominal Wall in Laparotomies With an Approved Abdominal 3M™ Steri-Drape™ Wound Edge Protector and Standard Woven, Swabs
- Trial name
- BaFo (NCT01181206)
- Testing
- Intervention Arm 1: Covering with approved abdominal 3M™ Steri-Drape™ Wound Edge Protector Intervention Arm 2: Covering with standard woven swabs
- Where
- Germany
- Volunteers
- 516 people
- Sponsor
- Technical University of Munich
Surgery
Effect of Acute Normovolemic Haemodilution on Allogenic Transfusion Needs In Laparotomy
This study is aimed to determine if acute normovolemic hemodilution (ANH), an established blood conservation technique, reduces the requirement for allogeneic blood transfusion in operations with prediction of surgical bleeding…
- Trial name
- ANH (NCT02290964)
- Testing
- ANH
- Where
- Indonesia
- Volunteers
- 34 people
- Sponsor
- Universitas Padjadjaran
Acute Abdomen, Abdominal Trauma
Enhanced Recovery After Surgery (ERAS) in Patients Undergoing Emergency Laparotomy
The goal of this clinical trial is to test the safety and effectiveness of the ERAS protocols compared to a conventional care protocols in patients who received emergency laparotomy.
- Conditions
- Acute Abdomen, Abdominal Trauma, Emergency Surgery
- Trial name
- ERAS (NCT06182488)
- Testing
- ERAS protocols, Conventional protocols
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tianjin Medical University
Postoperative Pulmonary Atelectasis, Surgery
Prophylactic nCPAP in the PACU Following Elective Laparotomy for Bowel Surgery
The purpose of this study is to determine whether prophylactic nasal continuous positive airway pressure (nCPAP) in the post-anaesthesia care unit (PACU) improves post-operative pulmonary function following elective bowel…
- Trial name
- NCT02077842
- Testing
- Nasal Continuous Positive Airway Pressure, Low Flow Oxygen
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Saskatchewan
Advanced Colorectal Cancer in Elderly Patient
The Management of Complicated Colo-rectal Cancer in Older Patients in the Emergency Setting: the CO-OLDER Study
This is a multicenter observational study aimed to investigate the management of older patients aged 75 years old and over admitted to the emergency department with complicated colorectal cancer.
- Trial name
- CO-OLDER (NCT05788224)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Poissy-Saint Germain Hospital
Incisional Hernia of Midline of Abdomen
Barbed Suture for Emergency Midline Laparotomy Closure
Urgency surgeries are often performed in a stressful setting with critical patient involved. In this context, laparotomy closure can sometimes be the most neglected part of the procedure.
- Trial name
- BAROTOMY (NCT05351970)
- Testing
- Barbed
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Endometriosis
Laparoscopy Versus Laparotomy for Colorectal Endometriosis
Study hypothesis: equivalency of laparoscopic compared to laparotomic colorectal resection for endometriosis on digestive, gynaecologic, general symptoms and quality of life.
- Trial name
- NCT00939861
- Testing
- laparoscopy, laparotomy
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Tenon Hospital, Paris
Gynecologic Neoplasms, Abdominal Neoplasms
Augmented Pulse Pressure Variation to Predict Fluid Responsiveness in Open Laparotomy
Pulse pressure variation (PPV) is a well-known and widely used dynamic preload indicator based on heart-lung interaction to predict fluid responsiveness.
- Trial name
- NCT02653469
- Testing
- Augmented ventilation, Fluid loading
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Samsung Medical Center
Wound Infection; Wounds; Dehisence; Cosmesis; Home Care; Length of Hospital Stay
Prophylactic Negative Wound Therapy in Laparotomy Wounds.
Post-operative wound issues in abdominal surgery have a significant impact on patient outcomes. The impact of different types of wound therapy are not clear in the literature.
- Trial name
- PROPEL (NCT03871023)
- Testing
- Smith & Nephew PICO Negative wound pressure versus standard dresing, PREVENA Negative pressure wound versus standard dressing
- Where
- Ireland
- Volunteers
- 240 people
- Sponsor
- St. James's Hospital, Ireland