Clinical trials: LRTI
Lower Respiratory Tract and Lung Infections
DNA-based Testing in BAL of Lung Transplant Recipients With Suspected Non-viral Lower Respiratory Tract Infection
Lung transplantation (LTx) , DNA-based testing. Performance of DNA-based testing of bacterial and fungal pathogens in comparison to standard testing. Experimental intervention: DNA-based testing of BAL fluid.
- Trial name
- NCT02568358
- Testing
- Experimental Intervention: DNA-based testing of BAL fluid
- Volunteers
- 48 people
- Sponsor
- Hannover Medical School
Influenza, Pneumonia
Oseltamivir Randomised Controlled Efficacy Trial
Background In preparation for a global influenza pandemic, there is an urgent need for representative data from populations and settings where the pandemic is most likely to arise.
- Conditions
- Influenza, Pneumonia, Lower Respiratory Tract Infection, Upper Respiratory Tract Infection
- Trial name
- NCT00707941
- Testing
- Oseltamivir
- Where
- Bangladesh
- Volunteers
- 1,190 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Lower Respiratory Tract Infection
Evaluate the Safety and Efficacy of Nirsevimab in Healthy Preterm and Term Infants in China
The purpose of this study is to evaluate the Safety and Efficacy of Nirsevimab, in Healthy Preterm and Term Infants in China
- Trial name
- CHIMES (NCT05110261)
- Testing
- Nirsevimab
- Where
- 30 sites in China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Lower Respiratory Tract Infection, Upper Respiratory Tract Infection
Antiviral Activity of Oral Probiotics
The aim of this study is to test saliva samples obtained from healthy human participants for anti-viral activity after they have consumed S. salivarius probiotic in a powder format.
- Trial name
- NCT05374070
- Testing
- Streptococcus salivarius K12 Powder 1 Billion colony forming units /g), Streptococcus salivarius K12 Powder (1 Billion colony forming units /g) with a prebiotic included, Streptococcus salivarius M18 Powder (1 Billion colony forming units /g)
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- John Hale
Lower Respiratory Tract Infection
Procalcitonin and Lung Ultrasonography Guided Antibiotherapy in Emergency Departments
Acute respiratory infections are a common reason of attendance at emergency departments. It is also the main reason of unnecessary antibiotic prescription.
- Trial name
- PLUS-IS-LESS (NCT05463406)
- Testing
- The PLUS algorithm, Usual care
- Where
- 9 sites in Switzerland
- Volunteers
- 1,407 people
- Sponsor
- Dr Boillat-Blanco Noemie
COVID-19 Pneumonia, COVID-19
Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors
The purpose of this study is to test if visualizing the heart with cardiac MRI/echo will be important in the understanding cardiac function and prediction of cardiopulmonary symptoms, physical effort tolerance, and outcomes in…
- Conditions
- COVID-19 Pneumonia, COVID-19, COVID-19 Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05164744
- Testing
- Cardiac MRI, Echocardiogram, 6-minute walk test
- Where
- 3 sites in United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Respiratory Syncytial Virus
A Study in Belgian Children Hospitalized With Respiratory Syncytial Virus Related Acute Respiratory Infections
The purpose of the study is to assess viral kinetics and clinical symptoms kinetics in pediatric patients hospitalized with Respiratory Syncytial Virus (RSV) confirmed lower respiratory tract infection (LRTI).
- Trial name
- NCT02133092
- Testing
- No intervention
- Where
- 4 sites in Belgium
- Volunteers
- 62 people
- Sponsor
- Janssen Research & Development, LLC
Respiratory Syncytial Virus Infection
A One-Year Observation of Palivizumab in Infants at Risk for Respiratory Syncytial Virus Infection in Latin America
The study was designed to gather information regarding the use of palivizumab for the prophylaxis for respiratory syncytial virus (RSV) infection in high-risk infants in selected countries within Latin America.
- Trial name
- NCT01297504
- Where
- 24 sites in Argentina, Chile and 5 more
- Volunteers
- 464 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Lower Respiratory Tract Infection
Meropenem Dosage Strategy Based on PPK Model
To evaluate the clinical and economical benefits of a meropenem dosage strategy based on a population pharmacokinetic(PPK)-pharmacodynamic(PD) model in lower respiratory tract infection patients.
- Trial name
- NCT01944319
- Testing
- Routine meropenem therapy, Meropenem therapy based on a PPK and PD model
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Qingtao Zhou
COVID-19, Upper Respiratory Infection
A Noninvasive Multimodal Biosensing Device for Screening and Monitoring Response to Treatment of Infectious Respiratory Diseases
Background: The COVID-19 outbreak has strained the health care system. New tools are needed for diagnostic testing and monitoring of people who have the virus.
- Conditions
- COVID-19, Upper Respiratory Infection, Lower Respiratory Infection
- Trial name
- NCT05035420
- Testing
- Fitbit, Douglas Bag, Periflux 6000 EPOS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Lower Resp Tract Infection, Human Metapneumovirus Infection
Clinical Features, Outcome and Prognosis of Human Metapneumovirus (hMPV) Lower Respiratory Tract Infections in Adult Inpatients
The human metapneumovirus (hMPV) was first described in 2001. It belongs to the paramyxovirus family and is genetically close to the Respiratory Syncytial Virus (RSV).
- Trial name
- French-hMPV (NCT03460171)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Children Chest Infection
Bacterial Pathogens Associated With Community-acquired Pneumonia in Children
Pediatric community acquired pneumonia (CAP) is one of the most common reasons for hospital admission, there is no reliable way of distinguishing the causative organism based on clinical features.
- Trial name
- NCT06377163
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Delta University for Science and Technology
Pneumonia - Bacterial
Impact of BioFire FilmArray Pneumonia Panel vs Routine Diagnostics on Antimicrobial Outcomes (DOOR-MAT)
Multidrug-resistant bacterial infections are a growing global health concern. Hospital-acquired pneumonia is one of the most common infections occurring during hospitalization and can be associated with high mortality, reaching…
- Trial name
- NCT07585604
- Testing
- Multiplex PCR-based pneumonia panel (BIOFIRE® FILMARRAY® Pneumonia Panel)
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
COVID-19 Lower Respiratory Infection, Microbial Colonization
Oral Probiotics and Secondary Bacterial Pneumonia in Severe COVID-19
Background and aims: Patients with severe Coronavirus Disease 2019 (COVID-19) are prone to secondary bacterial pneumonia. The use of probiotics against oral pathogens might prevent lung colonization and progression to bacterial…
- Conditions
- COVID-19 Lower Respiratory Infection, Microbial Colonization, Severe COVID-19, Secondary Bacterial Pneumonia
- Trial name
- NCT05175833
- Testing
- Oral probiotics
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Universidade de Passo Fundo
Pneumnia, Chest Infection
Use of Simplified Lung Ultrasound Score for Predicting ICU Outcomes in Patients With Acute Respiratory Failure
This study aims to Primary Aims: Verify the predictability of the PLIS at admission in predicting major clinical outcomes including: ICU mortality (or discharge) and time to death (or discharge) Escalation of ventilatory support…
- Conditions
- Pneumnia, Chest Infection, Critically-ill Patients Admitted to the ICU for Acute Respitatory Failure, Regardless the Aetilogy
- Trial name
- NCT06678035
- Volunteers
- 72 people
- Sponsor
- Assiut University
Diarrhea, Pneumonia
Effect of Zinc and Vitamin A Supplementation on Diarrhea, Physical Growth and Immune Response in Malnourished Children
Zinc deficiency is common in developing country children, as food intakes are often low, foods from animal sources are infrequently used, the bioavailability of zinc from staple cereal-based diets is limited and zinc losses occur…
- Conditions
- Diarrhea, Pneumonia, Acute Respiratory Tract Infection
- Trial name
- NCT00272116
- Testing
- Zinc and vitamin A single dose at enrollment
- Where
- India
- Volunteers
- 2,482 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
Lower Respiratory Tract Infection
The Effect of a Family-Centered Care Approach on Infants Receiving High-Flow Nasal Oxygen Therapy
This research is an experimental study of randomized control with pre-test - post-test control group. The aim of this study is to determine the effect of family-centered care approach on physiological parameters and follow-up…
- Trial name
- NCT07183553
- Testing
- maintenance training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Acute Respiratory Infections, Pneumonia
Trial of Amoxicillin Compared With Placebo for Pneumonia in Children Aged 2-59 Months
Many children with "non-severe pneumonia" (cough and fast breathing) have neither clinical pneumonia as assessed by physicians nor pneumonia on chest radiographs.
- Trial name
- NCT00851487
- Testing
- Amoxicillin
- Where
- Pakistan
- Volunteers
- 900 people
- Sponsor
- Pakistan Institute of Medical Sciences
Pneumonia
Burden of Respiratory Viruses in India.
Trial Title: A Prospective Cohort Study To Compare The Burden Of Medically Attended and Community LRTI In Infants And Children Under 5 Years Of Age and adults (16-60 years) In India Primary Objectives: To determine the…
- Trial name
- NCT07403019
- Testing
- Nasopharyngeal swab for viral analysis
- Where
- India
- Volunteers
- 2,000 people
- Sponsor
- MAHAN Trust
Cystic Fibrosis
Efficacy and Safety of 28 or 56 Day Treatment for Pseudomonas Aeruginosa in Children With Cystic Fibrosis
This study assessed time to recurrence of infection with Pseudomonas aeruginosa following treatment of the initial infection with tobramycin nebuliser solution.
- Trial name
- ELITE (NCT00391976)
- Testing
- Tobramycin solution for inhalation 300 mg
- Volunteers
- 123 people
- Sponsor
- Novartis