Clinical trials: Knee Pain Chronic
Knee Osteoarthritis, Knee Pain Chronic
Gabapentin Regimens and Their Effects on Opioid Consumption
The purpose of this study is to determine the best strategy of administering gabapentin in connection with our current approach to perioperative pain management.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Opioid Use, Opioid Dependence
- Trial name
- NCT03334903
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Mastectomy, Upper Limb Amputation Below Elbow
Cryoanalgesia to Prevent Acute and Chronic Pain Following Surgery: A Randomized, Double-Masked, Sham-Controlled Study
The ultimate objective of the proposed line of research is to determine if cryoanalgesia is an effective adjunctive treatment for pain in the period immediately following various painful surgical procedures; and, if this…
- Conditions
- Mastectomy, Upper Limb Amputation Below Elbow, Upper Limb Amputation Above Elbow, Lower Limb Amputation Below Knee
- Trial name
- NCT03578237
- Testing
- Cryoneurolysis (active)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of California, San Diego
Pain, Low Back Pain
An Efficacy and Safety Study for Tapentadol Extended Release (JNS024ER) in Chronic Pain Participants
The purpose of this study is to evaluate the efficacy, safety and to explore the pharmacokinetics (how drugs are absorbed in the body, how they are distributed within the body and how they are removed from the body over time) of…
- Conditions
- Pain, Low Back Pain, Back Pain, Osteoarthritis, Knee
- Trial name
- NCT01124604
- Testing
- Tapentadol Hydrochloride
- Where
- 19 sites in Japan
- Volunteers
- 91 people
- Sponsor
- Janssen Pharmaceutical K.K.
Knee Osteoarthritis, Knee Pain Chronic
Molecular Pathways Involved in Knee Pain
Knee osteoarthritis (OA) is the most common form of arthritis and the most common cause of knee pain in the world. The rate of knee arthritis is as high as that of cardiac disease and is the most common problem in individuals…
- Trial name
- NCT04443452
- Testing
- Quantitative Sensory Testing, Radiographic Evaluation, Ultrasound-guided Aspiration
- Where
- United Kingdom
- Volunteers
- 71 people
- Sponsor
- University of Nottingham
Joint Disease, Pain, Acute
Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty
Post-discharge pain after total knee arthroplasty remains problematic; many patients have excessive pain at the 2 week time point (and often thereafter).
- Conditions
- Joint Disease, Pain, Acute, Pain, Chronic
- Trial name
- NCT03271151
- Testing
- Cymbalta
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Hospital for Special Surgery, New York
Pain
An Efficacy and Safety Study of Acetaminophen Plus Tramadol Hydrochloride (JNS013) in Participants With Chronic Pain
The purpose of this study is to evaluate the efficacy and safety of tramadol hydrochloride plus acetaminophen (JNS013) in participants with chronic pain accompanied by osteoarthritis (a progressive and degenerative joint disease…
- Trial name
- NCT00736853
- Testing
- Tramadol Hydrochloride Plus Acetaminophen (Open-Label), Tramadol Hydrochloride Plus Acetaminophen (Double-Blind)
- Where
- 20 sites in Japan
- Volunteers
- 321 people
- Sponsor
- Janssen Pharmaceutical K.K.
Chronic Pain, Osteoarthritis
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking Either WHO Step I or Step II Analgesics or no Regular Analgesic
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release in participants suffering from severe chronic pain due to osteoarthritis of the knee who are…
- Trial name
- NCT00983073
- Testing
- Tapentadol
- Where
- 24 sites in France, Germany and 3 more
- Volunteers
- 224 people
- Sponsor
- Grünenthal GmbH
Osteo Arthritis Knee
A Study to Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee
The purpose of this study is to evaluate the analgesic efficacy of V120083 twice daily compared to placebo in subjects with moderate to severe chronic pain due to OA of the knee.
- Trial name
- NCT03028870
- Testing
- V120083, Naproxen
- Where
- 30 sites in United States
- Volunteers
- 291 people
- Sponsor
- Purdue Pharma LP
Knee Osteoarthritis, Degenerative Joint Disease
Milnacipran for Chronic Pain in Knee Osteoarthritis
The patients are asked to take part in this study because you have chronic pain as a result of knee osteoarthritis. This study is done to investigate the pain relieving effects of the study drug Savella (milnacipran HCl) for…
- Conditions
- Knee Osteoarthritis, Degenerative Joint Disease, Chronic Pain
- Trial name
- KOA (NCT01510457)
- Testing
- Milnacipran
- Volunteers
- 46 people
- Sponsor
- Dr. Norman Harden
Chronic Knee Pain
Pharmacopuncture Therapy for Chronic Knee Pain
This study is a pragmatic randomized controlled trial. Condition/disease: Chronic Knee Pain. Intervention: Pharmacopuncture
- Trial name
- NCT06505681
- Testing
- Pharmacopuncture, Physical therapy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Jaseng Medical Foundation
Knee Osteoarthritis, Chronic Pain
Motor Cortex Plasticity and the Effect of Deep Intramuscular Needling Stimulation Therapy (DIMST) in Osteoarthritis Pain
The aim of this study is to evaluate the cortical excitability in pain of knee osteoarthritis (OA), as well as the effect of one session of a kind of electroacupuncture (deep needling intramuscular stimulation therapy - DIMST) in…
- Trial name
- NCT01855958
- Testing
- DIMST
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Autoimmune Diseases, Systemic Inflammatory Process
Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is a randomized clinical trial in 25,871 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids (Omacor® fish…
- Conditions
- Autoimmune Diseases, Systemic Inflammatory Process, Knee Pain Chronic, Osteoarthritis
- Trial name
- VITAL (NCT01351805)
- Testing
- Fish Oil, Vitamin D
- Where
- United States
- Volunteers
- 25,871 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Osteoarthritis, Knee
A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain
This is a phase 3, randomized, double-blind, placebo-controlled, single injection, 52-week study to evaluate the analgesic efficacy and safety of a single intra-articular (IA) CNTX-4975-05 (capsaicin), compared to IA placebo, in…
- Trial name
- NCT03429049
- Testing
- CNTX-4975-05
- Where
- 33 sites in United States
- Volunteers
- 332 people
- Sponsor
- Centrexion Therapeutics
Sedentary Lifestyle, Knee Osteoarthritis
NEAT!2 Sedentary Behavior Reduction for Individuals With Past or Present Knee Symptoms, Injuries, or Surgeries
This study will evaluate the effectiveness of an mHealth sedentary reduction program over a 6-month period of time in adults with past or present knee symptoms, injuries, or surgeries.
- Conditions
- Sedentary Lifestyle, Knee Osteoarthritis, Knee Injuries, Knee Pain Chronic
- Trial name
- NCT03987932
- Testing
- NEAT!2, NEAT!2+Calls, Delayed NEAT!2
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Osteoarthritis of the Knee
Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee
Subjects with chronic osteoarthritis of the knee will be assigned to receive an injection of either 1.2% sodium hyaluronate or buffered saline to evaluate its effectiveness and safety for 26 weeks.
- Trial name
- NCT00988091
- Testing
- 1.2% Sodium Hyaluronate, Buffered Saline
- Where
- 34 sites in United States
- Volunteers
- 596 people
- Sponsor
- Ferring Pharmaceuticals
Osteoarthritis
Safety and Efficacy of Buprenorphine Transdermal System in Subjects With Moderate to Severe Osteoarthritis of Hip or Knee
The objective of this study is to demonstrate the effectiveness and tolerability of the buprenorphine transdermal system (BTDS) (5, 10 and 20) in comparison to placebo transdermal system in subjects with moderate to severe…
- Trial name
- NCT00313846
- Testing
- Buprenorphine transdermal patch
- Where
- 44 sites in United States
- Volunteers
- 529 people
- Sponsor
- Purdue Pharma LP
Osteoarthritis, Knee
An Acupuncture Functional Magnetic Resonance Imaging (fMRI) Study on Chronic Pain: Response Reliability and Dose Effect
In this proposal, we plan to dynamically investigate brain response to verum acupuncture (of two different "doses") and placebo acupuncture, using a paradigm that approximates clinical acupuncture practice across multiple…
- Trial name
- NCT01079390
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Massachusetts General Hospital
Pain, Knee Osteoarthritis
A Study to Evaluate the Efficacy and Safety of CG5503 Prolonged Release (PR) in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
The purpose of this study is to evaluate whether tapentadol (CG5503) prolonged-release (PR) tablets at doses of 100-250 mg twice daily provide a better pain relief in patients with moderate to severe chronic pain due to…
- Trial name
- NCT00486811
- Testing
- Tapentadol ER (100 to 250 mg twice daily), Oxycodone CR (20 to 50 mg twice daily)
- Where
- 100 sites in Austria, Croatia and 11 more
- Volunteers
- 990 people
- Sponsor
- Grünenthal GmbH
Knee Osteoarthritis, Pain, Chronic
Association of Acupuncture and Cupping in Advanced Knee Osteoarthritis
Given the lack of studies in the literature associating the use of acupuncture and sliding suction cup in patients with advanced knee osteoarthritis, the objective of this study is to evaluate the benefits of this association in…
- Trial name
- NCT04168593
- Testing
- Acupuncture
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo General Hospital
Peripheral Neuropathies, Osteoarthritis
A Proof of Concept Study to Investigate the Effect of a New Treatment in Patient With Chronic Pain
The purpose of this clinical trial conducted in patients suffering from chronic pain is to study the relationship between individual patients' profile and their analgesic response
- Trial name
- NCT02459197
- Testing
- Heat Pain Stimuli A, Heat Pain Stimuli B, Positive Video
- Where
- 6 sites in Belgium, France
- Volunteers
- 114 people
- Sponsor
- Tools4Patient