Clinical trials: Knee Pain Arthritis
Arthritis Knee, Arthritis Hip
Developing an Opioid Taper Intervention Before Total Joint Arthroplasty
The goal of this clinical trial is to develop an pharmacist-led preoperative opioid taper intervention for patients undergoing total knee or hip replacement who are on chronic opioids before their surgery.
- Conditions
- Arthritis Knee, Arthritis Hip, Chronic Pain
- Trial name
- NCT05788016
- Testing
- opioid taper
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Knee Pain Chronic, Osteoarthritis, Knee
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
The main objective of the study is to evaluate the safety, performance and clinical benefits of the Persona implant and its instrumentation in primary total knee arthroplasty
- Conditions
- Knee Pain Chronic, Osteoarthritis, Knee, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT05787821
- Testing
- Total Knee Arthroplasty
- Where
- 16 sites in United States
- Volunteers
- 760 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee Pain Arthritis
Long-Term Study of CartiPRO for Knee Pain Due to Osteoarthritis or Cartilage Damage
This clinical trial aims to evaluate and compare the efficacy and safety of CartiPRO, an approved intra-articular atelocollagen injection, versus Synovian injection for the relief of knee pain in patients with knee…
- Conditions
- Osteoarthritis, Knee Pain Arthritis, Cartilage Defects of the Knee, Knee Osteoarthritis
- Trial name
- NCT07267793
- Testing
- CartiPRO, Synovian®
- Where
- 5 sites in South Korea
- Volunteers
- 194 people
- Sponsor
- DALIM TISSEN Co., Ltd.
Arthritis Knee, Postoperative Nausea
Oral Dexamethasone as an Intervention for Postoperative Pain and Nausea Management in Total Knee Arthroplasty
This study aims to determine if oral dexamethasone provides clinically significant improvement in postoperative outcomes, specifically nausea and pain scores.
- Conditions
- Arthritis Knee, Postoperative Nausea, Postoperative Pain
- Trial name
- NCT04432259
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Henry Ford Health System
Knee Pain Chronic, Osteoarthritis
Persona Ti-Nidium Post-Market Clinical Follow-up
The main objectives of this study are to evaluate overall clinical performance and safety of the Persona Ti-Nidium implant in total knee arthroplasty.
- Conditions
- Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- TKA (NCT04817969)
- Testing
- Zimmer Biomet Persona Ti-Nidium Total Knee System
- Where
- 7 sites in United States
- Volunteers
- 240 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthristis, Knee Pain Arthritis
Stimulation of Peripheral Afferents to Reduce Muscle Inhibition at the Knee
Knee osteoarthritis is a leading cause of disability, and the muscle weakness that limits walking in this population arises not only from the joint itself but from afferent signals that inhibit motor drive to the thigh muscle…
- Conditions
- Knee Osteoarthristis, Knee Pain Arthritis, Knee Pain Chronic
- Trial name
- SPARK (NCT07832669)
- Testing
- Peripheral Electrical Stimulation (PES), Paired Pulse Electrical Stimulation (ppES)
- Volunteers
- 50 people
- Sponsor
- Northeastern University
Osteo Arthritis of the Knee, Pain
The PERK Study: Predicting and Evaluating Response to Knee RFA Using fNIRS
The goal of this clinical trial is to understand whether changes in brain activity, measured using functional near-infrared spectroscopy (fNIRS), are related to how well patients with knee osteoarthritis respond to genicular…
- Trial name
- PERK (NCT07835269)
- Testing
- Radiofrequency ablation alone, Genicular Nerve Block
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
The goal of this clinical trial is to learn if GNSC-001 works to treat knee osteoarthritis in adults. It will also learn about the safety of GNSC-001. The main questions it aims to answer are: 1.
- Conditions
- Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis, Knee Arthritis, Knee Arthritis Disease
- Trial name
- RAPHAEL (NCT07831577)
- Testing
- Gene Therapy GNSC-001
- Volunteers
- 240 people
- Sponsor
- Genascence Corporation
Osteoarthritis (OA) of the Knee, Knee Pain Arthritis
Neurolysis for the Treatment of Medial Chronic Knee Pain Due to Osteoarthritis
This study involves the use of sound waves to block pain signals caused by osteoarthritis of the knee. The sound waves are tightly focused on a specific area of the nerve.
- Conditions
- Osteoarthritis (OA) of the Knee, Knee Pain Arthritis, Chronic Knee Pain
- Trial name
- NCT07178951
- Testing
- Neurotomy of the medial sensory articular branches
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- FUSMobile Inc.
Knee Arthritis, Osteoarthritis
Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain
The purpose of this superiority randomized controlled trial is to evaluate the effect of daily knee sleeve use on 5-year radiographic knee osteoarthritis progression and knee-related symptoms in older adults with chronic knee…
- Trial name
- NCT07674901
- Testing
- Knee sleeve
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Margaret L Gourlay, MD, MPH
Osteoarthritis,Knee, Osteoarthritis Knees Both
Coach2Move: Physical Therapy to Improve Physical Activity in Individuals With Chronic MSK Conditions
Chronic musculoskeletal conditions (chronic low back pain, knee osteoarthritis, hip osteoarthritis) are the most common causes of long-term disability resulting in a loss of quality-of life for affected individuals and high costs…
- Conditions
- Osteoarthritis,Knee, Osteoarthritis Knees Both, Osteoarthritis Hip, Low Back Pain
- Trial name
- Coach2Move (NCT07806318)
- Testing
- motivational enhancement and planning
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Utah
Osteoarthitis, Osteoarthritic Knee Pain
Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee.
- Conditions
- Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
- Trial name
- Medial OA CSI (NCT07804446)
- Testing
- Anteromedial Injection, Anterolateral Injection
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Chicago
Osteo Arthritis Knee, Worries; Pain or Disability
The Role of Rumination and Worry in Pain and Functional Limitation in Knee Osteoarthritis
Knee osteoarthritis is a common degenerative joint disease in which pain severity often does not fully correspond with radiographic disease severity.
- Conditions
- Osteo Arthritis Knee, Worries; Pain or Disability, Rumination
- Trial name
- NCT07609056
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Knee Arthritis Osteoarthritis, Chronic Knee Pain
The Predictive Value of Ultrasonographic Quadriceps Muscle Parameters for Genicular Nerve Block Outcomes in Knee Osteoarthritis
The goal of this observational study is to learn whether thigh muscle structure can help predict pain relief after a genicular nerve block in people with knee osteoarthritis.
- Trial name
- NCT07781059
- Testing
- genicular nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Marmara University
Chronic Pain, PERIPHERAL NEUROPATHY
Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain
To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.
- Conditions
- Chronic Pain, PERIPHERAL NEUROPATHY, Occipital Neuralgia, Chronic Hip Pain
- Trial name
- NCT07639060
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Yale University
Osteoarthritis, Knee, Insomnia
Added Value of Cognitive Behavioural Therapy for Insomnia in Persons With Knee Osteoarthritis
Knee osteoarthritis (KOA) is the leading and fastest increasing cause of disability in older adults. It is a serious health issue related with a high health care utilisation.
- Trial name
- PREMEO (NCT05387473)
- Testing
- Cognitive behavioral therapy for insomnia (CBT-I) integrated in best-evidence usual care (CBTi-UC), Best-evidence usual care (UC) plus information sessions
- Where
- Belgium
- Volunteers
- 128 people
- Sponsor
- Vrije Universiteit Brussel
Osteo Arthritis Knee, Knee Pain Chronic
Optimizing Pain Self-Management in Total Knee Arthroplasty
The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee…
- Conditions
- Osteo Arthritis Knee, Knee Pain Chronic, Surgery
- Trial name
- NCT06038240
- Testing
- Savoring Meditation, Pain Self-Management and Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Virginia
Osteo Arthritis Knee, Pain, Postoperative
Extended Oral Tranexamic Acid After Total Knee Arthroplasty
The utilization of intraoperative tranexamic acid (TXA), whether administered intravenously or orally, has become a standard practice in total joint arthroplasty (TJA).
- Trial name
- NCT06618820
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Campbell Clinic
Osteoarthritis (OA) of the Knee, Knee Pain Arthritis
Imageless Navigation Versus Image-Based Navigation in Robotic-Assisted Total Knee Arthroplasty for Knee Osteoarthritis
The goal of this clinical trial is to learn if imageless navigation is not inferior to image-based navigation in robotic-assisted total knee arthroplasty (RA-TKA) for treating patients with knee osteoarthritis.
- Conditions
- Osteoarthritis (OA) of the Knee, Knee Pain Arthritis, Total Knee Arthroplasty (TKA), Robotic Assisted Arthroplasty
- Trial name
- NCT07522489
- Testing
- Imageless Robotic-Assisted Total Knee Arthroplasty, Image-based Robotic-Assisted Total Knee Arthroplasty
- Where
- Poland
- Volunteers
- 146 people
- Sponsor
- Medical University of Warsaw
Low Back Pain, Knee Arthritis Osteoarthritis
How Patient Education Helps Patients With Chronic Musculoskeletal Disorders Stick to Home Exercise for Pain Relief.
The study aims to evaluate the effectiveness of a structured patient education program in enhancing adherence to prescribed home exercise regimens in individuals with chronic low back pain, knee osteoarthritis, and shoulder pain.
- Conditions
- Low Back Pain, Knee Arthritis Osteoarthritis, Shoulder Disease, Shoulder and Upper Arm Injury
- Trial name
- NCT07764354
- Testing
- Educational with musculoskeletal condition, Standard physical therapy program
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- Imam Abdulrahman Bin Faisal University