OsteoarthitisMedial OA CSINCT07804446
Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
A study testing Anteromedial Injection and Anterolateral Injection in people with Osteoarthitis and Osteoarthritic Knee Pain, run by University of Chicago at 5 sites in United States.
Trial summary
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will: 1. Read more about this study
- Who is it for?
- Ages 40 years and older
- Conditions the study is for
- Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis (OA)
- What is being tested?
- Anteromedial Injection and Anterolateral Injection
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 140 participants
- Where
- 5 sitesUnited States
- Study dates
- 31 Aug 2026to 1 May 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥ 40
- Clinical diagnosis of knee OA with predominant medial compartment symptoms
- Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
- Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
- Able to provide informed consent
- Able to complete phone, email, or MyChart follow-ups in English
Who cannot join
- Predominant lateral compartment OA or patellofemoral-only OA
- Inflammatory arthritis (RA, gout flare, etc.)
- Suspected or confirmed joint infection or overlying cellulitis
- Prior knee arthroplasty on the index knee
- Planned surgery for index knee within 12-week follow-up
- Inability to complete follow-up assessments
- Other clinician-determined contraindication to CSI
Trial locations and contacts
5 sites in 1 country. Contact the study team or a site near you to ask about taking part.
5 sites in 1 country
United States5 sites, 5 recruiting
- Recruiting
Bolingbrook Clinic
Bolingbrook, Illinois, 60440
Brandon Pardi, M.D., 630-759-1248, brandon.pardi.md@adventhealth.com
Brandon Pardi, M.D.
- Recruiting
Hyde Park Clinic
Chicago, Illinois, 60637
Sara J Wallace, M.D./M.P.H., 773-834-3531, swallace2@bsd.uchicago.edu
Malik Scott, B.A., mjscott1@uchicago.edu
- Recruiting
La Grange Clinic
La Grange, Illinois, 60525
Sara JS Wallace, M.D./M.P.H., 773-834-3531, swallace2@bsd.uchicago.edu
Sara JS Wallace, M.D./M.P.H.
- Recruiting
Orland Park Clinic
Orland Park, Illinois, 60462
Sara JS Wallace, M.D./M.P.H., 888-824-0200, swallace2@bsd.uchicago.edu
Malik J Scott, B.A., mjscott1@uchicago.edu
- Recruiting
Woodridge Clinic
Woodridge, Illinois, 60517
Brandon Pardi, M.D., 630-759-1248, brandon.pardi.md@adventhealth.com
Brandon Pardi, M.D.
About this study
Official title: Does Injection Site (Anteromedial vs Anterolateral) Affect Pain Relief After Intra-Articular Corticosteroid Injection in Moderate-to-Severe Medial Knee Osteoarthritis?
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:
- Be randomly divided into getting their steroid injection on the inside or outside of their knee.
- Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.
- Conditions
- Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Osteoarthritis in the Knee
- Being tested
- Anteromedial Injection, Anterolateral Injection
- Keywords
- osteoarthritis, arthritis, corticosteroid, steroid injection, pain, pain control, pain survey, knee, knee arthritis, knee osteoarthritis, knee pain, knee injection
- Medical subject headings
- Osteoarthritis, Arthritis, Pain, Agnosia, Osteoarthritis, Knee
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Anteromedial InjectionProcedure or surgery
If randomized to this intervention, patients will receive a corticosteroid injection in the anteromedial side of their knee.
Anterolateral InjectionProcedure or surgery
If randomized to this intervention, patients will receive a corticosteroid injection on the anterolateral side of their knee.
| Study group | Role | What they receive |
|---|---|---|
| Anterolateral | Active comparator | These patients will receive their corticosteroid injections on their anterolateral knees. Receives: Procedure: Anterolateral Injection |
| Anteromedial | Active comparator | This group of patients will receive injections on the anteromedial side of their knee. Receives: Procedure: Anteromedial Injection |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numeric Pain Rating Scale
This survey asks patients to rate their pain on a scale from 0 to 10.
Measured: Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection
Knee Osteoarthritis and Outcome Score-Joint Replacement
This standardized survey asks patients to describe the impact of their knee stiffness and pain on daily tasks.
Measured: Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection
Secondary outcomes (2)
Institutional Survey on Satisfaction with Injection
This survey asks patients to rate their satisfaction with their corticosteroid injection on a scale from 0 to 10.
Measured: 2 weeks, 6 weeks, and 12 weeks post-injection
Patient Global Impression of Change
This survey asks patients to rate their overall health status on a scale from 1 to 7.
Measured: 2 weeks, 6 weeks, and 12 weeks post-injection
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Sep 2026
- Study start31 Aug 2026
- Primary completion1 Apr 2027 (estimated)
- Study completion1 May 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (25)Papers the sponsor has linked to this study.
- Other trials for OsteoarthitisStudies of the same condition, open and under way.
- More trials run by University of ChicagoThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The population will be adults with symptomatic, radiographically moderate-to-severe medial compartment knee osteoarthritis who are already undergoing corticosteroid injections as part of routine care on their native knee. They wil be randomized to receive their injection on either the anteromedial or anterolateral knee.
- Masking
- None (open label)
- Enrolment
- 140 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Chicago
- Sponsor type
- University, hospital or other
- Collaborators
- AdventHealth
- Responsible party
- Sponsor
- Investigators
- Sara JS Wallace, M.D./M.P.H., Principal investigator, The University of Chicago Medical CenterBrandon Pardi, M.D., Principal investigator, AdventHealth
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07804446
- Sponsor's protocol ID
- IRB26-0169
- Acronym
- Medial OA CSI
- Status last verified
- Aug 2026
- First submitted
- 31 Aug 2026
- Last updated
- 4 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: IPD may not be shared due to privacy concerns, but the authors will consider sharing de-identified data upon reasonable request.
Publications
Hanley MA, Jensen MP, Ehde DM, Robinson LR, Cardenas DD, Turner JA, Smith DG. Clinically significant change in pain intensity ratings in persons with spinal cord injury or amputation. Clin J Pain. 2006 Jan;22(1):25-31. doi: 10.1097/01.ajp.0000148628.69627.82.
PubMed 16340590Salaffi F, Stancati A, Silvestri CA, Ciapetti A, Grassi W. Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale. Eur J Pain. 2004 Aug;8(4):283-91. doi: 10.1016/j.ejpain.2003.09.004.
PubMed 15207508Dworkin RH, Turk DC, Wyrwich KW, Beaton D, Cleeland CS, Farrar JT, Haythornthwaite JA, Jensen MP, Kerns RD, Ader DN, Brandenburg N, Burke LB, Cella D, Chandler J, Cowan P, Dimitrova R, Dionne R, Hertz S, Jadad AR, Katz NP, Kehlet H, Kramer LD, Manning DC, McCormick C, McDermott MP, McQuay HJ, Patel S, Porter L, Quessy S, Rappaport BA, Rauschkolb C, Revicki DA, Rothman M, Schmader KE, Stacey BR, Stauffer JW, von Stein T, White RE, Witter J, Zavisic S. Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations. J Pain. 2008 Feb;9(2):105-21. doi: 10.1016/j.jpain.2007.09.005. Epub 2007 Dec 11.
PubMed 18055266Toda Y, Tsukimura N. A comparison of intra-articular hyaluronan injection accuracy rates between three approaches based on radiographic severity of knee osteoarthritis. Osteoarthritis Cartilage. 2008 Sep;16(9):980-5. doi: 10.1016/j.joca.2008.01.003. Epub 2008 Mar 12.
PubMed 18339561Courtney P, Doherty M. Joint aspiration and injection and synovial fluid analysis. Best Pract Res Clin Rheumatol. 2013 Apr;27(2):137-69. doi: 10.1016/j.berh.2013.02.005.
PubMed 23731929Hermans J, Bierma-Zeinstra SM, Bos PK, Verhaar JA, Reijman M. The most accurate approach for intra-articular needle placement in the knee joint: a systematic review. Semin Arthritis Rheum. 2011 Oct;41(2):106-15. doi: 10.1016/j.semarthrit.2011.02.007.
PubMed 22036252Huang Y, Liu P. Expert consensus on glucocorticoids injection for knee osteoarthritis. J Orthop Surg Res. 2026 Jan 8;21(1):25. doi: 10.1186/s13018-025-06363-1.
PubMed 41508090van Middelkoop M, Arden NK, Atchia I, Birrell F, Chao J, Rezende MU, Lambert RG, Ravaud P, Bijlsma JW, Doherty M, Dziedzic KS, Lohmander LS, McAlindon TE, Zhang W, Bierma-Zeinstra SM. The OA Trial Bank: meta-analysis of individual patient data from knee and hip osteoarthritis trials show that patients with severe pain exhibit greater benefit from intra-articular glucocorticoids. Osteoarthritis Cartilage. 2016 Jul;24(7):1143-52. doi: 10.1016/j.joca.2016.01.983. Epub 2016 Feb 2.
PubMed 26836288Najm A, Alunno A, Gwinnutt JM, Weill C, Berenbaum F. Efficacy of intra-articular corticosteroid injections in knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials. Joint Bone Spine. 2021 Jul;88(4):105198. doi: 10.1016/j.jbspin.2021.105198. Epub 2021 Apr 24.
PubMed 33901659Wylde V, Beswick A, Bruce J, Blom A, Howells N, Gooberman-Hill R. Chronic pain after total knee arthroplasty. EFORT Open Rev. 2018 Aug 16;3(8):461-470. doi: 10.1302/2058-5241.3.180004. eCollection 2018 Aug.
PubMed 30237904Waimann CA, Fernandez-Mazarambroz RJ, Cantor SB, Lopez-Olivo MA, Zhang H, Landon GC, Siff SJ, Suarez-Almazor ME. Cost-effectiveness of total knee replacement: a prospective cohort study. Arthritis Care Res (Hoboken). 2014 Apr;66(4):592-9. doi: 10.1002/acr.22186.
PubMed 24124052Lutzner J, Kasten P, Gunther KP, Kirschner S. Surgical options for patients with osteoarthritis of the knee. Nat Rev Rheumatol. 2009 Jun;5(6):309-16. doi: 10.1038/nrrheum.2009.88.
PubMed 19491912Silverstein FE, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, Makuch R, Eisen G, Agrawal NM, Stenson WF, Burr AM, Zhao WW, Kent JD, Lefkowith JB, Verburg KM, Geis GS. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA. 2000 Sep 13;284(10):1247-55. doi: 10.1001/jama.284.10.1247.
PubMed 10979111McGettigan P, Henry D. Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies. PLoS Med. 2011 Sep;8(9):e1001098. doi: 10.1371/journal.pmed.1001098. Epub 2011 Sep 27.
PubMed 21980265McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmander S, Rannou F, Roos EM, Underwood M. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014 Mar;22(3):363-88. doi: 10.1016/j.joca.2014.01.003. Epub 2014 Jan 24.
PubMed 24462672
Study at a glance
From the registry record, last updated by the sponsor on 4 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Does Injection Site (Anteromedial vs Anterolateral) Affect Pain Relief After Intra-Articular Corticosteroid Injection in Moderate-to-Severe Medial Knee Osteoarthritis?
- ClinicalTrials.gov ID
- NCT07804446
- Acronym / sponsor ID
- Medial OA CSI / IRB26-0169
- Conditions
- Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Osteoarthritis in the Knee
- Keywords
- osteoarthritis, arthritis, corticosteroid, steroid injection, pain, pain control, pain survey, knee
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 140 participants (estimated)
- Lead sponsor
- University of ChicagoUniversity, hospital or other
- Collaborators
- AdventHealth
- Study start
- 31 Aug 2026 (actual)
- Primary completion
- 1 Apr 2027 (estimated)
- Study completion
- 1 May 2027 (estimated)
- First posted
- 4 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:
- Be randomly divided into getting their steroid injection on the inside or outside of their knee.
- Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- The population will be adults with symptomatic, radiographically moderate-to-severe medial compartment knee osteoarthritis who are already undergoing corticosteroid injections as part of routine care on their native knee. They wil be randomized to receive their injection on either the anteromedial or anterolateral knee.
| Arm | Type | Receives |
|---|---|---|
| Anterolateral | Active comparator | Procedure: Anterolateral InjectionThese patients will receive their corticosteroid injections on their anterolateral knees. |
| Anteromedial | Active comparator | Procedure: Anteromedial InjectionThis group of patients will receive injections on the anteromedial side of their knee. |
Who may qualify
- Ages
- 40 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Age ≥ 40
- Clinical diagnosis of knee OA with predominant medial compartment symptoms
- Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
- Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
- Able to provide informed consent
Key exclusion criteria (7 listed)
- Predominant lateral compartment OA or patellofemoral-only OA
- Inflammatory arthritis (RA, gout flare, etc.)
- Suspected or confirmed joint infection or overlying cellulitis
- Prior knee arthroplasty on the index knee
- Planned surgery for index knee within 12-week follow-up
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Anteromedial InjectionIf randomized to this intervention, patients will receive a corticosteroid injection in the anteromedial side of their knee. | Procedure or surgery | Anteromedial |
| Anterolateral InjectionIf randomized to this intervention, patients will receive a corticosteroid injection on the anterolateral side of their knee. | Procedure or surgery | Anterolateral |
Primary outcome
Numeric Pain Rating Scale
Time frame: Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection
This survey asks patients to rate their pain on a scale from 0 to 10.
Knee Osteoarthritis and Outcome Score-Joint Replacement
Time frame: Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection
This standardized survey asks patients to describe the impact of their knee stiffness and pain on daily tasks.
2 secondary outcomes
Institutional Survey on Satisfaction with Injection
Time frame: 2 weeks, 6 weeks, and 12 weeks post-injection
Patient Global Impression of Change
Time frame: 2 weeks, 6 weeks, and 12 weeks post-injection
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Sep 2026.
- Background: PubMed 16340590Hanley MA, Jensen MP, Ehde DM, Robinson LR, Cardenas DD, Turner JA, Smith DG. Clinically significant change in pain intensity ratings in persons with spinal cord injury or amputation. Clin J Pain. 2006 Jan;22(1):25-31. doi: 10.1097/01.ajp.0000148628.69627.82.
- Background: PubMed 15207508Salaffi F, Stancati A, Silvestri CA, Ciapetti A, Grassi W. Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale. Eur J Pain. 2004 Aug;8(4):283-91. doi: 10.1016/j.ejpain.2003.09.004.
- Background: PubMed 18055266Dworkin RH, Turk DC, Wyrwich KW, Beaton D, Cleeland CS, Farrar JT, Haythornthwaite JA, Jensen MP, Kerns RD, Ader DN, Brandenburg N, Burke LB, Cella D, Chandler J, Cowan P, Dimitrova R, Dionne R, Hertz S, Jadad AR, Katz NP, Kehlet H, Kramer LD, Manning DC, McCormick C, McDermott MP, McQuay HJ, Patel S, Porter L, Quessy S, Rappaport BA, Rauschkolb C, Revicki DA, Rothman M, Schmader KE, Stacey BR, Stauffer JW, von Stein T, White RE, Witter J, Zavisic S. Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations. J Pain. 2008 Feb;9(2):105-21. doi: 10.1016/j.jpain.2007.09.005. Epub 2007 Dec 11.
- Background: PubMed 18339561Toda Y, Tsukimura N. A comparison of intra-articular hyaluronan injection accuracy rates between three approaches based on radiographic severity of knee osteoarthritis. Osteoarthritis Cartilage. 2008 Sep;16(9):980-5. doi: 10.1016/j.joca.2008.01.003. Epub 2008 Mar 12.
- Background: PubMed 23731929Courtney P, Doherty M. Joint aspiration and injection and synovial fluid analysis. Best Pract Res Clin Rheumatol. 2013 Apr;27(2):137-69. doi: 10.1016/j.berh.2013.02.005.
- Background: PubMed 22036252Hermans J, Bierma-Zeinstra SM, Bos PK, Verhaar JA, Reijman M. The most accurate approach for intra-articular needle placement in the knee joint: a systematic review. Semin Arthritis Rheum. 2011 Oct;41(2):106-15. doi: 10.1016/j.semarthrit.2011.02.007.
- Background: PubMed 41508090Huang Y, Liu P. Expert consensus on glucocorticoids injection for knee osteoarthritis. J Orthop Surg Res. 2026 Jan 8;21(1):25. doi: 10.1186/s13018-025-06363-1.
- Background: PubMed 26836288van Middelkoop M, Arden NK, Atchia I, Birrell F, Chao J, Rezende MU, Lambert RG, Ravaud P, Bijlsma JW, Doherty M, Dziedzic KS, Lohmander LS, McAlindon TE, Zhang W, Bierma-Zeinstra SM. The OA Trial Bank: meta-analysis of individual patient data from knee and hip osteoarthritis trials show that patients with severe pain exhibit greater benefit from intra-articular glucocorticoids. Osteoarthritis Cartilage. 2016 Jul;24(7):1143-52. doi: 10.1016/j.joca.2016.01.983. Epub 2016 Feb 2.
- Background: PubMed 33901659Najm A, Alunno A, Gwinnutt JM, Weill C, Berenbaum F. Efficacy of intra-articular corticosteroid injections in knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials. Joint Bone Spine. 2021 Jul;88(4):105198. doi: 10.1016/j.jbspin.2021.105198. Epub 2021 Apr 24.
- Background: PubMed 30237904Wylde V, Beswick A, Bruce J, Blom A, Howells N, Gooberman-Hill R. Chronic pain after total knee arthroplasty. EFORT Open Rev. 2018 Aug 16;3(8):461-470. doi: 10.1302/2058-5241.3.180004. eCollection 2018 Aug.
- Background: PubMed 24124052Waimann CA, Fernandez-Mazarambroz RJ, Cantor SB, Lopez-Olivo MA, Zhang H, Landon GC, Siff SJ, Suarez-Almazor ME. Cost-effectiveness of total knee replacement: a prospective cohort study. Arthritis Care Res (Hoboken). 2014 Apr;66(4):592-9. doi: 10.1002/acr.22186.
- Background: PubMed 19491912Lutzner J, Kasten P, Gunther KP, Kirschner S. Surgical options for patients with osteoarthritis of the knee. Nat Rev Rheumatol. 2009 Jun;5(6):309-16. doi: 10.1038/nrrheum.2009.88.
- Individual participant dataSharing planned: Undecided. IPD may not be shared due to privacy concerns, but the authors will consider sharing de-identified data upon reasonable request.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Sara JS Wallace, M.D./M.P.H. principal investigator
The University of Chicago Medical Center
Brandon Pardi, M.D. principal investigator
AdventHealth
5 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Anteromedial Injection and Anterolateral Injection in people with Osteoarthitis and Osteoarthritic Knee Pain, run by University of Chicago at 5 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 4 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 5 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Malik J Scott, B.A. (773-834-3531, mjscott1@uchicago.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numeric Pain Rating Scale (time frame: Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07804446, which also lists 25 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Sep 2026.