Clinical trials: Intubated ICU Patients
Intracranial Pressure Measurement, Measurement of Optic Nerve Sheath Diameter
IJV Catheterization and Intracranial Pressure Via ONSD
The aim of this study is to evaluate the effect of internal jugular vein catheterization on intracranial pressure in intubated patients in the intensive care unit using optic nerve sheath diameter
- Trial name
- NCT07465419
- Testing
- Internal jugular vein catheterization
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Cumhuriyet University
Invasive Mechanical Ventilation, Ventilator-Induced Lung Injury
Effects of Large Tidal Volumes Despite Minimal Inspiratory Support in Spontaneously Ventilated Intubated Resuscitation Patients. Pathophysiological Exploratory Study.
Some ICU ventilated patients might present with large tidal volume despite very low or inexistant presser support. Patient-Self Inflicted Lung Injury (P-SILI) might appear related with large alveolar stretch an distension.
- Conditions
- Invasive Mechanical Ventilation, Ventilator-Induced Lung Injury, Patient-Self Inflicted Lung Injury, Encephalopathy
- Trial name
- InLarge (NCT05056961)
- Testing
- Multiparametric mesurements
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Intubated ICU Patients
Shortened Preoperative Fasts in ICU
Randomized controlled trial assessing the safety and benefits of shortening preoperative fasts on intubated ICU patients undergoing tracheotomy.
- Trial name
- NCT03031379
- Testing
- shortened fast
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Montefiore Medical Center
ICU Patients, Intubation
Pulmonary and Ventilatory Effects of Trigger Modulation in Intubated ICU
Pressure support ventilation allows intubated ICU patients to breathe spontaneously. Among specific settings, the adjustment of the trigger value (or threshold for triggering the ventilator) has not been explored to date.
- Conditions
- ICU Patients, Intubation, Spontaneously Breathing, Pulmonary Function
- Trial name
- Trigger (NCT04041817)
- Testing
- Trigger setting of pressure support ventilation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Bacterial Pneumonia
Assessment of the Diagnostic Capacity of the Mini-broncho Alveolar Lavage Performed Through a Suction Catheter
The aim of this study is to develop a safe and effective technique to take sample for lower respiratory tract cultures easy to perform in conditions of acute respiratory failure and spontaneous ventilation for patients admitted…
- Trial name
- Mini-LBA (NCT00763620)
- Testing
- catheter for mini bronchoalveolar lavage
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intensive Care Unit ICU, Intubation
The Effects of Endotracheal Suctioning on Pain and Serum Markers
The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients.
- Conditions
- Intensive Care Unit ICU, Intubation, Critical Illness, Mechanical Ventilation
- Trial name
- NCT06692400
- Testing
- endotracheal tube suctioning
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Loma Linda University
Mechanically Ventilated ICU Patients
Effect of Homeopathic Remedy Kalium Bichromicum on Viscosity and Amount of Sputum Mechanically Ventilated ICU Patients.
The purpose of this study is to determine whether the homeopathic remedy Kali Bichromium is effective in reducing the amount of tracheal secretions in patients intubated with a conventional endotracheal tube and receiving…
- Trial name
- NCT00326365
- Testing
- Kali bichromicum 10-60 (C30)
- Where
- Israel
- Volunteers
- 56 people
- Sponsor
- Shaare Zedek Medical Center
Sedation
Risk Prediction of Dexmedetomidine-associated Hemodynamic Instability
Hypotension and bradycardia have been commonly associated with dexmedetomidine therapy, occurring in 13% to 68% and 1% to 42% of patients, respectively.
- Trial name
- DEXSEDATION (NCT03285087)
- Testing
- DEX 0.2 μg/kg/h.
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Assiut University
Patients Requiring Endotracheal Intubation
Intubated ICU Patients
The purpose of this research study is to determine how cell changes during endotracheal intubation and artificial lung ventilation affect lung inflammation.
- Trial name
- NCT02171091
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Washington University School of Medicine
Infection, Intensive Care (ICU)
The Effect of an Suction Toothbrush on the Development of Ventilator-Associated Pneumonia
Literature suggests that suction toothbrushes may improve oral care in intubated patients by facilitating secretion removal and reducing microaspiration.
- Conditions
- Infection, Intensive Care (ICU), Intubation, Intubation Complication
- Trial name
- Toothbrush (NCT07125495)
- Testing
- Suction tootbrush and distiled water, suction tootbrush and .12% chlorhexidine gluconate, Oral care sponge and with 15 ml of 0.12% chlorhexidine gluconate oral solution
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Koç University
Intubated ICU Patients
Respiratory Muscle Training in the ICU: IMT vs Diaphragmatic NMES
This study aimed to compare the effects of Inspiratory Muscle Training (IMT) and Diaphragmatic Neuromuscular Electrical Stimulation (NMES) on inspiratory muscle strength, mechanical ventilator parameters, and functional levels in…
- Trial name
- NCT07571642
- Testing
- Diaphragmatic Neuromuscular Electric Stimulation (NMES), Inspiratory muscle training (IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Ali Yalman
Mechanical Ventilation Complication
Automated Secretion Removal in ICU Patients
SUMMARY Rationale In intubated and mechanically ventilated critically ill patients, removal of airway secretions is typically performed by tracheal suctioning, an intervention that is labor-intensive and very unpleasant for the…
- Trial name
- TrachFlush (NCT05056103)
- Testing
- TrachFlush
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mucus Retention, Mechanical Ventilation Complication
Efficacity and Safety of Mechanical Insufflation-exsufflation on ICU
Critically ill and intubated patients on mechanical ventilation (IMV) often present retention of respiratory secretions, increasing the risk of respiratory infections and associated morbidity.
- Conditions
- Mucus Retention, Mechanical Ventilation Complication, Mucus; Plug, Tracheobronchial
- Trial name
- NCT03316079
- Testing
- Chest physiotherapy techniques, Mechanical insufflation-exsufflation
- Where
- 3 sites in France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Bordeaux
COVID-19
High Dose Inhaled Nitric Oxide for COVID-19 (ICU Patients)
Novel therapies are desperately needed for treatment of COVID-19 patients. At present, there are no proven interventions to prevent progression of the disease or to rapidly treat patients with COVID-19 related respiratory…
- Trial name
- NCT04383002
- Testing
- Nitric Oxide
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University Health Network, Toronto
Pain, ICU Delirium
Validation of the Polish Version of CPOT
Pain experienced by critically ill patients is a major problem affecting nearly 50% of the patients. Assessing pain in critically ill patients is a challenge even in an intensive care unit (ICU) with a minimal opioid-based…
- Trial name
- POL-CPOT (NCT03024528)
- Testing
- CPOT assessment
- Where
- Poland
- Volunteers
- 71 people
- Sponsor
- Pomeranian Medical University Szczecin
Intubated Patient Requiring a Gastric Tube
Impact of the Choice of Gastric Tube Placement Sites on the Incidence of Ventilator Associated Pneumonia
In intensive care, many gastric tubes are inserted on a regular basis. There are different practices in terms of the location of the gastric tube.
- Trial name
- SONG (NCT05915663)
- Testing
- nasogastric tube and orogastric tube, orogastric tube and nasogastric tube
- Where
- 16 sites in France
- Volunteers
- 2,400 people
- Sponsor
- Centre Hospitalier le Mans
Critical Illness
Oral Care to Reduce Mouth and Throat Infections in Critically Ill Patients
This study will evaluate whether a program of systematic oral care can help prevent hospital-acquired respiratory infections in patients in intensive care units.
- Trial name
- NCT00078663
- Testing
- Oral Care
- Where
- 5 sites in United States
- Volunteers
- 800 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP)
Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients
This prospective observational cohort study aims to evaluate the role of innate immune immunoparalysis in the development of ventilator-associated pneumonia (VAP) in critically ill mechanically ventilated patients.
- Conditions
- Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP), Immunoparalysis
- Trial name
- IMP-VM (NCT07551258)
- Where
- Spain
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Respiratory Failure, All Intubated Patients
Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients
Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both like PCV and PSV automatically. Some studies suggest that ASV can reduce the weaning time in ICU patients.
- Trial name
- NCT01472302
- Testing
- Adaptive Support Ventilation, Pressure Controlled Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 229 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Insertion of a Nasogastric Tube, Intubated Patient
Verification of Correct Positioning of a Gastric Tube by Ultrasonography
There are several ways to verify the correct positioning of a gastric tube. Radiography is considered the reference method. The use of ultrasonography could diminish the number of radiographies necessary.
- Conditions
- Insertion of a Nasogastric Tube, Intubated Patient, Patients Hospitalized in the Surgery Intensive Care Unit
- Trial name
- SNG echo (NCT02866123)
- Testing
- ultrasonography, pulmonary radiography
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire Dijon