Clinical trials: Intravitreal Injections
Intraocular Inflammation, Intravitreal Injections
Real-World Incidence of Intraocular Inflammation Following Intravitreal Treatment With Aflibercept 8 mg
Aflibercept 8 mg is a high-concentration anti-vascular endothelial growth factor therapy developed to extend treatment intervals for retinal diseases while maintaining the efficacy and safety of aflibercept 2 mg.
- Trial name
- NCT07849309
- Testing
- Aflibercept (Eylea)
- Where
- Denmark
- Volunteers
- 3,690 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Neovascular Age-Related Macular Degeneration (nAMD), Diabetic Macular Edema
Speculum-Free Intravitreal Injection Using Cotton-Tipped Applicator Retraction: Pain, Procedure Time, Patient Satisfaction, and Safety
This randomized controlled trial compares two techniques for eyelid retraction during intravitreal injection (IVI): an adjustable solid-blade eyelid speculum (Group A) and single-hand retraction of the upper eyelid with one…
- Conditions
- Neovascular Age-Related Macular Degeneration (nAMD), Diabetic Macular Edema, Retinal Vein Occlusion, Intravitreal Injections
- Trial name
- IVI-RETRACT (NCT07481500)
- Testing
- Eyelid Speculum Retraction, Cotton-Tipped Applicator Retraction
- Where
- Thailand
- Volunteers
- 129 people
- Sponsor
- Jakkrit Juhong
Endophthalmitis, Endophthalmitis Postoperative
Phacovitrectomy Versus Pars Plana Vitrectomy Alone for Post-Intravitreal Injection Endophthalmitis
This prospective comparative interventional study evaluated the anatomical and visual outcomes of phacovitrectomy versus pars plana vitrectomy (PPV) alone in patients with post-intravitreal injection endophthalmitis.
- Conditions
- Endophthalmitis, Endophthalmitis Postoperative, Intravitreal Injection Patients
- Trial name
- NCT07717944
- Testing
- Phacovitrectomy, Pars plana vitrectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Benha University
Diabetic Vitreous Hemorrhage, Intravitreal Injections
Outcomes of Intravitreal Ranibizumab Injection for Diabetic Vitreous Hemorrhage
This prospective interventional cohort study evaluates the outcomes of intravitreal ranibizumab injection in patients with diabetic vitreous hemorrhage secondary to proliferative diabetic retinopathy.
- Conditions
- Diabetic Vitreous Hemorrhage, Intravitreal Injections, Ranibizumab
- Trial name
- RANI-VH (NCT07690800)
- Testing
- Ranibizumab
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Diabetic Macular Edema, Neovascular (Wet) Age-Related Macular Degeneration
Effectiveness of Multidisciplinary Protocolised Interventions on IVT Non-adherence Rates
The purpose of this research study is to test whether a personalised care approach improves adherence compared to standard care.
- Conditions
- Diabetic Macular Edema, Neovascular (Wet) Age-Related Macular Degeneration, Intravitreal Injection
- Trial name
- ADHERE (NCT07567898)
- Testing
- multidisciplinary protocolized intervention (MPI), Routine medical care & monitoring
- Volunteers
- 200 people
- Sponsor
- Singapore Eye Research Institute
Intravitreal Injection
Endophthalmitis After Intravitreal Injection of Antiangiogenic Agents or Corticosteroids, a Cohort Study of the French Population of Patients Who Received Injections Over 9 Years
Intravitreal injections (IVI) of antiangiogenic agents (AA) have revolutionized the management of age-related macular degeneration (AMD) and diabetic macular edema (DME) in particular.
- Trial name
- ENIVAC (NCT03635268)
- Testing
- Data collection
- Volunteers
- 360,000 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Diabetic Retinopathy (DR), Diabetic Macular Edema (DME)
Comparing Single Versus Multiple Anti-VEGF Injections in Diabetic Patients Undergoing Cataract Surgery
Objective of this randomised controlled trial is to compare the efficacy of a single per operative anti VEGF injection with repeated postoperative anti VEGF injections in the prevention of diabetic retinopathy progression after…
- Conditions
- Diabetic Retinopathy (DR), Diabetic Macular Edema (DME), Cataract, Phacoemulfisication+IOL Implantation
- Trial name
- NCT07301775
- Testing
- Aflibercept (Eylea)
- Where
- 2 sites in Pakistan
- Volunteers
- 166 people
- Sponsor
- Ahmad Zeeshan Jamil
Intravitreal Injections
Eye Diseases "Treated" With Interoperable Medical Informatics
The overarching goal of EyeMatics is to promote an interoperable, sustainable infrastructure for the integration and sharing of data from clinical research to improve personalized medicine in ophthalmology.
- Trial name
- EyeMatics (NCT06810011)
- Where
- 6 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Muenster
Age Related Macular Degeneration, Intravitreal Injections
Aflibercept in Recurrent or Persistent CNV
Age-related macular degeneration (AMD) and diabetic retinopathy are among the most common disorders causing visual disability in elderly people. AMD leads to dysfunction and loss of photoreceptors in the central retina.
- Conditions
- Age Related Macular Degeneration, Intravitreal Injections, Diabetic Macular Edema
- Trial name
- OPHTH-010915 (NCT02669953)
- Testing
- Aflibercept
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna
Retinal Diseases - AMD - PAIN - Intravitreal Injection
Etude de l'ANesthésie Par Gel de Lidocaïne Pour Les Injections IntrA vitréennes
Purpose To assess the efficacy of preservative-free Lidocaine gel 2% (LG) in patients complaining of pain during intravitreal injection (IVI) despite standard topical anaesthesia.
- Trial name
- ANGLIA (NCT06493136)
- Testing
- lidocaine gel
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Institut Ophtalmologique de l'Ouest Jules Verne
Pain, Intravitreal Injection
Pain Reduction With Topical Bromfenac Versus Artificial Tear After Intravitreal Injection.
The purpose of this prospective interventional study is to compare post-intravitreal injection pain between eyes receiving topical bromfenac versus artificial tears as an analgesic after intravitreal injection.
- Conditions
- Pain, Intravitreal Injection, Pain, Acute
- Trial name
- NCT06130384
- Testing
- Use of bromfenac 0.09% to reduce intravitreal injection pain, Use of artificial tears to reduce intravitreal injection pain
- Where
- 5 sites in United States, Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Wills Eye
To Evaluate the Safety and Tolerability of Intravitreal Injection of LX109 in Patients With nAMD
An Exploratory Clinical Trial Evaluating LX109 Gene Therapy in Patients With nAMD
To evaluate the safety and tolerability of intravitreal injection of LX109 in patients with nAMD.
- Trial name
- NCT06022744
- Testing
- LX109
- Volunteers
- 12 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Intravitreal Injections, IVI
Control of Pain in Intravitreal Injections Using Topical NSAIDs
Intravitreal injections (IVI) are a common form of treatment for multiple retinal pathologies. The investigators hypothesize that an intervention with a topical NSAID will alleviate pain experienced at intravitreal injection…
- Trial name
- COPIVIN (NCT04343222)
- Testing
- Bromfenac, Artificial tears
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Wisconsin, Madison
Diabete Type 2, Cataract
Corticosteroid Injection Combined With Cataract Surgery in Diabetic Eyes.
The investigators aim in this study to investigate the effect of intravitreal triamcinolone acetonide injection on the development of macular edema and the progression of diabetic retinopathy.
- Conditions
- Diabete Type 2, Cataract, Triamcinolone Acetonide, Intravitreal Injection
- Trial name
- NCT05413330
- Testing
- Triamcinolone Acetonide
- Where
- Syria
- Volunteers
- 73 people
- Sponsor
- Damascus University
Intravitreal Injection, Ocular Rinse
The Effect of Ocular Rinse Volume on Surface Irritation After Intravitreal Injections
This is the first randomized controlled trial looking into post-injection rinse volume of standard ophthalmic eyewash and its affect on patient comfort up to 72 hours after injections.
- Conditions
- Intravitreal Injection, Ocular Rinse, Age-Related Macular Degeneration, Diabetic Macular Edema
- Trial name
- NCT05615805
- Testing
- OSDI questionnaire, SPEEDII questionnaire
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Anesthesia, Local, Intravitreal Injection
Long Term Safety of Cooling Anesthesia for Intravitreal Injection
The purpose of this clinical study is to evaluate the long term safety and efficacy of cooling anesthesia application to the eye as anesthesia for intravitreal injection using a novel cooling anesthesia device.
- Conditions
- Anesthesia, Local, Intravitreal Injection, Macular Edema, Macular Degeneration
- Trial name
- COOL-2 (NCT03956797)
- Testing
- Recens Cooling Anesthesia Device
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Recens Medical, Inc.
Intravitreal Injection, Pain
Pain Control and Subconjunctival Hemorrhage Size After Intravitreal Injection
Intravitreal injections (IVI) are the mainstay of treatment modality in many ophthalmologic diseases including neovascular age-related macular degeneration (AMD), diabetic retinopathy and retinal vascular occlusions.
- Conditions
- Intravitreal Injection, Pain, Subconjunctival Hemorrhage
- Trial name
- NCT04827836
- Testing
- Cooled eye drops and povidone-iodine
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Wolfson Medical Center
Dry Age-related Macular Degeneration, Geographic Atrophy
Intravitreal AAVCAGsCD59 for Advanced Dry Age-related Macular Degeneration (AMD) With Geographic Atrophy (GA)
Patients with advanced dry AMD with GA meeting inclusion criteria will be randomized in one eye in a 1:1:1 ratio comparing intravitreal high or low dose AAVCAGsCD59 with a sham injection.
- Conditions
- Dry Age-related Macular Degeneration, Geographic Atrophy, Gene Therapy, Intravitreal Injection
- Trial name
- NCT04358471
- Testing
- Intravitreal AAVCAGsCD59
- Sponsor
- Hemera Biosciences
Anesthesia, Local, Intravitreal Injection
Cooling Anesthesia for Intravitreal Injection
The purpose of this clinical study is to evaluate the safety and efficacy of cooling anesthesia application to the eye as anesthesia for intravitreal injection using a novel cooling anesthesia device and determine the effects of…
- Conditions
- Anesthesia, Local, Intravitreal Injection, Macular Degeneration, Diabetic Macular Edema
- Trial name
- COOL-1 (NCT03732287)
- Testing
- Cooling Anesthesia
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Recens Medical, Inc.
Lens Opacification, Intravitreal Injections (IVT)
Objective Measurements of Lens Opacification After Intravitreal Injections
The main hypothesis is the opacification of the lens would be increase by the IVT. The opacification of the lens can be objectived by : the objective scatter index (OSI) on the OQAS device the average lens density (ALD) on the…
- Trial name
- MOC-IVT (NCT03964597)
- Testing
- Measurement of lens opacification
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild