Clinical trials: Intracerebral Haemorrhage, active
Hemorrhagic Stroke, Intracerebral, Subarachnoid Haemorrhage (SAH)
AI-based Algorithm Development for Improved Diagnostics in the Intensive Care and Acute Stroke Setting Using Electroencephalography
The goal of this observational study is to develop and validate artificial intelligence (AI) algorithms that use subhairline EEG (a simplified EEG patch placed on the forehead and behind the ears) to predict neurological outcome…
- Conditions
- Hemorrhagic Stroke, Intracerebral, Subarachnoid Haemorrhage (SAH), Postanoxic Coma
- Trial name
- SMART-EEG (NCT07886957)
- Where
- Netherlands
- Volunteers
- 825 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Intracerebral Haemorrhage
Efficacy and Safety of Mirabegron in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes without effective pharmacological treatment. Inflammation following ICH contributes to barrier disruption and peri-hematoma edema, leading to deterioration of…
- Trial name
- NCT05369351
- Testing
- Standard treatment+mirabegron, Standard treatment
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Tianjin Medical University General Hospital
Intracerebral Haemorrhage (ICH), Cerebral Infarction
The Erlanger Stroke Registry (ESPro) is the Only Ongoing Prospective Population-based Stroke Registry in Germany, Started in 1994. ESPro Includes All Hospitalized and Non-hospitalized Patients With Stroke in the Community of Erlangen (120.000 Inhabitants), With a Long-life Follow-up.
Stroke is a disease that primarily affects older adults and, with an estimated 64,000 deaths in 2024, is one of the leading causes of death in Germany.
- Conditions
- Intracerebral Haemorrhage (ICH), Cerebral Infarction, Cerebral Infarction Due to Thrombosis of Cerebral Arteries, Cerebral Infarction Due to Embolism of Cerebral Arteries
- Trial name
- ESPro (NCT07771335)
- Where
- 3 sites in Germany
- Volunteers
- 17,000 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Intracerebral Haemorrhage
Reducing the Burden of Cardiovascular Events With Antiplatelet Therapy in Patients With IntraCerebral Haemorrhage
BEAT ICH will be a pragmatic, randomised, placebo-controlled, blinded, superiority clinical trial aiming to recruit 5676 patients aged ≥18 years who survive ICH and assign them 1:1 to starting antiplatelet monotherapy (Aspirin 75…
- Trial name
- BEAT-ICH (NCT07243704)
- Testing
- Aspirin 75 mg daily
- Where
- 33 sites in India
- Volunteers
- 5,676 people
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Traumatic Brain Injury, Intracerebral Haemorrhage
The EBC Recovery Study
The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up…
- Conditions
- Traumatic Brain Injury, Intracerebral Haemorrhage, Subarachnoid Haemorrhagic Stroke
- Trial name
- NCT04712591
- Testing
- Auditory stimuli
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
Cerebrovascular Disease, Ischemic Stroke
Florida Cerebrovascular Disease Biorepository and Genomics Center
The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by…
- Conditions
- Cerebrovascular Disease, Ischemic Stroke, Transient Ischemic Attack, Intracerebral Hemorrhage
- Trial name
- NCT05491980
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Intracerebral Haemorrhage, ICH
Characterization of Peri-Hemorrhagic Cerebral Edema Using Synthetic Sodium Imaging With 7-Tesla and 3-Tesla MRI
Intracerebral haemorrhage is the type of stroke with the highest mortality rate, estimated at 40% in the acute phase. Among survivors, half will experience functional disability.
- Trial name
- TIPITCH-7T (NCT07789990)
- Testing
- Sodium tissue concentration will be measured in perihematomal oedema
- Volunteers
- 48 people
- Sponsor
- University Hospital, Lille
Intracerebral Haemorrhage, Paediatric Stroke
Master Study Protocol for the Cohort of the Specialist Network Stroke (SN Stroke)(Stroke-CORE)
The Stroke-CORE cohort aims to provide a comprehensive and up-to-date understanding of stroke care in Germany. To achieve this, patients are followed along the entire continuum of care-from initial management before hospital…
- Conditions
- Intracerebral Haemorrhage, Paediatric Stroke, Stroke Acute, Stroke
- Trial name
- Stroke-CORE (NCT07553650)
- Where
- 12 sites in Germany
- Volunteers
- 12,750 people
- Sponsor
- Charite University, Berlin, Germany
Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage
The Fifth INTEnsive pReventing Secondary Injury in Acute Cerebral Haemorrhage Trial Within ACT-GLOBAL
This is a domain within the ACT-GLOBAL platform trial to compare the effectiveness of early and appropriate pharmacological interventions in acute intracerebral hemorrhage (ICH) to control secondary brain injury.
- Conditions
- Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage, Supratentorial Intracerebral Haemorrhage, Acute Intracerebral Haemorrhage
- Trial name
- INTERACT5 (NCT06763055)
- Testing
- Colchicine 0.5 mg, Deferoxamine Mesylate, Control (Standard treatment)
- Where
- 2 sites in Australia, China
- Volunteers
- 2,000 people
- Sponsor
- The George Institute
Intracerebral Hemorrhage, Subarachnoid Hemorrhage
Improving Outcomes for Patients With Life-Threatening Neurologic Illness
Background: While the intensive care of patients with life-threatening brain illnesses has advanced tremendously, a large number of therapies are still without proper scientific support.
- Conditions
- Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Intraventricular Hemorrhage, Nontraumatic Haemorrhage
- Trial name
- REACH (NCT04189471)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Maryland, Baltimore
Intracerebral Haemorrhage
NICardipine for Fast Achievement of Systolic BP Targets in ICH
Quality improvement study with a quasi-randomized design. The study monitors the effect of a gradually implemented treatment algorithm prioritizing intravenous antihypertensives (e.g., nicardipine) over long-acting nitrate…
- Trial name
- NICFAST (NCT07044232)
- Testing
- Nicardipine, Glyceryl trinitrate
- Where
- Denmark
- Volunteers
- 88 people
- Sponsor
- Aarhus University Hospital
Intracerebral Hemorrhage, Intracerebral Haemorrhage
International Care Bundle Evaluation in Cerebral Hemorrhage Research
Spontaneous intracerebral haemorrhage (ICH) accounts for approximately 10-15% of all strokes but stands for 50% of stroke-related morbidity and mortality.
- Conditions
- Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage, Stroke
- Trial name
- I-CATCHER (NCT06429332)
- Testing
- Reversal of Oral anticoagulation within 30 minutes, Early intensive blood pressure lowering, Treatment of pyrexia
- Where
- 54 sites in United States, Australia and 6 more
- Volunteers
- 3,500 people
- Sponsor
- Region Skane
Stroke, Intracerebral Haemorrhage
Testing the Effectiveness of a Novel Intervention to Improve Medication Adherence in Stroke Survivors
The goal of this study is to test if Savvy, a multimodal intervention (consisting of psychological exercises, a weekly pill organizer, and a text message reminder system) can improve medication adherence in stroke survivors.
- Conditions
- Stroke, Intracerebral Haemorrhage, Ischemic Stroke, TIA (Transient Ischemic Attack)
- Trial name
- NCT07414732
- Testing
- Savvy Medication Adherence Intervention
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Stroke, Intracerebral Haemorrhage
Comparison of Blended Care Outpatient Neurorehabilitation With Traditional Outpatient Neurorehabilitation
What is this study about? Outpatient neurorehabilitation (therapy after leaving the hospital) is an important follow-up treatment for people who have had a stroke, brain bleeding, or serious head injury.
- Conditions
- Stroke, Intracerebral Haemorrhage, Brain Trauma
- Trial name
- NCT07458308
- Testing
- Blended care outpatient neurorehabilitation
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Luzerner Kantonsspital
Stroke, Ischemia Stroke
Minocycline in Stroke Study at Maimonides
The goal of this study is to determine if Minocycline, when added to standard care, can improve survival and functional outcomes in patients with moderate acute stroke (ischemic or hemorrhagic) aged 18 years and older.
- Conditions
- Stroke, Ischemia Stroke, Hemorrhagic Strokes, Mortality
- Trial name
- NCT07237048
- Testing
- Minocycline 200mg
- Where
- United States
- Volunteers
- 1,164 people
- Sponsor
- Joyce Chen
Stroke, Chronic Stroke
Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability
The main purpose of the current studies is to evaluate the safety and tolerability of psilocybin in patients with chronic stroke.
- Conditions
- Stroke, Chronic Stroke, Intracerebral Haemorrhage, Intracerebral Haemorrhage (ICH)
- Trial name
- PHATHOM (NCT07053917)
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Stroke, Intracerebral Hemorrhage
AI-assisted Transcranial Duplex Sonography for Early Detection of Intracerebral Haemorrhage: HYPER-AI-SCAN
The goal of this observational study is to evaluate whether transcranial Doppler ultrasound, combined with artificial intelligence (AI), can help identify intracerebral haemorrhage (ICH) in people with acute stroke (both men and…
- Conditions
- Stroke, Intracerebral Hemorrhage, Intracerebral Hemorrhage Basal Ganglia, Intracerebral Haemorrhage
- Trial name
- NCT07319013
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Intracerebral Haemorrhage, Minimally Invasive Treatment
Stereotactic Thrombolysis With Tenecteplase for Supratentorial Intracerebral Hemorrhage
This is an phase III prospective, multi-center, open-label, randomized controlled trial (RCT) with blinded endpoint assessment. It plans to enroll 768 subjects with spontaneous supratentorial intracerebral hemorrhage, who will be…
- Trial name
- STEPS (NCT07208097)
- Testing
- Stereotactic thrombolysis with Tenecteplase
- Where
- 2 sites in China
- Volunteers
- 768 people
- Sponsor
- Tongji Hospital
Intracerebral Hemorrhage Basal Ganglia, Intracerebral Haemorrhage
Minimally Invasive Surgery For Patients With Spontaneous Deep Intracerebral Hemorrhage
This observational cohort study evaluates the safety and effectiveness of minimally invasive surgery (MIS) compared with standard medical management in adults with spontaneous deep intracerebral hemorrhage.
- Trial name
- MISDIH (NCT07234955)
- Where
- Vietnam
- Volunteers
- 300 people
- Sponsor
- Huynh Quoc Huy
Intracerebral Haemorrhage, Intracerebral Hemorrhage
Timing and Outcomes of Recovery After intraCerebral Hemorrhage
The TORCH registry is a prospective, observational cohort study, which will collect detailed, longitudinal data on the clinical characteristics, treatment modalities, and outcomes of patients with ICH.
- Trial name
- TORCH (NCT07166146)
- Testing
- Surgical interventions
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing