Clinical trials: Intra-operative Bleeding
Blood Loss, Surgical
Prospective, Multicenter, Multidisciplinary, Controlled Clinical Investigation Evaluating the Safety and Efficacy of PerClot® Polysaccharide Hemostatic System
This is a prospective, multicenter, multidisciplinary, controlled clinical investigation evaluating the safety and efficacy of PerClot in achieving intraoperative hemostasis compared to a similar marketed hemostatic device.
- Trial name
- CLOT (NCT02359994)
- Testing
- PerClot Polysaccharide Hemostatic System, Arista AH
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Artivion Inc.
Blood Loss, Surgical, Intrapartum Hemorrhage
Efficacy of Carbetocin Versus Oxytocin Plus Misoprostol in Decreasing Blood Loss During Cesarean Section
The aim of this clinical trial is to test if carbetocin is as effective as oxytocin plus misoprostol in decreasing intraoperative blood loss in women undergoing planned cesarean section.
- Trial name
- NCT05664659
- Testing
- Oxytocin + misoprostol, Carbetocin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams Maternity Hospital
Blood Loss, Surgical
B-lynch Transverse Compression Suture
Is B-Lynch transverse compression suture safe and effective in controlling excessive blood loss during conservative management of women with placenta previa?
- Trial name
- NCT06359886
- Testing
- B-Lynch Transverse Compression Suture
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Alexandria University
Hemorrhage, Arthroplasty, Replacement, Hip
Tranexamic Acid vs. Quixil - Reducing Blood Loss in Joint Replacement
We will compare the effectiveness of Quixil and Tranexamic acid in reducing bleeding during hip and knee joint replacements.
- Conditions
- Hemorrhage, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- NCT00378872
- Testing
- IV Tranexamic acid 10mg/kg pt body weight, Quixil topical sealant
- Where
- United Kingdom
- Volunteers
- 132 people
- Sponsor
- Golden Jubilee National Hospital
Meningioma
Magnesium and Intraoperative Blood Loss in Meningioma Surgery
Meningioma is the most common central nervous system tumor and craniotomy with tumor removal was associated with moderate blood loss and blood transfusion.
- Trial name
- NCT03558516
- Testing
- Magnesium group, Normal saline group
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Blood Loss, Surgical, Blood Loss, Postoperative
Tranexamic Acid Versus Misoprostol to Reduce Blood Loss During and After Cesarean Section
Brief Summary The goal of this clinical trial is to compare two medicines, intravenous tranexamic acid and rectal misoprostol, for reducing blood loss in women undergoing cesarean section.
- Conditions
- Blood Loss, Surgical, Blood Loss, Postoperative, Cesarean Section
- Trial name
- NCT07712510
- Testing
- Intravenous Tranexamic Acid, rectal misoprostol
- Where
- Pakistan
- Volunteers
- 214 people
- Sponsor
- Medicare Hospital (Pvt) Limited
Hemostasis, Surgical Blood Loss
Hemocoll, Avitene, or Bone Wax for Cancellous Bone Bleeding After Single-Ray Amputation
This is a multicentre, prospective, three-arm, parallel-group randomized controlled superiority trial evaluating fibrillar Type-I collagen haemostat (Hemocoll®) FTC, Avitene™ Microfibrillar Collagen Hemostat (MCH), and…
- Conditions
- Hemostasis, Surgical Blood Loss, Amputation Stump, Hemorrhage
- Trial name
- CANHAEM-Ray (NCT07788846)
- Testing
- Hemocoll® Fibrillar type-I collagen haemostat, Bone wax, Avitene™ Microfibrillar Collagen Hemostat
- Where
- 3 sites in India
- Volunteers
- 135 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Hemorrhage, Platelets; Defect
Extended Cold Stored Apheresis Platelets in Cardiac Surgery Patients
This trial is being performed to evaluate the feasibility of the study protocol and to test the efficacy and safety of platelets stored at cold conditions (1-6°C) in 100% plasma for 10-14 days (CSP) in cardiac surgery patients…
- Conditions
- Hemorrhage, Platelets; Defect, Bleeding, Surgical Blood Loss
- Trial name
- CHASE (NCT05220787)
- Testing
- Cold stored platelets in 100% plasma stored for 10-14 days, Room temperature stored platelets in 100% plasma stored for up to 7 days
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Moritz Stolla, MD
Rhinosinusitis Chronic, Bleeding
This Study Aims to Assess the Impact of 50°C Saline Irrigation on the Overall Intraoperative Blood Loss and Surgical Visualization During Endoscopic Sinus Surgery for Rhinosinusitis.
Objectives: Intraoperative bleeding during endoscopic sinus surgery for severe rhinosinusitis may significantly compromise the surgical field.
- Trial name
- NCT07627789
- Testing
- Hot saline irrigation, Room-temperature saline irrigation
- Where
- Poland
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Military Institute of Aviation Medicine
Hypospadias
Effectiveness of Caudal Epidural Block on Intraoperative Blood Loss During Hypospadias Repair
From September 2014 to March 2015, 57 consecutive patients with hypospadias who are candidate for surgery will be enrolled in this randomized clinical trial.
- Trial name
- NCT02752308
- Testing
- Bupivacaine, General anesthesia, Dilute epinephrine injection
- Volunteers
- 60 people
- Sponsor
- Isfahan University of Medical Sciences
Craniosynostoses, Hypovolemia
Hemodynamic Monitoring During Craniosynostosis Surgery: Comparing Traditional and Newer Technology Monitors (CRASY-PRAM)
Hemodynamic evaluation during pediatric anesthesia is essential to care management. Intraoperative cardiovascular instability is frequent in major surgeries, and appropriate monitoring is necessary to ensure safe anesthetic…
- Conditions
- Craniosynostoses, Hypovolemia, Hemorrhage, Hemodynamic Instability
- Trial name
- CRASY-PRAM (NCT06263075)
- Testing
- Intraoperative monitoring
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Blood Loss, Surgical
Suction Drainage in the Management of Peri-operative Bleeding in Total and Unicomcompartmental Knee Arthroplasty
Although, suction drainage is routinely used in orthopedic clinical practice, there are still no precise guidelines on its use in total joint arthroplasty, particularly in total as well as unicompartmental knee arthroplasty.
- Trial name
- NCT04508101
- Volunteers
- 153 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Abdominal Hysterectomy
Intravenous Ascorbic Acid Administration in Hysterectomy
vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues…
- Trial name
- NCT03965637
- Testing
- vitamin C
- Where
- Iran
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Diabetic Retinopathy, Vitreous Hemorrhage
Preoperative Bevacizumab for Vitreous Hemorrhage
The purpose of this study is to determine whether preoperative intravitreal bevacizumab is effective in reducing intra-operative and postoperative bleeding in diabetic patients submitted to pars plana vitrectomy for vitreous…
- Trial name
- IBEVI (NCT00596297)
- Testing
- bevacizumab, pars plana vitrectomy
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- University of Sao Paulo
Head and Neck Cancer, Intraoperative Complications
Coagulation and Vitamin K in Head and Neck Microvascular Free Flap Surgery
For patients with large head and neck tumors the recommended treatment, in many cases, is a combination of extensive surgery and postoperative radiotherapy.
- Conditions
- Head and Neck Cancer, Intraoperative Complications, Coagulation Disorder, Blood, Vitamin K Deficiency
- Trial name
- MVL-COAG (NCT04517461)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Cesarean Sections
Delayed Umbilical Cord Clamping - C-section Pilot
This is a pilot study of delayed cord clamping (DCC) at progressively longer intervals (90 to 120 seconds) during elective cesarean deliveries of term infants.
- Trial name
- NCT02229162
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of California, Davis
Hemorrhage, Blood Loss
Clinical Investigation Evaluating a New Autotransfusion Device in Cardiac Surgery
Blood transfusion is at the heart of the therapeutic arsenal when there is a hemorrhage and/or blood loss during a surgery. There are two types of transfusion: the homologous one (blood from a compatible donor) and the autologous…
- Conditions
- Hemorrhage, Blood Loss, Surgical Blood Loss
- Trial name
- i-TRANSEP (NCT04588350)
- Testing
- i-SEP autotransfusion system
- Where
- 5 sites in France
- Volunteers
- 50 people
- Sponsor
- i-SEP
Shoulder Arthritis, Blood Loss, Surgical
Effect of TXA on Blood Loss in Reverse Total Shoulder Arthroplasty
Tranexamic acid (TXA) is a synthetic anti-fibrinolytic agent that has been well studied and routinely used for hip and knee arthroplasty.
- Conditions
- Shoulder Arthritis, Blood Loss, Surgical, Tranexamic Acid Adverse Reaction
- Trial name
- NCT06638749
- Testing
- Tranexamic Acid, Normal Saline
- Where
- United States
- Sponsor
- University of Kansas Medical Center
Intraoperative Bleeding, Functional Endoscopic Sinus Surgeries
Dexmedetomidine Versus Nitroglycerin on Surgical Field Quality and Drug Cost in Functional Endoscopic Sinus Surgeries
Sinus surgery is one of the most prevalent ear, nose, and throat (ENT) surgeries, which is mainly carried out nowadays through functional endoscopic sinus surgery (FESS) and leads to significant improvement in the clinical…
- Conditions
- Intraoperative Bleeding, Functional Endoscopic Sinus Surgeries, Hypotension
- Trial name
- NCT07585201
- Testing
- controlled hypotension using dexmedetomidine, controlled hypotension hypotension using nitroglycerin
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Zagazig University
Blood Loss, Surgical
Tranexamic Acid for Total Knee Arthroscopy
The purpose of this investigation is to determine the most effective regimen of administration of tranexamic acid to improve clinical outcome among patients undergoing total knee arthroplasty.
- Trial name
- NCT04443920
- Testing
- Tranexamic acid (TXA)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- The Miriam Hospital