Clinical trials: Intestinal Metaplasia, active
Gastric Intestinal Metaplasia
Efficacy and Safety of Weifuchun Tablet in Reversing Gastric Intestinal Metaplasia
The goal of this clinical trial is to investigate the efficacy and safety of Weifuchun tablet in treating gastric intestinal metaplasia in Helicobacter pylori-negative adults.
- Trial name
- NCT06610266
- Testing
- Weifuchun, Folic Acid
- Where
- 9 sites in China
- Volunteers
- 400 people
- Sponsor
- Yongquan Shi
Helicobacter Pylori, Atrophic Gastritis
Helicobacter Pylori, Atrophic Gastritis and Intestinal Metaplasia Registry and Prospective Study
Since much is unknown about factors that lead to progression of the pre-neoplastic lesions and cancer. In addition, there is ongoing debate on the optimal surveillance intervals and techniques.
- Conditions
- Helicobacter Pylori, Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- NCT05053945
- Testing
- Esophagogastroduodenoscopy
- Where
- 2 sites in Hong Kong
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
HELICOBACTER PYLORI INFECTIONS, Intestinal Metaplasia
Endoscopic Screening of Asymptomatic Patients for Helicobacter Pylori, Intestinal Metaplasia, and Barrett's Mucosa During Screening Colonoscopy
The goal of this observational study is to learn how common Helicobacter pylori (H. pylori) infection is in adults without stomach or upper gastrointestinal symptoms who are having a preventive screening colonoscopy.
- Conditions
- HELICOBACTER PYLORI INFECTIONS, Intestinal Metaplasia, Barett's Esophagus
- Trial name
- G-SCOGE (NCT07346521)
- Where
- Austria
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sigmund Freud PrivatUniversitat
Gastric Intestinal Metaplasia
Efficacy of an AI System in Training Endoscopists to Assess Gastric Intestinal Metaplasia Via the EGGIM Score
This prospective randomized controlled trial with a crossover design incorporated image-enhanced endoscopy (IEE) videos demonstrating complete standardized examinations of five standard gastric areas (antrum greater curvature…
- Trial name
- NCT07208864
- Testing
- AI-assisted EGGIM scoring, Conventional EGGIM scoring
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Qilu Hospital of Shandong University
Functional Dyspepsia, Gastritis
The Prevalence and the Pathophysiological Role of Non-Helicobacter Pylori Helicobacter Spp. in Well-defined Gastric Diseases and (Pre-) Malignancies
The goal of this clinical trial is to discover the prevalence of NHPH bacteria (Non-Helicobacter pylori Helicobacter species) in patients with one of the following conditions: 1.
- Conditions
- Functional Dyspepsia, Gastritis, Gastritis Chronic, Gastric Cancer (GC)
- Trial name
- HELIS (NCT07770126)
- Where
- 3 sites in Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Chronic Atrophic Gastritis (CAG)
Correlation Among Various OLGA and OLGIM Stages, Digestive Symptom Scores, and Acupuncture Treatment in Patients with Chronic Atrophic Gastritis
Brief Summary Template for the Study: The goal of this observational study is to examine the relationship between digestive symptom scores, serum pepsinogen indices, and histopathological OLGA and OLGIM systematic staging of the…
- Trial name
- NCT06707701
- Testing
- acupuncture
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yi Liang
Gastric Intestinal Metaplasia
Efficacy and Safety of Ursodeoxycholic Acid in Reversing Gastric Intestinal Metaplasia
The goal of this clinical trial is to investigate the efficacy of ursodeoxycholic acid in treating gastric intestinal metaplasia in Helicobacter pylori-negative adults. It will also learn about the safety of ursodeoxycholic acid.
- Trial name
- NCT06610760
- Testing
- Ursodeoxycholic Acid
- Where
- 6 sites in China
- Volunteers
- 196 people
- Sponsor
- Yongquan Shi
STOMACH NEOPLASM
Use of Pyrvinium to Reverse Stomach Precancerous Conditions
This study is carried out to find out if a drug called pyrvinium is able to convert pre-cancerous tissue in the stomach back to healthy tissue, to lower the chances of stomach cancer.
- Trial name
- NCT06782048
- Testing
- Pyrvinium, Blood biomarkers analyses, Oesophagogastroduodenoscopy (OGD) and biopsy
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- National University Hospital, Singapore
Intestinal Metaplasia of Gastric Mucosa
Intestinal Metaplasia Cohort for Gastric Cancer Prediction
In this study, we aim to establish a prospective cohort of patients with endoscopically and histologically confirmed intestinal metaplasia, collect gastric mucosal tissue samples from this cohort, and follow the development of…
- Trial name
- NCT06075199
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
Gastric Intestinal Metaplasia, Gastric Precancer
REVerse Intestinal Metaplasia in the Stomach (REVISE)
This study is designed to test the use of Pyrvinium vs placebo as a treatment for gastric intestinal metaplasia with features associated with increased risk of cancer.
- Trial name
- REVISE (NCT06590454)
- Testing
- Pyrvinium
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Katherine Garman
Gastric Atrophy, Gastric Intestinal Metaplasia
A Study Collecting Health Information to Understand and Prevent Gastric Cancer
The purpose of this study is to create a registry of participants with precursor lesions for gastric cancer, including gastric atrophy, intestinal metaplasia, and dysplasia.
- Conditions
- Gastric Atrophy, Gastric Intestinal Metaplasia, Dysplasia, Gastric Adenocarcinoma
- Trial name
- NCT06370143
- Testing
- Questionnaire
- Where
- 7 sites in United States
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stomach Neoplasm
Validation of a Molecular Test for Risk-stratification of Patients With High-risk Intestinal Metaplasia (GCEP2 Study)
This study is carried out to find out if a customized molecular test can identify a subgroup of patients with very-high-risk of developing stomach cancer within patients with intestinal metaplasia (IM).
- Trial name
- NCT05782465
- Testing
- Blood Collection, processing and analyses, Gastroscopy and biopsies collection, Urea Breath Test
- Where
- 8 sites in United States, Hong Kong and 4 more
- Volunteers
- 500 people
- Sponsor
- National University Hospital, Singapore
Atrophic Gastritis, Intestinal Metaplasia
SUrveillance of PREMalignant Stomach - Individualized Endoscopic Follow-up
Introduction: Gastric atrophy and intestinal metaplasia are the principal precursors for gastric cancer and, therefore, are considered gastric premalignant conditions.
- Conditions
- Atrophic Gastritis, Intestinal Metaplasia, Gastric Dysplasia, Gastric Cancer
- Trial name
- SUPREME (NCT04613570)
- Testing
- Upper gastrointestinal endoscopy
- Where
- Portugal
- Volunteers
- 912 people
- Sponsor
- Instituto Portugues de Oncologia, Francisco Gentil, Porto
Gastric Cancer, Intestinal Metaplasia of Gastric Mucosa
The GAstric Precancerous Conditions Study
Gastric cancer afflicts 27,000 Americans annually and carries a dismal prognosis. One reason for poor outcomes is late diagnosis, as the majority of gastric cancers in the United States are diagnosed at a relatively advanced…
- Conditions
- Gastric Cancer, Intestinal Metaplasia of Gastric Mucosa, Helicobacter Pylori Infection, Atrophic Gastritis
- Trial name
- GAPS (NCT04191551)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Stanford University
Intestinal Metaplasia of Gastric Mucosa, Artificial Intelligence
Artificial Intelligence in Assessing Gastric Intestinal Metaplasia Via the EGGIM Score
The endoscopic grading system (EGGIM) has been widely used to assess the extent of gastric intestinal metaplasia during endoscopy.
- Conditions
- Intestinal Metaplasia of Gastric Mucosa, Artificial Intelligence, Endoscopy
- Trial name
- NCT07257796
- Testing
- The diagnostic performance of AI system and endoscopists
- Where
- 3 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Qilu Hospital of Shandong University
Helicobacter Pylori, Early Gastric Cancer
Helicobacter Pylori Infection Status and Pathological Features for Predicting Gastric Cancer Biological Behavior and Prognosis: A Real-World Observational Study
This multicenter retrospective and prospective real-world observational study will evaluate the relationship of Helicobacter pylori (H.
- Trial name
- NCT07724496
- Testing
- 13C-Urea Breath Test, Serum Helicobacter pylori Antibody Testing, Pathological Assessment of Gastric Tissue
- Where
- 3 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Chinese PLA General Hospital
Gastric Intestinal Metaplasia
Multi-center Prospective Validation of Real-Time AI-EGGIM System
Gastric intestinal metaplasia (GIM) is a precancerous condition associated with an increased risk of gastric cancer. The endoscopic grading of gastric intestinal metaplasia (EGGIM) score evaluates the extent of GIM across five…
- Trial name
- NCT07915843
- Testing
- AI-EGGIM Assessment
- Where
- 3 sites in China
- Volunteers
- 540 people
- Sponsor
- Qilu Hospital of Shandong University
Gastric Intestinal Metaplasia
Efficacy and Safety of Berberine for Gastric Intestinal Metaplasia
The goal of this clinical trial is to investigate the efficacy of Berberine in treating gastric intestinal metaplasia in Helicobacter pylori-negative adults. It will also learn about the safety of Berberine.
- Trial name
- NCT07129460
- Testing
- Berberine hydrochloride
- Volunteers
- 204 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Gastric Carcinoma, Gastritis Chronic
Association Between Microplastic Exposure and the Pathological Progression of Gastric Carcinogenesis
The objective of this clinical trial is to explore the correlation between the level of microplastic exposure and the risk of gastric mucosal carcinogenesis, and to evaluate the strength of its effect as an independent risk…
- Conditions
- Gastric Carcinoma, Gastritis Chronic, Intestinal Metaplasia, Gastric Precancerous Lesions
- Trial name
- NCT07542652
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Yongquan Shi
Helicobacter Pylori Infection, Early Gastric Cancer
Effects of H. Pylori Eradication on the Gastric Preneoplastic Lesion and Neoplasm After ESD
This study evaluates whether Helicobacter pylori eradication improves precancerous lesions including glandular atrophy and intestinal metaplasia as well as metachronous cancers or dysplasias after endoscopic mucosal resection for…
- Conditions
- Helicobacter Pylori Infection, Early Gastric Cancer, Endoscopic Resection
- Trial name
- NCT02407119
- Testing
- 7 day H.pylori eradication Omeprazole or Rabeprazole, Clarithromycin, Amoxicillin
- Where
- South Korea
- Volunteers
- 470 people
- Sponsor
- National Cancer Center, Korea