Clinical trials: Intestinal Metaplasia
Gastric Intestinal Metaplasia
Efficacy of an AI System in Training Endoscopists to Assess Gastric Intestinal Metaplasia Via the EGGIM Score
This prospective randomized controlled trial with a crossover design incorporated image-enhanced endoscopy (IEE) videos demonstrating complete standardized examinations of five standard gastric areas (antrum greater curvature…
- Trial name
- NCT07208864
- Testing
- AI-assisted EGGIM scoring, Conventional EGGIM scoring
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Qilu Hospital of Shandong University
Gastric Dysplasia, Gastric Intestinal Metaplasia
Validation of an Artificial Intelligence System Based on Raman Spectroscopy for Diagnosis of Gastric Premalignant Lesions and Early Gastric Cancer
Early detection and treatment of gastric premalignant lesion and early gastric cancer (EGC) have been proposed to improve outcomes of gastric cancer.
- Conditions
- Gastric Dysplasia, Gastric Intestinal Metaplasia, Gastric Cancer
- Trial name
- NCT04869618
- Testing
- Raman spectroscopy based device (SPECTRA IMDx)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- Changi General Hospital
Helicobacter Pylori, the Operative Link on Gastric Intestinal Metaplasia
The Influence of Helicobacter Pylori Eradication on Gastric Pathology: a Long-term, Prospective Cohort Study
Helicobacter pylori (H. pylori) infection, affecting an estimated 50% of the global population, is a main cause of chronic gastritis, peptic ulcers and gastric cancer.
- Conditions
- Helicobacter Pylori, the Operative Link on Gastric Intestinal Metaplasia, Operative Link on Gastric Intestinal Assessment
- Trial name
- NCT02933229
- Testing
- biopsy, H. pylori eradication
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong University
Cancer
RAV12 in Treating Patients With Metastatic or Recurrent Adenocarcinoma
RATIONALE: Monoclonal antibodies, such as RAV12, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00101972
- Testing
- monoclonal antibody RAV12
- Where
- 5 sites in United States
- Volunteers
- 53 people
- Sponsor
- MacroGenics
Gastric Cancer, Gastric Intestinal Metaplasia
Chemoprevention of Gastric Carcinogenesis
A clinical study of the efficacy of oral alpha-difluoromethylornithine (eflornithine or DFMO) in male and female subjects ages 30-60 with gastric premalignant lesions in two high risk regions of Latin America.
- Trial name
- NCT02794428
- Testing
- Eflornithine
- Where
- 2 sites in Honduras, Puerto Rico
- Volunteers
- 91 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Gastric Cancer, Gastric Intestinal Metaplasia
Cytosponge for Gastric Intestinal Metaplasia
Gastric cancer has a very poor prognosis. The disease is often diagnosed at a late stage, when curative treatment options are limited or ineffective.
- Conditions
- Gastric Cancer, Gastric Intestinal Metaplasia, Gastric Atrophy
- Trial name
- CyGIM (NCT05657080)
- Testing
- Cytosponge-TFF3
- Where
- United Kingdom
- Volunteers
- 226 people
- Sponsor
- University of Cambridge
Gastric Intestinal Metaplasia
Confocal Laser Endomicroscopy With Cresyl Violet for in Vivo Diagnosis of Gastric Intestinal Metaplasia
Confocal laser endomicroscopy (CLE) is a novel endoscopic system which can provide approximately 1000-fold magnification of the gastrointestinal mucosa.
- Trial name
- NCT03672708
- Testing
- Cresyl violet
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shandong University
Intestinal Metaplasia, Metabolic Syndrome
Oxidative Stress in Intestinal Metaplasia and Metabolic Syndrome
Intestinal metaplasia is generally considered a precancerous lesion. Although it is associated with a very small increase of gastric cancer risk, European Endoscopic Society and other European academic companies highlighted the…
- Conditions
- Intestinal Metaplasia, Metabolic Syndrome, Oxidative Stress, Inflammatory Response
- Trial name
- NCT02695186
- Testing
- Gastroscopy
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- General Hospital of Filiates
Narrow-band Imaging, Magnifying Endoscopy
Endoscopic Grading of Intestinal Metaplasia
Long-term Helicobacter pylori infection causes premalignant gastric conditions, such as atrophic gastritis and intestinal metaplasia.
- Conditions
- Narrow-band Imaging, Magnifying Endoscopy, Gastric Intestinal Metaplasia
- Trial name
- NCT05345314
- Testing
- Narrow-band imaging endoscopy
- Where
- South Korea
- Volunteers
- 242 people
- Sponsor
- Soonchunhyang University Hospital
Gastric Xanthoma, Helicobacter Pylori Infection
A Study on the Relationship Between Gastric Xanthoma and Gastric Cancer and Precancerous Lesions
To explore the effects of gastric xanthoma on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.
- Conditions
- Gastric Xanthoma, Helicobacter Pylori Infection, Gastric Cancer, Intestinal Metaplasia
- Trial name
- NCT06282484
- Where
- China
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Gastric Intestinal Metaplasia
Confocal Endomicroscopy Detection of Gastric Preneoplasia and Neoplasia
This is a prospective randomised study investigating the use of chromoendoscopy and confocal laser endomicroscopy for the detection of preneoplastic neoplasm in patients at high-risk of gastric cancer.
- Trial name
- R-CE-GCEP (NCT01384201)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
Gastric Neoplasm, Gastric Cancer
Long-term Follow-up Prognosis of Atrophic Gastritis After 3 Years
Serum pepsinogen (PG) levels are considered reliable markers for progression of atrophic gastritis with a stepwise reduction in the serum PG I level or PG I/II ratio.
- Conditions
- Gastric Neoplasm, Gastric Cancer, Gastric Adenoma, Gastric Atrophy
- Trial name
- NCT01824953
- Where
- 2 sites in South Korea
- Volunteers
- 3,328 people
- Sponsor
- Konkuk University Medical Center
Helicobacter Pylori, Early Gastric Cancer
Helicobacter Pylori Infection Status and Pathological Features for Predicting Gastric Cancer Biological Behavior and Prognosis: A Real-World Observational Study
This multicenter retrospective and prospective real-world observational study will evaluate the relationship of Helicobacter pylori (H.
- Trial name
- NCT07724496
- Testing
- 13C-Urea Breath Test, Serum Helicobacter pylori Antibody Testing, Pathological Assessment of Gastric Tissue
- Where
- 3 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Chinese PLA General Hospital
Intestinal Metaplasia
Atrophic Gastritis and OLGIM Stage
Three clinical research coordinators recruited patients aged 40-75 who underwent screening endoscopy at the Digestive Endoscopy Center of Qilu Hospital from July 1, 2022, to July 30, 2024.
- Trial name
- NCT06585553
- Where
- China
- Volunteers
- 2,121 people
- Sponsor
- Shandong University
Gastric Intestinal Metaplasia
Efficacy and Safety of Weifuchun Tablet in Reversing Gastric Intestinal Metaplasia
The goal of this clinical trial is to investigate the efficacy and safety of Weifuchun tablet in treating gastric intestinal metaplasia in Helicobacter pylori-negative adults.
- Trial name
- NCT06610266
- Testing
- Weifuchun, Folic Acid
- Where
- 9 sites in China
- Volunteers
- 400 people
- Sponsor
- Yongquan Shi
Gastric Cancer
Novel Screening Modality for Early Gastric Cancer
Potential patients will be recruited at participating sites based on routine care with clinical indications for upper endoscopy.
- Trial name
- NCT04114006
- Where
- Honduras
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Helicobacter Pylori Infection, Atrophic Gastritis
Effect of H. Pylori Eradication on the Reversibility of Atrophic Gastritis and Intestinal Metaplasia in Korean Patients
Helicobacter pylori (H. pylori) infection has been associated with a development of atrophic gastritis and intestinal metaplasia. H.
- Conditions
- Helicobacter Pylori Infection, Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- NCT02691637
- Where
- South Korea
- Volunteers
- 1,450 people
- Sponsor
- Seoul National University Bundang Hospital
Autoimmune Diseases, Helicobacter Pylori Gastritis
Pyloric or Pseudopyloric Metaplasia of the Corpus Mucosa in Autoimmune Gastritis
The study is aimed to investigate the different rates of pyloric/ pseudopyloric metaplasia or spasmolytic polypeptide-expressing metaplasia (SPEM) of corpus between autoimmune gastritis and H. pylori-infected non-ulcer dyspepsia.
- Conditions
- Autoimmune Diseases, Helicobacter Pylori Gastritis, Anemia, Pernicious, Metaplasia
- Trial name
- PM_in_AIG (NCT05238181)
- Testing
- Assess pyloric or pseudopyloric metaplasia of corpus by H&E stains, Assess pyloric or pseudopyloric metaplasia of corpus by TFF2 immunohistochemistry stains, The assessment of corpus-predominant gastritis index (CGI), Operative Link for Gastritis Assessment (OLGA), and Operative Link on Gastric Intestinal Metaplasia assessment (OLGIM)
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Cheng-Kung University Hospital
Probe-based Confocal Laser Endomicroscopy, the Operative Link on Gastric Intestinal Metaplasia
The Efficacy of Probe-based Confocal Laser Endomicroscopy in Staging OLGIM
Gastric intestinal metaplasia (GIM) is an important premalignant lesion for gastric cancer. Precisely surveillance of patients with GIM may result in early detection and improved prognosis.
- Trial name
- NCT02932735
- Volunteers
- 30 people
- Sponsor
- Shandong University
Barrett Esophagus
Micro-Layer Ablation of Barrett's Metaplasia- A Two-Phase, Multi-Center Trial - Extension of Follow-up to 5 Years
This study was conducted in 2 serial phases (dosimetry phase and effectiveness phase) to evaluate a balloon-based ablation device (HALO360) that delivers a pre-set amount of energy density (J/cm2) to barrett's tissue.
- Trial name
- AIM (NCT00489268)
- Testing
- HALO Ablation System
- Where
- 10 sites in United States, Puerto Rico
- Volunteers
- 102 people
- Sponsor
- Covidien, GI Solutions