Clinical trials: Intervertebral Disc Disease
Degenerative Disc Disease, Degenerative Spondylolisthesis
Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion
The aim of this study is to evaluate the effectiveness and safety of Natural Matrix Protein™ (NMP™) fibers when used in cervical or lumbar interbody fusion in patients with degenerative disc disease (DDD), spinal stenosis…
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT06000319
- Testing
- Natural Matrix Protein (NMP) Fibers, Lumbar interbody fusion, Cervical interbody fusion
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Induce Biologics USA Inc.
Degenerative Disc Disease, Isthmic-lytic Spondylolisthesis
Efficacy of Using Solum IV and BMC With GFC in TLIF
The purpose of this study is to examine the efficacy of using Solum IV and bone marrow concentrate with general fluid concentrate in Transforaminal Lumbar Interbody Fusion (TLIF).
- Conditions
- Degenerative Disc Disease, Isthmic-lytic Spondylolisthesis, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT03223701
- Testing
- Solum IV, Bone Marrow Concentrate with general fluid concentrate (GFC) in Transforaminal Lumbar Interbody Fusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Seton Healthcare Family
Lumbar Disc Disease, Post-Op Complication
Fast-Track Eligibility and Hospital Discharge for Outpatient Lumbar Discectomy
122 ASA I-II patients were enrolled into the study. IV propofol, fentanyl and rocuronium were used for the induction and a total intravenous anesthesia technique for the maintenance of anesthesia.
- Trial name
- NCT04301232
- Testing
- Modified Aldrete Scoring System (mASS), White's Fast-Track Scoring System (WFTSS), SPEEDS criteria
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Gulhane School of Medicine
Degenerative Disc Disease
Trinity Elite in Lumbar Fusion
This prospective, post-market, open label clinical study is designed to examine the lumbar fusion rate at 24 months post operative in subjects who have undergone a lumbar fusion surgery using Trinity Elite with or without local…
- Trial name
- NCT02969616
- Testing
- Trinity Elite
- Volunteers
- 300 people
- Sponsor
- Orthofix Inc.
Radiating Leg Pain, Disc Protrusion
A Randomized, Controlled Trial of Treatment for Disc Herniation With Radiating Leg Pain
Hypothesis - This study is designed to evaluate the results of using the Orthotrac Pneumatic Vest versus an EZ form brace in patients with radiating leg pain from disc bulge / protrusion / herniation.
- Trial name
- NCT00220935
- Testing
- Orthotrac Pneumatic Vest
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Texas Back Institute
Postoperative Pain, Lumbar Disc Surgery
Efficacy and Safety of Ultrasound-guided Lateral Thoracolumbar Interfascial Plane Block (TLIPB) for Postoperative Pain in Patients Undergoing Herniated Lumbar Disc Surgery
Surgery of the lumbar spine is characterized by diffuse and severe postoperative pain. In recent years, some case reports indicate that the thoracolumbar interfascial plane block (TLIPB) can reduce postoperative pain after spinal…
- Trial name
- NCT03951038
- Testing
- PCIA group, Lateral TLIPB group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Lumbar Disc Herniation
Effect of Electromagnetic Field in Lumbar Disc Prolapse Patients
to investigate the effect of electromagnetic field therapy on sciatica and postural control in lumbar disc prolapse patients BACKGROUND: lumbar disc prolapse is a clinical condition resulting from compression of lumbar nerve…
- Trial name
- NCT05559723
- Testing
- electromagnetic field therapy, selected physical therapy program, Therapeutic ultrasound therapy
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- October 6 University
Degenerative Disc Disease (DDD)
Kineflex|C Artificial Disc System to Treat Cervical Degenerative Disc Disease (DDD)
The purpose of this study is to show that the Kineflex|C Spinal System is no worse than conventional Anterior Cervical Diskectomy with Fusion (ACDF) in patients with single level degenerative disc disease at any cervical level…
- Trial name
- NCT00374413
- Testing
- Artificial disk, Artificial disc
- Where
- 21 sites in United States
- Volunteers
- 343 people
- Sponsor
- SpinalMotion
Lumbar Disc Herniation
Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy
The purpose of this study is to determine a grading system for inflammation in lumbar disc herniation and which groups, if any, benefit most from the administration of an intra-operative epidural steroid.
- Trial name
- Intra-Op (NCT04182997)
- Testing
- Dexamethasone, saline 0.9%
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Missouri-Columbia
Lumbar Disc Herniation, Annular Disc Tear
A Post Marketing Surveillance Study
This study is a prospective, multi-center study to monitor the early safety and performance of one iteration of the Barricaid Anular Closure Device (ACD) - 6mm anchor width, when used as an adjunct to limited discectomy.
- Conditions
- Lumbar Disc Herniation, Annular Disc Tear, Annular Tear of Lumbar Disc
- Trial name
- 6MM (NCT03366779)
- Testing
- 6mm annular closure device
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 20 people
- Sponsor
- Intrinsic Therapeutics
Degenerative Disc Disease, Intervertebral Disc Disease
Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV)
In this study we want to evaluate the clinical use of allogenic mesenchymal stem cells (MSC), obtained from bone marrow of healthy donors, for treatment of Degenerative Disc Disease (DDD).
- Conditions
- Degenerative Disc Disease, Intervertebral Disc Disease, Low Back Pain
- Trial name
- Disc_allo (NCT01860417)
- Testing
- Allogenic Mesenchymal Stromal Cells, Mepivacaine
- Where
- 2 sites in Spain
- Volunteers
- 24 people
- Sponsor
- Red de Terapia Celular
Low Back Pain, Sciatica
Non-surgical Spinal Decompression in Patients With Chronic Low Back Pain
The goal of this quasi-experimental trial was to evaluate the effects of non-surgical spinal decompression on disability and pain in patients with chronic low back pain and sciatica throughout a two-month follow-up, and to…
- Conditions
- Low Back Pain, Sciatica, Lumbar Disc Herniation
- Trial name
- NCT06275750
- Testing
- Spinal decompression with BTL-6000 spinal decompression system (BTL Industries Ltd.)
- Where
- Mexico
- Volunteers
- 39 people
- Sponsor
- Hospital Civil de Guadalajara
Genetic Alteration, Low Back Pain
Genetic Alterations From Physical Therapy in Low Back Pain and Disc Degeneration
Background and Scientific Rationale: This prospective randomized controlled trial examines the combined effect of physiotherapy and vitamin D supplementation on pain, disability, interleukin-6 (IL-6) expression, and vitamin D…
- Conditions
- Genetic Alteration, Low Back Pain, Physiotherapy
- Trial name
- Low back pain (NCT07439874)
- Testing
- Interferential therapy
- Where
- Saudi Arabia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Tabuk
The Lumbar Spine Surgical Intervention, Arthrodesis
Evaluation of the Effect of Reiki on Pain After Lumbar Surgery
The goal of this clinical trial (prospective, comparative, and randomized double-blind study) is to learn if Reiki (a non-pharmacological intervention), when used alongside standard care, can treat and reduce postoperative pain…
- Conditions
- The Lumbar Spine Surgical Intervention, Arthrodesis, Severe Herniated Disc, Scoliosis
- Trial name
- REDAL (NCT07722117)
- Testing
- Reiki treatment and chirurgy
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinique Bizet
Degenerative Disc Disease, Spondylolisthesis, Grade 1
AccuLIF® PROSPECTIVE PATIENT OUTCOMES STUDY
This is a post-market clinical study of the AccuLIF expandable transforaminal lumbar interbody fusion (TLIF) cage in patients requiring surgery for degenerative disc disease (DDD) with up to Grade I spondylolisthesis or…
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Grade 1, Retrolisthesis
- Trial name
- APROPOS (NCT02704689)
- Testing
- AccuLIF expandable TLIF cage
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VB Spine, LLC
Lumbar Intervertebral Disc Herniation
Lumbar Disc Herniation Outcome Measures
This study is being conducted to examine outcome measurements on patients who undergo surgery to removed a damage lumbar spine disc versus those that chose not to have surgery.
- Trial name
- NCT01041391
- Testing
- Discectomy-lumbar spine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- State University of New York - Upstate Medical University
Disk, Herniated
A Pilot Study of the InterCushion Disc Nucleus Prosthesis (DNP) in Patients Receiving Discectomy
The primary endpoints of the investigation will include assessment of the maintenance of disc height demonstrated by radiographic evidence based on plain radiographs and MRI and relief of pain as measured by Visual Analog Scale…
- Trial name
- NCT01652053
- Testing
- Disc Nucleus Replacement (InterCushion DNP)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Vertebral Technologies, Inc.
Lumbar Disc Herniation, Radiculopathy Lumbar
Efficacy and Safety of Electroacupuncture on Lumbar Disc Herniation with Radiculopathy
Lumbar disc herniation with radiculopathy (LDHR) is the local displacement of the intervertebral disc and its contents beyond the edge of the normal intervertebral disc space, resulting in pain, weakness or numbness in the muscle…
- Trial name
- NCT06611332
- Testing
- Electroacupuncture
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Lumbar Disc Herniation
A Trial of Percutaneous Lumbar Discectomy Combined With Ozone for Treatment of LDH
Lumbar disc herniation (LDH) is a common pathological process leading to spinal surgery. Open discectomy used to be a widespread procedure for surgical treatment for symptomatic LDH.
- Trial name
- NCT02372032
- Testing
- percutaneous lumbar discectomy, ozone therapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zhongda Hospital
Neck Pain, Spondylosis
CEM-Plate and CEM-Cage First-In-Human Use Efficacy Study
The study is a prospective, first-in-human, multi-center, non-randomized, single-arm study to assess the safety and efficacy of the CEM-Cage used with the CEM-Plate in patients who are appropriate candidates for a 2-level…
- Conditions
- Neck Pain, Spondylosis, Spondylosis With Myelopathy, Spondylosis With Radiculopathy
- Trial name
- NCT04883411
- Testing
- CEM-Plate Anterior Cervical Plating System and CEM-Cage Cervical Interbody System
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- ReVivo Medical, Corp.