Clinical trials: ICU, active
Intensive Care Unit ICU, Vasopressor
Canadian Critical Care Comparative Effectiveness Platform
The Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques (CEPEC) is an international multi-centered randomized adaptive platform clinical trial.
- Conditions
- Intensive Care Unit ICU, Vasopressor, Platelet, Nutrition
- Trial name
- CEPEC (NCT06605144)
- Testing
- 1- Vasopressor - Mean arterial pressure 56-60, 2- Vasopressor - Mean arterial pressure 61-65, 3- Vasopressor - Mean arterial pressure 66-70
- Where
- 13 sites in Canada, New Zealand and 1 more
- Volunteers
- 5,500 people
- Sponsor
- Université de Sherbrooke
Respiratory Acidosis in ICU Patients, Right Ventricular (RV) Dysfunction
Right Ventricular Function and Respiratory Acidosis After Cardiac Surgery
Right heart dysfunction remains a frequent cause of morbidity and mortality after cardiac surgery. Respiratory acidosis, particularly when accompanied by hypoxemia, plays a significant role in right heart failure, primarily by…
- Conditions
- Respiratory Acidosis in ICU Patients, Right Ventricular (RV) Dysfunction, Hemodynamic Changes, Mechanical Ventilation
- Trial name
- NCT07619274
- Testing
- Not applicable- observational study
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Laval University
Spontaneous Breathing Trial in ICU
Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults
For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs.
- Trial name
- NCT07005505
- Testing
- Pressure Support Ventilation (PSV), Automatic tube compensation (ATC)
- Where
- United States
- Volunteers
- 880 people
- Sponsor
- Rush University Medical Center
Intensive Care Unit (ICU) Acquired Weakness (ICU - AW), Critical Illness
Effectiveness of Virtual Reality in Improving Upper Limb Function in Critically Ill Patients
Millions of people are hospitalized every year in Intensive Care Units (ICUs) with severe health conditions due to various causes and categories of diseases, such as stroke, Traumatic Brain Injuries (TBI), polytrauma, sepsis, and…
- Trial name
- EVOLUTION (NCT07901855)
- Testing
- Conventional Physiotherapy and Occupational Therapy, Fully Immersive Virtual Reality Training
- Where
- Greece
- Volunteers
- 48 people
- Sponsor
- National and Kapodistrian University of Athens
COPD Exacerbation, ICU
Characteristics and Outcomes of Patients Admitted to ICU for a Severe Acute Exacerbation of COPD.
The objective of this prospective observational study is to describe the epidemiological, clinical and biological characteristics of patients admitted in ICU for a severe acute exacerbation of COPD, and to assess the different…
- Trial name
- COPDregister (NCT06257329)
- Testing
- register
- Where
- 4 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Alexis FERRE
ICU-acquired Weakness
Evidence-based, Customized, Motion-recognition Rehabilitation System Development for Bed-ridden Patients - Validation of Effectiveness: Rehabit: Swim
This pilot study aims to evaluate the efficacy, safety, feasibility, and user satisfaction of "Rehabit: swim," a customized, evidence-based, motion-recognition-based rehabilitation exergame designed for hospitalized patients with…
- Trial name
- NCT07896057
- Testing
- Rehabilitation
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Implementation Science, Delirium
Behavioral Economic & Staffing Strategies in the ICU
The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill…
- Conditions
- Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication
- Trial name
- BEST-ICU (NCT06184945)
- Testing
- Realtime audit and feedback, RN Implementation Facilitator
- Where
- 3 sites in United States
- Volunteers
- 16,500 people
- Sponsor
- University of Nebraska
Critical Illness, ICU-acquired Weakness
Beyond Voluntary Effort: Reliability and Validity of Magnetic Femoral Nerve Stimulation for Assessing Quadriceps Strength in Critically Ill Patient
Intensive care unit-acquired weakness (ICU-AW) is a common complication of critical illness and can negatively affect recovery and long-term physical functioning.
- Trial name
- TWITCH FORCE (NCT07891273)
- Testing
- Magnetic Femoral Nerve Stimulation
- Volunteers
- 33 people
- Sponsor
- Daniel Langer
Sedation, Analgesia Assessment
A Prospective Multicenter Registry Study of Sedation and Analgesia in Critically Ill Patients
Sedation and analgesia are essential components of comprehensive care for intensive care unit (ICU) patients, particularly those receiving invasive mechanical ventilation, undergoing invasive procedures, or experiencing pain…
- Conditions
- Sedation, Analgesia Assessment, ICU
- Trial name
- NCT07885930
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Chao Yang Hospital
Sleep, Circadian Dysregulation
reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit
The goal of this pilot clinical trial is to learn whether a program to support sleep and the body's daily rhythms can be delivered safely and consistently to critically ill adults in intensive care units (ICUs).
- Conditions
- Sleep, Circadian Dysregulation, ICU, Delirium in Intensive Care Unit
- Trial name
- ALIGN ICU (NCT07886567)
- Testing
- Sleep chronobundle, Control
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
ICU Staff Attitudes Toward Family Presence, ICU Staff Experience of Family Presence
Attitudes, Experience and Adaptation to Family Presence in the ICU
The goal of the study is to verify how healthcare professionals in the Intensive Care Unit (ICU) experience the presence of family members before and after a more flexible visiting policy is introduced.
- Conditions
- ICU Staff Attitudes Toward Family Presence, ICU Staff Experience of Family Presence, Adaptation to Extended Family Presence in the ICU, Association Between Stress Sensitivity and Attitudes Toward Family Presence
- Trial name
- RUIMIZ (NCT07887009)
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Sleep, Delirium
Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion Bundle
Patients frequently experience problems with sleep while admitted to the ICU. Good sleep is important in ensuring that your immune system responds properly to infection, for your heart to function optimally, and to support normal…
- Conditions
- Sleep, Delirium, ICU Hospitalization, Critical Illness
- Trial name
- DELDEX (NCT06824077)
- Testing
- Dexmedetomidine
- Volunteers
- 50 people
- Sponsor
- University of Alberta
ICU Hospitalization, Circadian Rhythm
Sleep and Circadian Rhythm Intervention in ICU
Intensive care unit (ICU) patients are frequently exposed to various stressors that contribute to severe sleep disruption and circadian rhythm disturbances.
- Conditions
- ICU Hospitalization, Circadian Rhythm, Sleep Deprivation
- Trial name
- NCT07869901
- Testing
- Sound and Light Optimization, Night-time Patient Care Activities, Enhanced Daytime Mobility
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Kidney Injury in the ICU
Automated System for Monitoring Urine Output in Intensive Care Patients
Acute kidney injury is common among ICU-admitted patients, and is associated with increased morbidity and mortality. Early recognition is essential to prevent complications.
- Trial name
- NCT05232045
- Testing
- Automated urinary output collection system group (tight monitoring of urine output)
- Where
- Israel
- Volunteers
- 1,800 people
- Sponsor
- Meir Medical Center
Pupillometry, Behavioral Pain Scale
Pupillometry vs. BPS (Behavioral Pain Scale) for Analgesia Management in Inpatient Intensive Care Unit Patients on Invasive Mechanical Ventilation
Patients admitted to the intensive care unit (ICU) and receiving invasive mechanical ventilation (IMV) frequently require sedation and analgesia to ensure their comfort, prevent pain associated with invasive procedures, and…
- Conditions
- Pupillometry, Behavioral Pain Scale, Analgesia Assessment, Intensive Care Unit (ICU)
- Trial name
- GOLDEN EYE (NCT07867678)
- Testing
- PPI Measurement (Pupillary Pain Index), BPS Measurement (Behavioral Pain Scale)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
ICU, Sleep Deprivation
Evolution of Sleep in Intensive Care Unit Patients
Sleep plays a key role in immune, metabolic, and neurological regulation, particularly in critically ill patients. However, the intensive care environment significantly disrupts sleep due to noise, light exposure, and frequent…
- Trial name
- SOMNOREA (NCT07867912)
- Testing
- Sleep monitoring using Sleepscan®, Actigraphy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Intensive Care (ICU)
An Investigation of The Relationship Between Muscle Mass, Physiological Parameters, and Blood Gas Levels in Adult Patients Hospitalized in The Intensive Care Unit
This study was designed to investigate the relationship between muscle mass and physiological parameters and blood gas values in adult patients admitted to the intensive care unit.
- Trial name
- NCT07866625
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Communication Barriers, Eye-tracking Technology
Eye-Tracking Communication Tool for Non-verbal ICU Patients
The objectives of this clinical trial are to explore the feasibility of the eye-tracking communication tool in alleviating communication barriers among non-verbal ICU patients.
- Conditions
- Communication Barriers, Eye-tracking Technology, ICU Patients
- Trial name
- NCT07205419
- Testing
- Eye-Tracking communication tool, Conventional Techniques
- Volunteers
- 40 people
- Sponsor
- Shanghai Zhongshan Hospital
ICU Stay, Muscle Atrophy
Weaning Assessment by Peripheral Muscle Ultrasonography
In this study, which aims to investigate the relationship between the weaning process and respiratory muscles-assessed via ultrasonographic measurement of peripheral muscle thickness-in patients over the age of 18 who have been…
- Conditions
- ICU Stay, Muscle Atrophy, Ultrasonography, Weaning Mechanical Ventilation
- Trial name
- NCT07860879
- Testing
- Ultrasonography of peripheral muscle (rectus femoris or vastus intermedius), Ultrasonography of diaphragma
- Volunteers
- 100 people
- Sponsor
- Taksim Egitim ve Arastirma Hastanesi
ICU Patients
Music-Accompanied Nature Imagery on Blood Pressure and Pain in Intensive Care Unit Patients
The aim of this study is to evaluate the effect of viewing nature imagery accompanied by music on blood pressure and pain in intensive care unit patients compared with standard care.
- Trial name
- NCT07845734
- Testing
- Viewing Nature Imagery Accompanied by Music
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University