Clinical trials: ICU
Asthma Childhood
Ideal Steroids for Asthma Treatment in the PICU
Determine if differences in (1) pediatric intensive care unit length of stay, (2) continuous nebulized albuterol duration, and (3) a composite outcome of advanced asthma therapy incidence including use of non-invasive ventilation…
- Trial name
- iSTAT PICU (NCT03900624)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Johns Hopkins All Children's Hospital
Catheter-related Bloodstream Infection
Reducing Catheter-Related Bloodstream Infections in the ICU With a Chlorhexidine-Impregnated Sponge (BIOPATCH)
We proposed to perform a prospective randomized controlled trial to study the effect of the use of a commercially-available chlorhexidine-impregnated sponge (Biopatch) as part of central venous catheter care on catheter-related…
- Trial name
- NCT00548132
- Testing
- Chlorhexidine-impregnated foam dressing
- Where
- United States
- Volunteers
- 1,088 people
- Sponsor
- Washington University School of Medicine
Antibiotic Resistant Infection, Nosocomial Infection
Inulin for Infections in the Intensive Care Unit
Normal gut bacteria prevent colonization and subsequent infection with MDR organisms (MDROs) through competition for resources and other mechanisms.
- Conditions
- Antibiotic Resistant Infection, Nosocomial Infection, Pathogen Transmission, Nutrition Disorders
- Trial name
- NCT03865706
- Testing
- Inulin Oral Suspension, Broad-spectrum antibiotics
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Columbia University
Shock, Septic
COMPACT 2 - COMbining Plasma-filtration and Adsorption Clinical Trial 2
The study objective is to clarify whether the application of high doses CPFA (coupled plasma-filtration adsorption) in addition to the current clinical practice is able to reduce hospital mortality in septic shock patients in…
- Trial name
- COMPACT-2 (NCT01639664)
- Testing
- High doses CPFA
- Where
- 13 sites in Italy
- Volunteers
- 115 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Intensive Care Unit Syndrome
Feasibility, Acceptability, and Barriers to Implementation of a Geriatrics Bundle in the ICU
Despite the known benefits of geriatric care models among hospitalized older adults outside the intensive care unit (ICU), few studies have addressed the needs of older adults in the ICU; for example, sensory impairment…
- Trial name
- ACE-ICU (NCT04652453)
- Testing
- Geriatrics Bundle
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Yale University
Intensive Care Unit, Muscle Weakness
Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness
The purpose of this study is to investigate whether neuromuscular electrostimulation (NMES) will decrease ICU-associated weakness.
- Trial name
- NMES (NCT00709124)
- Testing
- Neuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab; McLean, VA)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johns Hopkins University
Mechanical Ventilation, Critical Illness
Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged sedation (> 24 hours) in critically ill patients who require mechanical ventilation.
- Trial name
- NCT01059929
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Chicago
Invasive Candidiasis
Anidulafungin Candidemia/Invasive Candidiasis Intensive Care Study
To evaluate the efficacy and safety of anidulafungin in the treatment of systemic fungal infections in intensive care and critical care unit patients.
- Trial name
- ICE (NCT00689338)
- Testing
- Anidulafungin, Fluconazole, Voriconazole
- Where
- 61 sites in Austria, Belgium and 17 more
- Volunteers
- 216 people
- Sponsor
- Pfizer
Muscle Weakness, Sepsis
Evaluating Muscle Weakness Improvement With Lorcaserin in ICU
ICU acquired muscle weakness is a significant problem in patients recovering from critical illness. This trial will evaluate the safety and efficacy of a drug in improving muscle weakness in critically ill patients.
- Trial name
- EMILI (NCT02523690)
- Testing
- Lorcaserin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Muscle Weakness
Effect of EPA and HMB on Strength in ICU Patients
The investigators will determine if administration of HMB (hydroxymethylbutyrate) or EPA (eicosapentaenoic acid) will increase diaphragm and limb muscle strength for patients on breathing machines in an intensive care unit.
- Trial name
- NCT01270516
- Testing
- HMB, hydroxymethylbutyrate, EPA, eicosapentaenoic acid, Saline
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Gerald Supinski
Coronary Artery Bypass Graft and/or Aortic Valve Replacement Surgery
Sugammadex and Decreased Time to Extubation
The purpose of this study is to demonstrate faster time to extubation after arrival in the cardiothoracic intensive care unit (ICU) in patients undergoing isolated coronary artery bypass grafting (CABG), AVR and AVR/CABG…
- Trial name
- NCT03196167
- Testing
- Sugammadex
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Yale University
Critical Illness, Acute Respiratory Failure
Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients (TOP-UP)
The specific aim of the proposed study is to conduct a pilot study involving 160 critically-ill lean and obese patients enrolled at 11 sites in Canada, the United States of America, Belgium and France in order to: Specific Aims…
- Trial name
- TOP-UP (NCT01206166)
- Testing
- Olimel (5.7%E / N9E)
- Where
- 12 sites in United States, Belgium and 2 more
- Volunteers
- 125 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Sepsis
Changes in Exhaled 13CO2/12CO2 Breath Delta Value as an Early Indicator of Infection in ICU Patients
Carbon-12 and carbon-13 are naturally-abundant isotopes in exhaled breath carbon dioxide. The ratio of carbon-13 to carbon-12 in exhaled breath is known as the breath delta value (BDV).
- Trial name
- NCT02327130
- Testing
- Isomark Canary™
- Where
- 6 sites in United States
- Volunteers
- 32 people
- Sponsor
- Isomark, LLC
Critically Ill
PEP uP Protocol in Surgical Patients
The main objective of this project is to asses for safety, feasibility and effectiveness of an aggressive feeding protocol, PEP uP (Enhanced Protein-Energy Provision via the Enteral Route Feeding Protocol) in increasing protein…
- Trial name
- NCT02459275
- Testing
- PEP uP Protocol, Metoclopramide
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Parenteral Nutrition
Study Comparing a Soybean Oil-Based With an Olive Oil-Based Lipid Emulsion in ICU Patients Requiring TPN
Many hospitalized patients who are malnourished or not eating receive intravenous feeding or total parenteral nutrition (TPN). Despite improving nutrition, TPN may increase the risk of infections and hospital complications.
- Trial name
- TPN2 (NCT00672854)
- Testing
- ClinOleic 20% Intravenous Emulsion, Intralipid, 20% Intravenous Emulsion
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Emory University
Atelectasis, Bronchoscopy
Evaluation of BAL Procedure With Ambu aScope 3 Large in Patients in an ICU Setting
An Investigation to determine the single-use scope's ability to suction secretion from the lungs to resolve the collapse of the lung.
- Trial name
- NCT03581474
- Testing
- Bronchoscopic procedure
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ambu A/S
Delirium
Effects of Scenario-based Education Initiative and OSCE for Recognition and Management of Delirium
Delirium is a disturbance in consciousness with reduced ability to focus, sustain, or shift attention that occurs over a short period of time and tends to fluctuate over the course of the day.
- Trial name
- NCT05623475
- Testing
- OSCEs, Lecture, E-learning
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Acute Kidney Injury
Rapid Evaluation of Acute Kidney Injury With NGAL in Acutely Ill Patients in the ICU
This is a multi-center, prospective, observational study of patients that are admitted to the intensive care unit (ICU). This study does not include any treatment or intervention and it is considered Nonsignificant Risk.
- Trial name
- REAL-ICU (NCT01294228)
- Where
- 28 sites in United States, Canada
- Volunteers
- 1,001 people
- Sponsor
- Abbott RDx Cardiometabolic
Neonatal Neuroimaging
Development of a MR Scanner Capable of Being Sited in a Neonatal Intensive Care Unit (Firefly Sheffield)
This study investigates a novel magnetic resonance imaging (MRI) system designed by GEHC for imaging viable neonate and infant populations.
- Trial name
- NCT02785588
- Testing
- 3.0 T Neonatal MRI scanner
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Neonatal Abstinence Syndrome
Methadone Demonstration Project With Neonatal Intensive Care Unit Infants Diagnosed With Neonatal Abstinence Syndrome
This is a non-randomized, un-blinded feasibility study project comparing the Length of Stay (LOS) of Neonatal Intensive Care Unit (NICU) infants diagnosed with Neonatal Abstinence Syndrome (NAS) treated with methadone with…
- Trial name
- NCT03134703
- Testing
- Methadone, Morphine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Johns Hopkins All Children's Hospital