Clinical trials: Hypoxia-Ischemia, Brain
Hypoxic Ischemic Encephalopathy
Magnetic Resonance Imaging and Spectroscopy Biomarkers of Neonatal Hypoxic Ischemic Encephalopathy
Neonatal hypoxic ischemic encephalopathy (HIE) is a serious neurological condition characterised by acute or subacute brain injury arising from perinatal hypoxia.
- Trial name
- NCT01481207
- Where
- Switzerland
- Volunteers
- 59 people
- Sponsor
- University Children's Hospital, Zurich
Cardiac Arrest, Post-Anoxic Coma
Evaluation of the "Pupillary Pain Index" in Neurological Prognosis After Cardiac Arrest
Two-thirds of patients admitted to the Intensive Care Unit after a cardiac arrest die in the context of treatment withdrawal after a multimodal evaluation that determines an unfavorable neurological outcome.
- Conditions
- Cardiac Arrest, Post-Anoxic Coma, Anoxic Brain Injury
- Trial name
- CAPPI (NCT04336930)
- Testing
- Pupillary pain index (PPI)
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Hypoxic-Ischemic Encephalopathy, Asphyxia
Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates
This is a prospective, single center, pharmacokinetic study of intravenous hydrocortisone therapy for systemic low blood pressure during hypothermia treatment in asphyxiated newborns.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Asphyxia, Hypotension, Circulatory Failure Neonatal
- Trial name
- UniCort (NCT05836610)
- Testing
- Hydrocortisone
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Hypoxic-Ischemic Encephalopathy
Developmental Outcomes
Determine whether the concentrations of UCH-L1 and GFAP measured in umbilical cord blood and in blood 0-6 hours postnatal accurately predict the extent of neurodevelopmental deficits and/or death at 18-20 months.
- Trial name
- NCT02264808
- Testing
- Developmental Outcomes
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Florida
Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia
EEG-Based Decision-Support Algorithm for Hypoxic-Ischemic Encephalopathy in Term Newborns
This retrospective, multicenter, observational study evaluates how well a decision-support algorithm can tell apart mild forms of hypoxic-ischemic encephalopathy (HIE) from moderate or severe forms in full-term newborns born…
- Conditions
- Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia, Neonatal Brain Injury
- Trial name
- COOLDECIDE (NCT07764315)
- Volunteers
- 310 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neonatal Seizures
NEMO1:NEonatal Seizure Using Medication Off-patent
NEMO is a multicentre pan European clinical trial with the aim to develop new treatment strategies for the treatment of neonatal seizures using the loop diuretic bumetanide.
- Trial name
- NEMO1 (NCT01434225)
- Testing
- Bumetanide
- Where
- 7 sites in Ireland, Netherlands and 2 more
- Volunteers
- 14 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Stroke, Acute, Hypoxia-Ischemia, Brain
Normobaric Hyperoxia Combined With Endovascular Therapy in Patients With Stroke Within 6 Hours of Onset：Longterm Outcome
The overall incidence of good outcome for AIS following endovascular treatment is only proximately 50%. Whether NBO was safe and effective to improve acute ischemic stroke prognosis is still unclear.
- Conditions
- Stroke, Acute, Hypoxia-Ischemia, Brain, ENDOVASCULAR TREATMENT
- Trial name
- NBOL (NCT05039697)
- Testing
- oxygen
- Where
- China
- Volunteers
- 282 people
- Sponsor
- Capital Medical University
Cerebral Palsy, Hypoxia-Ischemia, Brain
The TOBY Children Study
The aim of this study is to determine the efficacy of therapeutic hypothermia following perinatal asphyxia on neurological and neuropsychological outcomes and also to assess academic attainment and any additional health, societal…
- Trial name
- NCT01092637
- Where
- United Kingdom
- Volunteers
- 280 people
- Sponsor
- Imperial College London
Neonatal Hypoxic Ischemic Encephalopathy, Neonatal Stroke
Neonatal Brain Ultrasound With CEUS and Elastography
The aim of our study is to investigate changes of brain perfusion and elasticity in neonates during the time that a neonate is adapting to live outside the womb and during diseases that are suspected to affect neonatal brain…
- Conditions
- Neonatal Hypoxic Ischemic Encephalopathy, Neonatal Stroke, Neonatal Encephalopathy, Unspecified
- Trial name
- NCT05648812
- Testing
- Brain contrast enhanced ultrasound, brain ultrasound elastography, Sulfur Hexafluoride
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Cerebral Palsy, Hypoxic-Ischemic Encephalopathy
Therapeutic Intervention Supporting Development From NICU to 6 Months for Infants Post Hypoxic-Ischemic Encephalopathy
The purpose of this study is to evaluate the feasibility and begin to evaluate the effect of a sensorimotor intervention (SMI) provided in the first 6 months of life for infants with hypoxic-ischemic encephalopathy.
- Trial name
- NCT05130528
- Testing
- Sensorimotor Intervention
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- University of Southern California
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Ischemic-Hypoxic Encephalopathy
Long Term Prognostic of Neonatal Hypoxic Ischemic Encephalopathy With Hypothermia Treatment
The primary objective is to evaluate neonatal characteristics, and biological and clinical investigations as predictive factors of death, or of severe and moderate neurodevelopmental disability at 3 years, in a large…
- Trial name
- LyTONEPAL (NCT02676063)
- Where
- 22 sites in France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Grenoble
Brain Hypoxia Ischemia
Continuous, Non-invasive Monitoring of Intraoperative Cerebral Perfusion and Oxidative Metabolism (CPOM)
This study uses a CPOM Optical neuromonitor to assess the relationship between brain cytochrome C oxidase, cerebral oxygen saturation and blood pressure during surgery performed under general anesthesia.
- Trial name
- NCT03907904
- Testing
- CPOM Optical Neuromonitor
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Western University, Canada
Epilepsy, Dravet Syndrome
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic Encephalopathies
The purpose of this study is to investigate the effect on the frequency of all seizures (convulsive and drop) in participants treated with TAK-935 compared to placebo.
- Conditions
- Epilepsy, Dravet Syndrome, Lennox-Gastaut Syndrome
- Trial name
- ELEKTRA (NCT03650452)
- Testing
- TAK-935
- Where
- 44 sites in United States, Australia and 6 more
- Volunteers
- 141 people
- Sponsor
- Takeda
Anoxic Coma, Cardiac Arrest (CA)
Assessment of Structural Brain Changes Related to Anoxic Coma Using High-field and Very Low Field Mobile MRI
Standard predictors of outcome after cardiac arrest (CA) have substantial limitations in terms of reliability and generalizability.
- Conditions
- Anoxic Coma, Cardiac Arrest (CA), Anoxia-Ischemia, Brain, Coma
- Trial name
- CUBE (NCT07177755)
- Testing
- High-field and very-low-field MRI acquisitions
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
HIE - Hypoxic - Ischemic Encephalopathy, Language Delay
Speech of Kids After Neonatal Encephalopathy
The goal of this ambispective cohort study is to reveal the early indicators of delayed language development in children born with hypoxic-ischemic encephalopathy (HIE).
- Conditions
- HIE - Hypoxic - Ischemic Encephalopathy, Language Delay, Autism, ADHD - Attention Deficit Disorder With Hyperactivity
- Trial name
- SANE (NCT07136636)
- Where
- Hungary
- Volunteers
- 93 people
- Sponsor
- Semmelweis University
Neurological Conditions, Brain Diseases
NEO-REEDUC - Mixed Reality for Motor Rehabilitation: a Prospective, Multicenter, Controlled, Randomized, Open Study.
This study aims to assess the effectiveness of a motor rehabilitation protocol that includes mixed reality activities, compared to conventional rehabilitation, on postural stability in children and adult patients with…
- Conditions
- Neurological Conditions, Brain Diseases, Cerebral Palsy, Parkinson Disease (PD)
- Trial name
- NCT07063810
- Testing
- Mixed Reality Rehabilitation
- Where
- 5 sites in France
- Volunteers
- 76 people
- Sponsor
- Slb Pharma
Hypoxic Ischemic Encephalopathy
Targeted Temperature Management After In-Hospital Cardiac Arrest
The purpose of this study is to determine whether targeted temperature management at 36.0˚C(TTM-36) in patients who remain unconscious after resuscitation from in-hospital cardiac arrest(IHCA) will reduce death and disability…
- Trial name
- TTM36-IHCA (NCT02578823)
- Testing
- Arctic Sun®, Arcticgel™, Conventional antipyretic treatment
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Asphyxia Neonatorum, Neonatal Mortality
Neonatal Resuscitation in Zambia
Asphyxia is a leading cause of neonatal death in Zambia. This study will be conducted in two cities in Zambia to determine if the combined Neonatal Resuscitation Program/Essential Newborn Care Program compared to the new World…
- Conditions
- Asphyxia Neonatorum, Neonatal Mortality, Hypoxic Ischemic Encephalopathy
- Trial name
- NCT00097097
- Testing
- Neonatal Resuscitation
- Where
- Zambia
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Acquired Brain Injury
Effect of Methylphenidate on Ecologic Function in Paediatric Acquired Brain Injury Population
The purpose of this study is to investigate the influence of Methylphenidate in pediatric acquired brain injury population, regarding ecologic (every day) function.
- Trial name
- NCT02227056
- Testing
- Methylphenidate
- Where
- Israel
- Volunteers
- 34 people
- Sponsor
- Loewenstein Hospital