Clinical trials: Hypoxia-Ischemia, Brain
Cerebral Palsy, Hydrocephalus
Expanded Access Protocol: Umbilical Cord Blood Infusions for Children With Brain Injuries
This protocol is designed to enable access to intravenous infusions of banked umbilical cord blood (CB), that is thawed and not more than minimally manipulated, for children with various brain disorders.
- Conditions
- Cerebral Palsy, Hydrocephalus, Apraxia of Speech, Hypoxia Ischemia, Cerebral
- Trial name
- NCT03327467
- Testing
- Cord Blood Infusion
- Where
- United States
- Sponsor
- Joanne Kurtzberg, MD
Hypoxic-ischemic Encephalopathy (HIE)
The PROTECT-HIE Pilot Trial
Some babies experience a lack of oxygen and blood flow around the time of birth. This can lead to a serious condition called hypoxic-ischemic encephalopathy (HIE), which can injure the brain and other organs, including the heart.
- Trial name
- PROTECT-HIE (NCT07406477)
- Testing
- Dobutamine, TnECHO
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Perinatal Brain Injury
Neuro-MoD: Neuroplasticity With Motor Development
This study is for infants and toddlers between 8 and 24 months old who use one arm and/or hand differently following a perinatal brain injury.
- Trial name
- NCT07738432
- Testing
- Constraint-Induced Movement Therapy (CIMT), Transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Wisconsin, Madison
Neonatal Seizure, Neonatal Encephalopathy
A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures
The main purpose of this study is to determine the maximum safe tolerated dose of LEV in the treatment of neonatal seizures. Our hypothesis is that optimal dosing of Levetiracetam (LEV) to treat neonatal seizures is significantly…
- Conditions
- Neonatal Seizure, Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy, Seizure Newborn
- Trial name
- NEOLEV3 (NCT05610085)
- Testing
- Levetiracetam Injection, Phenobarbital Sodium Injection
- Where
- 6 sites in United States, New Zealand
- Volunteers
- 133 people
- Sponsor
- University of California, San Diego
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced
Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest.
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
- Trial name
- NCT05376267
- Testing
- Therapeutic Hypothermia
- Where
- 65 sites in United States, Australia and 3 more
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Neurologic Disorder, Disorder of Consciousness
Prognostic Factors to Regain Consciousness
The study aims to identify factors that predict the medium and long-term outcome of patients with disorders of consciousness (DOC) undergoing early neurological rehabilitation.
- Conditions
- Neurologic Disorder, Disorder of Consciousness, Traumatic Brain Injury, Stroke
- Trial name
- NCT04445649
- Testing
- Coma-Recovery-Scale-Revised (CRS-R)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Hypoxic Ischemic Encephalopathy of Newborn, Hypoxic Ischemic Encephalopathy
The HIEnome Study: Genome Sequencing for Perinatal HIE
Perinatal hypoxic-ischemic encephalopathy is a rare severe condition in which neonates present with encephalopathy and a clinical history suggestive of prenatal or perinatal hypoxic-ischemic injury.
- Conditions
- Hypoxic Ischemic Encephalopathy of Newborn, Hypoxic Ischemic Encephalopathy, Hypoxic Ischemic Encephalopathy (HIE)
- Trial name
- NCT06762795
- Testing
- Genome sequencing
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Baylor College of Medicine
Aquired Brain Injury, Stroke
Group-based Emotional Awareness and Expression Therapy to Support Recovery After Acquired Brain Injury: A Clinical Development and Evaluation Study
Difficulties in understanding and managing emotions may hinder recovery, rehabilitation, and participation in everyday life after acquired brain injury (ABI).
- Conditions
- Aquired Brain Injury, Stroke, MTBI - Mild Traumatic Brain Injury, mTBI
- Trial name
- NCT07852936
- Testing
- TAU + Group Therapy (EAET), Treatment as Usual (TAU)
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Uppsala University
Mild Hypoxic Ischemic Encephalopathy of Newborn
Cool Prime Comparative Effectiveness Study for Mild HIE
To determine effectiveness of therapy to improve neurodevelopmental outcomes in infants with mild HIE. To determine the adverse effects of Therapeutic Hypothermia (TH) in mild HIE on the neonate and his/her family.
- Trial name
- COOLPRIME (NCT04621279)
- Testing
- Normothermia, Whole body therapeutic hypothermia
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- University of Texas Southwestern Medical Center
Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication
ECMO ABI Detection With Hyperfine
The primary objective is to characterize the prevalence and type of ABI following cannulation for pediatric patients who require ECMO support.
- Conditions
- Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication, Hypoxia-Ischemia, Brain, Stroke, Acute
- Trial name
- NCT06469801
- Testing
- Hyperfine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Acute Brain Injury, Hypoxia, Brain
Portable MRI for Pediatric Hypoxic Ischemic Brain Injury
This study will evaluate the sensitivity and specificity of low field portable MRI (pMRI) for detection of hypoxic ischemic brain injuries in pediatric patients compared to clinically obtained neuroimaging to define pediatric…
- Conditions
- Acute Brain Injury, Hypoxia, Brain, Ischemia, Brain, Brain Injuries
- Trial name
- pMRI for HIBI (NCT07577336)
- Testing
- Portable MRI, Scavenged Sample Collection
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Mercy Hospital Kansas City
Effect of Reflexology, Hypoxic-Ischemic Encephalopathy, Neonatal
Foot Reflexology in Neonates With Hypoxic-Ischemic Encephalopathy
This randomized controlled trial aims to evaluate the effect of foot reflexology on comfort levels and physiological parameters in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia.
- Conditions
- Effect of Reflexology, Hypoxic-Ischemic Encephalopathy, Neonatal, Foot Reflexology, Therapeutic Hypothermia
- Trial name
- NCT07549789
- Testing
- Foot reflexology, Standard care
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Istanbul Nisantasi University
Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury
Cerebral Oximetry in Management of Post Cardiac Arrest
Resuscitation from a cardiac arrest is a common reason for admission to an intensive care unit (ICU). Because the brain is highly vulnerable to oxygen deprivation, severe brain damage often occurs during a cardiac arrest.
- Conditions
- Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury, Hypoxic-Ischemic Brain Injury
- Trial name
- COMPACT (NCT07829887)
- Testing
- Cerebral oximetry-guided treatment
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Calgary
Perinatal Arterial Ischemic Stroke, Perinatal Asphyxia
Intranasal Stem Cells to Treat Perinatal Brain Injury to Combat Cerebral Palsy
Hypoxic-ischemic brain injury (HIBI) is a leading cause of death and lifelong disability in near-term and term infants, most often caused by perinatal arterial ischemic stroke (PAIS, incidence approximately 1:5000 live births) or…
- Conditions
- Perinatal Arterial Ischemic Stroke, Perinatal Asphyxia, Hypoxic-Ischemic Brain Injury, PAIS
- Trial name
- iSTOP-CP (NCT07831746)
- Testing
- MSC, marrow
- Volunteers
- 162 people
- Sponsor
- UMC Utrecht
Perinatal Stroke
Baby Brain Recovery Study
This study will be a longitudinal multiple-visit observational study, done to identify possible bioindicators of recovery and repair of motor corticospinal pathways which may be targeted by future interventions in infants with…
- Trial name
- NCT05013736
- Testing
- Magnetic Resonance Imaging, Behavioral Assessments, Non invasive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Wisconsin, Madison
Stroke, Acute Ischemic, Brain Hemorrhage
Neuropsychological Rehabilitation Over the Internet
Helsinki University Hospital (HUS) has decided on a strategy to provide digital health care services for several medical specialties - a project called the Health Village (HealthVillage.fi).
- Conditions
- Stroke, Acute Ischemic, Brain Hemorrhage, Encephalitis, Hypoxia-Ischemia, Brain
- Trial name
- IRENE (NCT05413733)
- Testing
- Digital care pathway, Care as usual
- Where
- Finland
- Volunteers
- 21 people
- Sponsor
- Helsinki University Central Hospital
Cerebral Palsy, Stroke
Spinal Stimulation and Mobility Devices
This research study will combine non-invasive spinal stimulation with an ankle exoskeleton to examine the acute impact of the stimulation on gait in children with cerebral palsy.
- Conditions
- Cerebral Palsy, Stroke, Premature Birth, Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT05520359
- Testing
- Mobility Device, Spinal Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Neonatal Encephalopathy
Treatment of Neonatal Encephalopathy With Oral Sildenafil Suspension to Repair Brain Injury Secondary to Birth Asphyxia
Around the time of birth, some babies experience a condition called asphyxia, which means that their brain and other organs do not receive enough blood and/or oxygen to work properly.
- Trial name
- NCT06098833
- Testing
- Sildenafil, Ora-Blend
- Where
- 3 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Pia Wintermark
Epilepsy, Dravet Syndrome
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic Encephalopathies
The purpose of this study is to investigate the effect on the frequency of all seizures (convulsive and drop) in participants treated with TAK-935 compared to placebo.
- Conditions
- Epilepsy, Dravet Syndrome, Lennox-Gastaut Syndrome
- Trial name
- ELEKTRA (NCT03650452)
- Testing
- TAK-935
- Where
- 44 sites in United States, Australia and 6 more
- Volunteers
- 141 people
- Sponsor
- Takeda
Acquired Brain Injury Including Stroke, TBI
Effects of Neurofeedback Training and tRNS on Attentional Deficits in Patients With Acquired Brain Injury
The goal of this study is to investigate new neuromodulation therapies for attention deficits following acquired brain injury. Brain damage can affect various domains, including motor and cognitive functions.
- Conditions
- Acquired Brain Injury Including Stroke, TBI, Stroke, Anoxia-Ischemia, Brain
- Trial name
- NeMoRe II (NCT07817316)
- Testing
- verum tRNS + Neurofeedback
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospitales Nisa