Clinical trials: Hypothalamic Obesity
Prolactinoma, Insulin Resistance
Insulin Resistance in Women With Prolactinoma
Prolactin is suggested to influence insulin resistance, but scarce data is available on the metabolic profile of patients with prolactinoma.
- Conditions
- Prolactinoma, Insulin Resistance, Hyperlipidemia
- Trial name
- NCT00481299
- Where
- Brazil
- Volunteers
- 2,004 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Obesity, Type 2 Diabetes Mellitus
Influence of Liraglutide, a GLP-1 Receptor Agonist, on Brown Adipose Tissue (BAT) Activity in Humans
The purpose of this study is to access liraglutide influence brown adipose tissue recruitment and its thermogenic effect through hypothalamic activation in obese individuals.
- Trial name
- i-LAB (NCT02718950)
- Testing
- Liraglutide 3.0 mg
- Volunteers
- 20 people
- Sponsor
- University of Campinas, Brazil
Obesity
Deep Brain Stimulation for Human Morbid Obesity
The burden of morbid obesity to the circulatory, endocrine, and locomotor systems, as well as the psychological effects and related health-care costs, are well established in the medical literature.
- Trial name
- BLESS (NCT02232919)
- Testing
- Deep Brain Stimulation
- Where
- Brazil
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hospital do Coracao
Craniopharyngioma, Obesity
Multicenter Registry for Patients With Childhood.Onset Craniopharyngioma, Xanthogranuloma, Cysts of Rathke's Pouch, Meningioma, Pituitary Adenoma, Arachnoid Cysts
KRANIOPHARYNGEOM Registry 2019 will prospectively collect and descriptively analyse data on diagnostics, treatment, and follow-up of patients with craniopharyngioma.
- Trial name
- NCT04158284
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Klinikum Oldenburg gGmbH
Hypothalamic Obesity
Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy
To study the effect of combined diazoxide-metformin therapy on body weight in youth with hypothalamic obesity following treatment for craniopharyngioma.
- Trial name
- NCT00892073
- Testing
- Diazoxide, Metformin
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- The Hospital for Sick Children
Obese
Monounsaturated Fatty Acids and Brown/Beige Adipose Tissue in Humans
Considering the high prevalence of obesity its comorbidities in Brazil and in the world, different therapeutic measures have been suggested.
- Trial name
- NCT03024359
- Testing
- Extra virgin olive oil
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Hypothalamic Obesity
A Study of Octreotide Depot vs Saline Control in Pediatric Hypothalamic Obesity Patients
The extension protocol is designed to allow those patients randomized to placebo in the core portion of the protocol to receive a 6 month treatment of open label octreotide and allow those patients randomized to octreotide who…
- Trial name
- NCT00171613
- Testing
- Octreotide
- Volunteers
- 32 people
- Sponsor
- Novartis
Obesity, GHD
Replacement GH Therapy After Bariatric Surgery in Patients With Very Severe Obesity
Obesity and obesity-related diseases have reached epidemic proportions in Western countries (1-3). Laparoscopic-adjustable silicone gastric banding (LASGB) is a purely restrictive operation that determine effective weight loss…
- Trial name
- GH&LASGB (NCT00553852)
- Testing
- Recombinant GH Saizen (Merck-Serono)
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Federico II University
Childhood Obesity, Morbid Obesity
Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome
Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation.
- Trial name
- NCT02602769
- Testing
- Transcriptome profiling
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Obesity, Over-weight
An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Hypothalamic Injury
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of beloranib in obese subjects with hypothalamic injury.
- Conditions
- Obesity, Over-weight, Hypothalamic Injury, Craniopharyngioma
- Trial name
- NCT02063295
- Testing
- ZGN-440 sterile diluent, ZGN-440 for injectable suspension
- Where
- 4 sites in United States, Australia
- Volunteers
- 14 people
- Sponsor
- Zafgen, Inc.
Hypothalamic Obesity
Effects of Exenatide on Hypothalamic Obesity
The primary aim of this study is to evaluate the effect of Exenatide on weight status (change in body mass index) of children treated for craniopharyngioma that have developed hypothalamic obesity at Children's Hospitals and…
- Trial name
- NCT01061775
- Testing
- Exenatide
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Obesity, Childhood
Impact of Hypothalamic Gliosis on Appetite Regulation and Obesity Risk in Children
BEAM is a multi-site longitudinal cohort study of hypothalamic gliosis, central regulation of appetite and weight gain in children.
- Trial name
- NCT04260048
- Where
- 2 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Washington
Bardet-Biedl Syndrome, POMC Deficiency Obesity
Setmelanotide in Pediatric Participants With Rare Genetic Diseases of Obesity
This is a phase 3 open-label, clinical study to evaluate the efficacy, safety and tolerability of setmelanotide over 1 year of treatment, in pediatric participants aged 2 to <6 years with obesity due to either biallelic variants…
- Conditions
- Bardet-Biedl Syndrome, POMC Deficiency Obesity, PCSK1 Deficiency Obesity, LEPR Deficiency Obesity
- Trial name
- NCT04966741
- Testing
- Setmelanotide
- Where
- 6 sites in United States, Australia and 2 more
- Volunteers
- 12 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Hypothalamic Obesity, Prader-Willi Syndrome
A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
The purpose of this study is to evaluate the safety, tolerability, and PK of RM-718 in healthy subjects with obesity and in patients with MC4R Pathway Impairment
- Conditions
- Hypothalamic Obesity, Prader-Willi Syndrome, PWS
- Trial name
- NCT06239116
- Testing
- Part C: RM-718, Part D: RM-718
- Where
- 7 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Obstructive Sleep Apnea Syndrome, Obesity
Influence of nCPAP on Metabolic Consequences Associated With OSAS
Context: Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular morbidity. Recurrent episodes of occlusion of upper airways during sleep result in hormonal changes that may predispose to high cardiovascular…
- Trial name
- NCT00435643
- Testing
- nasal continuous positive airway pressure
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Prader-Willi Syndrome, PWS-like Syndrome
GROWing Up With Rare GENEtic Syndromes
Introduction Rare complex syndromes Patients with complex genetic syndromes, by definition, have combined medical problems affecting multiple organ systems, and intellectual disability is often part of the syndrome.
- Conditions
- Prader-Willi Syndrome, PWS-like Syndrome, Silver Russel Syndrome, Congenital Hypopituitarism
- Trial name
- GROW UR GENES (NCT04463316)
- Testing
- Retrospective file studies
- Where
- Netherlands
- Volunteers
- 600 people
- Sponsor
- dr. Laura C. G. de Graaff-Herder
Obesity, Childhood, Hyperphagia
Early Genetic Identification of Obesity
TITLE: Whole genetic approach in Early Genetic Identification of Obesity (WEGIO) DESIGN: Multicenter epidemiological study STUDY POPULATION: Participants at risk for a syndromic or a monogenic genetic obesity, incl.
- Conditions
- Obesity, Childhood, Hyperphagia, Retinopathy, Syndactyly
- Trial name
- WEGIO (NCT06239064)
- Testing
- Genetic testing via blood collection
- Where
- 37 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Rolfs Consulting und Verwaltungs-GmbH (RCV)
Anorexia Nervosa, Hypothalamic Amenorrhea
Hormone Dynamics and Bone Mineral Density in Anorexia Nervosa v. Hypothalamic Amenorrhea
The purpose of this study is to determine whether the hormone dynamics in women with anorexia nervosa and hypothalamic amenorrhea is related to bone loss in those populations.
- Conditions
- Anorexia Nervosa, Hypothalamic Amenorrhea, Obesity
- Trial name
- NCT00556036
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Obese Patients, Hypothalamic Neoplasms
KETO-TUMOR: a Study on Brain Tumors and Central Obesity
Hypothalamic-chiasmatic tumours account for 5-10% of CNS tumours in children and can compromise hypothalamic function, causing alterations in energy balance and weight gain.
- Trial name
- NCT07396896
- Testing
- Dietary intervention
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Meyer Children's Hospital IRCCS
Hypothalamic Obesity
A Long-Term Study of Bivamelagon in Participants With Hypothalamic Obesity (HO)
This is a long-term, open-label extension study of bivamelagon in participants with Hypothalamic Obesity (HO) who have transitioned from the index study, LG-MCCL005. The study will last up to 2 years.
- Trial name
- NCT07156578
- Testing
- Bivamelagon
- Where
- 9 sites in United States, United Kingdom
- Volunteers
- 25 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.