Clinical trials: Hyperpigmentation
Wrinkles, Fine Lines
Clinical Study to Assess Safety, Effectiveness and In-Use Tolerability of Saffron Extract Capsules for Improving Skin Health and Reducing Signs of Aging on Healthy Adult Male and Female Subjects.
This is a randomized, double-blind, comparative, two-arm, prospective, interventional, multi-centre clinical study to evaluate the safety, efficacy, and in-use tolerability of test products, standardized saffron extract capsules…
- Conditions
- Wrinkles, Fine Lines, Hyperpigmentation, Dark Spots
- Trial name
- GLOW (NCT07324759)
- Testing
- Standardized Saffron Extract (Crocus Sativus L) 10 mg Capsule
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Hyperpigmentation
Fractionated 1927nm Laser for Hyperpigmentation in Fitzpatrick Skin Phototypes V and VI
The primary objective of this study is to assess the efficacy of 1927nm non-ablative fractionated laser therapy to treat hyperpigmentation in patients ages 18-75 with Fitzpatrick Skin Phototypes V and VI and explore an effective…
- Trial name
- NCT05493280
- Testing
- MOXI
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Post Burn Facial Hyperpigmentation
Comparison of Effectiveness of Tranexamic Acid Mesotherapy Versus Glutathione Mesotherapy in Post Burn Facial Hyperpigmentation
INTERVENTION: Patch test on forearm will be performed in all patients before starting treatment to check the sensitivity. Site of burn in the enrolled patients will include either cheek or forehead and total area (cm2) on each of…
- Trial name
- NCT07263841
- Testing
- Tranexamic Acid
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- King Edward Medical University
Varicose Veins
Efficacy of the SALFOAM 3% Method Compared to the Conventional Polidocanol Foam Method (Tessari Method) for Treating Lower Limb Varicose Veins
This clinical trial aims to assess the efficacy and safety of the SALFOAM 3% method, which involves saline wash, polidocanol 3% foam injection, and extrinsic compression using Lidstop®, in comparison with the conventional Tessari…
- Trial name
- SALFOAM 3% (NCT06667570)
- Testing
- SALFOAM 3%, Control Group
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- Lidiane Rocha
Post Inflammatory Hyperpigmentation
A Novel Regimen for Treatment and Prevention of Post-Inflammatory Hyperpigmentation in Skin of Color
This is a single-center, prospective, non-blinded, non-randomized 12 week clinical study to evaluate the efficacy of a SkinCeuticals comprehensive skin care regimen in the reduction of post inflammatory hyperpigmentation (PIH) in…
- Trial name
- NCT06938815
- Testing
- Pigment Balancing Peel, Discoloration Defense Serum, LHA Cleansing Gel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Narrows Institute for Biomedical Research
Healthy, Melasma (Facial Melasma)
COMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYS
The goal of this clinical trial is to compare the dermatological tolerance and skin-lightening efficacy of a cosmetic depigmenting serum to a 4% hydroquinone-based product in adult male and female subjects aged 18-65 years with…
- Conditions
- Healthy, Melasma (Facial Melasma), Epidermal Melasma
- Trial name
- NCT07071363
- Testing
- Depigmenting Cosmetic Serum (Applied Morning and Evening)
- Where
- Mauritius
- Volunteers
- 40 people
- Sponsor
- Laboratoire Dermatologique ACM
Hyperpigmentation; Melanin
Study of Efficacy and Safety of Cream Infused With HuangQin (Root of Scutellaria Baicalensis) Extract for the Reduction of Hyperpigmentation
The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face.
- Trial name
- NCT07133204
- Testing
- Investigator developed cream infused with HuangQin extract
- Where
- Thailand
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mae Fah Luang University
Melasma, Post-acne Hyperpigmentation
Efficacy and Safety of a Combined Serum Containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES
The goal of this clinical trial is to evaluate the efficacy and safety of a combination serum containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES when used as a moisturizer after QS-Nd:YAG 1064 nm low-fluence laser…
- Trial name
- NCT07121439
- Testing
- a combination serum containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES, 2% hydroquinone cream
- Where
- Indonesia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
Hyperpigmentation, Gingival Hyperpigmentaion
Effectiveness of Omega-3 Poly Unsaturated Fatty Acids on The Treatment of Gingival Hyperpigmentation
This new study compares the effectiveness of scalpel surgery and omega-3 poly unsaturated fatty acid (PUF) injections in treating gingival hyperpigmentation.
- Trial name
- Omega-3 (NCT07067515)
- Testing
- non surgical with PUFA injection, surgical treatment
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Suez Canal University
Hyperpigmentation
The Effectiveness of a Novel Lip Product Containing Caulerpa Lentillifera Extract for Reducing Lip Hyperpigmentation
The goal of this clinical trial is to evaluate the efficacy of the novel lip product containing Caulerpa lentillifera extract on the appearance and perception of dark lips in Thai adults aged 18 to 60 who report concerns about…
- Trial name
- NCT07067879
- Testing
- Lip product
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Hyperpigmentation, Melasma
Annurca Apple Peel Oleolite for the Treatment of Skin Hyperpigmentation
The aim of this cosmetic clinical trial is to learn if an oleolite derived from Annurca Apple peel (AAO) works to enhance skin tone and luminosity, by counteracting the visibility of skin hyperpigmentation and dark spots in adult…
- Conditions
- Hyperpigmentation, Melasma, Skin Spots, Photodamaged Skin
- Trial name
- EAAO22G01 (NCT07040345)
- Testing
- Annurca apple oleolite
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ritamaria Di Lorenzo
Melasma, Treatment Outcome
Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of Melasma
This study compares the effectiveness of two oral medications-melatonin and tranexamic acid -in treating melasma, a common skin condition that causes dark facial patches.
- Conditions
- Melasma, Treatment Outcome, Recurrence
- Trial name
- TXA-MELA (NCT07034560)
- Testing
- Tranexamic Acid (TXA), melatonin (Circadin)
- Where
- Thailand
- Volunteers
- 75 people
- Sponsor
- Thammasat University
Acne Vulgaris
Efficacy, Safety Profile, and Post-Acne Sequelae of 0.025% Retinoic Acid Cream vs. 0.1% Adapalene Cream in Mild Acne Vulgaris in Fitzpatrick Skin Types III-V
The goal of this clinical trial is to compare the effectiveness, safety profile, and post-acne sequelae of 0.025% retinoic acid cream versus 0.1% adapalene cream for mild acne vulgaris in individuals with Fitzpatrick skin types…
- Trial name
- NCT07015931
- Testing
- retinoic acid cream 0.025%, adapalene cream 0.1%
- Where
- Indonesia
- Volunteers
- 23 people
- Sponsor
- Universitas Indonesia
Melanin Hyperpigmentation
Melanin Recurrence in Scalpel and LASER Gingival Depigmentation in Thin and Thick Phenotypes.
This study aimed to compare melanin pigmentation recurrence, pain perception and wound healing between laser and scalpel surgeries in thin and thick gingival phenotypes.Thirty patients (60 sites) were included in this study.
- Trial name
- NCT06886100
- Testing
- Diode laser, Scalpel No 15
- Where
- Yemen
- Volunteers
- 30 people
- Sponsor
- Thamar University
Hyperpigmentation, Varicosis
Brightening Cream and Lasers in Post-sclerotherapy Hyperpigmentation
The treatment of leg veins and varicosis with sclerotherapy is one of the most frequently performed medical intervention in the western world.
- Trial name
- NCT05165524
- Testing
- QS Nd:YAG laser, Triple cream
- Where
- Switzerland
- Volunteers
- 66 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Skin Quality, Skin Wrinkles
Evaluation of Effects on Skin Quality of a Centella Asiatica Extracellular Vesicle-based Skin Care Formulation.
The study evaluates the effects of a skin care formulation containing Centella asiatica extracellular vesicles as the main active ingredient on facial appearance and skin quality in healthy participants.
- Conditions
- Skin Quality, Skin Wrinkles, Melanin Hyperpigmentation, Skin Hydration
- Trial name
- NCT06850935
- Testing
- Centella asiatica extracellular vesicle formulation
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hungkuang University
Post Inflammatory Hyperpigmentation
The Efficacy of Bakuchiol in Treating PIH
Post-inflammatory hyperpigmentation (PIH) is an acquired hyper melanosis that occurs after cutaneous inflammation or injury frequently affecting darker skinned individuals.
- Trial name
- NCT06833996
- Testing
- Bakuchiol, Vehicle
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Acne, Post-inflammatory Hyperpigmentation
Clinical Efficacy of the Product in the Management of Facial Post Inflammatory Hyperpigmentation (PIHP) Subjects
Double-blind, randomized, clinical study is designed to evaluate the efficacy of Niacinamide A in the management of facial Post Inflammatory Hyper Pigmentation (PIHP) in healthy female and male subjects with moderate to severe…
- Trial name
- NCT06822335
- Where
- Mauritius
- Volunteers
- 65 people
- Sponsor
- Cosmetique Active International
Tear Trough Eyelid Deformity, Dark Eyelids
Periocular Rejuvenation by Topical Hyaluronic Acid Nano Particles
In this study, The investigators aims to evaluate the efficacy and safety of topical hyaluronic acid nanoparticles as a novel nanodermatological tool in periocular rejuvenation as a replacement approach of invasive dermal filler…
- Conditions
- Tear Trough Eyelid Deformity, Dark Eyelids, Wrinkle
- Trial name
- NCT05742399
- Testing
- Hyaluronic acid NanoGel
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Acne, Postinflammatory Hyperpigmentation
Efficacy of La Roche Posay Routine in the Management of Facial Post Inflammatory Hyperpigmentation (PIHP)
The goal of this clinical trial is to test and compare La Roche Posay routine --the studied product-- with a comparator product in participants with acne.
- Trial name
- PIHP (NCT06770127)
- Where
- Mauritius
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International