Hyperpigmentation; MelaninNCT07133204
Study of Efficacy and Safety of Cream Infused With HuangQin (Root of Scutellaria Baicalensis) Extract for the Reduction of Hyperpigmentation
A study testing Investigator developed cream infused with HuangQin extract in people with Hyperpigmentation; Melanin, run by Mae Fah Luang University at 1 site in Thailand.
Trial summary
The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face. The study is experimental clinical pilot study as a single group pretest-posttest. A ROAT is conducted 1 week prior to the experiment. Read more about this study
- Who is it for?
- Ages 30 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Hyperpigmentation; Melanin
- What is being tested?
- Investigator developed cream infused with HuangQin extract
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 38 participants
- Where
- 1 siteThailand
- Study dates
- 1 Apr 2025to 20 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male or Female
- Has at least 1 hyperpigmentation spot (size > 3mm) on either side of the face
- 30-60 y/o
- Fitzpatrick skin types II-IV
- Agrees to use sunscreen SPF50+ and willing to avoid strong sunlight exposure during the study
Who cannot join
- Pregnant or lactating
- Use of whitening products or treatment within 1 month before this study
- Currently using contraceptives
- History of allergy to any ingredient in the intervention cream
- Has skin conditions which can interfere with the measurement (i.e. severe acne, eczema, herpes simplex)
- Severe disease (i.e. immunodeficiency, cancer)
- Enrolled in other clinical study within 3 month before this study
Trial locations and contacts
1 site in 1 country.
About this study
The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face.
The study is experimental clinical pilot study as a single group pretest-posttest.
A ROAT is conducted 1 week prior to the experiment. Participant apply the cream on the hypigmented area daily. Facial skin parameters (i.e. melanin index, erythema index) is evaluated at week 0, 1, 2 and 4.
- Conditions
- Hyperpigmentation; Melanin
- Being tested
- Investigator developed cream infused with HuangQin extract
- Keywords
- hyperpigmentation, scutellaria baicalensis, melanin index
- Medical subject headings
- Hyperpigmentation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Investigator developed cream infused with HuangQin extractOther
A water in oil emulsion with consistency similar to cold cream. Infused with organic extract of scutellaria baicalensis.
| Study group | Role | What they receive |
|---|---|---|
| Study arm | Experimental | Not described Receives: Other: Investigator developed cream infused with HuangQin extract |
What is being measured
The primary outcome is the main question the study is designed to answer.
Efficacy of hyperpigmentation reduction property of the intervention
Measured the melanin index of the hyperpigmented area
Measured: Week 0, 1, 2 and 4
Safefty profile of the intervention
Record and collect the adverse effect from the usage of the interventional cream
Measured: Week 1, 2 and 4
Secondary outcomes (2)
Efficacy of erythema reduction property of the intervention
Measured the erythema index of the hyperpigmented area
Measured: Week 0, 1, 2 and 4
Efficacy of skin hydration property of the intervention
Measured the skin hydration value of the hyperpigmented area
Measured: Week 0, 1, 2 and 4
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Aug 2025
- Study start1 Apr 2025
- Primary completion30 Jun 2025
- Study completion20 Jul 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hyperpigmentation; MelaninStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 38 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mae Fah Luang University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Chakree C Wattanasiri, RPh PhD, Principal investigator, Mae Fah Luang University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07133204
- Sponsor's protocol ID
- EC 24061-25
- Status last verified
- Aug 2025
- First submitted
- 13 Aug 2025
- Last updated
- 20 Aug 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Study of Efficacy and Safety of Cream Infused With HuangQin (Root of Scutellaria Baicalensis) Extract for the Reduction of Hyperpigmentation
- ClinicalTrials.gov ID
- NCT07133204
- Acronym / sponsor ID
- EC 24061-25
- Conditions
- Hyperpigmentation; Melanin
- Keywords
- hyperpigmentation, scutellaria baicalensis, melanin index
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 38 participants (actual)
- Lead sponsor
- Mae Fah Luang UniversityUniversity, hospital or other
- Study start
- 1 Apr 2025 (actual)
- Primary completion
- 30 Jun 2025 (actual)
- Study completion
- 20 Jul 2025 (actual)
- First posted
- 20 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face.
The study is experimental clinical pilot study as a single group pretest-posttest.
A ROAT is conducted 1 week prior to the experiment. Participant apply the cream on the hypigmented area daily. Facial skin parameters (i.e. melanin index, erythema index) is evaluated at week 0, 1, 2 and 4.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Study arm | Experimental | Other: Investigator developed cream infused with HuangQin extract |
Who may qualify
- Ages
- 30 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Male or Female
- Has at least 1 hyperpigmentation spot (size > 3mm) on either side of the face
- 30-60 y/o
- Fitzpatrick skin types II-IV
- Agrees to use sunscreen SPF50+ and willing to avoid strong sunlight exposure during the study
Key exclusion criteria (7 listed)
- Pregnant or lactating
- Use of whitening products or treatment within 1 month before this study
- Currently using contraceptives
- History of allergy to any ingredient in the intervention cream
- Has skin conditions which can interfere with the measurement (i.e. severe acne, eczema, herpes simplex)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Investigator developed cream infused with HuangQin extractA water in oil emulsion with consistency similar to cold cream. Infused with organic extract of scutellaria baicalensis. | Other | Study arm |
Primary outcome
Efficacy of hyperpigmentation reduction property of the intervention
Time frame: Week 0, 1, 2 and 4
Measured the melanin index of the hyperpigmented area
Safefty profile of the intervention
Time frame: Week 1, 2 and 4
Record and collect the adverse effect from the usage of the interventional cream
2 secondary outcomes
Efficacy of erythema reduction property of the intervention
Time frame: Week 0, 1, 2 and 4
Efficacy of skin hydration property of the intervention
Time frame: Week 0, 1, 2 and 4
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Aug 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Chakree C Wattanasiri, RPh PhD principal investigator
Mae Fah Luang University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Investigator developed cream infused with HuangQin extract in people with Hyperpigmentation; Melanin, run by Mae Fah Luang University at 1 site in Thailand.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Thailand. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Efficacy of hyperpigmentation reduction property of the intervention (time frame: Week 0, 1, 2 and 4). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Aug 2025.