Clinical trials: Hyperoxia
Pulmonary Disease, Chronic Obstructive
Breathing Helium-Hyperoxia During Exercise in Patients With Chronic Obstructive Pulmonary Disease
Regular exercise can help patients with the lung disease, chronic obstructive pulmonary disease (COPD). But COPD patients have a hard time with training because of their breathing.
- Trial name
- NCT01283685
- Testing
- breathing helium-hyperoxia, breathing supplemental oxygen
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- West Park Healthcare Centre
Respiratory Failure
Hyperoxia, Erythropoiesis and Microcirculation in Critically Ill Patient
Prospective observational study in 40 adult critically ill patients. Patients were eligible if they were mechanically ventilated with an FiO2 ≤0.5 and PaO2/FiO2 ≥200 mmHg and hemodynamically stable with a hemoglobin ≥9 g/dL, no…
- Trial name
- NCT02481843
- Testing
- 2 hours of hyperoxia (FiO2 = 1)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università Politecnica delle Marche
Trauma
Apoptosis in Polymorphonuclear Cells and Inflammatory Cytokines of Trauma Patients
This study tries to find how hypoxia and hyperoxia, among types of the respiratory failure induced cell damage that can arise in the course of traumatic damage and treatment, influences apoptosis of PMN cells and IL-6 and tumor…
- Trial name
- NCT03319017
- Testing
- Multiple-trauma patients
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Guro Hospital
Stroke, Endovascular Treatment
Normobaric Hyperoxia Combined With Endovascular Treatment for Acute Ischemic Stroke
The purpose of this study is to evaluate the safety and efficiency of normobaric hyperoxia combined with endovascular treatment for acute ischemic stroke patients with stroke onset 6-24 hours.
- Conditions
- Stroke, Endovascular Treatment, Neuroprotection
- Trial name
- NCT05128422
- Testing
- Normobaric oxygen therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Capital Medical University
Low Back Pain
ReOxy Therapy in the Rehabilitation of Chronic Low Back Pain Patients With Comorbidity
The aim of this study is to assess the effect of the respiratory therapy method based on short-term intermittent exposures to hypoxia and hyperoxia (ReOxy therapy) on the pain intensity, restoration of the lumbar range of motion…
- Trial name
- NCT05053672
- Testing
- ReOxy
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- Moscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports Medicine
Hypertension
Intermittent Hypoxia-hyperoxia Conditioning as a New Therapeutic Intervention to Reduce Hypertension (HyperIHHC)
The primary objective of this project is to examine the efficiency of intermittent hypoxia-hyperoxia conditioning (IHHC) protocol to improve vascular health and reduce blood pressure in hypertensive patients (stage 1).
- Trial name
- HyperIHHC (NCT05603676)
- Testing
- Intermittent hypoxia-hyperoxia conditioning
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gregoire Millet
Premature Infant, Oxygen Therapy
SCO2T (Servo vs. Servo)
Most premature babies require oxygen therapy. There is uncertainty about what oxygen levels are the best. The oxygen levels in the blood are measured using a monitor called a saturation monitor and the oxygen the baby breathes is…
- Conditions
- Premature Infant, Oxygen Therapy, Hypoxia, Hyperoxia
- Trial name
- NCT04546568
- Testing
- Servo control (closed-loop automatic control of the inspiratory fraction of oxygen (FiO2)) - Leoni plus CLAC, Servo control (closed-loop automatic control of the inspiratory fraction of oxygen (FiO2)) - IntellO2 OAM
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Spinal Cord Injuries
Can Brief Exposure to Hyperoxia Improve Function After Chronic Spinal Cord Injury?
This proof-of-principle study will determine if breathing an increased concentration of oxygen above the concentration in normal room air results in changes in the sensory and motor function in people with subacute or chronic…
- Trial name
- NCT05467215
- Testing
- Pure oxygen (99%) from Praxair, Edmonton, DIN# 02014408
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Oxygen Toxicity, Pulmonary Injury
Hyperoxia Induced Pulmonary Inflammation and Organ Injury: a Human in Vivo Model
Oxygen is the most commonly administered therapy in critical illness. Accumulating evidence suggests that patients often achieve supra-physiological levels of oxygenation in the critical care environment.
- Conditions
- Oxygen Toxicity, Pulmonary Injury, Acute Lung Injury
- Trial name
- NCT05414370
- Testing
- Liquid oxygen, medical air
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Hyperoxia, Myocardial Infarction
Intraoperative Hyperoxia and MINS
Oxygen therapy is administered to all patients during general anesthesia to maintain tissue oxygenation and prevent hypoxia and ischemia.
- Conditions
- Hyperoxia, Myocardial Infarction, Myocardial Injury
- Trial name
- NCT04540276
- Testing
- Inspiratory oxygen fraction
- Where
- 8 sites in United States, Canada and 6 more
- Volunteers
- 7,700 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Hypoxia, Normoxia
Effects of Oxygen Status on Endotoxemia Induced Inflammation and Hypoxia Inducible Factor-1α
Oxygen is a widely available gas that is cheap, easy to get and extensively used in medicine. From animal studies it has become apparent that increasing or lowering the degree of oxygen in the blood, the inflammatory response can…
- Conditions
- Hypoxia, Normoxia, Hyperoxia
- Trial name
- NCT01978158
- Testing
- Lipopolysaccharide
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hyperoxia / High FiO₂ Exposure, Interval Training
Oxygen as a Metabolic Modulator: Divergent Physiological Adaptations to Hypoxic and Hyperoxic Tabata Training.
The purpose of this study is to examine how breathing air with different oxygen concentrations (higher or lower than normal) during high-intensity interval training affects: Aerobic capacity (VO₂max) Ventilatory thresholds Blood…
- Conditions
- Hyperoxia / High FiO₂ Exposure, Interval Training, HIIT, High Intensity Interval Training
- Trial name
- NCT07551869
- Testing
- FIO2 modulation during HIIT protocol on assault bike
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Haute Ecole Bruxelles-Brabant
Hypoxia, Hyperoxia
Different Preoxygenation Methods In Cesarean Section
The study aimed to evaluate different preoxygenation methods (tidal volume for 3 minutes and 4 deep breaths) in pregnant women with oxygen reserve index (ORI).
- Trial name
- NCT05395975
- Testing
- Oxygen Reserve Index
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Retinal Oxygenation, Retinal Blood Flow
Effect of Systemic Hypoxia and Hyperoxia on Retinal Oxygen Saturation
Adequate perfusion and oxygenation is essential for the function of the inner retina. Although it is known that oxygen tension is very well autoregulated in the retina, the physiological mechanisms behind this regulation process…
- Trial name
- NCT01692821
- Testing
- 100% oxygen breathing, 15% oxygen in N2 breathing, 12% oxygen in N2 breathing
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Stroke, Acute, Neuroprotection
Treatment Duration on Normobaric Hyperoxia in Acute Ischemic Stroke
Normoxia Hyperoxia (NBO) is a neuroprotective approach that can be implemented early. NBO is simple and non-invasive and can be used at home or in an ambulance to ensure the shortest possible time after cerebral ischemia occurs.
- Conditions
- Stroke, Acute, Neuroprotection, Endovascular Treatment
- Trial name
- NCT05404373
- Testing
- Normobaric Hyperoxia (NBO), Low flow oxygen
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Capital Medical University
COPD Exacerbation, Hypoxia
Oxygen Control and Weaning by O2matic to Patients Admitted With an Exacerbation of COPD
The aim of the study is to examine if automated oxygen delivery with O2matic allows for faster weaning from oxygen and better oxygen control than manually controlled oxygen therapy for patients admitted with an exacerbation of…
- Conditions
- COPD Exacerbation, Hypoxia, Hypoxemia, Hyperoxia
- Trial name
- O2MATIC-WEAN (NCT03661086)
- Testing
- O2matic
- Where
- 5 sites in Denmark
- Volunteers
- 157 people
- Sponsor
- Hvidovre University Hospital
Chronic Obstructive Pulmonary Disease, Asthma
Hyperoxia During Pulmonary Rehabilitation in Chronic Lung Disease - Does it Matter?
Chronic respiratory diseases are a global burden. Treatment options have improved in recent years, pulmonary rehabilitation plays a key role.
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Pulmonary Hypertension, Interstitial Lung Disease
- Trial name
- NCT06174207
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
Hyperoxia
Electronic Optimization of Inspired Oxygen During Mechanical Ventilation, a Pragmatic Randomized Trial (OPTI-Oxygen)
OPTI-Oxygen is a single center, stepped wedged, cluster-randomized, un-blinded, pragmatic, comparing the use of a combined inspired oxygen (FiO2) and peripheral oxygen saturation (SpO2) titration strategy utilizing electronic…
- Trial name
- NCT05923853
- Testing
- FiO2 titration using electronic alert system
- Where
- United States
- Volunteers
- 936 people
- Sponsor
- Ohio State University
Hyperoxia
Hyperoxia and Pulmonary Complications After Cardiac Surgery
The main objective is to demonstrate that hyperoxia in cardiac surgery increase the occurrence of post-operative pulmonary complications
- Trial name
- HYPER-CARDIO (NCT04278066)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Cardiac Surgery, Delirium - Postoperative
Effect of Hyperoxia or Hypoxemia on the Incidence of Delirium in Patients After Cardiac Surgery
Our goal was to study the effect of hyperoxia or hypoxemia on the incidence of delirium in patients after cardiac surgery.
- Conditions
- Cardiac Surgery, Delirium - Postoperative, Hyperoxia, Hypoxemia
- Trial name
- NCT07548905
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Southeast University, China