Clinical trials: Hemodynamic Management
Radical Cystectomy, Perioperative Complications
Advanced Hemodynamic Monitoring for Goal-directed Hemodynamic Management During Radical Cystectomy
The purpose of this study is to determine whether increasing cardiac output by a combination of intravenous fluids and inotropic drugs can reduce mortality and morbidity in radical cystectomy operations.
- Conditions
- Radical Cystectomy, Perioperative Complications, Hemodynamic Monitoring
- Trial name
- NCT00966147
- Testing
- Increasing oxygen delivery .
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Heart Failure
Chronicle Offers Management to Patients With Advanced Signs and Symptoms of Heart Failure (COMPASS-HF)
COMPASS-HF was a prospective, two-arm, randomized (1:1), multi-center, parallel controlled study. The purpose of the randomized study was to test the safety of an implantable hemodynamic monitor (IHM) and pressure sensor lead.
- Trial name
- NCT00643279
- Testing
- Chronicle Implantable Hemodynamic Monitor, Standard of Care
- Where
- 28 sites in United States
- Volunteers
- 277 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Intensive Care Unit Syndrome
Hemodynamic Impact of the Administration of PAracetamol in Patients Hospitalized in the Intensive Resuscitation Medicine Department [PAREA]
Paracetamol is commonly used in case of pain or fever. Few previously clinical studies has highlighted an arterial hypotension linked to intravenous administration of paracetamol.
- Trial name
- PAREA (NCT06430697)
- Testing
- paracetamol administration
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Trauma, Pelvic Fracture
Pelvic Fractures in Polytraumatized Patients With Hemodynamic Instability: Angioembolization vs Preperitoneal Packing
Pelvic fracture is a usual injury in trauma patients. An unstable trauma patient with a pelvic fracture has an elevated risk of death due to pelvic bleeding and the associated injuries.
- Conditions
- Trauma, Pelvic Fracture, Hemodynamic Instability
- Trial name
- NCT04764864
- Testing
- Angioembolization, Preperitoneal Pelvic Packing
- Where
- Spain
- Sponsor
- Nuria Llorach-Perucho
Perioperative Care, Hemodynamics
ImPortance of Arterial Measurement Sites (IPAMS) on Intraoperative Hemodynamic Management
The goal of this clinical trial is to demonstrate the importance of arterial pressure measurement sites during major abdominal surgeries.
- Conditions
- Perioperative Care, Hemodynamics, Monitoring Blood Pressure, Arterial Lines
- Trial name
- IPAMS (NCT06982001)
- Testing
- Brachial line guided hemodynamic management, Radial line guided hemodynamic management, Radial line catheterization
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Surgery-Complications
Restrictive- vs Individualized Goal Directed Fluid Therapy in Liver Surgery
"Low central venous pressure (low-CVP) or a restrictive fluid administration strategy is usually used worldwide during major liver resection surgery.
- Trial name
- REVOLUTION (NCT05704387)
- Testing
- individualized GDFT, Restrictive fluid therapy strategy
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intraoperative Hypotension
Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia
This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia.
- Trial name
- NCT07301307
- Testing
- Acumen IQ sensor with Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) software, Conventional Intraoperative Hemodynamic management
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Supine Hypotensive Syndrome
Hemodynamic Management in Women With SHS
Supine hypotensive syndrome often occurs following spinal anesthesia for cesarean delivery.In our study we base the regulation and drug administration both on the regular monitor and on a novel monitor which reflects upon the…
- Trial name
- NCT05341362
- Testing
- LiDCOrapid
- Where
- China
- Volunteers
- 60 people
- Sponsor
- China Medical University, China
Laminectomy
Esmolol Infusion During Laminectomy: Effect on Quality of Recovery
The purpose of this study is to evaluate the effects of esmolol, a drug which is commonly administered during surgery to help control blood pressure and heart rate, on postoperative pain levels and requirements for pain…
- Trial name
- NCT01179113
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Cedars-Sinai Medical Center
Fluid Management
Hemodynamic Optimization Based on a Dynamic Elastance Protocol
In this study investigators explore the effects of a dynamic elastance guided protocol compared to a stroke volume variation fluid therapy on lactate levels during major abdominal surgery.
- Trial name
- NCT05187273
- Testing
- Elastance Group
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Migraine, Headache
The Hemodynamic Effects of PACAP38 After Glibenclamide Administration in Healthy Volunteers
To investigate the hemodynamic effects of PACAP38 after glibenclamide administration.
- Conditions
- Migraine, Headache, Pain
- Trial name
- NCT04960657
- Testing
- glibenclamide, PACAP38
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Remimazolam, Propofol
Remimazolam on the Incidence of Postoperative Acute Kidney Injury
We hypothesized that in patients undergoing elective hepatobiliary-pancreatic surgery, the group in which anesthesia is induced and maintained with remimazolam during surgery would maintain hemodynamic stability and reduce the…
- Conditions
- Remimazolam, Propofol, Acute Kidney Injury, Hemodynamic Stability
- Trial name
- NCT07674719
- Testing
- Remimazolam (Byfavo), propofol
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Seoul National University Bundang Hospital
Type 2 Respiratory Failure
BIPAP vs CPAP Effects on Type 2 Respiratory Failure Patients
Effectiveness of BIPAP is evaluated in Type-2 failure but evaluation of effectiveness of CPAP in Type-2 respiratory failure in post cardiac surgery patients was not done.
- Trial name
- NCT04020627
- Testing
- BiPAP Group, CPAP Group
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Riphah International University
Pulmnary Hypertension, COPD
Hemodynamic Effects of Inhaled Iloprost in PH-COPD (HOLLYWOOD)
Study Title: A Clinical Study of Inhaled Iloprost for the Treatment of Pulmonary Hypertension in Patients With Chronic Obstructive Pulmonary Disease (HOLLYWOOD) The goal of this clinical study is to learn if the inhaled drug…
- Conditions
- Pulmnary Hypertension, COPD, Pulmonary Hypertension Secondary to Lung Disease and/or Hypoxia
- Trial name
- HOLLYWOOD (NCT07263958)
- Testing
- Iloprost is a synthetic molecule with pharmacological action
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo General Hospital
Hemodynamic (MAP) Stability, Fluid Management
Hemodynamic Optimization Using an Artificial Intelligenze System
This study will investigate the impact of using an automated fluid management system on intraoperative fluid therapy in patients undergoing colorectal surgery.
- Trial name
- SIMPLY (NCT07366164)
- Testing
- assisted fluid therapy
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke
Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD)
Endovascular thrombectomy (EVT) improves outcomes in acute ischemic stroke caused by large vessel occlusion. Despite successful recanalization, early neurological deterioration (END) remains frequent and is associated with poor…
- Conditions
- Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke, Acute Ischemic Stroke, Cardioembolic Stroke
- Trial name
- NCT07013396
- Testing
- Transcranial Doppler (TCD) examination
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Ovarian Cancer, Hemodynamic Instability
Proactive Hemodynamic Management During Cytoreductive Surgery and HIPEC
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a complex surgical procedure carried out through laparotomic approach.
- Conditions
- Ovarian Cancer, Hemodynamic Instability, Fluid Overload
- Trial name
- HEMOPEC (NCT07070973)
- Testing
- Assisted Fluid Management, Goal Directed Fluid Therapy (GDT)
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Neoplasm, Cancer
Using Artificial Intelligence to Guide Fluid Therapy During Major Cancer Surgery: A Randomized Controlled Trial
The goal of this clinical trial is to learn if using artificial intelligence to guide intravenous fluid therapy during major cancer surgery can help keep blood pressure more stable compared with usual care in adult patients…
- Conditions
- Neoplasm, Cancer, Hemodynamic (MAP) Stability, Cancer Surgery
- Trial name
- FOCUS-AFM (NCT07314853)
- Testing
- Artificial Intelligence-Assisted Fluid Management, Standard fluid management
- Where
- Italy
- Volunteers
- 176 people
- Sponsor
- National Cancer Institute, Naples
Postoperative Nausea and Vomiting, Hysterectomy
Effect of SmtO2 Guided Care on PONV (iMODIPONV)
This randomized controlled trial is to investigate if SmtO2-guided management on top of the usual care, compared with the usual care only, during laparoscopic hysterectomy significantly reduces the incidence of PONV.
- Conditions
- Postoperative Nausea and Vomiting, Hysterectomy, Tissue Oxygenation, Cardiac Output Management
- Trial name
- iMODIPONV (NCT03641625)
- Testing
- Muscular tissue oxygen saturation guided care
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Yale University
Acute Kidney Injury
Circulatory Management and Acute Kidney Injury in Patients Undergoing Partial Nephrectomy
The purpose of this study is to investigate whether circulatory management based on LiDCOrapid hemodynamic monitoring can reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy when compared with…
- Trial name
- NCT02803372
- Testing
- Goal-directed circulatory management, Routine circulatory management
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Peking University First Hospital