Perioperative CareIPAMSNCT06982001
ImPortance of Arterial Measurement Sites (IPAMS) on Intraoperative Hemodynamic Management
A study testing Brachial line guided hemodynamic management, Radial line guided hemodynamic management and Radial line catheterization in people with Perioperative Care and Hemodynamics, run by Ciusss de L'Est de l'Île de Montréal at 1 site in Canada.
Trial summary
The goal of this clinical trial is to demonstrate the importance of arterial pressure measurement sites during major abdominal surgeries. This randomized controlled trial will compare arterial pressure measurements obtained from radial artery catheterization (the current standard method of monitoring) with those… Read more about this study
- Who is it for?
- Ages 18 to 90 years
- Conditions the study is for
- Perioperative Care, Hemodynamics, Monitoring Blood Pressure
- What is being tested?
- Brachial line guided hemodynamic management, Radial line guided hemodynamic management and Radial line catheterization
- Type of treatment
- Medical device, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 204 participants
- Where
- 1 siteCanada
- Study dates
- Sep 2025to Dec 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 90 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients between 18 and 90 years of age;
- Major abdominal surgery via laparoscopy or laparotomy under general anesthesia - with or without concomitant use of regional or neuraxial anesthesia;
- Expected anesthesia time of more than 120 minutes.
Who cannot join
- Known peripheral severe vascular disease with subclavian artery stenosis,
- Significant arterial gradient between arms with preoperative non-invasive bloop pressure measurements (>25 mm Hg of systolic blood pressure or 10 mm Hg of mean arterial pressure);
- Inability or contraindications to insert arterial line on either arm (arteriovenous fistula, surgical sterility);
- Known allergies, intolerance, other medical conditions that precludes the use of prescribed general anesthesia protocol for this trial;
- Inability to communicate in French or English.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pascal Laferriere-Langlois, MD, MSc contact
Canada1 site
Maisonneuve-Rosemont Hospital
Montreal, Quebec, H1T2M4
Pascal Laferriere-Langlois, MD, MSc, +1-514-252-3400 ext. 3193, Pascal.laferriere-langlois@umontreal.com
Pascal Laferriere-Langlois, MD, MSc
About this study
Official title: Importance of Arterial Measurement Sites on Intraoperative Hemodynamic Management of Major Abdominal Surgeries and Artificial Intelligence-based Prediction of Arterial Gradient Using Peripheral Radial Pressure Waveform Analysis
The goal of this clinical trial is to demonstrate the importance of arterial pressure measurement sites during major abdominal surgeries. This randomized controlled trial will compare arterial pressure measurements obtained from radial artery catheterization (the current standard method of monitoring) with those obtained from brachial artery catheterization (a more accurate reflection of central arterial pressure). At the end of the study, we are looking to answer the following questions:
- Does arterial pressure measurement sites influence the amount of vasopressors that is administered during major abdominal surgeries?
- What are the instances where there is a difference between peripheral (radial catheter) and central (brachial catheter) monitoring and what are the risk factors leading to the appearance of this radial-brachial pressure gradient?
- With the data collected, can artificial intelligence based analysis help predict the reliability of a radial monitoring and help guide clinicians on choosing a peripheral versus central arterial pressure monitoring site? All adult participants who are scheduled for elective major abdominal surgeries and meeting our inclusion criteria will be approached and included if they consent. Participants will be randomized 1:1 in the intervention group and the standard of care group. In the intervention group, the brachial arterial line will be used intraoperatively to guide vasopressor and fluid administration. A radial line will also be installed to measure the radial arterial pressure simultaneously, but will not be used to guide hemodynamic management. In the standard of care group, both lines will be installed just like in the intervention group, however, it is the radial arterial line that will guide fluid and vasopressor administration. In both groups, the anesthesia protocol will be standardized and the anesthesiologist will be blinded to the arterial pressure measurement site.
- Conditions
- Perioperative Care, Hemodynamics, Monitoring Blood Pressure, Arterial Lines, Anesthesia, Vasopressor
- Being tested
- Brachial line guided hemodynamic management, Radial line guided hemodynamic management, Radial line catheterization, Brachial line catheterization
- Keywords
- Comparison of arterial catheterization sites on hemodynamic monitoring, Incidence of radial-brachial pressure gradient, Risk factors of radial-brachial pressure gradient, Effect of arterial catheterization sites on hemodynamic management, Effect of peripheral vs central arterial pressure measurements in intraoperative hemodynamic management
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Brachial line guided hemodynamic managementBehavioural
Anesthesiologists in charge of the patients will guide their hemodynamic management based on the monitoring of brachial/humeral arterial line, instead of the most frequently used radial line.
Radial line guided hemodynamic managementBehavioural
The anesthesiologist will guide their hemodynamic management on the classically used radial arterial line.
Radial line catheterizationDevice
An arterial line will be inserted in the radial artery of the patient.
Brachial line catheterizationDevice
An arterial line will be inserted in the brachial artery of the patient.
| Study group | Role | What they receive |
|---|---|---|
| Brachial artery-guided interventions | Experimental | In this experimental group, hemodynamic management will be guided by using the brachial arterial line. Both a radial and a brachial line will be inserted for simultaneous monitoring, but the anesthesiologist will only see the brachial arterial line and will guide his drug administration and hemodynamic management on the brachial measurements. Receives: Behavioral: Brachial line guided hemodynamic management; Device: Radial line catheterization; Device: Brachial line catheterization |
| Radial artery-guided interventions | Active comparator | In this group, hemodynamic management will be guided by using the radial arterial line. Both a radial and a brachial line will be inserted for simultaneous monitoring, but the anesthesiologist will only see the radial arterial line and will guide his drug administration and hemodynamic management on the brachial measurements. Receives: Behavioral: Radial line guided hemodynamic management; Device: Radial line catheterization; Device: Brachial line catheterization |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time-weighted average administration of noradrenaline
The administration of norepinephrine will be continuously monitored during the surgery, and the time-weighted dose per kilograms will be extracted between the surgical incision and the last skin suture.
Measured: Intraoperative administration
Secondary outcomes (12)
Total amount of noradrenaline administered
Total dose of norephinephrine from skin incision to skin suture.
Measured: Intraoperative administration
Total time of hypotension
Total time and time weighted spent below the inferior threshold (baseline MAP-20%), measured independently by the radial line and the brachial line.
Measured: Intraoperative
Occurrence and depth of radial-to-brachial gradient
The depth-weighted time spent with a pressure gradient between the radial and brachial arterial pressures
Measured: Intraoperative
Dose of other inotropes and vasopressors
Any administration of vasopressor or inotropes, other than the noradrenaline measured in the primary outcome. Total dose and time weighted if perfused.
Measured: Intraoperative administration
Fluid balance
Total and time weighted fluid administered intraoperatively (volume and nature)
Measured: Intraoperative administration
Urine output
Total and time weighted output of urine, measured every hour
Measured: Intraoperative
Total consumption of opioids
Total and time weighted dose of opioids (remifentanil) administered intraoperatively
Measured: Intraoperative
Total consumption of hypnotic drug
Total and time-weighted dose of hypnotic drug administered.
Measured: Intraoperative
Cumulative duration of burst suppression and low BIS values
Total, time weighted and importance weighted duration of BIS value below 40, and total and time-weighted duration of burst suppression (suppression time).
Measured: Intraoperative
Troponin and Creatinine lab measurements
Value of troponin and creatinine of the patient
Measured: Post-anesthesia care unit and post-operative day 1,3 and 7
Clavien-Dindo Score
A validated score evaluating the occurence of post-operative complications.
Measured: Post-operative day 1,3 and 7
Composite occurence of postoperative complications
Composite outcome comprising the occurrence of myocardial injury after non-cardiac surgery (MINS), stroke, arrythmia, and death.
Measured: Post-operative day 1,3 and 7
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 May 2025
- Study startSep 2025 (estimated)
- Primary completionSep 2028 (estimated)
- Study completionDec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Perioperative CareStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Outcomes assessor
- Enrolment
- 204 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ciusss de L'Est de l'Île de Montréal
- Sponsor type
- University, hospital or other
- Collaborators
- Fondation Anesthesiologistes du Quebec, Fonds de la Recherche en Santé du Québec
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06982001
- Sponsor's protocol ID
- 2023-3299
- Acronym
- IPAMS
- Status last verified
- Oct 2024
- First submitted
- 13 May 2025
- Last updated
- 21 May 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: IPD might not be shared depending on the ethical consideration of sharing the information. We are currently working on a central database for perioperative research data collected at our institution, which will structure all IPD. Depending on the advancement of this initiative, we might enable IPD.
Publications
Wijnberge M, Geerts BF, Hol L, Lemmers N, Mulder MP, Berge P, Schenk J, Terwindt LE, Hollmann MW, Vlaar AP, Veelo DP. Effect of a Machine Learning-Derived Early Warning System for Intraoperative Hypotension vs Standard Care on Depth and Duration of Intraoperative Hypotension During Elective Noncardiac Surgery: The HYPE Randomized Clinical Trial. JAMA. 2020 Mar 17;323(11):1052-1060. doi: 10.1001/jama.2020.0592.
PubMed 32065827Futier E, Lefrant JY, Guinot PG, Godet T, Lorne E, Cuvillon P, Bertran S, Leone M, Pastene B, Piriou V, Molliex S, Albanese J, Julia JM, Tavernier B, Imhoff E, Bazin JE, Constantin JM, Pereira B, Jaber S; INPRESS Study Group. Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery: A Randomized Clinical Trial. JAMA. 2017 Oct 10;318(14):1346-1357. doi: 10.1001/jama.2017.14172.
PubMed 28973220Galluccio ST, Chapman MJ, Finnis ME. Femoral-radial arterial pressure gradients in critically ill patients. Crit Care Resusc. 2009 Mar;11(1):34-8.
PubMed 19281442Ahuja S, Mascha EJ, Yang D, Maheshwari K, Cohen B, Khanna AK, Ruetzler K, Turan A, Sessler DI. Associations of Intraoperative Radial Arterial Systolic, Diastolic, Mean, and Pulse Pressures with Myocardial and Acute Kidney Injury after Noncardiac Surgery: A Retrospective Cohort Analysis. Anesthesiology. 2020 Feb;132(2):291-306. doi: 10.1097/ALN.0000000000003048.
PubMed 31939844Renaud-Roy E, Stockle PA, Maximos S, Brulotte V, Sideris L, Dube P, Drolet P, Tanoubi I, Issa R, Verdonck O, Fortier LP, Richebe P. Correlation between incremental remifentanil doses and the Nociception Level (NOL) index response after intraoperative noxious stimuli. Can J Anaesth. 2019 Sep;66(9):1049-1061. doi: 10.1007/s12630-019-01372-1. Epub 2019 Apr 17.
PubMed 30997633Tang Y, Zhu C, Liu J, Wang A, Duan K, Li B, Yuan H, Zhang H, Yao M, Ouyang W. Association of Intraoperative Hypotension with Acute Kidney Injury after Noncardiac Surgery in Patients Younger than 60 Years Old. Kidney Blood Press Res. 2019;44(2):211-221. doi: 10.1159/000498990. Epub 2019 Mar 29.
PubMed 30928979
Study at a glance
From the registry record, last updated by the sponsor on 21 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Importance of Arterial Measurement Sites on Intraoperative Hemodynamic Management of Major Abdominal Surgeries and Artificial Intelligence-based Prediction of Arterial Gradient Using Peripheral Radial Pressure Waveform Analysis
- ClinicalTrials.gov ID
- NCT06982001
- Acronym / sponsor ID
- IPAMS / 2023-3299
- Conditions
- Perioperative Care, Hemodynamics, Monitoring Blood Pressure, Arterial Lines, Anesthesia, Vasopressor
- Keywords
- Comparison of arterial catheterization sites on hemodynamic monitoring, Incidence of radial-brachial pressure gradient, Risk factors of radial-brachial pressure gradient, Effect of arterial catheterization sites on hemodynamic management, Effect of peripheral vs central arterial pressure measurements in intraoperative hemodynamic management
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 204 participants (estimated)
- Lead sponsor
- Ciusss de L'Est de l'Île de MontréalUniversity, hospital or other
- Collaborators
- Fondation Anesthesiologistes du Quebec, Fonds de la Recherche en Santé du Québec
- Study start
- Sep 2025 (estimated)
- Primary completion
- Sep 2028 (estimated)
- Study completion
- Dec 2028 (estimated)
- First posted
- 21 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to demonstrate the importance of arterial pressure measurement sites during major abdominal surgeries. This randomized controlled trial will compare arterial pressure measurements obtained from radial artery catheterization (the current standard method of monitoring) with those obtained from brachial artery catheterization (a more accurate reflection of central arterial pressure). At the end of the study, we are looking to answer the following questions:
- Does arterial pressure measurement sites influence the amount of vasopressors that is administered during major abdominal surgeries?
- What are the instances where there is a difference between peripheral (radial catheter) and central (brachial catheter) monitoring and what are the risk factors leading to the appearance of this radial-brachial pressure gradient?
- With the data collected, can artificial intelligence based analysis help predict the reliability of a radial monitoring and help guide clinicians on choosing a peripheral versus central arterial pressure monitoring site? All adult participants who are scheduled for elective major abdominal surgeries and meeting our inclusion criteria will be approached and included if they consent. Participants will be randomized 1:1 in the intervention group and the standard of care group. In the intervention group, the brachial arterial line will be used intraoperatively to guide vasopressor and fluid administration. A radial line will also be installed to measure the radial arterial pressure simultaneously, but will not be used to guide hemodynamic management. In the standard of care group, both lines will be installed just like in the intervention group, however, it is the radial arterial line that will guide fluid and vasopressor administration. In both groups, the anesthesia protocol will be standardized and the anesthesiologist will be blinded to the arterial pressure measurement site.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Brachial artery-guided interventions | Experimental | Behavioral: Brachial line guided hemodynamic management, Device: Radial line catheterization, Device: Brachial line catheterizationIn this experimental group, hemodynamic management will be guided by using the brachial arterial line. Both a radial and a brachial line will be inserted for simultaneous monitoring, but the anesthesiologist will only see the brachial arterial line and will guide his drug administration and hemodynamic management on the brachial measurements. |
| Radial artery-guided interventions | Active comparator | Behavioral: Radial line guided hemodynamic management, Device: Radial line catheterization, Device: Brachial line catheterizationIn this group, hemodynamic management will be guided by using the radial arterial line. Both a radial and a brachial line will be inserted for simultaneous monitoring, but the anesthesiologist will only see the radial arterial line and will guide his drug administration and hemodynamic management on the brachial measurements. |
Who may qualify
- Ages
- 18 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Patients between 18 and 90 years of age;
- Major abdominal surgery via laparoscopy or laparotomy under general anesthesia - with or without concomitant use of regional or neuraxial anesthesia;
- Expected anesthesia time of more than 120 minutes.
Key exclusion criteria (5 listed)
- Known peripheral severe vascular disease with subclavian artery stenosis,
- Significant arterial gradient between arms with preoperative non-invasive bloop pressure measurements (>25 mm Hg of systolic blood pressure or 10 mm Hg of mean arterial pressure);
- Inability or contraindications to insert arterial line on either arm (arteriovenous fistula, surgical sterility);
- Known allergies, intolerance, other medical conditions that precludes the use of prescribed general anesthesia protocol for this trial;
- Inability to communicate in French or English.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Brachial line guided hemodynamic managementAnesthesiologists in charge of the patients will guide their hemodynamic management based on the monitoring of brachial/humeral arterial line, instead of the most frequently used radial line. | Behavioural | Brachial artery-guided interventions |
| Radial line guided hemodynamic managementThe anesthesiologist will guide their hemodynamic management on the classically used radial arterial line. | Behavioural | Radial artery-guided interventions |
| Radial line catheterizationAn arterial line will be inserted in the radial artery of the patient. | Device | Brachial artery-guided interventions, Radial artery-guided interventions |
| Brachial line catheterizationAn arterial line will be inserted in the brachial artery of the patient. | Device | Brachial artery-guided interventions, Radial artery-guided interventions |
Primary outcome
Time-weighted average administration of noradrenaline
Time frame: Intraoperative administration
The administration of norepinephrine will be continuously monitored during the surgery, and the time-weighted dose per kilograms will be extracted between the surgical incision and the last skin suture.
12 secondary outcomes
Total amount of noradrenaline administered
Time frame: Intraoperative administration
Total time of hypotension
Time frame: Intraoperative
Occurrence and depth of radial-to-brachial gradient
Time frame: Intraoperative
Dose of other inotropes and vasopressors
Time frame: Intraoperative administration
Fluid balance
Time frame: Intraoperative administration
Urine output
Time frame: Intraoperative
Total consumption of opioids
Time frame: Intraoperative
Total consumption of hypnotic drug
Time frame: Intraoperative
Cumulative duration of burst suppression and low BIS values
Time frame: Intraoperative
Troponin and Creatinine lab measurements
Time frame: Post-anesthesia care unit and post-operative day 1,3 and 7
Clavien-Dindo Score
Time frame: Post-operative day 1,3 and 7
Composite occurence of postoperative complications
Time frame: Post-operative day 1,3 and 7
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 May 2025.
- Background: PubMed 32065827Wijnberge M, Geerts BF, Hol L, Lemmers N, Mulder MP, Berge P, Schenk J, Terwindt LE, Hollmann MW, Vlaar AP, Veelo DP. Effect of a Machine Learning-Derived Early Warning System for Intraoperative Hypotension vs Standard Care on Depth and Duration of Intraoperative Hypotension During Elective Noncardiac Surgery: The HYPE Randomized Clinical Trial. JAMA. 2020 Mar 17;323(11):1052-1060. doi: 10.1001/jama.2020.0592.
- Background: PubMed 28973220Futier E, Lefrant JY, Guinot PG, Godet T, Lorne E, Cuvillon P, Bertran S, Leone M, Pastene B, Piriou V, Molliex S, Albanese J, Julia JM, Tavernier B, Imhoff E, Bazin JE, Constantin JM, Pereira B, Jaber S; INPRESS Study Group. Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery: A Randomized Clinical Trial. JAMA. 2017 Oct 10;318(14):1346-1357. doi: 10.1001/jama.2017.14172.
- Background: PubMed 19281442Galluccio ST, Chapman MJ, Finnis ME. Femoral-radial arterial pressure gradients in critically ill patients. Crit Care Resusc. 2009 Mar;11(1):34-8.
- Background: PubMed 31939844Ahuja S, Mascha EJ, Yang D, Maheshwari K, Cohen B, Khanna AK, Ruetzler K, Turan A, Sessler DI. Associations of Intraoperative Radial Arterial Systolic, Diastolic, Mean, and Pulse Pressures with Myocardial and Acute Kidney Injury after Noncardiac Surgery: A Retrospective Cohort Analysis. Anesthesiology. 2020 Feb;132(2):291-306. doi: 10.1097/ALN.0000000000003048.
- Background: PubMed 30997633Renaud-Roy E, Stockle PA, Maximos S, Brulotte V, Sideris L, Dube P, Drolet P, Tanoubi I, Issa R, Verdonck O, Fortier LP, Richebe P. Correlation between incremental remifentanil doses and the Nociception Level (NOL) index response after intraoperative noxious stimuli. Can J Anaesth. 2019 Sep;66(9):1049-1061. doi: 10.1007/s12630-019-01372-1. Epub 2019 Apr 17.
- Background: PubMed 30928979Tang Y, Zhu C, Liu J, Wang A, Duan K, Li B, Yuan H, Zhang H, Yao M, Ouyang W. Association of Intraoperative Hypotension with Acute Kidney Injury after Noncardiac Surgery in Patients Younger than 60 Years Old. Kidney Blood Press Res. 2019;44(2):211-221. doi: 10.1159/000498990. Epub 2019 Mar 29.
- Individual participant dataSharing planned: Undecided. IPD might not be shared depending on the ethical consideration of sharing the information. We are currently working on a central database for perioperative research data collected at our institution, which will structure all IPD. Depending on the advancement of this initiative, we might enable IPD.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Pascal Laferriere-Langlois, MD, MSc contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Brachial line guided hemodynamic management, Radial line guided hemodynamic management and Radial line catheterization in people with Perioperative Care and Hemodynamics, run by Ciusss de L'Est de l'Île de Montréal at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 21 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Pascal Laferriere-Langlois, MD, MSc (+1-514-252-3400 ext. 3193, Pascal.laferriere-langlois@umontreal.ca), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time-weighted average administration of noradrenaline (time frame: Intraoperative administration). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06982001, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 May 2025.