Clinical trials: Healthy Participants, active
Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
Background: This study is designed to provide samples to help us study the genes your blood cells are making as well as the proteins, sugars, fats, vitamins and other metabolites found in your blood or urine.
- Conditions
- Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States, Healthy Volunteers
- Trial name
- NCT03253705
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthy Volunteer Samples
Connors Protocol for the Management and Use of Stored Human Specimens (Stored Human Specimens)
Background: The HIV research program is part of the National Institute of Allergy and Infectious Diseases. The program aims to learn more about HIV. It also aims to improve the health of people with HIV and create HIV vaccines.
- Trial name
- NCT03895645
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Volunteer, Muscular Atrophy, Spinal
A Study to Learn About the Safety of BIIB115 Injections and How BIIB115 is Processed in the Bodies of Healthy Adult Male Volunteers and of Pediatric Participants With Spinal Muscular Atrophy Who Previously Took Onasemnogene Abeparvovec
In this study, researchers will learn about a study drug called BIIB115 in healthy adult male volunteers and in participants with spinal muscular atrophy (SMA). This study will focus on children with SMA.
- Trial name
- NCT05575011
- Testing
- BIIB115
- Where
- 16 sites in Belgium, Canada and 7 more
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Biogen
Healthy
Establishment of Biobank of Nasal Epithelium Samples From Healthy Volunteers
Background: Infections in the lower respiratory tract (lungs) are the leading cause of death from infectious disease worldwide. This was true even before the COVID-19 pandemic. Respiratory viruses are still a major health threat.
- Trial name
- NCT06120244
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Volunteer
Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial
Background: As people age, the cells in the pancreas that produce insulin begin to release less of this hormone, and levels of blood glucose (sugar) rise. This can lead to illnesses such as diabetes.
- Trial name
- NCT06274749
- Testing
- Urolithin A
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- National Institute on Aging (NIA)
Healthy Volunteer, Obestity
Assessing the Impact of Perceptions of Unpredictability on Objective Measures of Food Consumption and Metabolism
Background: Many people in the United States are overweight or obese. This natural history study will look into how life events during childhood can impact eating behaviors and weight gain as adults.
- Trial name
- NCT06690294
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cerebral Palsy Children, Healthy Adults
Evaluating the Effects of an Electrical Stimulator on Improving the Walking Ability of Children With Cerebral Palsy
The goal of this study is to see if gentle electrical stimulation can help children with cerebral palsy (CP) walk more easily. This stimulation, called neuromuscular electrical stimulation (NMES), sends small pulses to muscles to…
- Trial name
- CP (NCT06811545)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Healthy Volunteers
Phase I Trial of High-Density Theta Burst Stimulation (hdTBS)
Background: Transcranial magnetic stimulation (TMS) uses magnetic pulses to affect brain activity. A type of TMS called theta burst stimulation (TBS) is approved to treat people with major depression.
- Trial name
- NCT06868914
- Testing
- TMS (MagVenture MagPro 100 with MagOption)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy Volunteers, Attentional Capture
Attentional Capture by Real-life Episodic Information
Attention facilitates the allocation of processing resources and the control of behavior among competing stimuli. Current research focuses primarily on attention control networks in the dorsal frontoparietal (DAN) and ventral…
- Trial name
- EPICAPTURE (NCT06934902)
- Testing
- Old vs new objects" encoding phase and fMRI, " incongruent vs. congruent contexts " encoding phase and fMRI
- Where
- France
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Healthy
A Study of V118E in Healthy Participants (V118E-003)
Researchers are looking for new vaccines to prevent illnesses caused by a type of bacteria called Streptococcus pneumoniae. There are many different types of Streptococcus pneumoniae bacteria, called serotypes.
- Trial name
- NCT07168915
- Testing
- V118E, PREVNAR 20™, Saline
- Where
- 4 sites in United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer s Disease, Mild Cognitive Impairment
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
Background: About 5 million adults in the United States have age-related brain disorders. These include Alzheimer disease (AD), mild cognitive impairment (MCI), and other dementias.
- Conditions
- Alzheimer s Disease, Mild Cognitive Impairment, Healthy
- Trial name
- NCT07169630
- Testing
- 18F-PF974, 18F-florbetaben
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Nephrotic Syndrome, Lipodystrophy
Effects of Meal Macronutrients on Postprandial Lipids
Background: Abnormal fats in the blood can lead to many problems, including heart disease. Researchers want to learn more about how eating meals with different levels of nutrients affects fats in the blood.
- Conditions
- Nephrotic Syndrome, Lipodystrophy, Metabolic Syndrome, Healthy Volunteer
- Trial name
- NCT07313787
- Testing
- High carb then high fat breakfast, High fat then high carb breakfast
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy Participants
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Food Effect of JZP047 in Healthy Participants
This is a Phase 1, double-blind, sponsor-unblinded, randomized, placebo-controlled study designed to characterize the safety, tolerability, and PK of JZP047 in healthy participants following single-ascending doses of study…
- Trial name
- NCT07377539
- Testing
- JZP047
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Jazz Pharmaceuticals
Healthy Volunteers
Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers
Background: Opioid drugs are often prescribed for acute and chronic pain. But these drugs are addictive, and they lead to more than 14,000 overdose deaths in the United States each year.
- Trial name
- NCT07504601
- Testing
- (2R,6R)-Hydroxynorketamine
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Healthy Adult
Modulation of Appetite Signaling Through Enterohormone Stimulation by DNF-10
This is a pilot, proof-of-concept, exploratory, randomized, double-blind, placebo-controlled crossover study. The study will be conducted in 50 healthy volunteers with a body mass index (BMI) between 18.5 and 29.9 kg/m².
- Trial name
- DNF10-APET (NCT07621393)
- Testing
- DNF-10: 500 mg/day
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fytexia
Healthy Volunteer
Discovering Determinants of Food Intake by Application of Artificial Intelligence to Complex, High-Dimensional Data
Background: Many people in the United States are overweight or obese. Researchers want to learn why some people can overeat and not gain weight, whereas others who do not overeat still gain weight.
- Trial name
- NCT07637656
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy Subjects (HS), Exercise
Methodological Study of Exercise and Hypoxic Conditions in Healthy Subjects
The aim of this protocol is to assess physiological responses during various physical exercise protocols (whole-body exercise such as cycling or treadmill running, or localised exercise such as knee extension) and during…
- Conditions
- Healthy Subjects (HS), Exercise, Hypoxia
- Trial name
- ExHyp (NCT07671638)
- Testing
- Exercise and hypoxia
- Where
- France
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Healthy Volunteers
Survey to Determine Incarcerated Persons' Views on Surrogate Decision Making
Background: About 180,000 of the people in US prisons are over 55 years old. Aging people often cannot make medical decisions on their own.
- Trial name
- NCT07751731
- Testing
- Survey
- Where
- United States
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthy Volunteer
Visual Attention, Object Recognition, and Eye Movements in Healthy Volunteers
Background: Vision is vital for many of our daily activities. Researchers want to learn more about how we aim our eyes (that is, what images, such as faces, immediately attract our attention) and how we direct our attention (that…
- Trial name
- NCT07756853
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Eye Institute (NEI)
Healthy Volunteers
Dynamic Magnetic Resonance Imaging of Human Subarachnoid Space Using Intrathecal Gadolinium Contrast
Background: Cerebrospinal fluid (CSF) is the liquid that fills the space around the brain and spinal cord. Researchers do not fully understand how CSF flows and drains around the brain.
- Trial name
- NCT07796360
- Testing
- Gadobutrol
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)