Healthy Subjects (HS)ExHypNCT07671638
Methodological Study of Exercise and Hypoxic Conditions in Healthy Subjects
A study testing Exercise and hypoxia in people with Healthy Subjects (HS) and Exercise, run by University Hospital, Grenoble at 1 site in France.
Trial summary
The aim of this protocol is to assess physiological responses during various physical exercise protocols (whole-body exercise such as cycling or treadmill running, or localised exercise such as knee extension) and during inhalation of a gas mixtures with various oxygen contents (similar to exposure at high altitude). Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Subjects (HS), Exercise, Hypoxia
- What is being tested?
- Exercise and hypoxia
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 305 participants
- Where
- 1 siteFrance
- Study dates
- 19 Oct 2026to 31 Mar 2032
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy male or female volunteers
- Aged 18-55
- Body Mass Index <30 kg/m²
- Participants covered by a social security scheme
- Participants capable of signing an informed consent form
- Negative pregnancy test and highly effective contraception for women of childbearing age
Who cannot join
- Cardiorespiratory, metabolic and neurological disorders, or other conditions assessed during the inclusion consultation that may affect physiological responses to exercise or hypoxia
- Pharmacological treatment taken during the study, other than oral or implantable contraceptive medication for female volunteers of childbearing age
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
CReSI (centre de recherche en santé intégrée)
La Tronche, 38700
Samuel VERGES, +33456589900, SVerges@chu-grenoble.fr
About this study
The aim of this protocol is to assess physiological responses during various physical exercise protocols (whole-body exercise such as cycling or treadmill running, or localised exercise such as knee extension) and during inhalation of a gas mixtures with various oxygen contents (similar to exposure at high altitude).
- Conditions
- Healthy Subjects (HS), Exercise, Hypoxia
- Being tested
- Exercise and hypoxia
- Medical subject headings
- Motor Activity, Hypoxia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exercise and hypoxiaCombination product
Subjects will perform an exercise test while inhaling a hypoxic gas mixture
| Study group | Role | What they receive |
|---|---|---|
| Exercise and hypoxia | Experimental | Exercise test performed while inhaling a gas mixture Receives: Combination Product: Exercise and hypoxia |
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle oxygenation
Measured by NIRS in % saturation
Measured: During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test
Secondary outcomes (3)
Gas exchange
Oxygen consumption and cardon dioxide production measured at the mouth, measured in ml/min
Measured: During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test
Heart rate
Measured by ECG in bpm
Measured: During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test
Limb blood flow
Measured by Doppler ultrasound in ml/min
Measured: During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jun 2026
- Study start19 Oct 2026
- Primary completion15 Oct 2031 (estimated)
- Study completion31 Mar 2032 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Healthy Subjects (HS)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 305 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Grenoble
- Sponsor type
- University, hospital or other
- Collaborators
- University Grenoble Alps
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07671638
- Sponsor's protocol ID
- ExHyp
- Acronym
- ExHyp
- Status last verified
- Oct 2026
- First submitted
- 26 May 2026
- Last updated
- 23 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Mazzeo RS. Physiological responses to exercise at altitude : an update. Sports Med. 2008;38(1):1-8. doi: 10.2165/00007256-200838010-00001.
PubMed 18081363Hansford HJ, Wewege MA, Cashin AG, Hagstrom AD, Clifford BK, McAuley JH, Jones MD. If exercise is medicine, why don't we know the dose? An overview of systematic reviews assessing reporting quality of exercise interventions in health and disease. Br J Sports Med. 2022 Jun;56(12):692-700. doi: 10.1136/bjsports-2021-104977. Epub 2022 Feb 15.
PubMed 35168956