Clinical trials: Heal Wound
Wound Heal
Amnion Membrane Powder Mohs Study
The purpose of this research study is to test the safety of the amnion membrane powder to see if it improves wound healing in patients undergoing Mohs surgery on the scalp.
- Trial name
- NCT07680023
- Testing
- Amnion Membrane Powder, Standard of Care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Wound Heal, Ulcer
IDEAL: Efficacy of Porcine Placental Extracellular Matrix Augmented Plus Standard of Care (SOC) Versus SOC Alone for the Management of Diabetic Foot Ulcers
A multi-center, prospective, observer-blinded, randomized controlled clinical trial to evaluate the efficacy of PPECM augmented standard of care versus standard of care alone in the management of hard-to-heal diabetic foot ulcers.
- Trial name
- IDEAL (NCT06616844)
- Testing
- InnovaMatrix® AC
- Where
- 21 sites in United States
- Volunteers
- 235 people
- Sponsor
- ConvaTec Inc.
Pyoderma Gangrenosum, Skin Diseases
Guselkumab in the Treatment of Adults With Pyoderma Gangrenosum (PG)
A single-arm open-label study assessing short-term (week 6, 16) and long-term (week 32) efficacy of guselkumab in adult participants with pyoderma gangrenosum (PG)
- Conditions
- Pyoderma Gangrenosum, Skin Diseases, Wound Heal, Pyoderma
- Trial name
- GEORGE (NCT06563323)
- Testing
- Guselkumab
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Oregon Health and Science University
Recession, Gingival, Surgical Procedure, Unspecified
Alternative Gingival De-Epithelialization Techniques
The goal of this clinical trial is to compare different de-epithelialization methods in patients undergoing soft tissue augmentation surgery.
- Conditions
- Recession, Gingival, Surgical Procedure, Unspecified, Graft Complication, Wound Heal
- Trial name
- NCT05947305
- Testing
- Surgical Blade, Mucotome, Diamond Bur
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Negative-Pressure Wound Therapy, Wound Heal
Compare Stoma Reversal Wound Outcomes Between NPWT and Secondary Intention Healing
This was a single-center, parallel-group randomized controlled trial conducted in 2025 at the General Surgery Ward of the Sindh Institute of Urology and Transplantation (SIUT), Karachi.
- Conditions
- Negative-Pressure Wound Therapy, Wound Heal, Stoma Site Infection, Surgical Site Infection
- Trial name
- NCT07258134
- Testing
- Negative Pressure Wound Therapy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Maryam Arbab
Hard-to-heal Wounds, Diabetic Foot Ulcer
Clinical Investigation of Sorbact® Dressings
The main purpose of this exploratory clinical investigation is to study the binding of bacteria and fungi from hard-to-heal wounds to the DACC-coated dressings.
- Conditions
- Hard-to-heal Wounds, Diabetic Foot Ulcer, Venous Leg Ulcer, Pressure Ulcer
- Trial name
- NCT05089890
- Testing
- Sorbact® Compress, Sorbact® Gel Dressing, Sorbact® Ribbon Gauze
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- ABIGO Medical AB
Wound Heal
Dermabrasion in Mohs: Split-Scar Trial
The purpose of this study is to determine the potential influence of intraoperative dermabrasion on scars following Mohs Micrographic Surgery (MMS).
- Trial name
- NCT07213921
- Testing
- Dermabrasion
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Surgical Wound, Wound Heal
Influence of Sun Protection and Linear Repair of Cutaneous Surgical Defects
The purpose of this study is to determine the potential influence of sun protection on the aesthetic outcome of post-surgical scars following the reconstruction of Mohs micrographic surgery defects via linear repair.
- Conditions
- Surgical Wound, Wound Heal, Wound of Skin, Scar
- Trial name
- NCT05074238
- Testing
- Zinc containing suncreen
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Davis
Diabetic Foot Disease, Diabetic Foot Infection
Effect of a Coordinated Primary-care-Based MDT-model on the Treatment of Hard-to-heal Ulcers
The TSS project is a study of the effects of treating hard-to-heal ulcers in a multidisciplinary cross sectional team, meaning that nurse and doctor from a hospital based wound healing clinic and wound care nurse from the primary…
- Conditions
- Diabetic Foot Disease, Diabetic Foot Infection, Diabetic Foot Ulcer (DFU), Ulcer
- Trial name
- TSS (NCT07747896)
- Testing
- coordinated primary-care-based MDT-model, Standard Care (in control arm)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Nordsjaellands Hospital
Wound Heal
Vacuum Sealing Drainage (VSD) in Promoting Wound Healing and Reducing Complications in Post-Infected Obstetric and Gynecological Surgical Sites
This study aims to evaluate the efficacy of VSD in promoting wound healing and reducing complications, such as re-infection, prolonged hospitalization, and need for further surgical interventions, in obstetric and gynecological…
- Trial name
- NCT07525674
- Testing
- Conventional Wound Care Group, Vacuum Sealing Drainage (VSD) Group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Wound Heal
Management and Short Term Outcome of Traumatic Wounds in the Emergency Department
Identify the risk factors for complications as well as study the evolution of wounds sutured in the emergency room towards complications such as superinfections, necrosis, disunity of the stitches linked to inadequate initial…
- Trial name
- SUTURES (NCT05510362)
- Where
- Tunisia
- Volunteers
- 3,000 people
- Sponsor
- University of Monastir
Diabetic Foot, Diabetic Foot Ulcer
Feasibility and Effectiveness of a Remote Monitoring Program for the Treatment of Diabetic Foot Ulcers
The feasibility phase of the study was conducted to assess the feasibility of a novel, patient-centered, remote wound management system.
- Conditions
- Diabetic Foot, Diabetic Foot Ulcer, Wound; Foot, Wound Leg
- Trial name
- NCT05579743
- Testing
- Remote wound monitoring technology
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Johns Hopkins University
Periodontal Diseases, Wound Heal
Hyaluronic Acid and Polynucleotides for Supra-bony Defects
The goal of this pilot study is to describe the early wound healing molecular events and the vascularization pattern associated with the treatment of supra-bony defects with access flap alone or in association with a combined…
- Conditions
- Periodontal Diseases, Wound Heal, Periodontal Inflammation, Periodontal Pocket
- Trial name
- NCT06309719
- Testing
- Periodontal Access Flap (AF) + Combined Formulation of Hyaluronic acid and Polydeoxyribonucleotides (PNHA), Periodontal Access Flap (AF)
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- Queen Mary University of London
Negative-Pressure Wound Therapy, Amputation
The Effect of Negative Pressure Wound Therapy on Wound Healing in Major Amputations of the Lower Limb
The socioeconomic costs of problematic and delayed wound healing following lower limb amputations are enormous to the society. Lower limb amputations is one of the longest known surgical treatments, but also one of the least…
- Conditions
- Negative-Pressure Wound Therapy, Amputation, Wound Heal
- Trial name
- NCT04618406
- Testing
- PICO VAC, Standard care
- Where
- Denmark
- Volunteers
- 158 people
- Sponsor
- University of Southern Denmark
Wound of Skin, Wound Heal
Efficacy and Safety of 0.25% Timolol Gel in Enhancing Full Thickness Skin Grafts Healing and Cosmetic Outcomes
The use of topical beta-blockers, such as 0.25% timolol, in promoting wound healing is currently emerging in the academic literature.
- Conditions
- Wound of Skin, Wound Heal, Surgical Wound, Full Thickness Skin Graft Healing
- Trial name
- FTSG (NCT03579160)
- Testing
- 0.25% timolol gel with full-thickness skin grafts, Vaseline dressing
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Wound Heal, Wound of Skin
Aesthetic Outcome of Complex Linear Closure vs Second Intention Healing: Below the Knee
The purpose of this study is to determine whether complex linear closure vs second intention healing for cutaneous wounds below the knee affects esthetic outcomes (primary outcome).
- Trial name
- NCT05074212
- Testing
- Factorial Assignment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, Davis
Wound Heal
Safety of Microporous Annealed Particle (MAP) Wound Matrix in Patients With Clean Surgical Wounds.
A randomized, open-label, investigational safety evaluation of the Microporous Annealed Particle (MAP) Wound Matrix (TT101) device as a volumetric biomaterial scaffold applied to clean wounds after skin cancer surgery with Mohs…
- Trial name
- MOSAIC (NCT06600152)
- Testing
- MAP Wound Matrix, DuoDerm
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Tempo Therapeutics
Hard-to-heal Wounds, AI (Artificial Intelligence)
AI-Based Wound Monitoring: Automated Wound Progression Assessment Via Marker-Free Image Sequence
This study aims to develop a low-cost, marker-free intelligent wound assessment system that can analyze wound photos taken with a standard smartphone.
- Conditions
- Hard-to-heal Wounds, AI (Artificial Intelligence), Wound Care, Pressure Injuries
- Trial name
- NCT07619430
- Testing
- Marker-free wound image registration technology
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- National Taiwan University Hospital
Wound of Skin, Wound Heal
Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds
The use of topical beta-blockers, such as 0.25% timolol, in promoting wound healing is currently emerging in the academic literature.
- Conditions
- Wound of Skin, Wound Heal, Wound Open, Surgical Wound
- Trial name
- NCT03452072
- Testing
- 0.25% Timolol gel with paraffin gauze dressings, Vaseline dressing
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Fracture of Tibia, Wound Heal
Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures
This is a multi-center, pragmatic, parallel arm randomized controlled trial (RCT) of 352 patients with high-risk open or closed tibial plateau fracture, high-risk open or closed tibial pilon fracture, or open tibial shaft…
- Conditions
- Fracture of Tibia, Wound Heal, Infected Wound, Wound Complication
- Trial name
- iVAC (NCT06337292)
- Testing
- Incisional Negative Pressure Wound Therapy (NPWT)
- Where
- 6 sites in United States
- Volunteers
- 352 people
- Sponsor
- Major Extremity Trauma Research Consortium