Clinical trials: Guidelines
Depression
Cluster Randomized Trial of Stepped Care Intervention vs. Treatment as Usual for Patients With Depression
The main aim of the project is the implementation and evaluation of a stepped care model (SCM) for patients with depression with 6 treatment options of varying intensity and setting, including innovative technologies (e-mental…
- Trial name
- SCM (NCT01731717)
- Testing
- Active monitoring, Bibliotherapy, Online self-help
- Where
- Germany
- Volunteers
- 737 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Guidelines, Diabetes Mellitus Type 2
Adherence to Clinical Guidelines for Management of Patients With Type 2 Diabetes Mellitus and Obesity
Observational study in physicians regarding their adherence to clinical guidelines (by American Diabetes Association 2025) for the management of type 2 diabetes mellitus and obesity via questionnaire
- Conditions
- Guidelines, Diabetes Mellitus Type 2, Obesity Type 2 Diabetes Mellitus, Obesity (BMI > 35) and Diabetes Mellitus
- Trial name
- NCT07839546
- Testing
- Questionnaire regarding the adherence to American Diabetes Association
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Heart Failure, Acute Myocardial Infarction (AMI)
Efficacy and Safety of Early Initiation of Vericiguat in Heart Failure After Acute Myocardial Infarction
Heart failure (HF) is a severe cardiovascular disease with extremely high morbidity and mortality rates worldwide, and ischemic cardiomyopathy is an important cause of heart failure.
- Conditions
- Heart Failure, Acute Myocardial Infarction (AMI), Acute Heart Failure (AHF)
- Trial name
- VIC-MI (NCT06812546)
- Testing
- Vericiguat
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Dongying Zhang
Homozygous Familial Hypercholesterolemia (HoFH), Coronary Computed Tomography Angiography
Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Coronary Plaque Volumes Measured by Coronary Computed Tomography Angiography (CCTA) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)
This observational, multicenter, retrospective and prospective study aims to evaluate the impact of intensified lipid-lowering therapy including Evinacumab on coronary atherosclerotic plaque burden in patients with Homozygous…
- Trial name
- EVOLVE-HoFH (NCT07447648)
- Where
- 13 sites in France, Italy and 2 more
- Volunteers
- 52 people
- Sponsor
- Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi)
Amblyopia, Strabismus
Multimodal Physician Intervention to Detect Amblyopia
Current research shows low rates of quantitative vision screening at preschool ages in the medical home. This study targets providers (PCPs) to evaluate the effectiveness of a web-based intervention to improve knowledge about…
- Trial name
- EPPICC (NCT01109459)
- Testing
- Pediatric blood pressure screening, Pediatric vision screening
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Alabama at Birmingham
Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension
Pulmonary Embolism Registry From Short-Term Emergency to Long-Term Follow-Up and Surveillance
PERSEUS is an academic, investigator-initiated, multicenter observational registry of adults with acute pulmonary embolism (PE), promoted by Azienda Ospedaliero-Universitaria Careggi (Florence, Italy).
- Conditions
- Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension, Right Ventricular Dysfunction, Pulmonary Embolism (PE)
- Trial name
- PERSEUS (NCT07855679)
- Testing
- Routine clinical care (no study intervention)
- Where
- 16 sites in Italy, Poland and 1 more
- Volunteers
- 5,000 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Retinitis Pigmentosa
Retina Implant Pilot Trial to Evaluate Safety & Efficacy in Blind Patients Having Degenerated Photo-receptors
The outcome of this trial will reveal the possibilities of the retinal implant to improve the situation of patients with hereditary retinal blindness caused by degenerations of the outer retina.
- Trial name
- NCT00515814
- Testing
- Retina implant is surgically placed into subretinal position
- Where
- 2 sites in Germany
- Volunteers
- 15 people
- Sponsor
- Retina Implant AG
Pain, Back
Implementation of the ACP Guideline for Low Back Pain (IMPACt-LBP)
The purpose of this study is to assess whether the primary spine practitioner (PSP) model of care will lead to improvements in patient outcomes, as compared to usual care, based on change in patient-reported PROMIS Pain…
- Trial name
- IMPACt-LBP (NCT05626049)
- Testing
- Primary Spine Provider Model, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 1,800 people
- Sponsor
- Duke University
Osteoarthritis, Pain
An Investigation Into the Role of Walking in Treating the Symptoms of Knee Osteoarthritis: The WalkOut Study
There are over 8.75 million people in the United Kingdom with osteoarthritis in their knees. The effect of this condition can be debilitating. Symptoms are due to wear and tear of the knee joint.
- Conditions
- Osteoarthritis, Pain, Arthritis, Gonarthritis
- Trial name
- WalkOut (NCT02748291)
- Testing
- Walking, Department of Health Physical Activity Guidelines
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Diverticulitis
Improving the Treatment of Acute Uncomplicated Diverticulitis in Routine Care
Acute uncomplicated diverticulitis is often treated with antibiotics, although current evidence shows that antibiotics are not always necessary.
- Trial name
- AUD (NCT07824180)
- Testing
- standardized treatment algorithm
- Volunteers
- 800 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Heart Failure With Reduced Ejection Fraction
Email Nudges to Improve GDMT (MRA) Adherence in Heart Failure
The Email Nudges to Improve GDMT (MRA) Adherence in Heart Failure (ENIGMA-HF) study is a pragmatic parallel-arm randomized control trial of a quality improvement (QI) intervention involving email nudges to cardiology clinic…
- Trial name
- ENIGMA-HF (NCT05806970)
- Testing
- Email Nudge
- Where
- United States
- Sponsor
- University of California, Los Angeles
Kidney Transplantation
Imlifidase for Highly Sensitized Kidney Transplant Recipients With a posItive crossmAtch Against a Deceased Donor: Results of Kidney Transplantations Performed in Accordance to the French Guidelines.
Imlifidase is a recombinant cysteine protease derived from Streptococcus pyogenes and produced in Escherichia coli, which has the ability to cleave and degrade all human IgGs.
- Trial name
- ISKIA (NCT07379957)
- Where
- 20 sites in France
- Volunteers
- 450 people
- Sponsor
- University Hospital, Bordeaux
Clinical Decision Support, Clinical Practice Guidelines
Professional Development in Emergency Medical Services
The ProDEms-trial focuses on nurses and ambulance drivers working in prehospital care, taking care on the one hand of patients suffering from time-sensitive critical conditions like STEMI, acute stroke or severe traumatic brain…
- Conditions
- Clinical Decision Support, Clinical Practice Guidelines, Emergency Medical Services
- Trial name
- ProDEms (NCT02365792)
- Testing
- Clinical Decision Support Tool for Prehospital Care
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- KU Leuven
Atrial Fibrillation, Atrial Flutter
Get With the Guidelines Atrial Fibrillation Registry
Get With The Guidelines-Atrial Fibrillation is designed to assist hospital care teams in consistently providing the latest evidence-based treatment for their AFib patients.
- Trial name
- GWTG-AF (NCT06245187)
- Testing
- GWTG Atrial Fibrillation program
- Where
- United States
- Volunteers
- 17,198 people, healthy volunteers welcome
- Sponsor
- American Heart Association
Overweight, Obesity
Network Meta-analyses of Artificially Sweetened Beverages and Cardiometabolic Risk
Sugars especially in form or sugar-sweetened beverages (SSBs) have been singled out as one of the prime culprits in the dual epidemics of obesity and diabetes.
- Trial name
- NCT02879500
- Testing
- Diet beverages
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Patient With Dyslipidemia
Assessment of Compliance With European and French Guidelines for the Management of Dyslipidaemias
Cardiovascular disease (CVD) due to atherosclerosis of the arterial vessel wall and to thrombosis is the foremost cause of premature mortality and of disability-adjusted life years in Europe, and is also increasingly common in…
- Trial name
- OBDYSLIP (NCT03449784)
- Testing
- Detection of patients with dyslipidemia
- Where
- France
- Volunteers
- 977 people
- Sponsor
- University Hospital, Montpellier
Status Epilepticus
Improving Emergency Management of Status Epilepticus
In the trial the effectiveness of pre-briefing physicians with the current guideline on Status epilepticus (SE) treatment or a consolidated "one page" guideline regarding quality enhancement of the physician's clinical…
- Trial name
- SESIM (NCT03883516)
- Testing
- Pre-briefing with the current SE treatment guidelines, Pre-briefing with a consolidated "one page" SE treatment guide, No Pre-briefing
- Where
- Switzerland
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Soft Tissue Sarcoma
Patient Directed Intervention to Improve the Quality of Life for Patients With Soft Tissue Sarcoma
The primary objective of the study is to compare quality of life (QoL) between patients suffering from soft tissue sarcoma, receiving a multidimensional intervention with those receiving standard treatment.
- Trial name
- YonLife (NCT02204111)
- Testing
- Intervention
- Where
- 7 sites in Germany
- Volunteers
- 77 people
- Sponsor
- GWT-TUD GmbH
Cervical Cancer Screening, Gynecologic Cancers
Compliance to Cervical Cancer Chemoradiation Guidelines: A Multicentric Implementation Audit and Resource Assessment Initiative of National Cancer Grid of India
This is a combination of retrospective and prospective observational study that will be performed across NCG and other participating centers to report compliance to chemoradiation for cervical cancer.
- Conditions
- Cervical Cancer Screening, Gynecologic Cancers, Treatment Compliance, Chemoradiotherapy
- Trial name
- NCG-Compliance (NCT07290972)
- Testing
- Not applicable- observational study
- Where
- 2 sites in India
- Volunteers
- 618 people
- Sponsor
- Tata Memorial Hospital
Fever, Anxiety
LázBarát™ (FeverFriend™) Projekt: Attitude Toward Fever and Its Change in the Healthcare System
The positive effects of fever are supported by a number of physiological, pathophysiological and clinical evidence. However, the negative attitude toward fever is widespread and have become persistent.
- Conditions
- Fever, Anxiety, Help-Seeking Behavior, Virus Diseases
- Trial name
- NCT04633603
- Testing
- FeverFriend mobile application
- Where
- Hungary
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Pecs