Clinical trials: Gonorrhea
Gonorrhoea
Mucosal Immunity Against Neisseria Gonorrhoeae After 4CMenB Vaccination
This is a Phase 2 mechanistic clinical trial to assess the systemic and mucosal immunogenicity of the multicomponent meningococcal serogroup B vaccine (4CMenB or Bexsero (R)) (group 1, 40 subjects) against Neisseria gonorrhoeae…
- Trial name
- NCT04722003
- Testing
- Meningococcal Group B Vaccine
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sexually Transmitted Infection (STI), Gonorrhea
A Clinical Study to Assess the Efficacy of Weekly Doxycycline Prophylaxis to Reduce Bacterial Sexually Transmitted Infections (STI) in Young African Women
This study is for people who may get sexually transmitted infections (STIs). Approximately 580 African adolescent and young adult women ages 13-34 in Africa will be included in this study.
- Conditions
- Sexually Transmitted Infection (STI), Gonorrhea, Syphilis, Chlamydia
- Trial name
- NCT07884240
- Testing
- Doxycycline hyclate, Standard of Care for STI prevention
- Where
- 4 sites in Botswana, Eswatini and 2 more
- Volunteers
- 580 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chlamydia Trachomatis Infection, Neisseria Gonorrhoeae Infection
Optimizing Antibiotic Prescription in STI Clinics Using Rapid POCT
Sexually transmitted infections (STIs) caused by Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are increasing in France, with a significant proportion of asymptomatic infections.
- Conditions
- Chlamydia Trachomatis Infection, Neisseria Gonorrhoeae Infection, Sexually Transmitted Infections, Antimicrobial Resistance / Antibiotic Overuse
- Trial name
- OPTIMISE (NCT07884656)
- Testing
- cobas® Liat® CT/NG Point-of-Care Test
- Where
- 2 sites in France
- Volunteers
- 404 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Gonorrhea, Chlamydia
Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections
The goal of this open-label, randomized trial is to assess the efficacy of doxycycline prophylaxis in reducing incidences of bacterial sexually transmitted infections (STIs) among adolescent and young adult females while also…
- Conditions
- Gonorrhea, Chlamydia, Syphilis, Sexually Transmitted Infections (STIs)
- Trial name
- NCT06738407
- Testing
- Doxycycline hyclate delayed released 200 mg, Doxycycline hyclate delayed released 200 mg weekly, Per standard of care with quarterly STI testing/treatment and sexual health counseling
- Where
- 13 sites in United States
- Volunteers
- 760 people
- Sponsor
- Westat
HIV, Gonorrhea
Improving Clinic Delivery of HIV-related Anal Health Services
This project will test ways to reduce stigma in healthcare settings so that more providers offer, and more patients receive, important anal sex-related HIV services, including anorectal sexually transmitted infection (STI)…
- Conditions
- HIV, Gonorrhea, Chlamydia, Anal Cancer Squamous Cell
- Trial name
- PEACHES 2 (NCT07464236)
- Testing
- PEACHES 2.0 Implementation Strategies
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Neisseria Gonorrhoeae Infection, Chlamydia Trachomatis Infection
Outcomes From Point-of-Care Sexually Transmitted Infection (STI) Testing in an Urban Sexual Health Clinic: A Randomized Trial
The goal of this clinical trial is to learn about the impact of a point-of-care test for gonorrhea and chlamydia in people without symptoms who are seeking sexually transmitted infection testing.
- Trial name
- NCT07399873
- Testing
- Point-of-care assay for chlamydia and gonorrhea, Laboratory-based chlamydia and gonorrhea NAAT, CRISPR-based assay
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gonorrhea Infection
A Study to Evaluate the Performance, Usability, and Contrived Result Interpretation of iStatis Gonorrhea Antigen Test
The objective of this study is to evaluate the performance, usability, and contrived result interpretation of iStatis Gonorrhea Antigen Test (iStatis Gonorrhea Test) in the intended near-patient or point-of-care setting by…
- Trial name
- NCT07569900
- Testing
- iStatis Gonorrhea Antigen Test
- Where
- 3 sites in South Africa
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- bioLytical Laboratories
Neisseria Gonorrhea
Safety and Immunogenicity Study of a Multivalent Gonorrhoea Vaccine
The main goal of this trial is to evaluate the safety and immunogenicity of the candidate N. gonorrhoeae vaccine, LTB-NG6.
- Trial name
- LTBNG601 (NCT07758972)
- Testing
- LTB-NG6, Sodium Chloride 0.9%
- Where
- Germany
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- LimmaTech Biologics AG
Chlamydia, Gonorrhea
A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities
This study includes testing for four STIs (chlamydia, gonorrhea, syphilis, and HIV) at no cost. If positive, individual subjects will also be counseled and offered options for treatment for themselves and their sex partners that…
- Conditions
- Chlamydia, Gonorrhea, Hiv, Syphilis
- Trial name
- NCT06428643
- Testing
- Chlamydia, gonorrhea, syphilis, and HIV screening
- Where
- United States
- Volunteers
- 2,322 people, healthy volunteers welcome
- Sponsor
- Tulane University
Gonorrhea Female, Chlamydia Females
The Integrated Female Sexually Transmitted Infection Testing for HIV Epidemic Control Through PrEP (IN-STEP) Study
Globally, new HIV infections are concentrated in eastern and southern Africa where the infections are largely acquired by women outside of known key populations.
- Conditions
- Gonorrhea Female, Chlamydia Females, Syphilis Female, Trichomonas Vaginalis
- Trial name
- IN-STEP (NCT06743204)
- Testing
- Self-Reported Risk Screening for PrEP and Diagnostic STI testing, Self-reported risk screening for PrEP and syndromic management for STIs
- Where
- Uganda
- Volunteers
- 5,560 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV, Syphilis
Pilot HIV Self-Testing And Self-collected STI Testing Strategy for Sex Worker Empowerment Study
The goal of this clinical trial is to find out if sex work managers (also called "queen mothers") can help female sex workers (FSW) get tested for HIV and other sexually transmitted infections (STIs) by giving out and collecting…
- Conditions
- HIV, Syphilis, Gonorrhea, Chlamydia
- Trial name
- PHASES (NCT07829133)
- Testing
- Venue-based, peer-enhanced strategy for integrated HIV self-testing (and self-collected STI testing
- Where
- Zambia
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Neisseria Gonorrheae Infection
Master Protocol for Evaluating Multiple Infection Diagnostics for Ciprofloxacin-Resistant Neisseria Gonorrhoeae
The goal of this study is to learn if a few investigational tests can correctly find the gene mutation (mutant allele gyrA 91F) that predicts ciprofloxacin resistance in clinical specimens that harbor Neisseria gonorrhoeae.
- Trial name
- MASTERMINDRING (NCT06815536)
- Testing
- Investigational Reflex Test 1, Investigational Reflex Test 2, Investigational Reflex Test 3
- Where
- 8 sites in United States
- Volunteers
- 2,627 people
- Sponsor
- Duke University
HIV-1-infection, Gonorrhea Male
Expedited Partner Therapy and the HIV Prevention Cascade
The HIV epidemic in Peru remains concentrated in the subpopulation of men who have sex with men (MSM), where the prevalence of disease has been estimated between 10-22% in recent epidemiologic surveys.
- Conditions
- HIV-1-infection, Gonorrhea Male, Chlamydia, Partner Communication
- Trial name
- EPT and MSM (NCT04553211)
- Testing
- EPT
- Where
- Peru
- Volunteers
- 663 people
- Sponsor
- University of California, Los Angeles
HIV Infection, Syphilis
Strengthening, Guidance, Health, Empowerment
The goal of this interventional study is to describe the care pathway following the use of an innovative home self-sampling method for the screening of six sexually transmitted infections (STIs) among sex workers met during…
- Conditions
- HIV Infection, Syphilis, Gonorrhea Infection, Chlamydia Infection
- Trial name
- ROSE (NCT07788599)
- Testing
- Self-sampling for six sexually transmitted infections
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Bacterial Vaginosis, Vaginal Microbiome
Single Arm Trial of Menstrual Cups Among Economically Vulnerable Women to Reduce Bacterial Vaginosis and STIs
HIV remains a global pandemic with 37 million infected. In western Kenya, 16% of women in the general population and 29% of the poorest women have HIV.
- Conditions
- Bacterial Vaginosis, Vaginal Microbiome, Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection
- Trial name
- POWWERHealth (NCT05666778)
- Testing
- Menstrual Cup
- Where
- 2 sites in United States, Kenya
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Treponema Pallidum Infection, Chlamydia Trachomatis Infection
Improving Maternal and Child Health Through Point-of-care STI Testing
The goal of this clinical trial is to learn if point-of-care tests (POCTs) for sexually transmitted infections (STIs) improve the timely treatment of syphilis, chlamydia, gonorrhea, and trichomonas in pregnant women.
- Conditions
- Treponema Pallidum Infection, Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection, Trichomonas Vaginalis Vaginitis
- Trial name
- MATCH-POINT (NCT07290439)
- Testing
- Point-of-care STI tests, Standard of care STI testing
- Where
- United States
- Volunteers
- 756 people, healthy volunteers welcome
- Sponsor
- Emory University
HIV, Chlamydia
National Rapid TLC: Testing and Linkage to Care
The goal of this cross-sectional study is to learn if the GeneXpert system is a practical system for HIV and STBBI testing in community-based organizations and health clinics.
- Conditions
- HIV, Chlamydia, Gonorrhea, HCV
- Trial name
- NCT07730801
- Testing
- Xpert® HIV-1 Qual XC
- Where
- 2 sites in Canada
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Gonococcal Infection
Safety and Efficacy Study of Meningococcal Group B Vaccine rMenB+OMV NZ (Bexsero) to Prevent Gonococcal Infection
This is a Phase II, randomized, observer-blind, placebo-controlled, multi-site trial of the FDA licensed rMenB+OMV NZ vaccine, Bexsero.
- Trial name
- NCT04350138
- Testing
- Meningococcal Group B Vaccine
- Where
- 13 sites in United States, Malawi and 1 more
- Volunteers
- 2,606 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Gonorrhea Infection
500-mg Versus 1000-mg Ceftriaxone for Uncomplicated Gonorrhea Infection
This is a study to compare the treatment effect of different doses of ceftriaxone for gonorrhea.
- Trial name
- NCT07710118
- Testing
- ceftriaxone 500-mg, ceftriaxone 1000-mg
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Chlamydia Females, Gonorrhea Female
A Randomized Controlled Trial of Doxycycline Post Exposure Prophylaxis to Prevent Incident Bacterial STIs Among Women in the United States
The bacterial sexually transmitted infections (STIs) chlamydia, gonorrhea, and syphilis cause multiple adverse outcomes in women, and prevention strategies are critically needed.
- Conditions
- Chlamydia Females, Gonorrhea Female, Syphilis Female, Adherence
- Trial name
- NCT07704957
- Testing
- Doxycycline, Standard of Care (SOC)
- Volunteers
- 519 people
- Sponsor
- Tulane University