Clinical trials: General Anesthesia
Any Patient Under General Anesthesia With Propofol Induction
A Novel Two-Step Dosing Induction Strategy (The Propofol Challenge Test) to Minimize Propofol Injection Pain
Propofol is the most widely used intravenous hypnotic agent for the induction of general anesthesia owing to its rapid onset and short duration of action.
- Trial name
- PROTECT (NCT07763548)
- Testing
- Bolus injection, Fractionned onjection
- Where
- Belgium
- Volunteers
- 2,000 people
- Sponsor
- Erasme University Hospital
Gynecologic Surgery, General Anesthesia
Long-term Follow-up of Bio-signals and Quality of Recovery Following Implementation of ERAS Based on the Mobile Application
The goal of this clinical trial is to evaluate the effect of an Enhanced Recovery After Surgery (ERAS) protocol in patients undergoing gynecologic laparoscopic or robotic surgery under general anesthesia.
- Trial name
- NCT07868952
- Testing
- Enhanced Recovery After Surgery, Usual Care
- Where
- South Korea
- Volunteers
- 350 people
- Sponsor
- Wonju Severance Christian Hospital
Intubation, Endotracheal Tube Cuff Pressure
Effect of a Brief Educational Intervention on Endotracheal Tube Cuff Pressure
Endotracheal tube cuff pressure outside the recommended range of 20-30 cmH₂O is common in routine anesthesia practice. Over-inflation can injure the tracheal mucosa, while under-inflation increases the risk of aspiration and…
- Conditions
- Intubation, Endotracheal Tube Cuff Pressure, Anesthesia, Anesthesia,General
- Trial name
- NCT07891195
- Testing
- Brief educational intervention (educational video and reminder posters)
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital
Airway Management, Anesthesia, General
Video Laryngeal Mask SaCoVLM Versus LMA Supreme and Ambu AuraGain in Children
This randomised controlled trial compares three supraglottic airway devices (laryngeal masks) in children with a body weight of 3-30 kg undergoing elective surgery under general anaesthesia: the SaCoVLM video laryngeal mask (UE…
- Conditions
- Airway Management, Anesthesia, General, Pediatric Anesthesia
- Trial name
- SACOVLM-PEDI (NCT07891832)
- Testing
- SaCoVLM video laryngeal mask, LMA Supreme, Ambu AuraGain
- Where
- Czechia
- Volunteers
- 135 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Obesity (BMI>30), General Anesthesia
Frontal EEG Dynamics During Anesthesia in Patients With Obesity and Normal Weight
This prospective observational study aims to compare frontal electroencephalographic (EEG) spectral dynamics between patients with obesity and normal weight undergoing general anesthesia.
- Trial name
- NCT07877090
- Testing
- Frontal Electroencephalography Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Duzce University
General Anesthesia, Testosterone
Comparison of the Effect of Testosterone Administered for Micropenis Hypospadias Surgery With Bispectral Index
The aim of this observational study is to learn the effects of hormone therapy (testosterone) applied in micropenis hypospadias surgery on the depth of anesthesia under general anesthesia.
- Conditions
- General Anesthesia, Testosterone, BIS
- Trial name
- NCT06606496
- Testing
- Bispectral index (BIS)
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Namik Kemal University
Post Operative Pulmonary Complications, Neuromuscular Blockade
Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease
The purpose of the study is to determine which combination of neuromuscular blocking agent and reversal agent is safer to use during anesthesia for patients with chronic kidney disease.
- Conditions
- Post Operative Pulmonary Complications, Neuromuscular Blockade, General Anesthesia
- Trial name
- NCT07203287
- Testing
- Rocuronium, Cisatracurium, Sugammadex
- Where
- United States
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Airway Management, General Anesthesia
Comparison of Three Airway Intubation Devices for First-Attempt Success in General Anesthesia Patients
The goal of this clinical trial is to compare three airway intubation devices in adult patients undergoing general anesthesia who require tracheal intubation.
- Conditions
- Airway Management, General Anesthesia, Tracheal Intubation
- Trial name
- NCT07699653
- Testing
- SPHJ-II, Video lighted stylet, Visual intubation fiberscope
- Where
- China
- Volunteers
- 542 people
- Sponsor
- Guangzhou University of Chinese Medicine
Patients Undergoing General Anesthesia
Deep Neuromuscular Block With Pipecuronium in Patients Undergoing Robotic Thoracic Surgery
Robotic-assisted surgery is rapidly expanding across surgical specialties, including thoracic surgery. Compared with conventional techniques, robotic surgery provides the surgeon with a three-dimensional view and highly precise…
- Trial name
- Deep block (NCT07868094)
- Testing
- Electromiograph
- Where
- Hungary
- Volunteers
- 19 people
- Sponsor
- University of Debrecen
Anesthesia, General, Airway Management
Effect of Laryngeal Mask Cuff Shape on Pharyngeal Stress
Laryngeal masks are widely used supraglottic airway devices, but their cuffs differ considerably in shape and design. The cuff exerts pressure on the pharyngeal structures, which may provoke a physiological stress response and…
- Conditions
- Anesthesia, General, Airway Management, Postoperative Sore Throat
- Trial name
- CUFFSTRESS (NCT07868848)
- Testing
- SaCoVLM video laryngeal mask, LMA Supreme, Ambu AuraGain
- Where
- 2 sites in Czechia
- Volunteers
- 162 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Analgesics, Opioid, Anesthesia, General
Asleep Fiberoptic vs Direct Laryngoscopy Effect on Hemodynamic Stability Using Opioid Free Anesthesia Induction
The goal of this clinical trial is to compare heart rate between the fiberoptic and direct oral intubation using opioid free anesthesia induction.
- Conditions
- Analgesics, Opioid, Anesthesia, General, Heart Rate, Blood Pressure
- Trial name
- NCT06487988
- Testing
- direct conventional laryngoscopy, fiberoptic guided intubation
- Where
- Lebanon
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Pediatric Anesthesia, Airway Management
Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children
This study uses a prospective, up-and-down sequential allocation method to determine the median effective dose (ED50) and 95% effective dose (ED95) of alfentanil combined with propofol for successful laryngeal mask airway (LMA)…
- Conditions
- Pediatric Anesthesia, Airway Management, General Anesthesia, LMA
- Trial name
- NCT07581665
- Testing
- Alfentanil
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Intraoperative Hypotension, Perioperative Care
Machine Learning-Assisted Management of Intraoperative Hypotension for Personalized Treatment
Intraoperative hypotension, defined as a drop in blood pressure during surgery, is a frequent event in patients undergoing general anesthesia.
- Conditions
- Intraoperative Hypotension, Perioperative Care, Hemodynamic Monitoring, Blood Pressure
- Trial name
- HYPOGUARD (NCT07396636)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Nevsehir Public Hospital
Minimal Flow Anesthesia, General Anaesthesia
Minimal Flow Anesthesia and Infection Risk
This study is being done to find out if the heat and moisture that build up during minimal flow anesthesia can lead to the growth of germs (microorganisms) inside the anesthesia equipment.
- Conditions
- Minimal Flow Anesthesia, General Anaesthesia, Inhalation Anesthesia, Infection Risk
- Trial name
- NCT07092046
- Testing
- Sevoflurane (Volatile Anesthetic), Propofol 1%, Remifentanil 2 MG
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
General Anesthesia, Hemodynamics
Effect of Operating Room Noise on BIS and Hemodynamics Under General Anesthesia
This prospective observational study aims to evaluate the impact of operating room noise on bispectral index (BIS) and hemodynamic parameters in patients undergoing general anesthesia.
- Conditions
- General Anesthesia, Hemodynamics, Noise Exposure
- Trial name
- NCT07194707
- Testing
- Intraoperative Noise Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
General Anesthesia, Elective Surgery
Effect of Pre-injection of Rocuronium on Neuromuscular Blockade Onset Time and Hemodynamics During General Anesthesia Induction
This is a single-center, prospective, randomized, controlled trial comparing pre-injection versus standard bolus administration of rocuronium bromide for general anesthesia induction.
- Trial name
- NCT07716891
- Testing
- Rocuronium Bromide (Pretreatment Injection), Rocuronium Bromide (Conventional Injection)
- Where
- China
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Hypothermia Following Anesthesia, Intraoperative Complications
Goal-Directed Temperature Management During Prolonged Abdominal Surgery
During long operations on the abdomen, patients often get cold. Doctors call this perioperative hypothermia. Even a small drop in body temperature can cause problems, such as more bleeding, wound infection, and a longer stay in…
- Conditions
- Hypothermia Following Anesthesia, Intraoperative Complications, Body Temperature Changes, Anesthesia, General
- Trial name
- NCT07854704
- Testing
- Forced-air warming, Intravenous fluid warming, Unwarmed intravenous fluids
- Where
- Russia
- Volunteers
- 61 people
- Sponsor
- The Leningrad Regional Clinical Hospital
Patients Undergoing General Anesthesia
A Comparative Study of the Next-Generation TetraGraph® and Mechanomyography Neuromuscular Monitors in Clinical Settings
Background: Neuromuscular monitoring plays a critical role in reducing postoperative residual neuromuscular blockade (PRNB), a significant risk factor for respiratory complications.
- Trial name
- MMG vs EMG NG (NCT07750405)
- Testing
- Mechanomiograph (MMG), Electromiograph (EMG)
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- University of Debrecen
Hip Arthroplasty, Knee Arthroplasty
Anaesthesia for Hip and Knee Arthroplasty (SPIGA)
Beneficial and harmful effects of spinal versus general anaesthesia in patients undergoing hip and knee arthroplasty.
- Conditions
- Hip Arthroplasty, Knee Arthroplasty, Spinal Anesthesia, General Anesthesia
- Trial name
- SPIGA (NCT07834242)
- Testing
- Spinal anaesthesia, General anaesthesia
- Volunteers
- 3,000 people
- Sponsor
- Zealand University Hospital
Healthy Participants Study, General Anesthesia
Safety, Pharmacokinetics, and Pharmacodynamics of Continuous KL0011034 Infusion in Healthy Chinese Adults
This Phase 1 study will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of continuous intravenous infusion of KL0011034 Injection in healthy Chinese adults.
- Trial name
- NCT07841626
- Testing
- KL0011034 Injection, Propofol Injectable Emulsion
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University