Clinical trials: Functional Outcome
Type 2 Diabetes Mellitus
The HOME Trial: Hyperinsulinaemia: the Outcome of Its Metabolic Effects, a Randomized Controlled Trial
The HOME-trial is a prospective, randomized controlled trial. The purpose of this study is to investigate the effects of metformin HCL in patients with type 2 diabetes mellitus intensively treated with insulin on the quality of…
- Trial name
- NCT00375388
- Testing
- Metformin on top of intensive insulin therapy
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Bethesda General Hospital, Hoogeveen
Carpal Tunnel Syndrome (CTS)
Effect of Neural Mobilization on Carpal Tunnel Syndrome
The study group (G1) consisted of 15 patients treated by neural mobilization techniques targeting the median nerve, in addition to a selected physical therapy program including transcutaneous electrical nerve stimulation (TENS)…
- Trial name
- CTS (NCT07779096)
- Testing
- Neuromobilization
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Other Complications of Esophagostomy
Outcome Study of Restrictive vs. Liberal Intraoperative Fluid Management Guided by PPV in Esophagectomy
The purpose of this study is to determine whether intraoperative restrictive fluid management guided by pulse pressure variation produces a better effect on the postoperative lung function, kidney function, inflammatory response…
- Trial name
- PPV (NCT01933451)
- Testing
- Intraoperative fluid therapy
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital
Acute Ischemic Stroke (AIS)
Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial
Acute ischemic stroke caused by blockage of a large artery in the brain is one of the leading causes of death and long-term disability worldwide.
- Trial name
- TOPAZ (NCT07734792)
- Testing
- Tirzepatide, Standard Medical Care (SMC)
- Where
- China
- Volunteers
- 726 people
- Sponsor
- yifang zhu
Cranial Neurosurgery
Heart Rate Variability and Processed EEG Features as Predictors of Postoperative Outcomes After Cranial Neurosurgery
Patients undergoing cranial neurosurgery face a high-risk postoperative period, particularly during emergence from anesthesia and early recovery in the post-anesthesia care unit (PACU).
- Trial name
- HERO-PACU (NCT07443072)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
COVID-19
Retrospective Study of COVID-19 on Reproductive Function
This multi-center, retrospective cohort study aimed to determine which factors are associated with ongoing pregnancy rates in infertile patients received ART treatments during the current outbreak of COVID-19 infection.Couples…
- Trial name
- NCT05685966
- Testing
- no intervention
- Where
- 3 sites in China
- Volunteers
- 400 people
- Sponsor
- Jinling Hospital, China
Psychosis
Efficiency of a Composite Personalised Care on Functional Outcome in Early Psychosis
Chronic psychosis, including schizophrenia is now viewed as a progressive disorder where cognitive deficits predate the clinical onset.
- Trial name
- PSYCARE (NCT05796401)
- Testing
- Cognitive training, Personalized neuroprotective strategies : Vitamin B12, folinic acid, Omega 3, NAC, Treatment as usual (TAU)
- Where
- 13 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier St Anne
Ischemic Stroke, Acute, Blood Pressure Variability
Continuous Blood Pressure Variability and Small Vessel Disease in Acute Ischemic Stroke
This prospective observational cohort study examines whether blood pressure variability and nighttime blood pressure patterns, measured non-invasively over 72 hours with a cuffless ring-type wearable device, help predict recovery…
- Conditions
- Ischemic Stroke, Acute, Blood Pressure Variability, Cerebral Small Vessel Disease, White Matter Hyperintensity
- Trial name
- COMPASS (NCT07903922)
- Testing
- Cuffless ring-type continuous blood pressure monitor
- Where
- South Korea
- Volunteers
- 450 people
- Sponsor
- Minyoul Baik
Osteoarthritis Knee
Effect of Mesenchymal Stem Cells in Primary Knee Osteoarthritis
Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. Incidence and prevalence of osteoarthritis rise with increasing age.
- Trial name
- NCT05783154
- Testing
- Autologous Adipose Tissue-Derived Mesenchymal Stem Cell
- Where
- Bangladesh
- Volunteers
- 84 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Erectile Dysfunction
Primary Care ERectile Function Outcome Registry for Men
The PERFORM registry is a structured, real-world data platform designed to systematically capture patient characteristics, disease severity and treatment patterns of Erectile Dysfunction (ED) across Pakistan.
- Trial name
- PERFORM (NCT07356609)
- Volunteers
- 255 people
- Sponsor
- Nabiqasim Industries (Pvt) Ltd
Osteoarthritis, Knee
Outcome Following Hylan F- 20 (Synvisc) + Corticosteroid Injections for the Treatment of Osteoarthritis of the Knee
The goal of viscosupplementation is to replenish synovial fluid, which will improve patient symptoms and mobility. Viscosupplementation of the knee with hyaluronic acid injections has been shown to improve symptoms in patients…
- Trial name
- NCT00312533
- Testing
- Hylan F- 20
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Steadman Hawkins Research Foundation
Rectus Abdominus; Diastasis, Complicating Delivery
Abdominal Trunk Function After Surgical Repair of Abdominal Rectus Muscle Diastasis
There is insufficient evidence regarding the benefit from surgical reconstruction of post-partum abdominal rectus muscle diastasis.
- Trial name
- NCT03623594
- Testing
- Surgical repair of the diastasis
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Heart; Surgery, Heart, Functional Disturbance as Result, Pediatric ALL
Oblique Versus Transverse Orientation Approach for Internal Jugular Venous Cannulation in Pediatrics
this study aimed to compare oblique versus transverse orientation approach in jugular venous cannulation in term of cannulation success in pediatric heart surgery patients
- Trial name
- NCT05656937
- Testing
- internal jugular venous cannulation
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Brain Damage, Cerebral Palsy
Efficacy of Modified Constraint-induced Movement Therapy in Children With Brain Damage
This research centers on the comparison of the immediate efficacy (right after therapy) and the maintained efficacy (3 months and 6 months) between "Modified Constraint-Induced Movement Therapy" (mCIMT) group and control group at…
- Conditions
- Brain Damage, Cerebral Palsy, Traumatic Brain Damage
- Trial name
- NCT01076257
- Testing
- Modified Constraint-induced Movement Therapy
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Chang Gung Memorial Hospital
Ischemic Stroke, Cognitive Impairment
Cognitive Impairment and Outcome of Acute Ischemic Stroke.
The aim of this study is to assess the use of ASPECTS and stroke biomarkers to predict the outcome and cognitive impairment in acute ischemic stroke.
- Conditions
- Ischemic Stroke, Cognitive Impairment, Outcome, Fatal
- Trial name
- NCT04235920
- Testing
- Montreal Cognitive Assessment (MoCA)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Mansoura University Hospital
Ventricular Septal Defect
Cardiopulmonary Function in Adults Born With a Ventricular Septal Defect
The overall objective for this study is to evaluate the cardiopulmonary function of VSD-patients compared with healthy age- and gender-matched controls.
- Trial name
- NCT03684161
- Testing
- Cardiopulmonary function
- Where
- Denmark
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Knee Osteoarthritis, Arthropathy of Knee Joint
Outcome After Total Knee Arthroplasty Under General or Spinal Anesthesia
Previous retrospective database studies suggest that total knee arthroplasty (TKA) surgery under spinal anesthesia has less complications than when performed under general anesthesia.
- Conditions
- Knee Osteoarthritis, Arthropathy of Knee Joint, Knee Pain Chronic, Rheumatoid Arthritis
- Trial name
- NCT03364088
- Testing
- Spinal anesthesia with tourniquet, Spinal anesthesia without tourniquet, General anesthesia with tourniquet
- Where
- Finland
- Volunteers
- 402 people
- Sponsor
- Riku Antero Palanne
Interpersonal Functioning, Psychological Distress
Assessing the Mechanism of Change of Functional Analytic Psychotherapy
This study seeks to assess the mechanisms of change of Functional Analytic Psychotherapy (FAP). FAP is a process-outcome psychotherapy that focuses on the therapeutic relationship, providing services to participants presenting…
- Trial name
- FAP (NCT03562962)
- Testing
- Functional Analytic Psychotherapy
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Heart; Surgery, Heart, Functional Disturbance as Result, Anxiety
Combination of Music and Relaxing Light on the Patient's Anxiety After Cardiac Surgery in the Intensive Care Unit
Cardiac surgery is not trivial. It requires opening the thorax in certain indications: coronary artery bypass grafting, valve replacements or plasties, aortic dissection, etc.
- Conditions
- Heart; Surgery, Heart, Functional Disturbance as Result, Anxiety, Pain, Postoperative, Delirium
- Trial name
- RéaRelax (NCT05178680)
- Testing
- relaxation session combining music and soft light
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Poitiers University Hospital
Acute Stroke, Ischemic Stroke
Impact of Stroke Unit Care on Acute Stroke Outcomes
This observational study is designed to evaluate and compare the recovery outcomes of patients who have experienced their first acute stroke.
- Conditions
- Acute Stroke, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT07750860
- Volunteers
- 140 people
- Sponsor
- Assiut University