Clinical trials: Functional Neurological Disorder
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis, Functional Neurological Disorders
Bridging Gaps in the Multidimensional Assessment and Management of Overlapping Symptoms in Multiple Sclerosis and Functional Motor Disorders: Prevalence and Rehabilitation Effectiveness
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system that may cause a broad range of motor and non-motor symptoms.
- Trial name
- NCT07856485
- Testing
- Functional Motor Disorder-Specific Multidisciplinary Rehabilitation, Conventional Multiple Sclerosis Rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 192 people
- Sponsor
- IRCCS San Raffaele
Functional Neurological Disorders, Multiple Sclerosis
Assessment of the Frequency of Functional Neurological Disorders in Multiple Sclerosis and Analysis of Clinical and Psychological Determinants
Multiple sclerosis (MS) and functional neurological disorders (FND) share clinical features, which may result in FND being overlooked in patients with MS.
- Trial name
- FTNF-SEP (NCT07849816)
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Functional Neurological Symptom Disorder
Measuring Change in Individuals With Functional Neurological Symptom Disorder
Functional Neurological Symptom Disorders (FNSD) are one of the commonest reasons why patients are referred to neurologists. They are as disabling as neurological disorders causing similar symptoms related to more readily…
- Trial name
- NCT07864454
- Testing
- STH Specialist Neurology Pyschotherapy
- Where
- United Kingdom
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Functional Neurological Symptom Disorder, Functional Seizures
Accelerated TMS for Seizure-Type Functional Neurologic Disorders
The purpose of this project is to assess the feasibility, tolerability, and preliminary efficacy of using an accelerated, intermittent theta burst stimulation (a-iTBS-rTMS) protocol targeting the left dorsolateral prefrontal…
- Trial name
- FND-seiz (NCT07059325)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Functional Neurological Symptom Disorder
Cognitive Disengagement Syndrome in Functional Neurological Symptom Disorder
This cross-sectional observational case-control study aims to investigate symptoms of sluggish cognitive tempo (SCT), also known as cognitive disengagement syndrome (CDS), in adults diagnosed with Functional Neurological Symptom…
- Trial name
- NCT07451821
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Elazığ Mental Health and Diseases Hospital
Functional Neurological Disorders
Functional Neurological Disorders in Patients Admitted in Stroke Units
Functional neurological disorders are an important subgroup of patients with stroke mimics admitted to stroke unit.Their clinical profile and outcome are poorly known.
- Trial name
- NEUROFON (NCT04662372)
- Testing
- Description
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Functional Neurological Disorder, Conversion Disorder
Restoring Independence With Stimulation-Enhanced Treatment for People With Functional Neurological Disorder
The goal of this clinical trial is to test a new treatment for adults with walking problems due to Functional Neurological Disorder (FND).
- Trial name
- RISE-FND (NCT07769970)
- Testing
- Stimulation-Enhanced Physical Therapy, Active Comparator
- Where
- New Zealand
- Volunteers
- 60 people
- Sponsor
- University of Auckland, New Zealand
Functional Neurological Disorder
Clinical Evaluation of HRV Biofeedback in Functional Neurological Disorders Compared to Placebo
Evaluation of the clinical effects of the Heart Rate Variability biofeedback training with patients suffering from Functional neurological Disorders compared with placebo.
- Trial name
- HRV_BFB_FND (NCT06422819)
- Testing
- Heart rate variability Biofeedback [HRV-BFB], Pseudo HRV-BFB
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Functional Neurological Disorder
Psilocybin in Functional Neurological Disorder
The goal of this study is to learn about the brain network response in people who have functional neurological disorder who are administered with a single dose of the psychedelic psilocybin with therapeutic support.
- Trial name
- PsiFUND (NCT05723276)
- Testing
- Psilocybin
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College London
Functional Neurological Disorder, Motor Symptoms
Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND)
This clinical study will test if adding a non-invasive stimulation of the vagus nerve through the ear during physiotherapy brings an improvement to FND (Functional Neurological Disorder) patients with motor symptoms.
- Trial name
- TMS-VNS (NCT07710677)
- Testing
- Vagial Nerve Stimulation (VNS) active stimulation
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Functional Neurological Disorder
Pilot Neurobehavioral Therapy for Functional Neurological Disorder
The goal of this pilot randomized clinical trial is to learn if Neurobehavioral Therapy (NBT) works to treat motor functional neurological disorder (mFND) (also referred to as functional motor disorder).
- Trial name
- NBT for mFND (NCT06873698)
- Testing
- Neuro-behavioral Therapy, Standard Medical Care (SMC)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rhode Island Hospital
Functional Neurological Disorder
Dance/Movement Therapy for Functional Neurological Disorder
Building on evidence for somatic or physical interventions in functional neurological disorder (FND), the goal of this study is to test the feasibility of a structured dance/movement task in individuals with FND, and explore the…
- Trial name
- DMTforFND (NCT07378488)
- Testing
- Structured dance/movement, Physical exercise/body coordination
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College London
Functional Neurological Disorder, Convulsion, Non-Epileptic
Establishment of an Interdisciplinary Functional Neurological Disorder (FND) Treatment Program and Development of a Clinical Care Pathway for FND
The purpose of this study is to help providers develop an interdisciplinary treatment pathway for functional neurological disorder (FND) at University of Alabama at Birmingham (UAB), and will involve psychiatry, speech therapy…
- Conditions
- Functional Neurological Disorder, Convulsion, Non-Epileptic, Functional Seizure
- Trial name
- NCT06362161
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- University of Alabama at Birmingham
Functional Neurological Disorder
Feasibility of Remotely Measured Activity Behavior for Individuals With Functional Neurologic Disorder
This study evaluates whether remotely measured daily activity behavior, captured through a thigh-worn accelerometer, can serve as a reliable and ecologically valid indicator of symptom impact in individuals with Functional…
- Trial name
- NCT07478666
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Functional Neurological Disorder, Functional Movement Disorder
The Effect of Psychoeducational Diagnosis Communication on Perception of Illness, Satisfaction, and Behavioral Intentions Among Patients With Functional Neurological Movement Disorders
Functional neurological movement disorders are common conditions that can lead to significant limitations in daily life. They result from a functional disorder in the brain.
- Trial name
- NCT07588282
- Testing
- Psychoeducational communication guide for first-diagnosis of FND
- Where
- Austria
- Volunteers
- 35 people
- Sponsor
- Medical University of Graz
Functional Movement Disorder, Functional Neurological Disorder
Tremor Retrainer Software Application for Functional Tremor
The purpose of this clinical trial is to learn about the Tremor Retrainer smartphone application and Simplified Functional Movement Disorder Rating Scale in patients with functional tremor.
- Conditions
- Functional Movement Disorder, Functional Neurological Disorder, Functional Neurological Symptom Disorder
- Trial name
- NCT06257069
- Testing
- Tremor Retrainer Smartphone Application
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Functional Neurological Disorder, Motor FND
Impact of Theta Burst Repetitive Transcranial Magnetic Stimulation on the Patient's Self-reported Improvement in Their Motor Functional Neurological Disorder
Functional neurological disorder (FND) is a condition that causes significant suffering and disability. It is defined by the presence of neurological symptoms that interfere with an individual's functioning and are not consistent…
- Trial name
- Thêta-mTNF (NCT07527403)
- Testing
- theta-burst rTMS (repetitive transcranial magnetic stimulation)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Hospital Center Guillaume Régnier
Functional Neurological Disorder
Investigation of Patients Presenting With Acute Functional Neurological Symptoms
Retrospective Single-center Analysis of Patients Presenting With Acute Neurological Symptoms, Aiming to Characterize the Frequency, Clinical Features, Diagnostic Pathways, and Healthcare Utilization of Patients with Functional…
- Trial name
- FONDA (NCT07538414)
- Testing
- collection of patient data
- Where
- Switzerland
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Functional Neurological Symptom Disorder
Trial Of Neurostimulation Treatment and Investigation for Causes of Functional Motor Symptoms: a Pilot Study
A pilot randomised controlled trial (RCT) of single-pulse transcranial magnetic stimulation (TMS) over the motor cortex to investigate efficacy in improving motor FND symptoms and to make a preliminary investigation of predictors…
- Trial name
- TONICS (NCT05829005)
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- King's College London